Vitamin B5 supplementation enhances intestinal development and alters microbes in weaned piglets
This study explored the effects of different vitamin B5 (VB5) levels on intestinal growth and function of weaned piglets. Twenty-one piglets (7.20 ± 1.11 kg) were included in a 28-day feeding trial with three treatments, including 0 mg/kg (L-VB5), 10 mg/kg (Control) and 50 mg/kg (H-VB5) of VB5 supplement. The results showed that: Large intestine weight/body weight was the highest in H-VB5 group, Control and H-VB5 groups had significantly higher villus height and villus height/crypt depth than the L-VB5 in the ileum (p < .05). Goblet cells (ileal crypt) and endocrine cells (ileal villus) significantly increased in Contr...
Source: Animal Biotechnology - April 8, 2024 Category: Biotechnology Authors: Xin Wang Yan Qin Jianzhong Li Pengfei Huang Yali Li Jing Huang Qiye Wang Huansheng Yang Source Type: research
Vitamin B5 supplementation enhances intestinal development and alters microbes in weaned piglets
This study explored the effects of different vitamin B5 (VB5) levels on intestinal growth and function of weaned piglets. Twenty-one piglets (7.20 ± 1.11 kg) were included in a 28-day feeding trial with three treatments, including 0 mg/kg (L-VB5), 10 mg/kg (Control) and 50 mg/kg (H-VB5) of VB5 supplement. The results showed that: Large intestine weight/body weight was the highest in H-VB5 group, Control and H-VB5 groups had significantly higher villus height and villus height/crypt depth than the L-VB5 in the ileum (p < .05). Goblet cells (ileal crypt) and endocrine cells (ileal villus) significantly increased in Contr...
Source: Animal Biotechnology - April 8, 2024 Category: Biotechnology Authors: Xin Wang Yan Qin Jianzhong Li Pengfei Huang Yali Li Jing Huang Qiye Wang Huansheng Yang Source Type: research
Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells
ConclusionsThe derangement of multiple glucose-independent metabolic pathways, which are often upregulated in therapy-resistant cancer, and concomitantcMyc downregulation coordinately contribute to the anti-proliferative effect of metformin in liver cancer cells. These are reversible and may influence its therapeutic utility. (Source: Metabolomics)
Source: Metabolomics - February 27, 2024 Category: Biology Source Type: research
A new case of sodium-dependent multivitamin transporter defect occurring as a life-threatening condition responsive to early vitamin supplementation and literature review
CONCLUSION: SMVT deficiency is a vitamin-responsive inborn error of metabolism that can lead to a wide range of symptoms. Increased and isolated excretion of urinary 3-hydroxyisovaleric acid may suggest, in the absence of markedly reduced biotinidase activity, a SMVT deficiency. Prompt supplementation with high doses of biotin and pantothenic acid should be initiated while awaiting results of SLC5A6 sequencing as this condition may be life-threatening.PMID:38407570 | PMC:PMC10847706 | DOI:10.1002/mgg3.2388 (Source: Molecular Medicine)
Source: Molecular Medicine - February 26, 2024 Category: Molecular Biology Authors: F-X Van Vyve N Mercier J Papadopoulos C Heijmans H Dessy O Monestier J P Dewulf D Roland Source Type: research
A new case of sodium ‐dependent multivitamin transporter defect occurring as a life‐threatening condition responsive to early vitamin supplementation and literature review
ConclusionSMVT deficiency is a vitamin-responsive inborn error of metabolism that can lead to a wide range of symptoms. Increased and isolated excretion of urinary 3-hydroxyisovaleric acid may suggest, in the absence of markedly reduced biotinidase activity, a SMVT deficiency. Prompt supplementation with high doses of biotin and pantothenic acid should be initiated while awaiting results ofSLC5A6 sequencing as this condition may be life-threatening. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - February 7, 2024 Category: Genetics & Stem Cells Authors: F. ‐X. Van Vyve,
N. Mercier,
J. Papadopoulos,
C. Heijmans,
H. Dessy,
O. Monestier,
J. P. Dewulf,
D. Roland Tags: CLINICAL REPORT Source Type: research
Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS
AbstractErigeron bonariensis is widely distributed throughout the world's tropics and subtropics. In folk medicine,E. bonariensis has historically been used to treat head and brain diseases. Alzheimer ’s disease (AD) is the most widespread form of dementia initiated via disturbances in brain function. Herein, the neuroprotective effect of the chemically characterizedE. bonariensis ethanolic extract is reported for the first time in an AD animal model. Chemical profiling was conducted using UPLC –ESI-MS analysis. Female rats underwent ovariectomy (OVX) followed by 42 days of D-galactose (D-Gal) administration (150 mg...
