Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs (U01)
The objectives of this project are to conduct a prospective PK/PD study in hypertensive patients to link the PK profiles to the time-course of PD activity of metoprolol, therefore, to identify the key product attributes and patient factors that may impact the therapeutic equivalence of metoprolol products. The specific objectives of the study were to:
1) Evaluate the PK-PD relationship;
2) Evaluate the effect of treatment (before and after switching metoprolol products) on the PK-PD relationship;
3) Evaluate the effect of pH variation in the population and rate of delivery on the PK-PD relationship;
4) Evaluate th...
Source: Grants.gov - April 18, 2014 Category: Research Tags: Health Science and Technology and other Research and Development Source Type: funding
Pharmacokinetic and Pharmacodynamic (PK-PD) Studies of Cardiovascular Drugs (U01)
Funding Opportunity RFA-FD-14-024 from the NIH Guide for Grants and Contracts. The purpose of this project is to conduct a prospective PK/PD study to identify the key product attributes and patient factors that may impact the PK/PD and therapeutic equivalence of metoprolol products. The findings from the PK/PD study will help establish scientific and regulatory standards for assuring therapeutic equivalence of generic metoprolol products. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - April 16, 2014 Category: Research Source Type: funding
