Combined Lanreotide Autogel and Temozolomide Treatment of Progressive Pancreatic and Intestinal Neuroendocrine Tumors: The Phase II SONNET Study
CONCLUSIONS: LAN plus TMZ is a treatment option for patients with progressive GEP-NET with more aggressive biological profile showing a manageable safety profile.PMID:38206830 | DOI:10.1093/oncolo/oyad325 (Source: The Oncologist)
Source: The Oncologist - January 11, 2024 Category: Cancer & Oncology Authors: Marianne Pavel Harald Lahner Dieter H örsch Anja Rinke Timm Denecke Arend Koch Benjamin Regnault Dorit Helbig Philipp Hoffmanns Markus Raderer Source Type: research
Cancers, Vol. 16, Pages 331: The Versatile Attributes of MGMT: Its Repair Mechanism, Crosstalk with Other DNA Repair Pathways, and Its Role in Cancer
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O6-methylguanine-DNA methyltransferase (MGMT or AGT) is a DNA repair protein with the capability to remove alkyl groups from O6-AlkylG adducts. Moreover, MGMT plays a crucial role in repairing DNA damage induced by methylating agents like temozolomide and chloroethylating agents such as carmustine, and thereby contributes to chemotherapeutic resistance when these agents are used. This review delves into the structural roles and repair mechanisms of MGMT, with emphasis on the potential structural and functional roles of the N-terminal domain of MGMT. It also explores the development of cancer therapeutic strategies th...
Source: Cancers - January 11, 2024 Category: Cancer & Oncology Authors: Qingming Fang Tags: Review Source Type: research
GSE229136 Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells
Contributors : William Hart ; Matthew LazzaraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn glioblastoma, a mesenchymal phenotype is associated with especially poor patient outcomes. Various glioblastoma microenvironmental factors and therapeutic interventions are purported drivers of the mesenchymal transition, but the degree to which these cues promote the same mesenchymal transitions and the uniformity of those transitions, as defined by molecular subtyping systems, is unknown. Here, we investigate this question by analyzing publicly available patient data, surveying commonly...
Source: GEO: Gene Expression Omnibus - January 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Pediatric H3K27M ‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review
Oncol Lett. 2023 Dec 7;27(2):48. doi: 10.3892/ol.2023.14181. eCollection 2024 Feb.ABSTRACTH3K27M-mutant diffuse midline glioma (DMG) is a type of high-grade glial tumor, which occurs in the midline structure and develops mostly in children. Extraneural metastases (ENM) are exceedingly rare in patients with H3K27M-mutant DMG. A 9-year-old male patient presented with a headache, nausea and vomiting. Following magnetic resonance imaging and immunohistochemical molecular testing examination, the patient was diagnosed with H3K27M-mutant DMG and received chemoradiotherapy plus five cycles of chemotherapy with temozolomide interm...
Source: Oncology Letters - January 9, 2024 Category: Cancer & Oncology Authors: Xiaohui Ge Yu Yang Wenyan Wang Lei Tian Ge Zhang Zhesen Tian Xiaoying Xue Source Type: research
Uncovering potential diagnostic and pathophysiological roles of α‐synuclein and DJ‐1 in melanoma
Conclusionα-synuclein, together with DJ-1, may play a role in melanoma progression and chemosensitivity, constituting novel targets for therapeutic intervention, and possible biomarkers for melanoma. (Source: Cancer Medicine)
Source: Cancer Medicine - January 8, 2024 Category: Cancer & Oncology Authors: Agathe Quesnel,
Leya Danielle Martin,
Chaimaa Tarzi,
Vasileios P. Lenis,
Nathan Coles,
Meez Islam,
Claudio Angione,
Tiago F. Outeiro,
Ahmad A. Khundakar,
Panagiota S. Filippou Tags: RESEARCH ARTICLE Source Type: research
Endosome associated trafficking regulator 1 promotes tumor growth and invasion of glioblastoma multiforme via inhibiting TNF signaling pathway
ConclusionOur results indicated that ENTR1 played an important role in cell proliferation, invasion and chemotherapeutic sensitivity of GBM, suggesting that ENTR1 might be a novel prognostic marker and significant therapeutic target for GBM. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 8, 2024 Category: Cancer & Oncology Source Type: research
Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme
In this study, a series of N-alkyl-N-benzoyl and N-alkyl-N-benzyl thiazoles were designed and prepared using a scaffold-hopping strategy and evaluated as TRPC6 antagonists. This resulted in the discovery of 15g, a potent TRPC antagonist that exhibited suitable inhibitory micromolar activities against TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7 and displayed noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines. In addition, 15g featured an acceptable pharmacokinetic profile and exhibited better in vivo potency (25 mg/kg/d) than the frontline therapeutic agent temozolomide (50 mg/kg/d) in xenograft models. Taken t...
Source: European Journal of Medicinal Chemistry - January 7, 2024 Category: Chemistry Authors: Shanshan Wang Xiaoxue Li Yuemiao Hu Lin Wang Guangyao Lv Yuxin Feng Ziqiang Sun Zhengyu Cao Yi Liu Hongbo Wang Source Type: research
Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme
In this study, a series of N-alkyl-N-benzoyl and N-alkyl-N-benzyl thiazoles were designed and prepared using a scaffold-hopping strategy and evaluated as TRPC6 antagonists. This resulted in the discovery of 15g, a potent TRPC antagonist that exhibited suitable inhibitory micromolar activities against TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7 and displayed noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines. In addition, 15g featured an acceptable pharmacokinetic profile and exhibited better in vivo potency (25 mg/kg/d) than the frontline therapeutic agent temozolomide (50 mg/kg/d) in xenograft models. Taken t...
