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Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone − a first pediatric case report - Kacirova I, Grundmann M, Kolek M, Vyskocilova-Hrudikova E, Urinovska R, Handlos P.
We present a pediatric case... (Source: SafetyLit)
Source: SafetyLit - July 7, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

AstraZeneca signs deal to sell commercial rights for Seloken in Europe
AstraZeneca has entered an agreement to provide the commercial rights for Seloken/Seloken ZOK (metoprolol tartrate and metoprolol succinate respectively) and associated Logimax fixed-dose combination (metoprolol succinate and felodipine) treatments i … (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - May 22, 2017 Category: Pharmaceuticals Source Type: news

AstraZeneca enters agreement with Recordati for Seloken in Europe
AstraZeneca announced today that it has entered into an agreement with Recordati S.p.A (Recordati) for the commercial rights to Seloken/Seloken ZOK (metoprolol tartrate and metoprolol succinate respectively) and associated Logimax fixed-dose combination (metoprolol succinate and felodipine) treatments in Europe. (Source: World Pharma News)
Source: World Pharma News - May 22, 2017 Category: Pharmaceuticals Tags: Featured AstraZeneca Business and Industry Source Type: news

How Metoprolol Reduces Infarct Size: Simply'Stunning'How Metoprolol Reduces Infarct Size: Simply'Stunning '
The beta-blocker, given early after MI onset, is cardioprotective at least partly due to an anti-inflammatory neutrophil-stunning effect, say researchers; implications may go beyond acute MI therapy.Heartwire from Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 9, 2017 Category: Consumer Health News Tags: Cardiology News Source Type: news

Scientists discover how a decades-old drug reduces the size of a heart attack
Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered a new mechanism of action of metoprolol, a drug that can reduce the damage produced during a heart attack if administered early. The team led by Dr. Borja Ibáñez, Clinical Research Director at the CNIC and cardiologist at the Fundación Jiménez Díaz University Hospital Health Research Institute (IIS-FJD), has identified the mechanism that explains why this drug is so beneficial: rapid administration of metoprolol during a heart attack directly inhibits the inflammatory action of neutroph...
Source: World Pharma News - April 18, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

CNIC scientists discover how a decades-old drug reduces the size of a heart attack
(Centro Nacional de Investigaciones Cardiovasculares) The beta-blocker metoprolol can limit cardiac damage in patients having a heart attack. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 18, 2017 Category: Global & Universal Source Type: news

Make the Diagnosis: Guess the Vessel
(MedPage Today) -- Case Findings: A 50-year old male with family history significant for premature CAD presents with chest pain which started 3 hours ago. Blood pressure 150/90 mm Hg, HR 60/min. EKG in the emergency department is shown (see image below). Successful intervention of the culprit coronary artery is performed with one drug eluting stent. He is started on aspirin, ticagrelor, atorvastatin and metoprolol. Next morning he is found to be hypotensive to SBP 90s. Hemoglobin, creatinine and electrolytes are normal. Right groin access site is without any hematoma. A stat bedside echocardiogram reveals ejection fraction...
Source: MedPage Today Cardiovascular - January 30, 2017 Category: Cardiology Source Type: news

Patient With Chest Pain and Shortness of Breath Shows Standardized Treatment Doesn't Work for All Patients
John, a 65-year-old male, is sitting in a chair in the corner of the room as you and your partner enter his house. John tells you he's the only one home and called 9-1-1 because he can't breathe and his chest is killing him. His skin is ashen and his breathing is rapid. You can palpate a weak irregular pulse and you note his skin is warm and diaphoretic. He describes his shortness of breath as increasing in severity over the last couple of hours with the chest discomfort. With a pulse oximetry reading of 78% on room air, you apply oxygen via a non-rebreathing mask. Physical exam reveals bibasilar crackles on pulmonary ausc...
Source: JEMS Patient Care - December 30, 2016 Category: Emergency Medicine Authors: Dennis Edgerly, EMT-P Tags: Columns Patient Care Source Type: news

Lopressor HCT (Metoprolol Tartrate and Hydochlorothiazide) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 6, 2016 Category: Drugs & Pharmacology Source Type: news

