Clinicopathologic features and survival outcomes of CD30 expression in extranodal natural killer/T-cell lymphoma
CONCLUSIONS: Positive CD30 expression was a favorable prognostic factor for ENKTL, and CD30 expression could restratify the survival of patients in clinical subgroups.PMID:38387041 | DOI:10.1093/ajcp/aqae012 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 22, 2024 Category: Pathology Authors: Ziyuan Shen Yubo Wang Ruiyang Xie Qing Zhang Xing Xing Shuo Zhang Hui Liu Wei Sang Source Type: research
Clinicopathologic features and survival outcomes of CD30 expression in extranodal natural killer/T-cell lymphoma
CONCLUSIONS: Positive CD30 expression was a favorable prognostic factor for ENKTL, and CD30 expression could restratify the survival of patients in clinical subgroups.PMID:38387041 | DOI:10.1093/ajcp/aqae012 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 22, 2024 Category: Pathology Authors: Ziyuan Shen Yubo Wang Ruiyang Xie Qing Zhang Xing Xing Shuo Zhang Hui Liu Wei Sang Source Type: research
Cancers, Vol. 16, Pages 861: JAK Inhibitors in Cutaneous T-Cell Lymphoma: Friend or Foe? A Systematic Review of the Published Literature
In conclusion, using JAK inhibitors for CTCL treatment seems promising with acceptable side effects, especially in patients with SPTCL. Some biomarkers, like pS6, showed an association with better responses. Caution should be taken when treating patients with an underlying autoimmune disease and prior immunosuppression. (Source: Cancers)
Source: Cancers - February 21, 2024 Category: Cancer & Oncology Authors: Seyed Mohammad Vahabi Saeed Bahramian Farzad Esmaeili Bardia Danaei Yasamin Kalantari Patrick Fazeli Sara Sadeghi Nima Hajizadeh Chalid Assaf Ifa Etesami Tags: Systematic Review Source Type: research
Genomic features reveal potential benefit of adding anti-PD-1 immunotherapy to treat non-upper aerodigestive tract natural killer/T-cell lymphoma
Leukemia, Published online: 20 February 2024; doi:10.1038/s41375-024-02171-4Genomic features reveal potential benefit of adding anti-PD-1 immunotherapy to treat non-upper aerodigestive tract natural killer/T-cell lymphoma (Source: Leukemia)
Source: Leukemia - February 20, 2024 Category: Hematology Authors: Zegeng Chen He Huang Huageng Huang Le Yu Huawei Weng Jian Xiao Liqun Zou Huilai Zhang Chaoyong Liang Hui Zhou Hongqiang Guo Zhao Wang Zhiming Li Tao Wu Hongyu Zhang Huijing Wu Zhigang Peng Linzhu Zhai Xinggui Chen Yang Liang Huangming Hong Tongyu Lin Source Type: research
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
In this study, we have performed non-GLP (Good Laboratory Practice) toxicology, pharmacokinetics, immunogenicity studies of CCR4-IL2-IT in both rats and minipigs. CCR4-IL2-IT demonstrated excellent safety profiles in both rats and minipigs. The maximum tolerated dose of CCR4-IL2-IT was determined as 0.4 mg/kg in both rats and minipigs. Complete blood count and chemistry analysis did not show significant difference for all measured parameters between the blood samples of pre-injection versus post-injection from the five-day toxicology studies of CCT4-IL2-IT in both rats and minipigs. Histology analysis did not show differen...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Wang Rashmi Ramakrishna Yong Wang Yue Qiu Jihong Ma Danielle Mintzlaff Huiping Zhang Bing Li Benjamin Hammell M Scott Lucia Elizabeth Pomfret An-Jey Su Kia M Washington David W Mathes Zhirui Wang Source Type: research
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
In this study, we have performed non-GLP (Good Laboratory Practice) toxicology, pharmacokinetics, immunogenicity studies of CCR4-IL2-IT in both rats and minipigs. CCR4-IL2-IT demonstrated excellent safety profiles in both rats and minipigs. The maximum tolerated dose of CCR4-IL2-IT was determined as 0.4 mg/kg in both rats and minipigs. Complete blood count and chemistry analysis did not show significant difference for all measured parameters between the blood samples of pre-injection versus post-injection from the five-day toxicology studies of CCT4-IL2-IT in both rats and minipigs. Histology analysis did not show differen...
