Metoprolol for the Prevention of Exacerbations of COPD
New England Journal of Medicine,Volume 382, Issue 14, Page 1374-1376, April 2020. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - April 1, 2020 Category: Internal Medicine Source Type: research

Widespread monitoring of chiral pharmaceuticals in urban rivers reveals stereospecific occurrence and transformation.
Abstract The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water in Beijing. Among which, 9 out of 11 were detected during the two sampling campaigns with N-O-Didesmethylvenlafaxine (NODDV) and α-hydroxymetoprolol confirmed in the catchment for the first time. Metoprolol acid (MTPA) was the most abundant up to 1508 ng L-1, followed by metoprolol and O-desmethylvenlafaxine (ODV). Most compounds showed 100...
Source: Environment International - March 30, 2020 Category: Environmental Health Authors: Ma R, Qu H, Wang B, Wang F, Yu G Tags: Environ Int Source Type: research

Carvedilol and metoprolol are both able to preserve myocardial function in type 2 diabetes
ConclusionsMetoprolol and carvedilol were found to have no effect on cardiac function in type 2 diabetes with preserved ejection fraction, and were similarly effective in preventing myocardial dysfunction in ZDF rats. (Source: Physiological Reports)
Source: Physiological Reports - March 18, 2020 Category: Physiology Authors: Carol T. Bussey, Aram A. Babakr, Rachael R. Iremonger, Isabelle Hout, Gerard T. Wilkins, Regis R. Lamberts, Jeffrey R. Erickson Tags: ORIGINAL RESEARCH Source Type: research

Zerumbone Modulates α2A-Adrenergic, TRPV1, and NMDA NR2B Receptors Plasticity in CCI-Induced Neuropathic Pain In Vivo and LPS-Induced SH-SY5Y Neuroblastoma In Vitro Models
Zerumbone has shown great potential in various pathophysiological models of diseases, particularly in neuropathic pain conditions. Further understanding the mechanisms of action is important to develop zerumbone as a potential anti-nociceptive agent. Numerous receptors and pathways function to inhibit and modulate transmission of pain signals. Previously, we demonstrated involvement of the serotonergic system in zerumbone’s anti-neuropathic effects. The present study was conducted to determine zerumbone’s modulatory potential involving noradrenergic, transient receptor potential vanilloid type 1 (TRPV1) and N-m...
Source: Frontiers in Pharmacology - March 3, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse effects of interactions between antipsychotics and medications used in the treatment of cardiovascular disorders.
CONCLUSIONS: Due to a high risk of interactions and related adverse effects, particular attention should be paid while using cardiovascular medications with antipsychotics. Clinical decisions should be preceded by a detailed analysis of safety, risk-benefit ratio to search for, as safe as possible, drug combinations. PMID: 32124390 [PubMed - as supplied by publisher] (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 2, 2020 Category: Drugs & Pharmacology Authors: Siwek M, Woroń J, Gorostowicz A, Wordliczek J Tags: Pharmacol Rep Source Type: research

Role of Metoprolol Succinate in the Treatment of Heart Failure and Atrial Fibrillation: A Systematic Review
Conclusions: Despite the introduction of newer beta-blockers with differing clinical characteristics since its introduction, metoprolol succinate remains a useful drug in both HF and AF. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - March 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review Source Type: research

In Vitro Demonstration of Drug-Reagent Interactions Among Commonly Used Parenteral Drugs in Cardiology.
CONCLUSION: Parenteral drugs used in cardiology can significantly interfere with troponin I, CK-MB mass, Nt-proBNP, and D-dimer tests in the analytical phase because of drug-reagent interactions. Minimal deviations in the CK, AST, and LDH tests were observed using spectrophotometric methods. Thus, changes in test results may be due to drug interference rather than the treatment itself. Clinicians should consider the possibility of drug interference in cases of doubtful cardiac test results that do not comply with the diagnosis. PMID: 32101135 [PubMed - as supplied by publisher] (Source: Cardiovascular and Hematological...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - February 28, 2020 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research

