ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis.
Abstract
Epidemiological investigations indicate that certain ingredients in tea bricks can antagonize the adverse effects of fluoride. Tea polyphenols (TPs), the most bioactive ingredient in tea bricks, have been demonstrated to be potent bone-supporting agents. ClC‑7 is known to be crucial for osteoclast (OC) bone resorption. Thus, in this study, we investigated the potential protective effects of TPs against fluorosis using a mouse model and explored the underlying mechanisms with particular focus on ClC‑7. A total of 40, healthy, 3‑week‑old male C57BL/6 mice were randomly divided into 4 gr...
Source: International Journal of Molecular Medicine - March 22, 2017 Category: Molecular Biology Authors: Li BY, Gao YH, Pei JR, Yang YM, Zhang W, Sun DJ Tags: Int J Mol Med Source Type: research
The Effect of Green Tea Consumption on Prostate Cancer Risk and Progression: A Systematic Review.
Abstract
This systematic review aimed to assess the clinical benefits of green tea consumption on the progression and prevention of prostate cancer (PCa). A systematic search was performed across the following databases: PubMed, Excerpta Medica dataBASE, Database of Abstracts of Reviews of Effects, Current Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials. We included studies from database inception to September 2015. Studies must report on the effect of green tea consumption on PCa. ...
Source: Nutrition and Cancer - March 15, 2017 Category: Cancer & Oncology Authors: Jacob SA, Khan TM, Lee LH Tags: Nutr Cancer Source Type: research
Characterization of white tea metabolome: Comparison against green and black tea by a nontargeted metabolomics approach
This study offers a comprehensive characterization of the metabolites and their changes in white tea. Graphical abstract (Source: Food Research International)
Source: Food Research International - March 12, 2017 Category: Food Science Source Type: research
Tea silkworm droppings as an enriched source of tea flavonoids
Publication date: Available online 25 January 2017 Source:Journal of Food and Drug Analysis Author(s): Tzu-Yun Chou, Meei-Ju Yang, Shih-Kung Tseng, Shoei-Sheng Lee, Chia-Chuan Chang Andraca droppings is the waste excreted from the tea biter Andraca theae. Its chemical constituents and potential medical use, unlike those of the traditional Chinese medicine silkworm droppings, have not been reported yet. To explore new nutraceuticals, the chemical constituents of this substance were investigated. Since the bioactive ingredients are generally present in the EtOAc-soluble fraction. This fraction, obtained from the ethan...
Source: Journal of Food and Drug Analysis - March 8, 2017 Category: Food Science Source Type: research
Green tea and its anti-angiogenesis effects
Publication date: May 2017 Source:Biomedicine & Pharmacotherapy, Volume 89 Author(s): Bahman Rashidi, Mehrnoush Malekzadeh, Mohammad Goodarzi, Aria Masoudifar, Hamed Mirzaei The development of new blood vessels from a pre-existing vasculature (also known as angiogenesis) is required for many physiological processes including embryogenesis and post-natal growth. However, pathological angiogenesis is also a hallmark of cancer and many ischaemic and inflammatory diseases. The pro-angiogenic members of the VEGF family (vascular endothelial growth factor family), VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growt...
Source: Biomedicine and Pharmacotherapy - March 8, 2017 Category: Drugs & Pharmacology Source Type: research
Green tea and its anti-angiogenesis effects.
Abstract
The development of new blood vessels from a pre-existing vasculature (also known as angiogenesis) is required for many physiological processes including embryogenesis and post-natal growth. However, pathological angiogenesis is also a hallmark of cancer and many ischaemic and inflammatory diseases. The pro-angiogenic members of the VEGF family (vascular endothelial growth factor family), VEGF-A, VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF), and the related receptors, VEGFR-1, VEGFR-2 and VEGFR-3 have a central and decisive role in angiogenesis. Indeed, they are the targets for anti-an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 8, 2017 Category: Drugs & Pharmacology Authors: Rashidi B, Malekzadeh M, Goodarzi M, Masoudifar A, Mirzaei H Tags: Biomed Pharmacother Source Type: research
Tea catechin and caffeine activate brown adipose tissue and increase cold-induced thermogenic capacity in humans.
Conclusion: Orally ingested tea catechin with caffeine acutely increases EE associated with increased BAT activity and chronically elevates nonshivering CIT, probably because of the recruitment of BAT, in humans. These trials were registered at www.umin.ac.jp/ctr/ as UMIN000016361.
PMID: 28275131 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - March 7, 2017 Category: Nutrition Authors: Yoneshiro T, Matsushita M, Hibi M, Tone H, Takeshita M, Yasunaga K, Katsuragi Y, Kameya T, Sugie H, Saito M Tags: Am J Clin Nutr Source Type: research
TeA is a key virulence factor for Alternaria alternata (Fr.) Keissler infection of its host
Publication date: Available online 4 March 2017 Source:Plant Physiology and Biochemistry Author(s): Ye Kang, Hongwei Feng, Jingxu Zhang, Shiguo Chen, Bernal E. Valverde, Sheng Qiang A toxin-deficient mutant strain, HP001 mutant of Alternaria alternata, whose mycelium is unable to infect its host, produces little tenuazonic acid (TeA) toxin. How TeA plays a role in initiating host infection by A. alternata remains unclear. In this research we use Imaging-PAM based on chlorophyll fluorescence parameters and transmission electron microscopy to explore the role of TeA toxin during the infection process of A. alternata....
