Comparative Lipidomics and Metabolomics Reveal the Underlying Mechanisms of Taurine in the Alleviation of Nonalcoholic Fatty Liver Disease Using the Aged Laying Hen Model
ConclusionThis study firstly reveals underlying metabolic mechanisms of taurine alleviating NAFLD using the aged hen model, thereby laying the foundation for taurine's application in the prevention of NAFLD in both human and poultry. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - November 2, 2023 Category: Food Science Authors: Zhengwang Yu,
Manman Cheng,
Shimei Luo,
Jingjing Wei,
Tieping Song,
Yanzhang Gong,
Zhongxin Zhou Tags: Research Article Source Type: research
From seeds to survival rates: investigating Linum usitatissimum ’s potential against ovarian cancer through network pharmacology
This study combines data mining, network pharmacology, and molecular docking analysis to pioneer an innovative approach for ovarian cancer treatment by identifying potent phytochemicals. Findings of current study revealed that Apigenin, Vitamin E, Palmitic acid, Riboflavin, Isolariciresinol, 5-Dehydro-avenasterol, Cholesterol, Pantothenic acid, Nicotinic acid, Campesterol, Beta-Sitosterol, Stigmasterol, Daucosterol, and Vitexin suppress tumor growth by influencing AKT1, JUN, EGFR, and VEGFA. Kaplan–Meier survival analysis spotlighted AKT1, JUN, EGFR, and VEGFA as potential diagnostic and prognostic biomarkers for ovarian...
Source: Frontiers in Pharmacology - October 30, 2023 Category: Drugs & Pharmacology Source Type: research
GSE221164 The coenzyme A precursor pantethine restrains sarcoma growth through promotion of type 1 immunity
Contributors : Richard MIALLOT ; Virginie MILLET ; Anais ROGER ; Romain FENOUIL ; Catherine TARDIVEL ; Jean-Charles MARTIN ; Laetitia SHINTU ; Paul BERCHARD ; Juliane SOUSA LANZA ; Bernard MALISSEN ; Sandrine HENRI ; Sophie UGOLINI ; Aur élie DUTOUR ; Pascal FINETTI ; François BERTUCCI ; Jean-Yves BLAY ; Franck GALLAND ; Philippe NAQUETSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe tumor microenvironment is a dynamic network of stromal, cancer and immune cells that interact and compete for resources. Mitochondria play an essential role in the control of metabo...
Source: GEO: Gene Expression Omnibus - October 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Element and Water-Soluble Vitamins Profile of Rhus coriaria L. (Sumac) Grown in Different Regions
In this study, the amounts of some elements and water-soluble vitamins in Rhus coriaria L. (Sumac) samples grown in different regions were analyzed by ICP-OES and HPLC, respectively. The maximum amount of Na, K, Mg, and P was determined in the sumac samples of Kadana, Sheladize, Maraş, and Derishke regions, respectively. The richest regions in terms of trace elements such as Zn, Cu, Fe, Se, Mn, Cr, Mo, Ni, and B were Charput, Derishke, Ranya, Charput, Ranya, Derishke, Elazığ, Derishke, and Kadana, respectively. The highest amount of As, Cd, Pb, and Hg in sumac samples were determined in Kadana, Kadana, Trawanish, and Ch...
Source: Biological Trace Element Research - September 30, 2023 Category: Biology Authors: Haval Mohammed Ali Fikret Karata ş Dursun Özer Sinan Saydam Source Type: research
Element and Water-Soluble Vitamins Profile of Rhus coriaria L. (Sumac) Grown in Different Regions
In this study, the amounts of some elements and water-soluble vitamins in Rhus coriaria L. (Sumac) samples grown in different regions were analyzed by ICP-OES and HPLC, respectively. The maximum amount of Na, K, Mg, and P was determined in the sumac samples of Kadana, Sheladize, Maraş, and Derishke regions, respectively. The richest regions in terms of trace elements such as Zn, Cu, Fe, Se, Mn, Cr, Mo, Ni, and B were Charput, Derishke, Ranya, Charput, Ranya, Derishke, Elazığ, Derishke, and Kadana, respectively. The highest amount of As, Cd, Pb, and Hg in sumac samples were determined in Kadana, Kadana, Trawanish, and Ch...
Source: Biological Trace Element Research - September 30, 2023 Category: Biology Authors: Haval Mohammed Ali Fikret Karata ş Dursun Özer Sinan Saydam Source Type: research
DNA damage-induced senescence is associated with metabolomic reprogramming in breast cancer cells
Biochimie. 2023 Sep 25:S0300-9084(23)00248-1. doi: 10.1016/j.biochi.2023.09.021. Online ahead of print.ABSTRACTSenescence due to exogenous and endogenous stresses triggers metabolic reprogramming and is associated with many pathologies, including cancer. In solid tumors, senescence promotes tumorigenesis, facilitates relapse, and changes the outcomes of anti-cancer therapies. Hence, cellular and molecular mechanisms regulating senescent pathways make attractive therapeutic targets. Cancer cells undergo metabolic reprogramming to sustain the growth-arrested state of senescence. In the present study, we aimed to understand t...