Molecules, Vol. 25, Pages 1031: Poultry Farms as a Potential Source of Environmental Pollution by Pharmaceuticals
dia Wolska Industrial poultry breeding is associated with the need to increase productivity while maintaining low meat prices. Little is known about its impact on the environment of soil pollution by pharmaceuticals. Breeders routinely use veterinary pharmaceuticals for therapeutic and preventive purposes. The aim of this work was to determine the influence of mass breeding of hens on the soil contamination with 26 pharmaceuticals and caffeine. During two seasons—winter and summer 2019—15 soil samples were collected. Liquid extraction was used to isolate analytes from samples. Extracts were ...
Source: Molecules - February 25, 2020 Category: Chemistry Authors: Katarzyna Wychodnik Gra żyna Gałęzowska Justyna Rogowska Marta Potrykus Alina Plenis Lidia Wolska Tags: Article Source Type: research

The effects of intraperitoneal metoprolol administration on healing of bone defects in rat tibia: a pilot study
AbstractObjectivesMetoprolol is a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties, devoid of intrinsic sympathomimetic activity. Various studies have suggested the effect of beta-blockers on bone remodeling. We aimed to investigate whether metoprolol affects bone remodeling by altering anti-inflammatory and pro-inflammatory cytokines.Materials and methodsSurgical defects of 3  mm diameter were created in tibiae of 72 Sprague-Dawley rats. Rats were randomly assigned to a control group without metoprolol treatment (n = 36), and a test group treated with 0....
Source: Clinical Oral Investigations - February 21, 2020 Category: Dentistry Source Type: research

Wastewater ‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water
AbstractPharmaceuticals are widely detected in aquatic environments, and their potential risks to aquatic species are of concern because they are designed to be biologically active. Here, we used an in vitro assay, called the transforming growth factor α shedding assay, to measure the biological activities of G protein‐coupled receptor (GPCR)‐acting pharmaceuticals present in river water and effluents from municipal wastewater treatment plants (WWTPs) in Japan from 2014 to 2016. Antagonistic activities against angiotensin (AT1), dopamine (D2) , adrenergic (β1), acetylcholine (M1) and histamine (H1) receptors...
Source: Journal of Applied Toxicology - February 20, 2020 Category: Toxicology Authors: Masaru Ihara, Seiya Hanamoto, Mariko O. Ihara, Han Zhang, Hiroaki Tanaka Tags: RESEARCH ARTICLE Source Type: research

SnO2@ZnS photocatalyst with enhanced photocatalytic activity for the degradation of selected pharmaceuticals and personal care products in model wastewater
This study demonstrates a simple route to develop low-cost photocatalysts for the efficient removal of PPCPs by utilizing zinc sulfide-bearing industrial waste.Graphical abstract (Source: Journal of Alloys and Compounds)
Source: Journal of Alloys and Compounds - February 20, 2020 Category: Chemistry Source Type: research

Wastewater ‐derived antagonistic activities of G protein‐coupled receptor‐acting pharmaceuticals in river water
AbstractPharmaceuticals are widely detected in aquatic environments, and their potential risks to aquatic species are of concern because they are designed to be biologically active. Here, we used an in vitro assay, called the transforming growth factor α shedding assay, to measure the biological activities of G protein‐coupled receptor (GPCR)‐acting pharmaceuticals present in river water and effluents from municipal wastewater treatment plants (WWTPs) in Japan from 2014 to 2016. Antagonistic activities against angiotensin (AT1), dopamine (D2) , adrenergic (β1), acetylcholine (M1) and histamine (H1) receptors...
Source: Journal of Applied Toxicology - February 20, 2020 Category: Toxicology Authors: Masaru Ihara, Seiya Hanamoto, Mariko O. Ihara, Han Zhang, Hiroaki Tanaka Tags: RESEARCH ARTICLE Source Type: research

Temozolomide Is a Potential Therapeutic Tool for Patients With Metastatic Pheochromocytoma/Paraganglioma —Case Report and Review of the Literature
Conclusions: TMZ is effective and safe in MPP patients, and, it may work better on patients with SDHB-related MPP. Measurement of MGMT expression might help assess the tumor sensitivity to TMZ but this needs further systematic investigation. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 18, 2020 Category: Endocrinology Source Type: research

