GSE262491 XPO1 blockade with KPT-330 promotes apoptosis in Cutaneous T- cell Lymphoma by activating the p53-p21 and p27 pathways
Contributors : Nitin Chakravarti ; Amy Boles ; Rachel Burzinski ; Paola Sindaco ; Colleen Isabelle ; Kathleen McConnell ; Anjali Mishra ; Pierluigi PorcuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo assess the effects of XPO1 inhibition with small molecule inhibitor KPT-330 on Cutaneous T-cell Lymphoma after 48 hours of treatment (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Novel agents and regimens in relapsed or refractory peripheral T-cell lymphoma: latest updates from 2023 ASH annual meeting
AbstractPeripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological malignancies with poor survival, while treatment options for relapsed or refractory (R/R) disease remain quite limited, with a median progression-free survival of only 3 –4 months. Notably, the emergence of innovative therapeutic agents and regimens holds promise for durable responses and improved survival for patients with R/R PTCL. We summarize recent advances in the treatment of R/R PTCL from the 2023 ASH Annual Meeting, highlighting novel agents targeting EZH1 /2, JAK1, PI3K, KIR3DL2, CD38/CD3xCD28, or CDK9, as well as therapeutic reg...
Source: Experimental Hematology and Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Editors ’ Picks
Cutaneous T-cell lymphomas (CTCLs) comprise an incurable form of non-Hodgkin lymphoma, and advanced-stage forms of this disease, mycosis fungoides and Sezary syndrome, have poor prognosis. Previous case series documented long-lasting remission due to a graft-versus-lymphoma effect in patients treated with allogeneic hematopoietic stem cell transplantation (HSCT). In these studies, lymphoma relapse was common, and treatment-related morbidity and mortality were noted, leading to weaker recommendations for HSCT in this patient population. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 19, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research
A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Primary cutaneous anaplastic large-cell lymphoma resembling infratemporal space infection: a case report
Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) is a rare T-cell lymphoma belonging to the CD30 + T-cell lymphoproliferative disorders. The case of PC-ALCL in the temporal region is exceedingly rare... (Source: BMC Oral Health)
Source: BMC Oral Health - April 18, 2024 Category: Dentistry Authors: Xiaohan Yan, Wenhao Ren, Shaoming Li, Zhuang Zhu, Ling Gao and Keqian Zhi Tags: Case Report Source Type: research
Diagnosis of bone marrow involvement in angioimmunoblastic T-cell lymphoma should be based on both [ < sup > 18 < /sup > F]FDG-PET/CT and bone marrow biopsy findings
CONCLUSION: In AITL patients, PET/BM-positive results may obviate the necessity for repeat BMB to ascertain confirm BM involvement. PET/BM-negative results do not definitively exclude BM involvement. The combined use of [18F]FDG-PET/CT and BMB can increase the diagnostic accuracy of BM involvement for AITL patients.PMID:38626218 | DOI:10.1080/03007995.2024.2337670 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 16, 2024 Category: Research Authors: Xinyu Liang Chunli Yang Minggang Su Liqun Zou Source Type: research
Prognostic Utility of a Novel Prognostic Model Consisting of Age, CRP, Ki67, and POD24 in Patients with Angioimmunoblastic T-Cell Lymphoma
AbstractTo find the independent factors affecting the prognosis of AITL patients, establish a novel predictive model, and stratify the prognosis of AITL patients. We retrospectively analyzed the clinical data of 86 patients diagnosed with AITL in the First Affiliated Hospital of Wenzhou Medical University from December 2010 to March 2022. The clinical features, recurrence time, and death time of patients were collected and analyzed statistically. The median age of our patients was 68 years old, and the male-to-female ratio was 2.2: 1. There are differences between males and females in ECOG PS score (p = 0.037), β2 m...
Source: Indian Journal of Hematology and Blood Transfusion - April 12, 2024 Category: Hematology Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
Clinical characteristics and prognostic analysis of primary extranodal non-Hodgkin lymphoma of the head and neck
CONCLUSIONS: The most common site of PE-NHL in these Chinese patients was the Waldeyer's ring, but the incidence in the nasal cavity was higher than that reported in Western countries. Radiotherapy combined with chemotherapy had better efficacy than chemotherapy alone, and the prognosis depended on the ECOG score and clinical stage. IPI had a better prognostic value in patients in the high-risk group of head and neck PE-NHL.PMID:38604163 | DOI:10.18632/aging.205726 (Source: Aging)
Source: Aging - April 11, 2024 Category: Biomedical Science Authors: Jiamu Lv Yining Jiang Tingting Yu Shengrui Gao Wanzhong Yin Source Type: research
HELLS regulates transcription in T-cell lymphomas by reducing unscheduled R-loops and by facilitating RNAPII progression
In this study, by integrating different multi-omics and functional approaches, we characterized the transcriptional landscape of HELLS in ALCL. We explored the clinical impact of its transcriptional program in a large cohort of 44 patients with ALCL. We demonstrated that HELLS, loaded at the level of intronic regions of target promoters, facilitates RNA Polymerase II (RNAPII) progression along the gene bodies by reducing the persistence of co-transcriptional R-loops and promoting DNA damage resolution. Importantly, selective knockdown of HELLS sensitizes ALCL cells to different chemotherapeutic agents, showing a synergisti...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Annalisa Tameni Selene Mallia Veronica Manicardi Benedetta Donati Federica Torricelli Emanuele Vitale Elisa Salviato Giulia Gambarelli Silvia Muccioli Magda Zanelli Stefano Ascani Giovanni Martino Francesca Sanguedolce Elisabetta Sauta Ione Tamagnini Noem Source Type: research