Source: Plant Physiology and Biochemistry - March 4, 2017 Category: Biochemistry Source Type: research
Antimutagenic and anticlastogenic effects of Turkish Black Tea on TA98 and TA100 strains of Salmonella typhimurium (in vitro) and mice (in vivo).
CONCLUSION: Results indicated that TBT can be considered as genotoxically safe, because it did not exert any mutagenic and clastogenic effects. As a result, TBT exhibited antimutagenic effects more apparently after metabolic activation in bacterial test system and had an anticlastogenic effect in mice.
PMID: 28245735 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - March 3, 2017 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Green tea and the risk of prostate cancer: A systematic review and meta-analysis
In conclusion, our dose–response meta-analysis evaluated the association of green tea intake with PCa risk systematically and quantitatively. And this is the first meta-analysis of green tea catechins consumption and PCa incidence. Our novel data demonstrated that higher green tea consumption was linearly reduced PCa risk with more than 7 cups/day and green tea catechins were effective for preventing PCa. However, further studies are required to substantiate these conclusions. (Source: Medicine)
Source: Medicine - March 1, 2017 Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observational Studies in Epidemiology Source Type: research
Updated association of tea consumption and bone mineral density: A meta-analysis
Background: Current studies evaluating the association of tea consumption and bone mineral density (BMD) have yielded inconsistent findings. Therefore, we conducted a meta-analysis to assess the relationship between tea consumption and BMD.
Methods: The PubMed, Embase, and Cochrane Library databases were comprehensively searched, and a meta-analysis performed of all observational studies assessing the association of tea consumption and BMD. Forest plots were used to illustrate the results graphically. The Q-test and I2 statistic were employed to evaluate between-study heterogeneity. Potential publication bias was assessed...
Source: Medicine - March 1, 2017 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Coffee, tea, caffeine, and risk of hypertension: The Singapore Chinese Health Study
ConclusionsDrinking coffee<1 cup/week or ≥3 cups/day had lower risk than drinking one cup/day. Caffeine may account for increased risk in daily tea drinkers and in those who drank one cup of coffee/day. The inverse U-shaped association with coffee suggests that at higher doses, other ingredients in coffee may offset the effect of caffein e and confer benefit on blood pressure. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - February 28, 2017 Category: Nutrition Source Type: research
Does tea consumption during early pregnancy have an adverse effect on birth outcomes?
ConclusionsWe did not identify a consistent association between frequency of tea consumption or tea strength and adverse birth outcomes among Chinese pregnant women with low tea consumption. Our findings suggest that occasional tea drinking during pregnancy is not associated with increased risk of preterm birth or abnormal fetal growth. Given the high overall number of annual births in China, our findings have important public health significance. (Source: Birth)
Source: Birth - February 28, 2017 Category: OBGYN Authors: Jin ‐Hua Lu, Jian‐Rong He, Song‐Ying Shen, Xue‐Ling Wei, Nian‐Nian Chen, Ming‐Yang Yuan, Lan Qiu, Wei‐Dong Li, Qiao‐Zhu Chen, Cui‐Yue Hu, Hui‐Min Xia, Suzanne Bartington, Kar Keung Cheng, Kin Bong Hubert Lam, Xiu Qiu, Tags: ORIGINAL ARTICLE Source Type: research
Applications of chitosan nanoparticles to enhance absorption and bioavailability of tea polyphenols: A review
Publication date: August 2017 Source:Food Hydrocolloids, Volume 69 Author(s): Jin Liang, Hua Yan, Pradeep Puligundla, Xueling Gao, Yibin Zhou, Xiaochun Wan Tea polyphenols find a wide range of applications in food, medical and pharmaceutical fields owing to their multi-health benefits including antioxidant and antibacterial activities, cancer prevention, anti-radiation and immune enhancement. However, the low absorption rate of tea polyphenols impedes their bioactivity in vivo. The low absorption and bioavailability have been attributed to their poor stability, passive diffusion, and active efflux in the gastroint...
Source: Food Hydrocolloids - February 28, 2017 Category: Food Science Source Type: research
APOE and CETP TaqIB polymorphisms influence metabolic responses to Hibiscus sabdariffa L. and Gynostemma pentaphyllum Makino tea consumption in hypercholesterolemic subjects.
CONCLUSIONS: HS consumption may have beneficial effects with respect to TG concentrations in the B2 carriers, but it may adversely affect HDL-C concentrations in homozygous B1B1 and E4 carriers. In contrast, GP consumption may have favorable effects on TC and FBG concentrations but not on HDL-C concentrations for B2 and/or non-E4 carriers.
PMID: 28244718 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - February 28, 2017 Category: Nutrition Authors: Jeenduang N, Sangkaew B, Chantaracha P, Chanchareonsri S, Plyduang T, Thitdee W, Samae C, Pitumanon W Tags: Asia Pac J Clin Nutr Source Type: research