Source: European Journal of Medicinal Chemistry - January 7, 2024 Category: Chemistry Authors: Shanshan Wang Xiaoxue Li Yuemiao Hu Lin Wang Guangyao Lv Yuxin Feng Ziqiang Sun Zhengyu Cao Yi Liu Hongbo Wang Source Type: research
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
AbstractGlioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans, exhibiting very bad prognosis. Treatment with surgery, radiotherapy, and chemotherapy (mainly using temozolomide), generates as much one-year survival. The circadian clock controls different aspects of tumor development, and its role in GBM is beginning to be explored. Here, the role of the canonic circadian clock genebmal1 was studied in vivo in a nude mice model bearing human GBMs from LN229 cells xenografted orthotopically in the dorsal striatum. For that aim, abmal1 knock-down was generate...
Source: Molecular Neurobiology - January 5, 2024 Category: Neurology Source Type: research
Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis
In conclusion, our results suggested that remodeling of the gut microbiome after stress may reverse stress-induced impairment of hippocampal neurogenesis and thereby promote recovery from stress-induced depression.PMID:38176570 | DOI:10.1016/j.nbd.2023.106396 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 4, 2024 Category: Neurology Authors: Haili He Zhihuang Zhao Chenghong Xiao Liangyuan Li Yu-E Liu Juan Fu Hongyu Liao Tao Zhou Jinqiang Zhang Source Type: research
Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease
Biochem Biophys Res Commun. 2023 Dec 25;695:149418. doi: 10.1016/j.bbrc.2023.149418. Online ahead of print.ABSTRACTGlioma is a highly recalcitrant disease with a 5-year survival of 6.8 %. Temozolomide (TMZ), first-line therapy for glioma, is more effective in O6-methylguanine-DNA methyltransferase (MGMT)-negative gliomas than in MGMT-positive gliomas as MGMT confers resistance to TMZ. Methionine restriction is effective for many cancers in mouse models including glioma. The concern is that methionine restriction could induce MGMT by decreasing DNA methylation and confer resistance to TMZ. In the present study, we investiga...
Source: Biochemical and Biophysical Research communications - January 4, 2024 Category: Biochemistry Authors: Yutaro Kubota Yusuke Aoki Noriyuki Masaki Koya Obara Kazuyuki Hamada Qinghong Han Michael Bouvet Takuya Tsunoda Robert M Hoffman Source Type: research
Gut microbiome promotes mice recovery from stress-induced depression by rescuing hippocampal neurogenesis
In conclusion, our results suggested that remodeling of the gut microbiome after stress may reverse stress-induced impairment of hippocampal neurogenesis and thereby promote recovery from stress-induced depression.PMID:38176570 | DOI:10.1016/j.nbd.2023.106396 (Source: Neurobiology of Disease)
Source: Neurobiology of Disease - January 4, 2024 Category: Neurology Authors: Haili He Zhihuang Zhao Chenghong Xiao Liangyuan Li Yu-E Liu Juan Fu Hongyu Liao Tao Zhou Jinqiang Zhang Source Type: research
Methionine restriction of glioma does not induce MGMT and greatly improves temozolomide efficacy in an orthotopic nude-mouse model: A potential curable approach to a clinically-incurable disease
Biochem Biophys Res Commun. 2023 Dec 25;695:149418. doi: 10.1016/j.bbrc.2023.149418. Online ahead of print.ABSTRACTGlioma is a highly recalcitrant disease with a 5-year survival of 6.8 %. Temozolomide (TMZ), first-line therapy for glioma, is more effective in O6-methylguanine-DNA methyltransferase (MGMT)-negative gliomas than in MGMT-positive gliomas as MGMT confers resistance to TMZ. Methionine restriction is effective for many cancers in mouse models including glioma. The concern is that methionine restriction could induce MGMT by decreasing DNA methylation and confer resistance to TMZ. In the present study, we investiga...
Source: Biochemical and Biophysical Research communications - January 4, 2024 Category: Biochemistry Authors: Yutaro Kubota Yusuke Aoki Noriyuki Masaki Koya Obara Kazuyuki Hamada Qinghong Han Michael Bouvet Takuya Tsunoda Robert M Hoffman Source Type: research
Bivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide
Cell Death & Disease, Published online: 04 January 2024; doi:10.1038/s41419-023-06392-wBivalent activity of super-enhancer RNA LINC02454 controls 3D chromatin structure and regulates glioma sensitivity to temozolomide (Source: Cell death and disease)
Source: Cell death and disease - January 4, 2024 Category: Internal Medicine Authors: Tengfei Shi Dianhao Guo Yaoqiang Zheng Wenbin Wang Jinfang Bi Anshun He Sibo Fan Guangsong Su Xueyuan Zhao Zhenhao Zhao Yingjie Song Shupeng Sun Peng Li Zhongfang Zhao Jiandang Shi Wange Lu Lei Zhang Source Type: research
Development of a prognostic model for glioblastoma multiforme based on the expression levels of efferocytosis-related genes
This study aimed to develop an efferocytosis-related prognostic model for GBM. The bioinformatic methods were utilized to analyze the transcriptomic data of GBM and normal samples. Clinical and RNA-seq data were sourced from TCGA database comprising 167 tumor samples and 5 normal samples, and 167 tumor samples for which survival information was available. Transcriptomic data of 1034 normal samples were collected from the Genotype-Tissue Expression (GTEx) database as a control sample supplement to the TCGA database. In the end, 167 tumor samples and 1039 normal samples were obtained for transcriptome analysis. Efferocytosis...
Source: Aging - December 30, 2023 Category: Biomedical Science Authors: Wenzhe Xu Lihui Han Pengfei Zhu Yufeng Cheng Xuan Chen Source Type: research