Source: European Journal of Pharmacology - February 17, 2024 Category: Drugs & Pharmacology Authors: Zhaohui Wang Rashmi Ramakrishna Yong Wang Yue Qiu Jihong Ma Danielle Mintzlaff Huiping Zhang Bing Li Benjamin Hammell M Scott Lucia Elizabeth Pomfret An-Jey Su Kia M Washington David W Mathes Zhirui Wang Source Type: research
Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. How... (Source: Molecular Cancer)
Source: Molecular Cancer - February 17, 2024 Category: Cancer & Oncology Authors: Zongyao Huang, Yao Fu, Hong Yang, Yehan Zhou, Min Shi, Qingyun Li, Weiping Liu, Junheng Liang, Liuqing Zhu, Sheng Qin, Huangming Hong and Yang Liu Tags: Review Source Type: research
Romidepsin Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Versus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-CHOP Trial
We report the planned final analysis 5 years after the last patient enrolled. With a median follow-up of 6 years, median progression-free survival (PFS) was 12.0 months compared with 10.2 months (hazard ratio [HR], 0.79 [95% CI, 0.62 to 1.005]; P = .054), while median overall survival was 62.2 months (35.7-86.6 months) and 43.8 months (30.1-70.2 months; HR, 0.88 [95% CI, 0.68 to 1.14]; P = .324) in the Ro-CHOP and CHOP arms, respectively. In an exploratory analysis, the median PFS in the centrally reviewed follicular helper T-cell lymphoma subgroup was significantly longer in the Ro-CHOP arm (19.5 v 10.6 months, HR, 0.703 ...
Source: Cancer Control - February 16, 2024 Category: Cancer & Oncology Authors: Vincent Camus Catherine Thieblemont Philippe Gaulard Morgane Cheminant Rene-Olivier Casasnovas Lo ïc Ysebaert Gandhi Laurent Damaj St éphanie Guidez Gian Matteo Pica Won Seog Kim Soon Thye Lim Marc Andre Norma Guti érrez Maria Jesus Penarrubia Philipp Source Type: research
Correlation of ex vivo and in vivo ammonia production with L-asparaginase biological activity in adults with lymphoid malignancies
Int J Hematol. 2024 Feb 16. doi: 10.1007/s12185-024-03718-y. Online ahead of print.ABSTRACTSilent inactivation of L-asparaginase (L-Asp) represents rapid clearance of L-Asp by anti-L-Asp IgG antibodies without clinical symptoms. Measurement of L-Asp activity is the gold standard for diagnosis of silent inactivation, but this test is not commercially available in Japan as of 2023. We evaluated ex vivo and in vivo ammonia production in relation to L-Asp activity. Blood samples from ten adult patients treated with L-Asp were collected to measure ammonia levels and L-Asp activity before the first dose and 24 h after the last d...
Source: International Journal of Hematology - February 16, 2024 Category: Hematology Authors: Takayuki Nakamura Shuki Oya Hidetoshi Ozawa Yoshimi Maehiro Seiya Muta Masahiro Umeda Yusuke Takaki Toshinobu Fukuyama Yoshitaka Yamasaki Maki Yamaguchi Kazutoshi Aoyama Fumihiko Mouri Yoshiki Naito Koji Nagafuji Source Type: research
Correlation of ex vivo and in vivo ammonia production with L-asparaginase biological activity in adults with lymphoid malignancies
Int J Hematol. 2024 Feb 16. doi: 10.1007/s12185-024-03718-y. Online ahead of print.ABSTRACTSilent inactivation of L-asparaginase (L-Asp) represents rapid clearance of L-Asp by anti-L-Asp IgG antibodies without clinical symptoms. Measurement of L-Asp activity is the gold standard for diagnosis of silent inactivation, but this test is not commercially available in Japan as of 2023. We evaluated ex vivo and in vivo ammonia production in relation to L-Asp activity. Blood samples from ten adult patients treated with L-Asp were collected to measure ammonia levels and L-Asp activity before the first dose and 24 h after the last d...