Songling Xuemaikang Capsule inhibits isoproterenol-induced cardiac hypertrophy via CaMKIIδ and ERK1/2 pathways
Publication date: Available online 13 February 2020Source: Journal of EthnopharmacologyAuthor(s): Jianyong Qi, Yafang Tan, Dancai Fan, Wenjun Pan, Juan Yu, Wen Xu, Jiashin Wu, Minzhou ZhangAbstractEthnopharmacological relevanceCardiac hypertrophy is a key pathologic process in heart failure. Songling Xuemaikang Capsule (SXC), is a formulae of Chinese Medicine commonly used in China to treat hypertension and heart failure. However, its mechanism of effects on cardiac hypertrophy is still unclear.Aim of the studyThe aims of the present study were to investigate the cardio-protection roles and detailed mechanisms of SXC on ca...
Source: Journal of Ethnopharmacology - February 14, 2020 Category: Drugs & Pharmacology Source Type: research

Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach
In conclusion, the LSS models provided accurate prediction of phenotypic indices for CYP1A2, CYP2C19, CYP2D6, CYP3A, and ABCB1, when using subtherapeutic doses of selective probes for these enzymes and transporter. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 14, 2020 Category: Drugs & Pharmacology Source Type: research

Ganoderic acid A protects neural cells against NO stress injury in vitro via stimulating β adrenergic receptors.
In this study, we investigated the effect of ganoderic acid A (GA A) against SNP injury in neural cells and the role of adrenergic receptors in GA A neuroprotection. We found that SNP (0.125-2 mM) dose-dependently decreased the viability of both SH-SY5Y and PC12 cells and markedly increased NO contents. Pretreatment with GA A (10 μM) significantly attenuated SNP-induced cytotoxicity and NO increase in SH-SY5Y cells, but not in PC12 cells. Furthermore, pretreatment with GA A caused significantly higher adrenaline content in SH-SY5Y cells than in PC12 cells. In order to elucidate the mechanism of GA A-protec...
Source: Acta Pharmacologica Sinica - February 11, 2020 Category: Drugs & Pharmacology Authors: Yu ZR, Jia WH, Liu C, Wang HQ, Yang HG, He GR, Chen RY, Du GH Tags: Acta Pharmacol Sin Source Type: research

Enantiomeric separation of six beta-adrenergic blockers on Chiralpak IB column and identification of chiral recognition mechanisms by molecular docking technique.
Abstract Enantiomeric separation of six beta-adrenergic blockers was first systematically studied on a polysaccharide-based chiral stationary phase, i.e., Chiralpak IB, under the normal phase mode. The effect of alcohol modifiers, alcohol content and basic additive on enantiomeric separation was evaluated and optimized. Under the optimal conditions, the enantiomers of atenolol, bevantolol, cartelol, esmolol, metoprolol and propranolol were all baseline resolved with the resolutions of 1.50, 8.56, 2.05, 2.11, 3.56 and 4.02, respectively. Additionally, the molecular docking was tried to explain chiral recognition me...
Source: Biomedical Chromatography : BMC - February 3, 2020 Category: Biomedical Science Authors: Li M, Jiang Z, Di X, Song Y Tags: Biomed Chromatogr Source Type: research

Pulmonary Delivery of Metoprolol Reduces Ventricular Rate During Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm
Conclusions: Intratracheal delivery of metoprolol effectively reduces ventricular rate during AF and accelerates conversion to normal sinus rhythm in a pig model of acetylcholine-induced AF. (Source: Journal of Cardiovascular Pharmacology)
Source: Journal of Cardiovascular Pharmacology - February 1, 2020 Category: Cardiology Tags: Original Article Source Type: research

Preparation and application of teicoplanin functionalized polymeric monolith for enantioseparation of chiral drugs
Publication date: Available online 27 January 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Rongying Luo, Hai Han, Jia Liu, Dongsheng Xu, Qiqin Wang, Salvatore Fanali, Zhengjin JiangAbstractA novel chiral stationary phase (CSP), based on a monolithic organic polymer chemically modified with teicoplanin, was fabricated within a 100 μm I.D. fused silica capillary. The teicoplanin was firstly derivatized with 2-isocyanatoethyl methacrylate (ICNEML) and then thermally co-polymerized with the crosslinker ethylene dimethacrylate (EDMA) in presence of porogens (methanol and dimethylsulfoxide). ...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 28, 2020 Category: Drugs & Pharmacology Source Type: research

