Molecules, Vol. 29, Pages 1682: New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy
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Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, the current focus on phyto...
Source: Molecules - April 8, 2024 Category: Chemistry Authors: Aleksandra Majchrzak-Celi ńska El żbieta Studzińska-Sroka Tags: Review Source Type: research
ETV6-NTRK2 Fusion in a Patient With Metastatic Pulmonary Atypical Carcinoid Successfully Treated With Entrectinib: A Case Report and Review of the Literature
We present a female patient with metastatic AC after complete resection. Due to low expression of somatostatin receptor in this case, somatostatin analogs and peptide receptor radionuclide therapy were not available. After pursuing other alternative treatments, including chemotherapy (ie, carboplatin, etoposide, capecitabine, temozolomide, and paclitaxel), everolimus, and atezolizumab, she returned with significant progression, including innumerable subcutaneous nodules, left pleura metastasis, multiple bone metastases, and brain metastases. New biopsy analysis revealed an ETV6-NTRK2 fusion. She was immediately administere...
Source: Clinical Lung Cancer - April 7, 2024 Category: Cancer & Oncology Authors: Wusheng Zhang Sen Tian Xiang Li Yilin Chen Xinyu Wang Yunshuo Zhang Lihui Lv Yonghua Li Hui Shi Chong Bai Source Type: research
ETV6-NTRK2 Fusion in a Patient With Metastatic Pulmonary Atypical Carcinoid Successfully Treated With Entrectinib: A Case Report and Review of the Literature
We present a female patient with metastatic AC after complete resection. Due to low expression of somatostatin receptor in this case, somatostatin analogs and peptide receptor radionuclide therapy were not available. After pursuing other alternative treatments, including chemotherapy (ie, carboplatin, etoposide, capecitabine, temozolomide, and paclitaxel), everolimus, and atezolizumab, she returned with significant progression, including innumerable subcutaneous nodules, left pleura metastasis, multiple bone metastases, and brain metastases. New biopsy analysis revealed an ETV6-NTRK2 fusion. She was immediately administere...
Source: Clinical Lung Cancer - April 7, 2024 Category: Cancer & Oncology Authors: Wusheng Zhang Sen Tian Xiang Li Yilin Chen Xinyu Wang Yunshuo Zhang Lihui Lv Yonghua Li Hui Shi Chong Bai Source Type: research
Cancers, Vol. 16, Pages 1432: Correction: Garza-Morales et al. Temozolomide Enhances Triple-Negative Breast Cancer Virotherapy In Vitro. Cancers 2018, 10, 144
mez-Gutierrez
Error in Figure [...] (Source: Cancers)
Source: Cancers - April 7, 2024 Category: Cancer & Oncology Authors: Rodolfo Garza-Morales Roxana Gonzalez-Ramos Akiko Chiba Roberto Montes de Oca-Luna Lacey R. McNally Kelly M. McMasters Jorge G. Gomez-Gutierrez Tags: Correction Source Type: research
Long non-coding RNA < em > LIP < /em > interacts with PARP-1 influencing the efficiency of base excision repair
Noncoding RNA Res. 2024 Mar 25;9(3):649-658. doi: 10.1016/j.ncrna.2024.03.010. eCollection 2024 Sep.ABSTRACTIn recent years, various long non-coding RNAs (lncRNAs) involved in DNA damage response (DDR) have been identified and studied to deepen our understanding. However, there are rare reports on the association between lncRNAs and base excision repair (BER). Our designed DNA microarray identified dozens of functionally unknown lncRNAs, and their transcription levels significantly increased upon exposure to DNA damage inducers. One of them, named LIP (Long noncoding RNA Interacts with PARP-1), exhibited a significant alte...
Source: Cell Research - April 5, 2024 Category: Cytology Authors: You Zuo Jiaqian He Zheng Zhou Jingjing Sun Can Ouyang Hui Huang Yajuan Wang Hairong Liu Simon H Reed Source Type: research
Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
Expert Rev Mol Med. 2024 Apr 2;26:e5. doi: 10.1017/erm.2024.8.ABSTRACTGlioblastoma IDH wild type (GBM) is a very aggressive brain tumour, characterised by an infiltrative growth pattern and by a prominent neoangiogenesis. Its prognosis is unfortunately dismal, and the median overall survival of GBM patients is short (15 months). Clinical management is based on bulk tumour removal and standard chemoradiation with the alkylating drug temozolomide, but the tumour invariably recurs leading to patient's death. Clinical options for GBM patients remained unaltered for almost two decades until the encouraging results obtained by t...
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Maria Patrizia Mongiardi Roberto Pallini Quintino Giorgio D'Alessandris Andrea Levi Maria Laura Falchetti Source Type: research
Regorafenib and glioblastoma: a literature review of preclinical studies, molecular mechanisms and clinical effectiveness
Expert Rev Mol Med. 2024 Apr 2;26:e5. doi: 10.1017/erm.2024.8.ABSTRACTGlioblastoma IDH wild type (GBM) is a very aggressive brain tumour, characterised by an infiltrative growth pattern and by a prominent neoangiogenesis. Its prognosis is unfortunately dismal, and the median overall survival of GBM patients is short (15 months). Clinical management is based on bulk tumour removal and standard chemoradiation with the alkylating drug temozolomide, but the tumour invariably recurs leading to patient's death. Clinical options for GBM patients remained unaltered for almost two decades until the encouraging results obtained by t...