Source: International Journal of Hematology - February 16, 2024 Category: Hematology Authors: Takayuki Nakamura Shuki Oya Hidetoshi Ozawa Yoshimi Maehiro Seiya Muta Masahiro Umeda Yusuke Takaki Toshinobu Fukuyama Yoshitaka Yamasaki Maki Yamaguchi Kazutoshi Aoyama Fumihiko Mouri Yoshiki Naito Koji Nagafuji Source Type: research
Correlation of ex vivo and in vivo ammonia production with L-asparaginase biological activity in adults with lymphoid malignancies
Int J Hematol. 2024 Feb 16. doi: 10.1007/s12185-024-03718-y. Online ahead of print.ABSTRACTSilent inactivation of L-asparaginase (L-Asp) represents rapid clearance of L-Asp by anti-L-Asp IgG antibodies without clinical symptoms. Measurement of L-Asp activity is the gold standard for diagnosis of silent inactivation, but this test is not commercially available in Japan as of 2023. We evaluated ex vivo and in vivo ammonia production in relation to L-Asp activity. Blood samples from ten adult patients treated with L-Asp were collected to measure ammonia levels and L-Asp activity before the first dose and 24 h after the last d...
Source: International Journal of Hematology - February 16, 2024 Category: Hematology Authors: Takayuki Nakamura Shuki Oya Hidetoshi Ozawa Yoshimi Maehiro Seiya Muta Masahiro Umeda Yusuke Takaki Toshinobu Fukuyama Yoshitaka Yamasaki Maki Yamaguchi Kazutoshi Aoyama Fumihiko Mouri Yoshiki Naito Koji Nagafuji Source Type: research
Low T3 syndrome as a predictor of poor prognosis in peripheral T-cell lymphomas
ConclusionsThe study indicated that low T3 syndrome may be a good candidate for predicting prognosis of peripheral T-cell lymphomas. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 16, 2024 Category: Cancer & Oncology Source Type: research
Extranodal natural killer/T cell lymphoma nasal type simulating osteoradionecrosis with metachronic B lymphoma in the pelvis: Case report
Indian J Pathol Microbiol. 2024 Jan-Mar;67(1):162-165. doi: 10.4103/ijpm.ijpm_296_22.ABSTRACTExtranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a non-Hodgkin extranodal lymphoma of unfavorable prognosis due to its aggressive nature. This neoplasm mainly affects the paranasal sinuses, nasopharynx, oropharynx, oral cavity, palate, and rarely intestinal, gastric and skin regions. 50-year-old female with a history of lymphoma in nasal and pelvic region. At four years of tumors-free, has facial asymmetry, accompanied by sub-palpebral, nasal and lip edema. Intraoral examination revealed a large ulceration su...
Source: Indian Journal of Pathology and Microbiology - February 15, 2024 Category: Pathology Authors: Frida S Col ín-Guadarrama Violeta E Flores-Solano Argelia Berenice-Rodr íguez V íctor H Toral-Rizo Source Type: research
Multicentric lymphoma in a donkey with intestinal and bone marrow involvement
CONCLUSIONS: To the authors' knowledge, this is the first time multicentric lymphoma is diagnosed in donkeys. Further studies of the genetic background, clinical, laboratory, histopathologic, and immunohistochemical, as well as the pathogenesis of lymphoma, is needed to better understand the uniquely low frequency of this neoplasm in donkeys.PMID:38360691 | DOI:10.1186/s12917-024-03903-5 (Source: Cell Research)
Source: Cell Research - February 15, 2024 Category: Cytology Authors: Georgios Paraschou Cynthia Xue Rebecca Egan Pompei Bolfa Source Type: research
Extranodal natural killer/T cell lymphoma nasal type simulating osteoradionecrosis with metachronic B lymphoma in the pelvis: Case report
Indian J Pathol Microbiol. 2024 Jan-Mar;67(1):162-165. doi: 10.4103/ijpm.ijpm_296_22.ABSTRACTExtranodal Natural Killer/T Cell Lymphoma Nasal Type (EN-NK/T-CL-NT) is a non-Hodgkin extranodal lymphoma of unfavorable prognosis due to its aggressive nature. This neoplasm mainly affects the paranasal sinuses, nasopharynx, oropharynx, oral cavity, palate, and rarely intestinal, gastric and skin regions. 50-year-old female with a history of lymphoma in nasal and pelvic region. At four years of tumors-free, has facial asymmetry, accompanied by sub-palpebral, nasal and lip edema. Intraoral examination revealed a large ulceration su...
Source: Indian Journal of Pathology and Microbiology - February 15, 2024 Category: Pathology Authors: Frida S Col ín-Guadarrama Violeta E Flores-Solano Argelia Berenice-Rodr íguez V íctor H Toral-Rizo Source Type: research