Source: Biochimie - September 27, 2023 Category: Biochemistry Authors: Neena George Manjunath B Joshi Kapaettu Satyamoorthy Source Type: research
DNA damage-induced senescence is associated with metabolomic reprogramming in breast cancer cells
Biochimie. 2023 Sep 25:S0300-9084(23)00248-1. doi: 10.1016/j.biochi.2023.09.021. Online ahead of print.ABSTRACTSenescence due to exogenous and endogenous stresses triggers metabolic reprogramming and is associated with many pathologies, including cancer. In solid tumors, senescence promotes tumorigenesis, facilitates relapse, and changes the outcomes of anti-cancer therapies. Hence, cellular and molecular mechanisms regulating senescent pathways make attractive therapeutic targets. Cancer cells undergo metabolic reprogramming to sustain the growth-arrested state of senescence. In the present study, we aimed to understand t...
Source: Biochimie - September 27, 2023 Category: Biochemistry Authors: Neena George Manjunath B Joshi Kapaettu Satyamoorthy Source Type: research
Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis
ConclusionGlycerolipid metabolism is significantly involved in BD and MDD. Pyruvate metabolism is significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for MDD to distinguish from BD, and pantothenic acid may be a potential biomarker for BD to distinguish from MDD. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - September 6, 2023 Category: Psychiatry Source Type: research
High plasma concentrations of vanin-1 in patients with coronary artery disease
Heart Vessels. 2023 Aug 15. doi: 10.1007/s00380-023-02305-1. Online ahead of print.ABSTRACTVanin-1 is a pantetheinase that hydrolyzes pantetheine to pantothenic acid and cysteamine. Vanin-1 has become recognized to be associated with oxidative stress and inflammation. In animal models, vanin-1 was reported to accelerate atherosclerosis. However, no study has reported blood vanin-1 concentrations in patients with coronary artery disease (CAD). We investigated plasma vanin-1 concentrations in 388 patients undergoing elective coronary angiography for suspected CAD. Patients with acute coronary syndrome were excluded. Of the 3...
Source: Atherosclerosis - August 15, 2023 Category: Cardiology Authors: Yoshimi Kishimoto Emi Saita Reiko Ohmori Kazuo Kondo Yukihiko Momiyama Source Type: research
High plasma concentrations of vanin-1 in patients with coronary artery disease
AbstractVanin-1 is a pantetheinase that hydrolyzes pantetheine to pantothenic acid and cysteamine. Vanin-1 has become recognized to be associated with oxidative stress and inflammation. In animal models, vanin-1 was reported to accelerate atherosclerosis. However, no study has reported blood vanin-1 concentrations in patients with coronary artery disease (CAD). We investigated plasma vanin-1 concentrations in 388 patients undergoing elective coronary angiography for suspected CAD. Patients with acute coronary syndrome were excluded. Of the 388 study patients, CAD was found in 207 patients [1-vessel (1-VD), n = 88; 2-v...
Source: Heart and Vessels - August 15, 2023 Category: Cardiology Source Type: research
Serum Metabolomic Markers of Dairy Consumption: Results from the Atherosclerosis Risk in Communities Study and the Bogalusa Heart Study
CONCLUSIONS: We identified metabolomic associations with dietary intake of dairy, including three associations found in two independent cohort studies. These results suggest that myristate (14:0) and pantothenate (vitamin B5) are candidate biomarkers of dairy consumption.PMID:37541543 | DOI:10.1016/j.tjnut.2023.08.001 (Source: Atherosclerosis)
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Lauren Bernard Jingsha Chen Hyunju Kim Zhijie Huang Lydia Bazzano Lu Qi Jiang He Varun S Rao Kaitlin S Potts Tanika N Kelly Kari E Wong Lyn M Steffen Bing Yu Eugene P Rhee Casey M Rebholz Source Type: research
Serum Metabolomic Markers of Dairy Consumption: Results from the Atherosclerosis Risk in Communities Study and the Bogalusa Heart Study
CONCLUSIONS: We identified metabolomic associations with dietary intake of dairy, including three associations found in two independent cohort studies. These results suggest that myristate (14:0) and pantothenate (vitamin B5) are candidate biomarkers of dairy consumption.PMID:37541543 | DOI:10.1016/j.tjnut.2023.08.001 (Source: Atherosclerosis)
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Lauren Bernard Jingsha Chen Hyunju Kim Zhijie Huang Lydia Bazzano Lu Qi Jiang He Varun S Rao Kaitlin S Potts Tanika N Kelly Kari E Wong Lyn M Steffen Bing Yu Eugene P Rhee Casey M Rebholz Source Type: research