Lopressor Injection (Metoprolol Tartrate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 6, 2016 Category: Drugs & Pharmacology Source Type: news

metoprolol (Lopressor, Toprol XL)
Title: metoprolol (Lopressor, Toprol XL)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 11/1/2016 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - November 1, 2016 Category: Cardiology Source Type: news

Sun Pharma strikes distribution alliance with Mitsubishi Tanabe in Japan
Sun ’s products are part of the long-listed and established prescription brands and includes Parlodel, Lamsil, Nitroderm and Lopressor. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - September 6, 2016 Category: Pharmaceuticals Source Type: news

Toprol XL (Metoprolol Succinate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 2, 2016 Category: Drugs & Pharmacology Source Type: news

Lopressor (Metoprolol Tartrate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 1, 2016 Category: Drugs & Pharmacology Source Type: news

Make the Diagnosis: Puzzling Palpitations
(MedPage Today) -- Case Findings: A 44-year-old male presents with palpitations of 3 months'duration. At first they were occasional and occurred about twice a week. However, they have increased over time with frequency up almost hourly. He has noticed a recent 10-pound weight gain, increased lower extremity swelling, and inability to lie flat. He denies any fevers or chills. His last exercise stress test 5 months ago was normal. His current medications include metoprolol 12.5 mg twice daily, lisinopril 10 mg daily, aspirin 81 mg daily, furosemide 40 mg daily. There have been no recent readjustments in his medical regimen. ...
Source: MedPage Today Cardiovascular - August 30, 2016 Category: Cardiology Source Type: news

Do Angioplasty Patients Really Need Beta-Blocker Drugs?
TUESDAY, Aug. 16, 2016 -- Doctors might be overprescribing beta-blocker medications to heart patients who aren't seriously ill, a new study contends. Beta blockers such as Inderal (propranolol) and Lopressor (metoprolol) reduce blood pressure and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - August 16, 2016 Category: Journals (General) Source Type: news

Make the Diagnosis: Dizziness Dilemma
(MedPage Today) -- Case Findings: A 42-year-old African American male presents with a report of dizziness and lightheadedness 3 days ago when he was standing up to go to the rest room. He denies any syncopal episodes. He has medically managed hypertension, hypercholesterolemia, and cardiomyopathy, and a last ejection fraction of 35% with defibrillator placement 4 months ago. His AICD did not fire during the dizziness episode. His last cardiac catheterization prior to AICD implantation revealed normal coronaries. The patient has been compliant with metoprolol 25 mg twice daily, lisinopril 10 mg daily, atorvastatin 40 mg dai...
Source: MedPage Today Cardiovascular - August 10, 2016 Category: Cardiology Source Type: news

Do you know the answer to this tough USMLE Step 2 question?
If you’re gearing up to take the United States Medical Licensing Examination® (USMLE®) Step 2, get this month’s exclusive scoop on the most missed USMLE Step 2 test prep question and expert strategies to help you master it. Think you have what it takes to rise above your peers? Test your USMLE knowledge, and view an expert video explanation of the answer from Kaplan Medical. Once you’ve got this question under your belt, be sure to test your knowledge with other posts in this series. Ready. Set. Go. This month’s question that stumped most students: A 57-year-old female with a his...
Source: AMA Wire - April 28, 2016 Category: Journals (General) Authors: Troy Parks Source Type: news

Make the Diagnosis: Dizziness Dilemma
(MedPage Today) -- Case Findings: The patient is a 42-year-old African American man who presents with a complaint of dizziness lightheadedness which occurred when he was standing up to go to the rest room 3 days ago. He denies any previous syncopal episodes. He has medically managed hypertension, hypercholesterolemia, cardiomyopathy with last ejection fraction of 35% with defibrillator placement 4 months previous. His ICD did not fire during the episode. His last cardiac catheterization prior to ICD implantation revealed normal coronaries. Patient has been compliant with metoprolol 25 mg twice daily, lisinopril 10 mg daily...
Source: MedPage Today Endocrinology - April 26, 2016 Category: Endocrinology Source Type: news

ACC: No Benefit for Beta-Blocker Before PCI
(MedPage Today) -- IV metoprolol was safe, but disappointing (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - April 5, 2016 Category: Cardiology Source Type: news

