Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Comparison of the Protective Effects of Nebivolol and Metoprolol against LPS-Induced Injury in H9c2 Cardiomyoblasts
Curr Issues Mol Biol. 2023 Nov 20;45(11):9316-9327. doi: 10.3390/cimb45110583.ABSTRACTHere, we, for the first time, compared the cardioprotective effects of third-generation vasodilating beta-blocker nebivolol (Neb) and conventional beta-blocker metoprolol (Met) on LPS-induced injury in H9c2 cardiomyoblasts. Our findings denoted that Neb and Met pretreatment diminish LPS-mediated cytotoxicity and oxidative stress. Concomitantly, LPS-triggered inflammatory cytokines activation was significantly suppressed by Neb but not by Met. Pretreatment with either Neb or Met alleviated LPS-mediated mitochondrial impairment by enhancing...
Source: Current Issues in Molecular Biology - November 24, 2023 Category: Molecular Biology Authors: Rukhsana Gul Meshail Okla Amer Mahmood Shahid Nawaz Amina Fallata Arwa Bazighifan Musaad Alfayez Assim A Alfadda Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
Effects of percutaneous coronary intervention via transradial artery access combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease
Gen Physiol Biophys. 2023 Nov;42(6):531-538. doi: 10.4149/gpb_2023028.ABSTRACTThis research was designed to unveil the impacts of percutaneous coronary intervention via transradial artery access (TRA-PCI) combined with metoprolol on cardiac function and vascular endothelial function in elderly patients with coronary heart disease (CHD). Collectively, 112 CHD patients were enrolled and allocated into a control group (patients treated with TRA-PCI) and an observation group (patients treated with TRA-PCI and metoprolol) following the random number table method (n = 56 patients). The treatment outcome, cardiac function indi...
Source: General Physiology and Biophysics - November 23, 2023 Category: Physiology Authors: Feng Cheng Juan Xu Source Type: research
