Beta-blocking patients with cardiac amyloidosis: Adelante cum juicio
Once upon a time, beta-blockers (BB) were simply forbidden for the treatment of patients with heart failure (HF): they were thought to worsen clinical severity of the disease, eliciting salt/water retention, reducing myocardial contractility, impairing hemodynamics. [1] Therefore, although the first evidence of metoprolol efficacy was given in 1975, only 20 years after, in 1993, the first randomized study paved the way to a widespread use, finally guideline-recommended since 1999 up to 2021. [2] In the meanwhile, Packer's neurohormonal model of HF overcame the cardiocirculatory and cardiorenal ones. (Source: Internation...
Source: International Journal of Cardiology - April 12, 2024 Category: Cardiology Authors: Michele Emdin, Alberto Aimo, Giuseppe Vergaro, Vincenzo Castiglione Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Molecules, Vol. 29, Pages 1480: Monitoring Pharmaceuticals and Personal Care Products in Healthcare Effluent Wastewater Samples and the Effectiveness of Drug Removal in Wastewater Treatment Plants Using the UHPLC-MS/MS Method
This study reveals the prevalence of several different drugs; mean concentrations of 702 μg L−1 of iomeprol, 48.8 μg L−1 of iopromide, 29.9 μg L−1 of gabapentin, 42.0 μg L−1 of caffeine and 82.5 μg L−1 of paracetamol were present. An analysis of 20 samples from ten WWTPs revealed different removal efficiencies for different analytes. Paracetamol was present in the inflow samples of all ten WWTPs and its removal efficiency was 100%. Analytes such as caffeine, ketoprofen, naproxen or atenolol showed hi...
Source: Molecules - March 27, 2024 Category: Chemistry Authors: Lucia Molnarova Tatana Halesova Daniela Tomesova Marta Vaclavikova Zuzana Bosakova Tags: Article Source Type: research
Physiologically based pharmacokinetic modeling of imatinib and N ‐desmethyl imatinib for drug–drug interaction predictions
AbstractThe first-generation tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and remains among the frontline treatments, for example, against chronic myeloid leukemia. As a substrate of cytochrome P450 (CYP) 2C8, CYP3A4, and various transporters, imatinib is highly susceptible to drug –drug interactions (DDIs) when co-administered with corresponding perpetrator drugs. Additionally, imatinib and its main metaboliteN-desmethyl imatinib (NDMI) act as inhibitors of CYP2C8, CYP2D6, and CYP3A4 affecting their own metabolism as well as the exposure of co-medications. This work pr...
Source: CPT: Pharmacometrics and Systems Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Helena Leonie Hanae Loer,
Christina Kovar,
Simeon R üdesheim,
Fatima Zahra Marok,
Laura Maria Fuhr,
Dominik Selzer,
Matthias Schwab,
Thorsten Lehr Tags: ARTICLE Source Type: research
Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal
Bioprocess Biosyst Eng. 2024 Mar 14. doi: 10.1007/s00449-024-02976-8. Online ahead of print.ABSTRACTUse of white-rot fungi for enzyme-based bioremediation of wastewater is of high interest. These fungi produce considerable amounts of extracellular ligninolytic enzymes during solid-state fermentation on lignocellulosic materials such as straw and sawdust. We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolytic enzymes in aqueous suspension. Crude enzyme suspensions of the three fungi, with laccase activity range 12-43 U/L and manganese peroxidase activ...
Source: Bioprocess and Biosystems Engineering - March 14, 2024 Category: Biomedical Engineering Authors: M Hultberg O Golovko Source Type: research
Use of sawdust for production of ligninolytic enzymes by white-rot fungi and pharmaceutical removal
Bioprocess Biosyst Eng. 2024 Mar 14. doi: 10.1007/s00449-024-02976-8. Online ahead of print.ABSTRACTUse of white-rot fungi for enzyme-based bioremediation of wastewater is of high interest. These fungi produce considerable amounts of extracellular ligninolytic enzymes during solid-state fermentation on lignocellulosic materials such as straw and sawdust. We used pure sawdust colonized by Pleurotus ostreatus, Trametes versicolor, and Ganoderma lucidum for extraction of ligninolytic enzymes in aqueous suspension. Crude enzyme suspensions of the three fungi, with laccase activity range 12-43 U/L and manganese peroxidase activ...
Source: Bioprocess and Biosystems Engineering - March 14, 2024 Category: Biomedical Engineering Authors: M Hultberg O Golovko Source Type: research
Physiologically based pharmacokinetic modeling of imatinib and N ‐desmethyl imatinib for drug–drug interaction predictions
AbstractThe first-generation tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and remains among the frontline treatments, for example, against chronic myeloid leukemia. As a substrate of cytochrome P450 (CYP) 2C8, CYP3A4, and various transporters, imatinib is highly susceptible to drug –drug interactions (DDIs) when co-administered with corresponding perpetrator drugs. Additionally, imatinib and its main metaboliteN-desmethyl imatinib (NDMI) act as inhibitors of CYP2C8, CYP2D6, and CYP3A4 affecting their own metabolism as well as the exposure of co-medications. This work pr...