Source: Molecular Medicine - April 2, 2024 Category: Molecular Biology Authors: Maria Patrizia Mongiardi Roberto Pallini Quintino Giorgio D'Alessandris Andrea Levi Maria Laura Falchetti Source Type: research
Real-world cost- effectiveness analysis: Tumor Treating Fields for newly diagnosed glioblastoma in China
ConclusionsThis cost-effectiveness analysis affirms that incorporating TTFields into TMZ treatment proves to be cost-effective, given a threshold three times the Chinese per capita GDP. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
ConclusionsOur data provide novel insights into the phenotypic adaptation of the heterogeneous TME instructed by GBM tumors. We show the key role of microglial phenotypic states in supporting GBM tumor growth and response to treatment. Our data place PDOXs as relevant models to assess the functionality of the TME and changes in the GBM ecosystem upon treatment.Graphical Abstract (Source: Genome Medicine)
Source: Genome Medicine - April 2, 2024 Category: Genetics & Stem Cells Source Type: research
Beyond fluorescence-guided resection: 5-ALA-based glioblastoma therapies
AbstractGlioblastoma is the most common primary malignant brain tumor. Despite advances in multimodal concepts over the last decades, prognosis remains poor. Treatment of patients with glioblastoma remains a considerable challenge due to the infiltrative nature of the tumor, rapid growth rates, and tumor heterogeneity. Standard therapy consists of maximally safe microsurgical resection followed by adjuvant radio- and chemotherapy with temozolomide. In recent years, local therapies have been extensively investigated in experimental as well as translational levels. External stimuli-responsive therapies such as Photodynamic T...
Source: Acta Neurochirurgica - April 2, 2024 Category: Neurosurgery Source Type: research
Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
In conclusion, our results position TSLP as a possible new growth factor in GBM and indicate its modulation of the tumor microenvironment, particularly through its interaction with PMN.PMID:38557942 | DOI:10.1007/s10571-024-01462-9 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 1, 2024 Category: Cytology Authors: Alejandra Infante Cruz Juan Valentin Coronel Paula Saibene V élez Federico Remes Lenicov Juan Iturrizaga Mart ín Abelleyro Micaela Rosato Carolina Maiumi Shiromizu Marianela Candolfi M ónica Vermeulen Carolina Jancic Ezequiel Yasuda Silvia Berner Marce Source Type: research
Relevance of Thymic Stromal Lymphopoietin on the Pathogenesis of Glioblastoma: Role of the Neutrophil
In conclusion, our results position TSLP as a possible new growth factor in GBM and indicate its modulation of the tumor microenvironment, particularly through its interaction with PMN.PMID:38557942 | PMC:PMC10984908 | DOI:10.1007/s10571-024-01462-9 (Source: Cellular and Molecular Neurobiology)
Source: Cellular and Molecular Neurobiology - April 1, 2024 Category: Cytology Authors: Alejandra Infante Cruz Juan Valentin Coronel Paula Saibene V élez Federico Remes Lenicov Juan Iturrizaga Mart ín Abelleyro Micaela Rosato Carolina Maiumi Shiromizu Marianela Candolfi M ónica Vermeulen Carolina Jancic Ezequiel Yasuda Silvia Berner Marce Source Type: research
Cancers, Vol. 16, Pages 1374: MGMT Methylation and Differential Survival Impact by Sex in Glioblastoma
Conclusions: In this study, females had higher mean and individual CpG site methylation and received a greater PFS and OS benefit by MGMT methylation that was not seen in males despite equal degrees of CpG methylation. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Addison E. Barnett Ahmad Ozair Anas S. Bamashmos Hong Li David S. Bosler Gabrielle Yeaney Assad Ali David M. Peereboom Justin D. Lathia Manmeet S. Ahluwalia Tags: Article Source Type: research
Elderly long-term survivors in the Nordic phase II study with first-line maintenance temozolomide for primary central nervous system lymphoma: a 10-year follow-up
Haematologica. 2024 Mar 28. doi: 10.3324/haematol.2024.285207. Online ahead of print.ABSTRACTNot available.PMID:38546689 | DOI:10.3324/haematol.2024.285207 (Source: Haematologica)
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Elisa Jacobsen Pulczynski Mikkel Runason Simonsen Outi Kuittinen Unn-Merete Fagerli Martin Erlanson Øystein Fluge Sirpa Lepp ä Bj ørn Østenstad Alexander Foss å Mikael Eriksson Tarec El-Galaly Hanne Kuitunen Karin Papworth Maria Ljungqvist Martin B P Source Type: research
