Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia
Yakugaku Zasshi. 2024;144(1):33-37. doi: 10.1248/yakushi.23-00161-3.ABSTRACTThe genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029T and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092T. On the other hand, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Masami Ishibashi Source Type: research
Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia
Yakugaku Zasshi. 2024;144(1):33-37. doi: 10.1248/yakushi.23-00161-3.ABSTRACTThe genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029T and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092T. On the other hand, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Masami Ishibashi Source Type: research
Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia
Yakugaku Zasshi. 2024;144(1):33-37. doi: 10.1248/yakushi.23-00161-3.ABSTRACTThe genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029T and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092T. On the other hand, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Masami Ishibashi Source Type: research
Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia
Yakugaku Zasshi. 2024;144(1):33-37. doi: 10.1248/yakushi.23-00161-3.ABSTRACTThe genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029T and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092T. On the other hand, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Masami Ishibashi Source Type: research
Learning from Natural Products: Study on Actinomycetes of the Genus Nocardia
Yakugaku Zasshi. 2024;144(1):33-37. doi: 10.1248/yakushi.23-00161-3.ABSTRACTThe genus Nocardia comprises gram-positive bacteria, most of which are pathogenic and cause opportunistic infections of the lungs, skin, and brain in humans. Based on a collaboration study with the Medical Mycology Research Center, Chiba University, we focused on Nocardia actinomycetes as a new natural-product resource. First, by culturing (monoculture) Nocardia in various media, we isolated a new aminocyclitol nabscessin A from Nocardia abscessus IFM10029T and a new γ-lactone inohanalactone from Nocardia inohanaensis IFM0092T. On the other hand, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 3, 2024 Category: Drugs & Pharmacology Authors: Masami Ishibashi Source Type: research
Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2 ’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid
Green Chem., 2024, Accepted Manuscript DOI: 10.1039/D3GC04344D, PaperPan Hu, Xiaofan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Zedu Huang, Fener Chen D-Pantothenic acid (D-PaA) is an essential vitamin for human beings, and the global market value of calcium pantothenate, the commercial form of D-PaA, has been estimated to be over one... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - January 3, 2024 Category: Chemistry Authors: Pan Hu Source Type: research
Inflammatory mediators, oxidative stress and genetic disturbance in rheumatoid arthritis rats supported by alfalfa seeds metabolomic constituents via blocking interleukin-1receptor
In conclusion, Trans-taxifolin was isolated for the first time from the genus Medicago. MS butanol fraction seeds extract and IL-1 RA were considered as anti-rheumatic agents.PMID:38158718 | DOI:10.1002/cbdv.202301653 (Source: Chemistry and Biodiversity)
Source: Chemistry and Biodiversity - December 30, 2023 Category: Biochemistry Authors: Asmaa F Aboul Naser Yomna R Ahmed Mona A Mohammed Mohamed Aboelmagd Mona E Aboutabl Entesar E S Hassan Wagdy K B Khalil Manal A Hamed Source Type: research
Preparation of potential organic fertilizer rich in γ-polyglutamic acid via microbial fermentation using brewer's spent grain as basic substrate
Bioresour Technol. 2023 Dec 18:130216. doi: 10.1016/j.biortech.2023.130216. Online ahead of print.ABSTRACTBrewer's spent grain (BSG) is a main byproduct of the beer industry. BSG is rich in a variety of nutrients, and the search for its effective, high-value utilization is ongoing. Environmental probiotic factor γ-PGA was produced by fermenting Bacillus subtilis with BSG substrate and the fermenting grain components were analyzed. The γ-PGA yield reached 31.58 ± 0.21 g/kg of BSG. Gas chromatography-mass spectrometry and non-targeted metabolomics analyses revealed 73 new volatile substances in the fermenting grains. Furt...
Source: Bioresource Technology - December 20, 2023 Category: Biotechnology Authors: Fengqing Wang Yanmei Chen Jia Zheng Can Yang Li Li Rong Li Meilin Shi Zhongxuan Li Source Type: research
Preparation of potential organic fertilizer rich in γ-polyglutamic acid via microbial fermentation using brewer's spent grain as basic substrate
Bioresour Technol. 2023 Dec 18:130216. doi: 10.1016/j.biortech.2023.130216. Online ahead of print.ABSTRACTBrewer's spent grain (BSG) is a main byproduct of the beer industry. BSG is rich in a variety of nutrients, and the search for its effective, high-value utilization is ongoing. Environmental probiotic factor γ-PGA was produced by fermenting Bacillus subtilis with BSG substrate and the fermenting grain components were analyzed. The γ-PGA yield reached 31.58 ± 0.21 g/kg of BSG. Gas chromatography-mass spectrometry and non-targeted metabolomics analyses revealed 73 new volatile substances in the fermenting grains. Furt...