Studying for USMLE Step 2? Master this most missed question
Studying for the United States Medical Licensing Examination® (USMLE®) Step 2 may seem daunting, but not to fear. Starting this month, we’re giving you an exclusive scoop on the most missed USMLE Step 2 test prep questions and expert strategies to help you beat them. Check out this month’s most challenging question, and view an expert video explanation of the answer from Kaplan Medical. Welcome to the first Step 2 post in AMA Wire’s® series, “Tutor talk: Tips from Kaplan Medical on the most missed USMLE test prep questions from Kaplan’s Qbank.” Each month, we’re ...
Source: AMA Wire - February 24, 2016 Category: Journals (General) Authors: Amy Farouk Source Type: news

Metoprolol Injection (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 26, 2016 Category: Drugs & Pharmacology Source Type: news

Identifying Acute STEMI in the Presence of Paced Rhythm
EMS responds to a local coffee shop for a 77-year-old male who has reportedly fainted. While en route the call is upgraded to an unconscious patient and an engine company is dispatched for backup. On arrival the patient is conscious but lethargic. He appears acutely ill. The skin is pale and diaphoretic. His past medical history includes hypertension, dyslipidemia, myocardial infarction, a coronary artery bypass graft and heart failure. His current medications are aspirin, metoprolol, atorvastatin, lisinopril and furosemide. Upon further questioning he admits to chest discomfort. His OPQRST assessment is as follows: ≫ On...
Source: JEMS Patient Care - January 18, 2016 Category: Emergency Medicine Authors: Tom Bouthillet, NREMT-P Tags: Case of the Month Special Topics Cardiac & Resuscitation Patient Care Source Type: news

Identifying Acute STEMI in the Presence of Paced Rhythm
EMS responds to a local coffee shop for a 77-year-old male who has reportedly fainted. While en route the call is upgraded to an unconscious patient and an engine company is dispatched for backup. On arrival the patient is conscious but lethargic. He appears acutely ill. The skin is pale and diaphoretic. His past medical history includes hypertension, dyslipidemia, myocardial infarction, a coronary artery bypass graft and heart failure. His current medications are aspirin, metoprolol, atorvastatin, lisinopril and furosemide. Upon further questioning he admits to chest discomfort. His OPQRST assessment is as follows: ≫ On...
Source: JEMS Special Topics - January 18, 2016 Category: Emergency Medicine Authors: Tom Bouthillet, NREMT-P Tags: Case of the Month Special Topics Cardiac & Resuscitation Patient Care Source Type: news

Metoprolol Injection (Updated - Currently in Shortage)
Updated Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - January 5, 2016 Category: Drugs & Pharmacology Source Type: news

Lopressor Injection (Metoprolol Tartrate Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 21, 2015 Category: Drugs & Pharmacology Source Type: news

Candesartan May Cut Cardiotoxicity in Breast Cancer PatientsCandesartan May Cut Cardiotoxicity in Breast Cancer Patients
Adjuvant candesartan (but not metoprolol) showed "significant but modest" attenuation of LVEF changes after cancer therapy. More research is needed, but "this study is a key first step," notes one expert. Heartwire from Medscape (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - November 12, 2015 Category: Cardiology Tags: Cardiology News Source Type: news

AHA: Candesartan May Preserve Cardiac Function in Breast Ca Patients
(MedPage Today) -- But no difference seen with beta-blocker metoprolol (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - November 11, 2015 Category: Primary Care Source Type: news

Diltiazem vs Metoprolol for AF With Rapid Ventricular RateDiltiazem vs Metoprolol for AF With Rapid Ventricular Rate
Which of these agents is more effective for the ED management of atrial fibrillation and flutter? A new study compares the efficacy. The Journal of Emergency Medicine (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - September 16, 2015 Category: Emergency Medicine Tags: Emergency Medicine Journal Article Source Type: news

