Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide
Cancers (Basel). 2024 Feb 26;16(5):936. doi: 10.3390/cancers16050936.ABSTRACTThe Epstein-Barr virus (EBV) is accepted as a primary risk factor for certain nasopharyngeal carcinoma (NPC) subtypes, where the virus persists in a latent stage which is thought to contribute to tumorigenesis. Current treatments are sub-optimal, and recurrence occurs in many cases. An alternative therapeutic concept is aimed at triggering the lytic cycle of EBV selectively in tumor cells as a means to add clinical benefit. While compounds able to stimulate the lytic cascade have been identified, their clinical application so far has been limited....
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Hannah Hartman-Houstman Steve Swenson Radu O Minea Uttam K Sinha Ming-Fu Chiang Thomas C Chen Axel H Sch önthal Source Type: research
Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide
Cancers (Basel). 2024 Feb 26;16(5):936. doi: 10.3390/cancers16050936.ABSTRACTThe Epstein-Barr virus (EBV) is accepted as a primary risk factor for certain nasopharyngeal carcinoma (NPC) subtypes, where the virus persists in a latent stage which is thought to contribute to tumorigenesis. Current treatments are sub-optimal, and recurrence occurs in many cases. An alternative therapeutic concept is aimed at triggering the lytic cycle of EBV selectively in tumor cells as a means to add clinical benefit. While compounds able to stimulate the lytic cascade have been identified, their clinical application so far has been limited....
Source: Herpes - March 13, 2024 Category: Infectious Diseases Authors: Hannah Hartman-Houstman Steve Swenson Radu O Minea Uttam K Sinha Ming-Fu Chiang Thomas C Chen Axel H Sch önthal Source Type: research
Unusual presentation of glioblastoma in the brainstem: a case report of a diffuse pontine glioblastoma multiforme and surgical management
Diffuse pontine glioblastoma multiforme is a rare subtype of glioblastoma associated with a poor prognosis. In this case report, we present a unique case of diffuse primary pontine glioblastoma multiforme in a patient without any supratentorial lesions. We review the symptoms, treatment options, and case management of patients with infratentorial glioblastoma multiforme and compare these with our patient. Our patient presented with symptoms including progressive diplopia, gait disturbance, and lower extremity weakness. Magnetic resonance imaging revealed a diffuse lesion involving the pons and biopsy revealed only mildly-a...
Source: Frontiers in Oncology - March 13, 2024 Category: Cancer & Oncology Source Type: research
Chemo-immunotherapy with dinutuximab beta in patients with relapsed/progressive high-risk neuroblastoma: does chemotherapy backbone matter?
This study presents the chemo-immunotherapy experience in patients with relapsed/progressive high-risk neuroblastoma treated within the off-label use program of the Neuroblastoma Committee of the French Society of Pediatric Oncology (SFCE). (Source: European Journal of Cancer)
Source: European Journal of Cancer - March 11, 2024 Category: Cancer & Oncology Authors: Patricia Raiser, Gudrun Schleiermacher, Marion Gambart, Benoit Dumont, Anne-Sophie Defachelles, Estelle Thebaud, Julie Tandonnet, Claudia Pasqualini, St éphanie Proust, Natacha Entz-Werle, Isabelle Aerts, Lee A. Ndounga-Diakou, Arnaud Petit, Chloe Puiseu Tags: Original Research Source Type: research
GINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas
Cell Death & Disease, Published online: 11 March 2024; doi:10.1038/s41419-024-06586-wGINS2 regulates temozolomide chemosensitivity via the EGR1/ECT2 axis in gliomas (Source: Cell death and disease)
Source: Cell death and disease - March 11, 2024 Category: Internal Medicine Authors: Hua He Lu Liang Shiyao Jiang Yueying Liu Jingjing Huang Xiaoyan Sun Yi Li Yiqun Jiang Li Cong Source Type: research
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity
Biochem Pharmacol. 2024 Mar 7:116113. doi: 10.1016/j.bcp.2024.116113. Online ahead of print.ABSTRACTGlioma is one of the most common primary malignant tumors of the central nervous system. Temozolomide (TMZ) is the only effective chemotherapeutic agent, but it easily develops resistance and has unsatisfactory efficacy. Consequently, there is an urgent need to develop safe and effective compounds for glioma treatment. The cytotoxicity of 30 candidate compounds to glioma cells was detected by the CCK-8 assay. Daurisoline (DAS) was selected for further investigation due to its potent anti-glioma effects. Our study revealed th...
Source: Biochemical Pharmacology - March 9, 2024 Category: Drugs & Pharmacology Authors: Hai-Tang Yin None Hui-Lu Ji-Hong Yang Qin Li Ming Li Qing-Qing Zhao Zhi-Peng Wen Source Type: research
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity
Biochem Pharmacol. 2024 Mar 7:116113. doi: 10.1016/j.bcp.2024.116113. Online ahead of print.ABSTRACTGlioma is one of the most common primary malignant tumors of the central nervous system. Temozolomide (TMZ) is the only effective chemotherapeutic agent, but it easily develops resistance and has unsatisfactory efficacy. Consequently, there is an urgent need to develop safe and effective compounds for glioma treatment. The cytotoxicity of 30 candidate compounds to glioma cells was detected by the CCK-8 assay. Daurisoline (DAS) was selected for further investigation due to its potent anti-glioma effects. Our study revealed th...
Source: Biochemical Pharmacology - March 9, 2024 Category: Drugs & Pharmacology Authors: Hai-Tang Yin None Hui-Lu Ji-Hong Yang Qin Li Ming Li Qing-Qing Zhao Zhi-Peng Wen Source Type: research
The role of adjuvant chemotherapy in patients with H3K27 altered diffuse midline gliomas: a multicentric retrospective study
ConclusionIn our series, adjuvant treatment after radiotherapy can be useful in improving OS of patients with H3K27-altered DMG. When feasible another systemic treatment after treatment progression could be proposed. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - March 8, 2024 Category: Cancer & Oncology Source Type: research
RND1 inhibits epithelial-mesenchymal transition and temozolomide resistance of glioblastoma via AKT/GSK3- β pathway
Cancer Biol Ther. 2024 Dec 31;25(1):2321770. doi: 10.1080/15384047.2024.2321770. Epub 2024 Mar 5.ABSTRACTGBM is one of the most malignant tumor in central nervous system. The resistance to temozolomide (TMZ) is inevitable in GBM and the characterization of TMZ resistance seriously hinders clinical treatment. It is worthwhile exploring the underlying mechanism of aggressive invasion and TMZ resistance in GBM treatment. Bioinformatic analysis was used to analyze the association between RND1 and a series of EMT-related genes. Colony formation assay and cell viability assay were used to assess the growth of U87 and U251 cells....
Source: Cancer Biology and Therapy - March 6, 2024 Category: Cancer & Oncology Authors: Qian Sun Junjie Xu Fan'en Yuan Yan Liu Qianxue Chen Lirui Guo Huimin Dong Baohui Liu Source Type: research