Association between beta-blocker use and obesity in Hong Kong Chinese elders: a post-hoc analysis.
Abstract INTRODUCTION: Studies of Caucasian populations have shown that beta-blockers may exacerbate weight gain, a risk factor for many chronic diseases. Still, beta-blockers are the most prescribed antihypertensives in the Chinese population in Hong Kong. We aimed to explore the association between beta-blocker use, hypertension, and weight status of this population. METHODS: A post-hoc analysis regarding subjects' body mass index (BMI) and the use of beta-blockers was performed based on the medication profile of community-dwelling elders. Their BMI, hypertension diagnosis, name, dose, frequency, route of a...
Source: Hong Kong Med J - January 22, 2020 Category: General Medicine Authors: Leung KL, Fong W, Freedman B, Bajorek B, Lee VWY Tags: Hong Kong Med J Source Type: research

Metabolomic profiling of metoprolol-induced cardioprotection in a murine model of acute myocardial ischemia
This study constructed the regulatory metabolic network map of Met, elucidated the endogenous metabolic pathway regulated by Met, and validated the new potential therapeutic targets of Met in MI, which might provide a further reference for the clinical application of Met. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 21, 2020 Category: Drugs & Pharmacology Source Type: research

Adverse effects of interactions between antidepressants and medications used in treatment of cardiovascular disorders.
CONCLUSIONS: Because of ahigh risk of interactions and related adverse effects, especially in older patients, each decision regarding combination of a particular antidepressant with a medication used in treatment of cardiovascular disorders should be preceded by a detailed analysis of safety and risk-benefit ratio, and also be associated with the search for the safest, alternative combinations of the above-mentioned medications. PMID: 31955180 [PubMed - in process] (Source: Psychiatria Polska)
Source: Psychiatria Polska - January 21, 2020 Category: Psychiatry Tags: Psychiatr Pol Source Type: research

Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study
AbstractPurposeThe β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the impact of CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patient s after myocardial infarction (MI).MethodsWe included 136 patients with MI discharged on treatment with metoprolol with a recommendation to the general practitioner (GP) to increase the metoprolol dose up to 200  mg/day within 2 months if possible. At follow-up, metoprolol dosage after up-titrat...
Source: European Journal of Clinical Pharmacology - January 15, 2020 Category: Drugs & Pharmacology Source Type: research

Neonatal effects of intrauterine metoprolol/bisoprolol exposure during the second and third trimester: a cohort study with two comparison groups
Conclusion: Long-term intrauterine exposure to metoprolol or bisoprolol may increase the risk of being born small-for-gestational-age. It is still a matter of debate to which extent maternal hypertension contributes to the lower birth weight. Serious neonatal symptoms are rare. Altogether, metoprolol and bisoprolol are well tolerated treatment options, but a case-by-case decision on close neonatal monitoring is recommended. (Source: Journal of Hypertension)
Source: Journal of Hypertension - January 10, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Metoprolol versus Carvedilol in Patients with Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, and Renal Failure
This study aims to compare the survival and the risk of heart failure, chronic obstructive pulmonary disease, diabetes mellitus, hypoglycemia, and renal failure hospitalizations in geriatric patients that were exposed to carvedilol or metoprolol. Danish administrative healthcare registers were used as data sources. Patients aged ≥ 65 and having heart failure, chronic obstructive pulmonary disease, and diabetes mellitus were followed for 1 year from the date of the first beta-blocker prescription redemption. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 9, 2020 Category: Cardiology Authors: Maurizio Sessa, Daniel Bech Rasmussen, Magnus Thorsten Jensen, Kristian Kragholm, Christian Torp-Pedersen, Morten Andersen Source Type: research