Podcast: Managing the crashing tox patient with ECMO
As I wrote about in a recent column for Emergency Medicine News, extracorporeal membrane oxygenation (ECMO) may be the next big thing in managing the severely ill, crashing overdose patient in whom usual therapy is not working. On the new podcast posted today at the EDECMO website, Steve Aks and I got together over Skype with Joe Bellezzo, Zack Shinar, and Scott Weingart to discuss the potential benefits, as well as the potential risks and complications, involved in using ECMO in the sickest tox patients. Some of the topics we discuss: What overdose patients might benefit most from ECMO? What vascular access is neede...
Source: The Poison Review - June 16, 2015 Category: Toxicology Authors: Leon Tags: Medical ECMO edecmo extracorporeal membrane oxygenation podcast poisoning toxicology Source Type: news

Excellent review of lipid rescue therapy
3.5 out of 5 stars Intravenous Lipid Emulsion in the Emergency Department: A Systematic Review of Recent Literature. Cao D et al. J Emerg Med 2014 Dec 19 [Epub ahead of print] Abstract This excellent comprehensive review of lipid rescue therapy (LRT) is vitiated only by the unavoidable fact that available clinical evidence  is so inconclusive. As the authors point out, published literature consists mostly of case reports and small case series. The vast majority of these reported cases have good outcomes and reflect positive effects from ILE, but the evidence is marred by multiple confounding variables (such ...
Source: The Poison Review - February 25, 2015 Category: Toxicology Authors: Leon Tags: Medical intralipid lipid emulsion lipid rescue therapy lipid sink Review Source Type: news

FDA Recalls Another Batch of Generic Metoprolol (FREE)
By Larry Husten Edited by David G. Fairchild, MD, MPH, and Richard Saitz, MD, MPH, FACP, FASAM The FDA has recalled more than 13,000 bottles of metoprolol succinate extended-release tablets manufactured by Dr. Reddy's Laboratories, Reuters reported late last … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 25, 2014 Category: Primary Care Source Type: news

FDA Recalls Another Batch Of Generic Metoprolol
The FDA has recalled more than 13,000 bottles of metoprolol succinate extended release tablets manufactured by Dr. Reddy's Laboratories. Two months ago the agency recalled another lot of generic metoprolol from a different company, Wockhardt. Both recalls were for medicines manufactured at facilities in India. There have been multiple reports in recent years of problems with generic drugs made in India. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 24, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Generic Versions of Toprol XL, a Heart Drug, Are Recalled
Recalls by two large Indian manufacturers, Wockhardt and Dr. Reddy’s Laboratories, are the latest in a string of recent problems involving generic drugs. (Source: NYT Health)
Source: NYT Health - June 24, 2014 Category: Consumer Health News Authors: By KATIE THOMAS Tags: India Drugs (Pharmaceuticals) Food and Drug Administration Dr Reddys Laboratories Ltd RDY NYSE Recalls and Bans of Products Novartis AG NVS NYSE Source Type: news

India Generic Blood Pressure Drugs Recalled Again in U.S.
India's Dr Reddy's Laboratoriesis recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in the United States after the drug failed a dissolution test. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - June 19, 2014 Category: Pharmaceuticals Source Type: news

Dr Reddy's recalls over 13,000 bottles of hypertension drug: FDA
Dr Reddy's Laboratories Ltd is recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in US after it failed a dissolution test. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 19, 2014 Category: Pharmaceuticals Source Type: news

Dr Reddy's recalls over 13,000 bottles of hypertension drug- FDA
MUMBAI (Reuters) - India's Dr Reddy's Laboratories Ltd is recalling 13,560 bottles of the high blood pressure drug metoprolol succinate in the United States after it failed a dissolution test, the U.S. Food and Drug Administration said. (Source: Reuters: Health)
Source: Reuters: Health - June 19, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Wockhardt recalls 8,712 bottles of hypertension drug in US market
Wockhardt is recalling over 8,000 bottles of anti-hypertension drug Metoprolol Succinate extended-release tablets following failure of a dissolution test. (Source: The Economic Times)
Source: The Economic Times - June 5, 2014 Category: Consumer Health News Source Type: news

India's Wockhardt Recalls Generic Heart Pills
Mumbai-based Wockhardt is recalling 109,744 bottles of its generic version of AstraZeneca's hypertension drug Toprol XL in the U.S. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - May 15, 2014 Category: Pharmaceuticals Source Type: news