Source: Bioresource Technology - December 20, 2023 Category: Biotechnology Authors: Fengqing Wang Yanmei Chen Jia Zheng Can Yang Li Li Rong Li Meilin Shi Zhongxuan Li Source Type: research
MYC protein helps cancer to take its vitamins
Nature, Published online: 12 December 2023; doi:10.1038/d41586-023-03764-2Identifying nutrient dependencies of cancer cells is crucial for developing new therapies. The discovery that an aggressive type of cancer cell has a high uptake of vitamin B5 sheds light on the link between vitamin availability and tumour growth. (Source: Nature AOP)
Source: Nature AOP - December 12, 2023 Category: Research Authors: Martina Wallace Source Type: research
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Eur J Pharmacol. 2023 Nov 30:176220. doi: 10.1016/j.ejphar.2023.176220. Online ahead of print.ABSTRACTVanin1 (VNN1) is an exogenous enzyme with pantetheinase activity that mainly exerts physiological functions through enzyme catalysis products, including pantothenic acid and cysteamine. In recent years, the crosstalk between VNN1 and metabolism and oxidative stress has attracted much attention. As a result of the ability of VNN1 to affect multiple metabolic pathways and oxidative stress to exacerbate or alleviate pathological processes, it has become a key component of disease progression. This review discusses the functio...
Source: European Journal of Pharmacology - December 2, 2023 Category: Drugs & Pharmacology Authors: Hao Yu Yuying Cui Fangyue Guo YuTong Zhu Xiaonan Zhang Dong Shang Deshi Dong Hong Xiang Source Type: research
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Eur J Pharmacol. 2023 Nov 30:176220. doi: 10.1016/j.ejphar.2023.176220. Online ahead of print.ABSTRACTVanin1 (VNN1) is an exogenous enzyme with pantetheinase activity that mainly exerts physiological functions through enzyme catalysis products, including pantothenic acid and cysteamine. In recent years, the crosstalk between VNN1 and metabolism and oxidative stress has attracted much attention. As a result of the ability of VNN1 to affect multiple metabolic pathways and oxidative stress to exacerbate or alleviate pathological processes, it has become a key component of disease progression. This review discusses the functio...
Source: European Journal of Pharmacology - December 2, 2023 Category: Drugs & Pharmacology Authors: Hao Yu Yuying Cui Fangyue Guo YuTong Zhu Xiaonan Zhang Dong Shang Deshi Dong Hong Xiang Source Type: research
GSE191212 Engineering class-B vitamin biosynthesis in Saccharomyces cerevisiae
Contributors : Anna K Wronska ; Thomas Perli ; Marcel van den Broek ; Jean-Marc DaranSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeSaccharomyces cerevisiae is bradytroph for class B vitamins, it means that yeast cells exhibit slower growth in the absence of an external source of these metabolites. Alleviating these nutritional requirements for optimal growth performance would represent a valuable phenotypic characteristic for industrial strains since this would result in cheaper processes that would also be less susceptible to contaminations. In the present study, sub...
Source: GEO: Gene Expression Omnibus - December 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Saccharomyces cerevisiae Source Type: research
Novel missense variants cause intermediate phenotypes in the phenotypic spectrum of SLC5A6-related disorders
AbstractSLC5A6 encodes the sodium-dependent multivitamin transporter, a transmembrane protein that uptakes biotin, pantothenic acid, and lipoic acid. BiallelicSLC5A6 variants cause sodium-dependent multivitamin transporter deficiency (SMVTD) and childhood-onset biotin-responsive peripheral motor neuropathy (COMNB), which both respond well to replacement therapy with the above three nutrients. SMVTD usually presents with various symptoms in multiple organs, such as gastrointestinal hemorrhage, brain atrophy, and global developmental delay, at birth or in infancy. Without nutrient replacement therapy, SMVTD can be lethal in ...
Source: Journal of Human Genetics - November 27, 2023 Category: Genetics & Stem Cells Source Type: research
The effect of epigallocatechin gallate on laying performance, egg quality, immune status, antioxidant capacity, and hepatic metabolome of laying ducks reared in high temperature condition
In conclusion, 300 mg/kg dietary EGCG showed protection effects on the laying ducks reared in high temperature by improving the immune and antioxidant capacities, which contributed to the increase of laying performance of ducks. The potential mechanism could be that EGCG modulate the synthesis of key metabolites and associated metabolic pathways.PMID:37921498 | DOI:10.1080/01652176.2023.2280041 (Source: Veterinary Quarterly)
Source: Veterinary Quarterly - November 3, 2023 Category: Veterinary Research Authors: Yang Liu Xu Zhang Yaling Yao Xuan Huang Chuang Li Ping Deng Guitao Jiang Qiuzhong Dai Source Type: research