Effect of eliglustat on the pharmacokinetics of digoxin, metoprolol, and oral contraceptives and absorption of eliglustat when coadministered with acid-reducing agents
Publication date: Available online 7 January 2020Source: Molecular Genetics and MetabolismAuthor(s): Nathan Thibault, Jennifer Ibrahim, Judith Peterschmitt, Ana Cristina Puga, Leorah Ross, Lucie Vu, Yong Xue, Sandrine TurpaultAbstractEliglustat is an oral substrate reduction therapy indicated for patients with Gaucher disease type 1. Based on in vitro data, clinical trials were conducted to assess the potential for drug-drug interactions between eliglustat and digoxin (P-glycoprotein substrate), metoprolol (sensitive CYP2D6 substrate), a combined oral contraceptive (CYP3A substrate), and acid-reducing agents. Healthy subje...
Source: Molecular Genetics and Metabolism - January 8, 2020 Category: Genetics & Stem Cells Source Type: research

Catecholaminergic and opioidergic system mediated effects of reboxetine on diabetic neuropathic pain
ConclusionsOur findings indicate that the antihyperalgesic and antiallodynic effects of reboxetine are mediated by the catecholaminergic system; β2-adrenoceptors; D1-, D2/D3-dopaminergic receptors; and δ-opioid receptors. The results suggest that this analgesic effect of reboxetine, besides its neutral profile on glycemic control, may be advantageous in the pharmacotherapy of diabetic neuropathy–induced pain. (Source: Psychopharmacology)
Source: Psychopharmacology - January 7, 2020 Category: Psychiatry Source Type: research

Assessing Drug Release from Manipulated Abuse Deterrent Formulations.
Abstract There is a need to develop in vitro dissolution methods that discriminate for particle size of the manipulated abuse deterrent formulation (ADF) and that can be used for in vivo predictive models since dissolution methods developed for intact formulation might not be suitable for manipulated ones. A vertical diffusion cell (VDC) and United States Pharmacopeia (USP) Apparatus 1, 2, and 4 were evaluated for measuring the dissolution of intact and manipulated metoprolol succinate tablets with abuse deterrent-like properties. These tablets were physically manipulated to produce fine (106-500 μm) and c...
Source: AAPS PharmSciTech - January 2, 2020 Category: Drugs & Pharmacology Authors: Feng X, Zidan A, Kamal NS, Xu X, Sun D, Walenga R, Boyce H, Cruz CN, Ashraf M Tags: AAPS PharmSciTech Source Type: research

Bisoprolol/metoprolol
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2020 Category: Drugs & Pharmacology Source Type: research

Vestibular Migraine: Treatment and Prognosis
Semin Neurol DOI: 10.1055/s-0039-3402067Treatment of vestibular migraine currently lacks a firm scientific basis, as high quality randomized controlled trials are not available. Therefore, recommendations are largely borrowed from the migraine sphere. The first therapeutic step is explanation and reassurance. Many patients do not need pharmacological treatment, as attacks may be infrequent and tolerable. Acute attacks can be ameliorated in some patients with antiemetic drugs such as diphenhydramine, meclizine, and metoclopramide. Frequent attacks may warrant pharmacological prophylaxis with metoprolol, amitriptyline, topir...
Source: Seminars in Neurology - December 30, 2019 Category: Neurology Authors: von Brevern, Michael Lempert, Thomas Tags: Review Article Source Type: research

Degradation of the β-blocker propranolol by sulfite activation using FeS
Publication date: 1 April 2020Source: Chemical Engineering Journal, Volume 385Author(s): Yiqun Chen, Yang Tong, Yingwen Xue, Zizheng Liu, Min Tang, Li-Zhi Huang, Senlin Shao, Zheng FangAbstractA new advanced oxidation process, FeS-activated sulfite system, was firstly established to degrade β-blockers in water at near neutral pH. By choosing propranolol (PRO) as a model compound, the experimental conditions including FeS and sulfite doses, initial pH, dissolved oxygen, and co-existed components were investigated. Up to 95% of PRO was eliminated after 20 min reaction with FeS and sulfite doses being 20 mg/L a...
Source: Chemical Engineering Journal - December 29, 2019 Category: Chemistry Source Type: research