FDA Planning Study of Generic Metoprolol Over Safety, Efficacy Concerns (FREE)
Extract The FDA is planning an in-depth study of generic extended-release metoprolol succinate after receiving nearly 3500 complaints related to the blood pressure drug... (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - May 9, 2014 Category: Primary Care Source Type: news

Do two dissimilar cases represent a case series?
2 out of 5 stars High-dose Insulin and Intravenous Lipid Emulsion Therapy for Cardiogenic Shock Induced by Intentional Calcium-Channel Blocker and Beta-Blocker Overdose: A Case Series. Doepker B et al. J Emerg Med 2014 Apr;46:486-490.   Abstract The problems with this confused and confusing paper start with the title, which suggests that it will describe a series patients who presented with overdose of a calcium-channel blocker (CCB) and beta-blocker (BB), who were treated with high-dose insulin (HDI) and intravenous lipid emulsion (ILE). Well, this may be a case series, but the series includes only 2 patien...
Source: The Poison Review - April 3, 2014 Category: Toxicology Authors: Leon Tags: Medical beta blocker overdose calcium channel blocker overdose high-dose insulin intralipid intravenous fat emulsion Source Type: news

Benefits of treating heart attack patients with a cheap drug
One dose of the drug metoprolol, if given to heart attack patients early -- during ambulance transit to hospital -- can significantly improve the contractile strength of the heart muscle. And this improvement is maintained for at least six months after the intervention, according to new results. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 30, 2014 Category: Science Source Type: news

Asystole shortly after intravenous fat emulsion for overdose: causation or coincidence?
3 out of 5 stars Asystole Immediately Following Intravenous Fat Emulsion for Overdose. Cole JB et al. J Med Toxicol 2014 Feb 12. [Epub ahead of print] Abstract This case paper describes 2 patients who developed asystolic within 60 seconds of being given intravenous fat emulsion (IFE) bolus for treatment of severe cardiotoxicity. Both patients had return of spontaneous circulation (ROSC) after several minutes of cardiopulmonary resuscitation. Unfortunately, both patients died days after admission from multisystem organ failure. Patient A,  a 50-year-old woman, had ingested an undetermined about of metoprolol and b...
Source: The Poison Review - February 18, 2014 Category: Toxicology Authors: Leon Tags: Medical asystole bupropion cardiac arrest diltiazem intralipid intravenous fat emulsion therapy metoprolol propranolol Source Type: news

Wockhardt’s Main Drug Plant Added to FDA's "Red List"
The plant makes generic of Toprol-XL, a heart pill that accounts for about 14 percent of its sales (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - December 2, 2013 Category: Pharmaceuticals Source Type: news

Cardio Notes: IV Beta-Blocker Early on Shrinks Infarcts
(MedPage Today) -- The METOCARD-CNIC trial showed that intravenous metoprolol before patients go to the cath lab could have some benefit. Also, group heart failure appointments satisfied patients and office staff alike. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - October 7, 2013 Category: Consumer Health News Source Type: news

Cardio Notes: IV Beta-Blocker Given Early Shrinks Infarcts
(MedPage Today) -- The METOCARD-CNIC trial showed that intravenous metoprolol before patients go to the cath lab could have some benefit. Also, group heart failure appointments satisfied patients and office staff alike. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 7, 2013 Category: Cardiology Source Type: news

Inexpensive drug costing less than 3 dollars may minimize damage from heart attack
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Early treatment of heart attack patients with an inexpensive beta-blocker drug called metoprolol, while in transit to the hospital, can significantly reduce damage to the heart during a myocardial infarction. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2013 Category: Global & Universal Source Type: news

CNIC researchers minimize damage during a heart attack with a drug costing less than €2.00
(Centro Nacional de Investigaciones Cardiovasculares) Early treatment--during ambulance or helicopter transit to the hospital--with metoprolol, a cheap drug available for more than 30 years, significantly reduces damage to the heart during a myocardial infarction, according to the results of the METOCARD-CNIC study published in the latest edition of Circulation, the leading journal in the cardiovascular field. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 1, 2013 Category: Global & Universal Source Type: news