REGOMA-OSS: a large, Italian, multicenter, prospective, observational study evaluating the efficacy and safety of regorafenib in patients with recurrent glioblastoma
CONCLUSIONS: This large, real-world observational study showed similar OS with better tolerability of regorafenib in patients with relapsed glioblastoma compared with the REGOMA study.PMID:38492275 | DOI:10.1016/j.esmoop.2024.102943 (Source: Cancer Control)
Source: Cancer Control - March 16, 2024 Category: Cancer & Oncology Authors: M Caccese I Desideri V Villani M Simonelli M Buglione S Chiesa E Franceschi P Gaviani I Stasi C Caserta S Brugnara I Lolli E Bennicelli P Bini A S Cuccu S Scoccianti M Padovan S Gori A Bonetti P Giordano A Pellerino F Gregucci N Riva S Cinieri V Intern ò Source Type: research
Spinal and cervical nodal metastases in a patient with glioblastoma
This article presents the rare case of a 54-year-old gentleman with primary glioblastoma developing multiple extracranial metastases 7 months after diagnosis. Initially, the patient complained of progressive headaches, confusion, and weakness of the left arm. Magnetic resonance imaging of the brain showed a right temporoparietal tumor with substantial surrounding subcortical edema and midline shift to the left. Two consecutive craniotomies resulted in complete microsurgical resection of the lesion. Histology was consistent with a World Health Organization grade IV, IDH-wildtype glioblastoma. Further treatment was sta...
Source: Strahlentherapie und Onkologie - March 15, 2024 Category: Cancer & Oncology Source Type: research
Integrating and optimizing tonabersat in standard glioblastoma therapy: A preclinical study
In conclusion, this preclinical investigation highlights tonabersat’s potenti al as an effective adjuvant treatment for GB, and its established safety profile from clinical trials in migraine treatment presents a promising foundation for further exploration. (Source: PLoS One)
Source: PLoS One - March 15, 2024 Category: Biomedical Science Authors: Velislava Zoteva Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
Systemic treatment of adult gliomas: a narrative review
Magy Onkol. 2024 Mar 14;68(1):67-75. Epub 2024 Jan 4.ABSTRACTGliomas are considered as locally aggressive diseases, consequently, surgery and radiotherapy are the basic therapies of the glial tumors. Nevertheless, the long-term ineffectiveness of the local treatment modalities and the frequently observed relapses explain the unmet medical need for the elaboration of effective systemic treatment regimes. In the last few decades of the 20th century, the use of different chemotherapeutic agents and their combinations, and the alternative administration of drugs have been in the therapeutic forefront of gliomas, whereas, later...
Source: Magyar Onkologia - March 14, 2024 Category: Cancer & Oncology Authors: L ászló Mangel Source Type: research