Photodegradation of metoprolol in the presence of aquatic fulvic acids. Kinetic studies, degradation pathways and role of singlet oxygen, OH radicals and fulvic acids triplet states
In this study, metoprolol photodegradation, in the absence and in the presence of fulvic acids extracted from the Vouga River (Portugal) (VRFA), was assessed under simulated sunlight. While metoprolol direct photodegradation was deniable, indirect photolysis occurred under the presence of VRFA. It followed a pseudo-first order kinetics and after 72 h of irradiation there was a decrease of metoprolol concentration of ∼80 %. The OH radical (OH) was verified to be the main reactive species (RS) responsible for the photosensitized degradation of metoprolol, but other RS are also involved, probably triplet excited states ...
Source: Journal of Hazardous Materials - December 24, 2019 Category: Environmental Health Source Type: research

Sex Differences in Vasovagal Syncope: A Post Hoc Analysis of the Prevention of Syncope Trials (POST) I and II
Publication date: January 2020Source: Canadian Journal of Cardiology, Volume 36, Issue 1Author(s): Adam P. Deveau, Robert Sheldon, Connor Maxey, Deborah Ritchie, Steve Doucette, Ratika ParkashAbstractBackgroundVasovagal syncope (VVS) occurs in> 40% of individuals at least once in their lifetime. Sex-dependent differences in presentation and outcomes are not understood. We sought to determine differences in clinical presentation, treatment modalities, and outcomes of VVS between men and women.MethodsData were collected as part of the Prevention of Syncope Trials (POST) I and II, 2 multicenter, placebo-controlled, randomi...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research

Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature
AbstractWhile there is considerable evidence about sex-related differences between men and women in drug metabolism, efficacy and safety of frequently prescribed drugs such as analgesics, tranquillizers, statins and beta-blockers, clinicians ’ awareness of the implications on dosing and adverse event monitoring in routine practice is inadequate. Some drugs are more effective in men than women (e.g. ibuprofen) or vice versa (e.g. opioids, benzodiazepine), typically owing to pharmacodynamic causes. The 5-hydroxytryptamine (5-HT) recept or 3 antagonist alosetron is approved for women only since it largely lack...
Source: Advances in Therapy - December 23, 2019 Category: Drugs & Pharmacology Source Type: research

Hormonal status affects plasma exposure of tamoxifen and its main metabolites in tamoxifen-treated breast cancer patients.
CONCLUSION: The premenopausal status was associated with decreased endoxifen plasma concentrations by 135% compared to postmenopausal status. Thus, the endoxifen plasma concentrations should be monitored mainly in the premenopausal period to maintain plasma levels above the efficacy threshold value. TRIAL REGISTRATION: RBR-7tqc7k. PMID: 31852530 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - December 21, 2019 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea
Acta Pharmacologica Sinica, Published online: 20 December 2019; doi:10.1038/s41401-019-0323-8Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 20, 2019 Category: Drugs & Pharmacology Authors: Lin Yang Jing Zhao Yang Qu Qiang Sun Ting-ting Li Mei-ling Yan Ming-jing Duan Ke-xin Li Yan-ru Wang Si-yu Huang Shuai Zhang Yue Li Jing Ai Source Type: research

Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea.
In conclusion, metoprolol protects against neuronal dendritic remodeling in hippocampi and prefrontal cortices induced by chronic OSA in canine. PMID: 31863057 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - December 20, 2019 Category: Drugs & Pharmacology Authors: Yang L, Zhao J, Qu Y, Sun Q, Li TT, Yan ML, Duan MJ, Li KX, Wang YR, Huang SY, Zhang S, Li Y, Ai J Tags: Acta Pharmacol Sin Source Type: research

Dilated cardiomyopathy and aldosteronoma: a causal link?
AbstractThe aim of this study is to reveal the causal relationship between dilated cardiomyopathy and aldosteronoma. A 44 ‐year‐old male dilated cardiomyopathy patient with aldosteronoma, who demonstrated a worse cardiac function after 1 year therapy with optimized dosage of sacubirtil/valsartan, furosemide, metoprolol, and spironolactone. The patient shows a promising prognosis after aldosteronoma removal procedur e. Aldosteronoma may cause dilated cardiomyopathy. We assume that the optimal treatment for aldosteronoma‐induced dilated cardiomyopathy is surgical removal combined with drugs. (Source: ESC Heart Failure)
Source: ESC Heart Failure - December 19, 2019 Category: Cardiology Authors: Jiyu Zhang, Jin Yang, Yueliang Li Tags: Case Report Source Type: research

