Dihydroartemisinin suppresses glioma growth by repressing ERR α-mediated mitochondrial biogenesis
Mol Cell Biochem. 2023 Dec 11. doi: 10.1007/s11010-023-04892-z. Online ahead of print.ABSTRACTMalignant gliomas are an exceptionally lethal form of cancer with limited treatment options. Dihydroartemisinin (DHA), a sesquiterpene lactone antimalarial compound, has demonstrated therapeutic effects in various solid tumors. In our study, we aimed to investigate the mechanisms underlying the anticancer effects of DHA in gliomas. To explore the therapeutic and molecular mechanisms of DHA, we employed various assays, including cell viability, flow cytometry, mitochondrial membrane potential, glucose uptake and glioma xenograft mo...
Source: Molecular and Cellular Biochemistry - December 10, 2023 Category: Biochemistry Authors: Wenxin Zhang Yan Wang Lu Chen Haifei Chen Huijie Qi Yong Zheng Yongli Du Liudi Zhang Tianxiao Wang Qunyi Li Source Type: research
Dihydroartemisinin suppresses glioma growth by repressing ERR α-mediated mitochondrial biogenesis
Mol Cell Biochem. 2023 Dec 11. doi: 10.1007/s11010-023-04892-z. Online ahead of print.ABSTRACTMalignant gliomas are an exceptionally lethal form of cancer with limited treatment options. Dihydroartemisinin (DHA), a sesquiterpene lactone antimalarial compound, has demonstrated therapeutic effects in various solid tumors. In our study, we aimed to investigate the mechanisms underlying the anticancer effects of DHA in gliomas. To explore the therapeutic and molecular mechanisms of DHA, we employed various assays, including cell viability, flow cytometry, mitochondrial membrane potential, glucose uptake and glioma xenograft mo...
Source: Molecular and Cellular Biochemistry - December 10, 2023 Category: Biochemistry Authors: Wenxin Zhang Yan Wang Lu Chen Haifei Chen Huijie Qi Yong Zheng Yongli Du Liudi Zhang Tianxiao Wang Qunyi Li Source Type: research
Cancers, Vol. 15, Pages 5777: Association of MGMT Promoter and Enhancer Methylation with Genetic Variants, Clinical Parameters, and Demographic Characteristics in Glioblastoma
In this study, we investigated if methylation of the four enhancers is associated with SNP rs16906252, TERT promoter mutations C228T and C250T, TERT SNP rs2853669, proliferation index Ki-67, overall survival (OS), age, and sex of the patients. In general, associations with genetic variants, clinical parameters, and demographic characteristics were caused by a complex interplay of multiple CpGs in the MGMT promoter and of multiple CpGs in enhancer regions. The observed associations for intragenic enhancer 4, located in intron 2 of MGMT, differed from associations observed for the three intergenic enhancers. Some findings we...
Source: Cancers - December 9, 2023 Category: Cancer & Oncology Authors: Katja Zappe Katharina P ühringer Simon Pflug Daniel Berger Serge Weis Sabine Spiegl-Kreinecker Margit Cichna-Markl Tags: Article Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Mol Biol Cell - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
Interaction of SENP6 with PINK1 Promotes Temozolomide Resistance in Neuroglioma Cells via Inducing the Mitophagy
In this study, mitophagy levels in temozolomide-resistant and -sensitive cell lines were evaluated. The mechanisms underlying the regulation of mitophagy were explored through RNA sequencing, and the roles of differentially expressed genes in mitophagy and temozolomide resistance were investigated. We found that mitophagy promotes temozolomide resistance in glioma. Specifically, small ubiquitin-like modifier specific protease 6 (SENP6) promoted temozolomide resistance in glioma by inducing mitophagy. Protein-protein interactions between SENP6 and the mitophagy executive protein PTEN-induced kinase 1 (PINK1) resulted in a r...
Source: Molekuliarnaia Biologiia - December 8, 2023 Category: Molecular Biology Authors: Y W Wang K G Jia H J Xing Y Pan C S Zeng L Chen Q J Su W T Shen J Chen C Chen Q Cao Y Y Wang Source Type: research