Source: CPT: Pharmacometrics and Systems Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Authors: Helena Leonie Hanae Loer,
Christina Kovar,
Simeon R üdesheim,
Fatima Zahra Marok,
Laura Maria Fuhr,
Dominik Selzer,
Matthias Schwab,
Thorsten Lehr Tags: ARTICLE Source Type: research
The role of the peripheral and central adrenergic system in the construction of the subjective emotional experience of panic
ConclusionsThese results indicate that information from the peripheral and central adrenergic system does not play a major role in the construction of the subjective emotion. (Source: Psychopharmacology)
Source: Psychopharmacology - March 1, 2024 Category: Psychiatry Source Type: research
Molecules, Vol. 29, Pages 1087: Design of Experimental Approach for Development of Rapid High Performance Liquid Chromatographic Process for Simultaneous Estimation of Metoprolol, Telmisartan, and Amlodipine from Formulation: Greenness and Whiteness Evaluation
nroop B. Nair
The design of an experimental approach, the Box–Behnken design, was implemented to optimize the chromatographic condition to develop a rapid HPLC procedure for quantification of a ternary mixture of metoprolol (MET), telmisartan (TEL), and amlodipine (AML) from the formulation. The perturbation plots, contour, and 3D response surface pictures were developed to study the impact of each variable on the analytes’ retention time and the probable interaction between the parameters with fewer chromatographic runs. The optimized HPLC method separated the three analytes within 5 min wi...
Source: Molecules - February 29, 2024 Category: Chemistry Authors: Mahesh Attimarad Mohammed Jassim Alali Hussain Ali Alali Dana Hisham Alabdulmuhsin Aljohara Khalid Alnajdi Katharigatta Narayanaswamy Venugopala Anroop B. Nair Tags: Article Source Type: research
GSE234392 Effect of cAMP signaling activation during heart development in Pde2A deficient embryos.
Contributors : Silvia Cardarelli ; Martina Biglietto ; Valentina Fustaino ; Vladimir Benes ; Lucia Monaco ; Manuela PellegriniSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusBackground: Phosphodiesterases (PDEs) are the enzymes that hydrolyze cyclic nucleotides (cAMP and cGMP) playing a key role in the homeostasis of these two secondary messengers. PDE2A is a dual-specific PDE that breaks down both cAMP and cGMP and can be activated by cGMP. It appears peculiar that the Pde2A-deficient (Pde2A-/-) mouse model is embryonically lethal, likely due to a strongly reduced size of liver...
Source: GEO: Gene Expression Omnibus - February 27, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Evaluation of pharmaceutical consumption between urban and suburban catchments in China by wastewater-based epidemiology
Environ Res. 2024 Feb 24:118544. doi: 10.1016/j.envres.2024.118544. Online ahead of print.ABSTRACTWastewater-based epidemiology (WBE) is amply used for estimating human consumption of chemicals, yet information on regional variation of pharmaceuticals and their environmental fate are scarce. Thus, this study aims to estimate the consumption of three cardiovascular, four non-steroidal anti-inflammatory pharmaceuticals (NSAIDs), and four psychoactive pharmaceuticals between urban and suburban catchments in China by WBE, and to explore their removal efficiencies and ecological risks. Eleven analytes were detected in both infl...
Source: Environmental Research - February 26, 2024 Category: Environmental Health Authors: Zongrui Li Jincheng Li Yongxia Hu Yile Yan Shaoyu Tang Ruixue Ma Liangzhong Li Source Type: research
Evaluation of pharmaceutical consumption between urban and suburban catchments in China by wastewater-based epidemiology
Environ Res. 2024 Feb 24:118544. doi: 10.1016/j.envres.2024.118544. Online ahead of print.ABSTRACTWastewater-based epidemiology (WBE) is amply used for estimating human consumption of chemicals, yet information on regional variation of pharmaceuticals and their environmental fate are scarce. Thus, this study aims to estimate the consumption of three cardiovascular, four non-steroidal anti-inflammatory pharmaceuticals (NSAIDs), and four psychoactive pharmaceuticals between urban and suburban catchments in China by WBE, and to explore their removal efficiencies and ecological risks. Eleven analytes were detected in both infl...
Source: Environmental Research - February 26, 2024 Category: Environmental Health Authors: Zongrui Li Jincheng Li Yongxia Hu Yile Yan Shaoyu Tang Ruixue Ma Liangzhong Li Source Type: research