Oral chronic ulcer: a diagnosis challenge
An 85-year-old retired white man sought the dentistry service with an ulcerated lesion without symptomatology in the attached gingiva between upper molars. The ulcer presented approximately 1  × 1 cm surrounded by a white plaque. He has hypertension, hypercholesterolemia, hypothyroidism, and prostate alteration and regularly uses metoprolol, amlodipine, simvastatin, levothyroxine sodium, and finasteride. Hematologic, laboratory, and radiographic examinations are within the normal ra nge. The patient uses upper and lower partial dentures and denied smoking or drinking habits. (Source: Oral Surgery, Oral Medicine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: EDUARDO LIBERATO DA SILVA, VIN ÍCIUS COELHO CARRARD, FERNANDA VISIOLI, NATÁLIA BATISTA DAROIT, TATIANA WANNMACHER LEPPER, ISADORA LUANA FLORES, LAURA DE CAMPOS HILDEBRAND Source Type: research

Consensus of the Hellenic Headache Society on the diagnosis and treatment of migraine
AbstractMore than 0.6 million people suffer from disabling migraines in Greece causing a dramatic work loss, but only a small proportion of migraineurs attend headache centres, most of them being treated by non-experts. On behalf of the Hellenic Headache Society, we report here a consensus on the diagnosis and treatment of adult migraine that is based on the recent guidelines of the European Headache Federation, on the principles of Good Clinical Practice and on the Greek regulatory affairs. The purposes are three-fold: (1) to increase awareness for migraine in Greece; (2) to support Greek practitioners who are treating mi...
Source: The Journal of Headache and Pain - December 13, 2019 Category: Neurology Source Type: research

Metoprolol protects against myocardial infarction by inhibiting miR ‐1 expression in rats
ConclusionsMetoprolol relieves MI injury via suppression miR ‐1, thus increasing its target protein Cx43 and improving intercellular communication. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - December 10, 2019 Category: Drugs & Pharmacology Authors: Wei Qin, Longyin Zhang, Zhange Li, Dan Xiao, Yue Zhang, Huan Yang, Haiying Zhang, Chaoqian Xu, Yong Zhang Tags: Research Paper Source Type: research

β-blockers: their new life from hypertension to cancer and migraine
Publication date: Available online 3 December 2019Source: Pharmacological ResearchAuthor(s): Carlo Fumagalli, Niccolò Maurizi, Niccolò Marchionni, Diego FornasariAbstractThe pharmacological class of β-blockers includes a plea of molecules with largely different pharmacokinetic and pharmacodynamic characteristics with a protective effect that may span far beyond the cardiovascular system. Although all these compounds share the pharmacological blockade of the adrenergic receptors, each of them is characterized by specific pharmacological properties, including selectivity of action depending on the adrenerg...
Source: Pharmacological Research - December 5, 2019 Category: Drugs & Pharmacology Source Type: research

Thermal baths as sources of pharmaceutical and illicit drug contamination.
Á, Dobosy P, Kondor AC Abstract Despite the fact that there are tens of thousands of thermal baths in existence, knowledge about the occurrence of pharmaceutically active compounds (PhACs) in untreated thermal wastewater is very limited. Because used thermal water is typically legally discharged into surface waters without any treatment, the effluent poses environmental risks for the receiving water bodies. The aim of this study was to show the occurrence patterns and spatiotemporal characteristics of 111 PhACs in thermal wastewater. Six thermal water outflows of different thermal baths were tested in diffe...
Source: Environmental Science and Pollution Research International - December 2, 2019 Category: Environmental Health Authors: Jakab G, Szalai Z, Michalkó G, Ringer M, Filep T, Szabó L, Maász G, Pirger Z, Ferincz Á, Staszny Á, Dobosy P, Kondor AC Tags: Environ Sci Pollut Res Int Source Type: research

