Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research

A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research

Diagnosis of bone marrow involvement in angioimmunoblastic T-cell lymphoma should be based on both [ < sup > 18 < /sup > F]FDG-PET/CT and bone marrow biopsy findings
CONCLUSION: In AITL patients, PET/BM-positive results may obviate the necessity for repeat BMB to ascertain confirm BM involvement. PET/BM-negative results do not definitively exclude BM involvement. The combined use of [18F]FDG-PET/CT and BMB can increase the diagnostic accuracy of BM involvement for AITL patients.PMID:38626218 | DOI:10.1080/03007995.2024.2337670 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 16, 2024 Category: Research Authors: Xinyu Liang Chunli Yang Minggang Su Liqun Zou Source Type: research

Prognostic Utility of a Novel Prognostic Model Consisting of Age, CRP, Ki67, and POD24 in Patients with Angioimmunoblastic T-Cell Lymphoma
AbstractTo find the independent factors affecting the prognosis of AITL patients, establish a novel predictive model, and stratify the prognosis of AITL patients. We retrospectively analyzed the clinical data of 86 patients diagnosed with AITL in the First Affiliated Hospital of Wenzhou Medical University from December 2010 to March 2022. The clinical features, recurrence time, and death time of patients were collected and analyzed statistically. The median age of our patients was 68  years old, and the male-to-female ratio was 2.2: 1. There are differences between males and females in ECOG PS score (p = 0.037), β2 m...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research

Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research

Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research

Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research

HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression
In this study, by integrating different multi-omics and functional approaches, we characterized the transcriptional landscape of HELLS in ALCL. We explored the clinical impact of its transcriptional program in a large cohort of 44 patients with ALCL. We demonstrated that HELLS, loaded at the level of intronic regions of target promoters, facilitates RNA Polymerase II (RNAPII) progression along the gene bodies by reducing the persistence of co-transcriptional R-loops and promoting DNA damage resolution. Importantly, selective knockdown of HELLS sensitizes ALCL cells to different chemotherapeutic agents, showing a synergisti...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Annalisa Tameni Selene Mallia Veronica Manicardi Benedetta Donati Federica Torricelli Emanuele Vitale Elisa Salviato Giulia Gambarelli Silvia Muccioli Magda Zanelli Stefano Ascani Giovanni Martino Francesca Sanguedolce Elisabetta Sauta Ione Tamagnini Noem Source Type: research

A Nomogram Model Based on the Inflammation-Immunity-Nutrition Score (IINS) and Classic Clinical Indicators for Predicting Prognosis in Extranodal Natural Killer/T-Cell Lymphoma
CONCLUSION: Compared with traditional prognostic systems, the nomogram showed promising prospects for risk stratification in ENKTL patient prognosis, providing new insights into the personalized treatment.PMID:38595337 | PMC:PMC11001545 | DOI:10.2147/JIR.S452521 (Source: Cell Research)
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Yanxia He Zhumei Luo Haoqing Chen Liqing Ping Cheng Huang Yan Gao Huiqiang Huang Source Type: research

Paradoxical Psoriasis
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PP...
Source: Dermatologic Clinics - April 10, 2024 Category: Dermatology Authors: Mariam Abdelghaffar, Sita Kottilil, Michael J. Murphy, Jeffrey M. Cohen, William Damsky Source Type: research

Cistanche phenylethanoid glycosides induce apoptosis and pyroptosis in T-cell lymphoma
This study offers experimental support for the potential application of CPhGs in the treatment of TCL.PMID:38590417 | PMC:PMC10998756 | DOI:10.62347/GEZW9659 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Ying Tang Fangxin Zhao Xuan Zhang Yan Niu Xiulan Liu Renqiqige Bu Yunlong Ma Geyemuri Wu Beibei Li Hongxin Yang Jianqiang Wu Source Type: research

Misdiagnosis of lymphoma as vasculitis: A case report
This article describes a patient with NKTCL misdiagnosed as vasculitis who presented with sinusitis, abdominal pain, anorexia, and lung shadows, and also presented with eosinophilia, which was misdiagnosed as eosinophilic granuloma. The article describes the clinical features, diagnostic methods and differential diagnosis of lymphoma and highlights the importance of a multidisciplinary approach in accurate diagnosis and treatment. AbstractNK/T-cell lymphoma (NKTCL) is a highly aggressive malignant tumour with a very poor prognosis, which often poses diagnostic difficulties due to the non-specificity of its clinical present...
Source: Respirology Case Reports - April 9, 2024 Category: Respiratory Medicine Authors: Shushan Wei, Haobin Hu, Haoyue Helena Lan, Na Li, Qingling Zhang Tags: CASE REPORT Source Type: research

Folliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review
Clin Case Rep. 2024 Apr 5;12(4):e8731. doi: 10.1002/ccr3.8731. eCollection 2024 Apr.ABSTRACTKEY CLINICAL MESSAGE: F-MF is a rare non-classic variant of MF. In the case of hair loss, this should be a diagnostic consideration. The essence of the diagnosis of F-MF is a careful medical history, physical examination, and a combination of immunohistological and molecular analyses (Cureus. 2022; 14:e21231, Ann Saudi Med. 2012; 32:283, Oman Med J. 2012; 27:134, Int J Dermatol. 2016; 55:1396, Saudi Med J. 2018; 39:994 and Case Rep Oncol. 2018; 11:436).ABSTRACT: Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with mult...
Source: Ann Oncol - April 8, 2024 Category: Cancer & Oncology Authors: Majed Saleh Aldayhum Mohammed Saad Alshahrani Mahmoud Rezk A Hussein Abdulmajeed Saad Alshahrani Toka M R Hussein Source Type: research

Role of plasma EBV-DNA load and EBER status on newly diagnosed peripheral T-cell lymphoma
ConclusionEBER, DNA1, and DNA4 emerged as sensitive markers for prognosis. CHOP plus azacytidine might present a preferable option for PTCL patients with DNA methylation due to EBV infection. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research