Source: Inflammopharmacology - January 31, 2024 Category: Drugs & Pharmacology Source Type: research
Parasitic nematodes: dietary habits and their implications
Trends Parasitol. 2024 Jan 22:S1471-4922(23)00318-5. doi: 10.1016/j.pt.2023.12.013. Online ahead of print.ABSTRACTNematodes, a diverse group of roundworms, exhibit a wide range of dietary habits, including parasitism of animals and plants. These parasites cause substantial economic losses in agriculture and pose significant health challenges to humans and animals. This review explores the unique adaptations of parasitic nematodes, emphasizing their nutritional requirements and metabolic dependencies. Recent research has identified cross-kingdom compartmentalization of vitamin B5 biosynthesis in some parasitic nematodes, sh...
Source: Trends in Parasitology - January 23, 2024 Category: Parasitology Authors: Ching-Jung Lin Shahid Siddique Source Type: research
Engineered ketoreductase-catalyzed stereoselective reduction of ethyl 2 ′-ketopantothenate and its analogues: chemoenzymatic synthesis of D-pantothenic acid
Green Chem., 2024, Advance Article DOI: 10.1039/D3GC04344D, PaperPan Hu, Xiaofan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Zedu Huang, Fener Chen An asymmetric sustainable route toD-pantothenic acid was developed, centering on the reduction of ethyl 2 ′-ketopantothenate to ethyl (R)-pantothenate, enabled by anE. coli strain co-expressing an engineered ketoreductase and glucose dehydrogenase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - January 12, 2024 Category: Chemistry Authors: Pan Hu Source Type: research
Pantothenic acid - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 13;67. doi: 10.29219/fnr.v67.10255. eCollection 2023.ABSTRACTPantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Riitta Freese Tonje E Aarsland Maja Bj ørkevoll Source Type: research
Pantothenic acid - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 13;67. doi: 10.29219/fnr.v67.10255. eCollection 2023.ABSTRACTPantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Riitta Freese Tonje E Aarsland Maja Bj ørkevoll Source Type: research
Pantothenic acid - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 13;67. doi: 10.29219/fnr.v67.10255. eCollection 2023.ABSTRACTPantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Riitta Freese Tonje E Aarsland Maja Bj ørkevoll Source Type: research
Pantothenic acid - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 13;67. doi: 10.29219/fnr.v67.10255. eCollection 2023.ABSTRACTPantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Riitta Freese Tonje E Aarsland Maja Bj ørkevoll Source Type: research
Pantothenic acid - a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 13;67. doi: 10.29219/fnr.v67.10255. eCollection 2023.ABSTRACTPantothenic acid, also referred to as vitamin B5, is a water-soluble vitamin that has essential functions in the body as a component of coenzyme A (CoA) and acyl carrier protein (ACP). It is widely distributed in animal and plant-source foods. Nutritional deficiency of pantothenic acid is rare and toxicity negligible. Information on pantothenic acid intakes in the Nordic countries is limited and biomarker data from Nordic and Baltic populations is missing. Due to a lack of data, no dietary reference values (DRVs) were given for pantothenic...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Riitta Freese Tonje E Aarsland Maja Bj ørkevoll Source Type: research