Anaphylaxis in Public Health.
Authors: Abstract The increasing number of patients with anaphylactic reactions is a modern challenge for healthcare professionals in clinical practice and public health professionals. It remains difficult to determine the prevalence or incidence of anaphylaxis in the population due to the long absence of a consensus definition, the fact that analyses are performed on various population groups and the use of different data collection methodologies. In the United States, anaphylaxis mortality ranges from 0.63 to 0.76 cases per million inhabitants, with 58% of these deaths due to drug anaphylaxis. The risk factors f...
Source: Neuroendocrinology Letters - December 1, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Sex-dependent changes in physical, mental, and quality of life outcomes in metoprolol-treated Chinese chronic heart failure patients
This study assessed sex differences in cardiac and motor functions, quality of life (QoL), and mental status in Chinese chronic heart failure (CHF) patients after metoprolol treatment. This single-center prospective study, conducted from February 2013 to April 2016, included CHF patients (men and women) with resting heart rate (HR)>80 beats/min using metoprolol continuous release tablets. Metoprolol-induced changes in cardiac and motor functions, QoL, and mental status at 1, 3, 6, 9, and 12 months from baseline, within and between the sexes, were analyzed. Descriptive data were represented as counts, percentages, and...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Supraventricular tachycardia of the sick, a unique entity.
CONCLUSION: 'AVNRT of the sick' has not been previously described in the medical literature, to our knowledge. It can be successfully treated with medications and the chance of recurrence after resolution of the acute illness is small. PMID: 31802764 [PubMed - in process] (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - December 1, 2019 Category: Cardiology Authors: Habash FJ, Card P, Madmani ME, Boye B, Paydak H Tags: Turk Kardiyol Dern Ars Source Type: research

Molecules, Vol. 24, Pages 4365: Catalytic Ozonation of Organics in Reverse Osmosis Concentrate with Catalysts Based on Activated Carbon
anbing Wang Acid-washed activated carbon (AC-A), nitric acid modified activated carbon (AC-NO2), aminated activated carbon (AC-NH2) and cerium-loaded activated carbon (Ce/AC) were prepared and characterized by BET procedure, Boehm titration and SEM. Their performances were investigated for the ozonation of p-chlorobenzoic acid (p-CBA) in its solution and organic compounds in reverse osmosis concentrate (ROC). Nitration and amination had little effect on the surface area of catalyst, but increased the concentration of surface acid and basic functional group respectively. After loading Ce, the surface area of the catalys...
Source: Molecules - November 29, 2019 Category: Chemistry Authors: Xieyang Xu Zhilin Xia Laisheng Li Qi Huang Can He Jianbing Wang Tags: Article Source Type: research

A narrow QRS tachycardia easily provoked by exercise during sinus rhythm
A 15-year-old boy was referred to our outpatient clinic for the evaluation of palpitations. They started 2 years ago, happening daily after light exercise. When exercise was continued, he noted acceleration of palpitations and onset of dyspnea. Those complaints were reason to reduce exercise as much as possible. The use of a β-blocking agent (metoprolol), prescribed by his general physician, resulted in less palpitations but they still appeared during exercise. (Source: Heart Rhythm)
Source: Heart Rhythm - November 27, 2019 Category: Cardiology Authors: Hein J. Wellens Tags: Josephson and Wellens ECG Lessons: A Monthly Visit to the 12 Lead ECG Source Type: research

Cesarean Section With Spinal Anesthesia in a Patient With Double Outlet Right Ventricle
A 26-YEAR-OLD gravida 2 at 38 weeks gestation was scheduled to undergo emergency lower segment cesarean section (LSCS). She had a known case of double outlet right ventricle (DORV). She had undergone a bidirectional Glenn (BDG) shunt at the age of 3 years. Her first pregnancy resulted in a preterm vaginal delivery, with the child dying on the 5th postpartum day. She was taking oral metoprolol, 50 mg, and torsemide, 5 mg, daily. In the operating room, her hemodynamics were as follows: initial heart rate 106 beats per minute, blood pressure 130/80 mmHg, sinus rhythm on electrocardiogram, and oxygen saturation 88% in room air...
Source: Journal of Cardiothoracic and Vascular Anesthesia - November 26, 2019 Category: Anesthesiology Authors: Upendra Hansda, Prasanta Kumar Das, Sangeeta Sahoo Tags: Letter to the Editor Source Type: research