KLRG1, Another Opportunity for a Breakthrough in MTCL
Clin Cancer Res. 2024 Apr 3. doi: 10.1158/1078-0432.CCR-24-0374. Online ahead of print.ABSTRACTOutcomes in mature T-cell lymphomas remain poor, with previous attempts at developing monoclonal antibodies (mAb) compromised by limited efficacy and significant immunocompromise. Anti-killer cell lectin-like receptor G1 mAbs may have greater selectivity and specificity for malignant T-cells and avoid the toxicity concerns with previous agents.PMID:38568191 | DOI:10.1158/1078-0432.CCR-24-0374 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 3, 2024 Category: Cancer & Oncology Authors: Gaurav Varma Catherine S Diefenbach Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
Adrenal Insufficiency after Long-term use of Topical Glucocorticoids in Patients with Advanced Cutaneous T-cell Lymphomas: A Case Series
Acta Derm Venereol. 2024 Apr 2;104:adv19672. doi: 10.2340/actadv.v104.19672.NO ABSTRACTPMID:38566532 | DOI:10.2340/actadv.v104.19672 (Source: Acta Derm Venereol A...)
Source: Acta Derm Venereol A... - April 3, 2024 Category: Dermatology Authors: Valerie Glutsch Patrick Schummer Ann-Cathrin Koschker Matthias Goebeler Marion Wobser Source Type: research
Analysis of the treatment and prognosis of 266 cases of extranodal natural killer/T-cell lymphoma, nasal type in a single medical center
ConclusionStages of the disease and whether CR was achieved following treatment are important factors determining the survival and prognosis of patients with ENKTL. Further researches focusing on disease onset and mechanisms of drug resistance will contribute to better management of ENKTL. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression
ConclusionsThe striking differences underlying the mutational landscapes between the primary and relapsed/refractory NKTCL patients highlight the importance of genomic instability in driving the progression of NKTCL. Our newly proposed molecular subtyping system is valuable in assisting patient stratification and novel treatment design towards a better prognosis in the age of precision medicine. (Source: Genome Medicine)
Source: Genome Medicine - April 2, 2024 Category: Genetics & Stem Cells Source Type: research
T-Cell Lymphoma Masquerading as Cellular Mediated Rejection in a Heart Transplant Patient
We present an unusual case of T cell infiltration of the heart masquerading as recurrent cellular rejection that was found to be due to peripheral T-cell lymphoma. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. O'Brien, J. Weinstein, N. Arva, S. Gong, P. Thrush, K. Gambetta Source Type: research
Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes
CONCLUSIONS: The presence of genetic variations in one or more TRM functional gene may predispose patients to develop MF. Further studies involving a larger patient population and a comparative analysis of protein expression will be necessary to validate these findings.PMID:38546260 | DOI:10.1177/03000605241239034 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Nour Almaani Fatima Farhan Salsabiela Bani Hamad Eman A Abuhawileh Lana Koubaitary Mamoun Ahram Tariq N Aladily Source Type: research
MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications
This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the PINK-E prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown (KD) in NK malignancy cell lines with MYC overexpression, resulting in significant viability reduction. RNA-sequencing (RNA-seq) used to determi...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Chengfeng Bi Yuhua Huang Roshia Ali Fang Wang Xia Yang Alyssa Bouska Lu Xu Xinbao Hao Matthew A Lunning Wing C Chan Javeed Iqbal Dennis D Weisenburger Julie M Vose Kai Fu Source Type: research
MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications
This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the PINK-E prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown (KD) in NK malignancy cell lines with MYC overexpression, resulting in significant viability reduction. RNA-sequencing (RNA-seq) used to determi...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Chengfeng Bi Yuhua Huang Roshia Ali Fang Wang Xia Yang Alyssa Bouska Lu Xu Xinbao Hao Matthew A Lunning Wing C Chan Javeed Iqbal Dennis D Weisenburger Julie M Vose Kai Fu Source Type: research
MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications
This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the PINK-E prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown (KD) in NK malignancy cell lines with MYC overexpression, resulting in significant viability reduction. RNA-sequencing (RNA-seq) used to determi...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Chengfeng Bi Yuhua Huang Roshia Ali Fang Wang Xia Yang Alyssa Bouska Lu Xu Xinbao Hao Matthew A Lunning Wing C Chan Javeed Iqbal Dennis D Weisenburger Julie M Vose Kai Fu Source Type: research
MYC overexpression in natural killer cell lymphoma: prognostic and therapeutic implications
This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the PINK-E prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown (KD) in NK malignancy cell lines with MYC overexpression, resulting in significant viability reduction. RNA-sequencing (RNA-seq) used to determi...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Chengfeng Bi Yuhua Huang Roshia Ali Fang Wang Xia Yang Alyssa Bouska Lu Xu Xinbao Hao Matthew A Lunning Wing C Chan Javeed Iqbal Dennis D Weisenburger Julie M Vose Kai Fu Source Type: research
GSE115917 RNAseq of human primary T cell lymphoma
Contributors : Karthik Ganapathi ; Huimin GengSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNAseq of 14 samples of human primary T cell lymphoma (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 28, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Targeting TGF-beta activation in cutaneous T-cell lymphomas
Cutaneous T-cell lymphomas (CTCL) are T-cell malignancies of the skin. In advanced-stage CTCL, the remissions are generally rare and short, and overall survival (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: J érôme GIUSTINIANI, Van Anh TA, Sadjia Belkhelouat, Maxime BATTISTELLA, Dina OUAHBI, Caroline RAM-WOLFF, Baptiste LOUVEAU, Samia MOURAH, Martine BAGOT, Hélène MOINS-TEISSERENC, Nicolas Ortonne, Armand BENSUSSAN, Adèle DE. MASSON Tags: Letters to the Editor Source Type: research
Targeting TGF- β Activation in Cutaneous T-Cell Lymphomas
Cutaneous T-cell lymphomas (CTCLs) are T-cell malignancies of the skin. In advanced-stage CTCLs, the remissions are generally rare and short, and overall survival is (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: J érôme Giustiniani, Van Anh Ta, Sadjia Belkhelouat, Maxime Battistella, Dina Ouahbi, Caroline Ram-Wolff, Baptiste Louveau, Samia Mourah, Martine Bagot, Hélène Moins-Teisserenc, Nicolas Ortonne, Armand Bensussan, Adèle De Masson Tags: Letters to the Editor Source Type: research
Allogeneic hematopoietic stem cell transplantation after mogamulizumab in T-cell lymphoma patients: a retrospective analysis
Int J Hematol. 2024 Mar 27. doi: 10.1007/s12185-024-03753-9. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important therapy for patients with T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), adult T-cell lymphoma (ATL), and peripheral T-cell lymphoma (PTCL). Mogamulizumab is an anti-CCR4 antibody that has been associated with an increased risk of transplant-related complications in retrospective analyses of ATL, particularly when administered within 50 days before transplantation. This post hoc analysis of 3 clinical trials examined safety and outcome data ...
Source: International Journal of Hematology - March 27, 2024 Category: Hematology Authors: Mary Jo Lechowicz Christy Smith Robert Ristuccia Karen Dwyer Source Type: research
