Block an Enzyme, Save a Life
Vern Schramm, professor of biochemistry at Albert Einstein College of Medicine, Bronx, New York. Credit: Albert Einstein College of Medicine.
Enzymes drive life. Without them, we couldn’t properly digest food, make brain chemicals, move—or complete myriad other vital tasks. Unfortunately, in certain cases, enzymes also can trigger a host of health problems, including cancer, bacterial infections, and hypertension (high blood pressure).
Understanding how enzymes work has been the research focus of Vern Schramm for more than 4 decades.
“When we started our work, we were driven not by the desire to find...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 26, 2019 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cellular Processes Diseases Precision Medicine Source Type: blogs
Revenge of the Giant Hogweed
If the day of the triffids were ever to come, then Heracleum mantegazzianum, would be the henchmen. The giant hogweed, also known as the cartwheel-flower, the giant cow parsnip, hogsbane, or giant cow parsley, is a nasty plant. It is called hogweed because the flowers smell of pigs. But, that is not the worst thing about it. You may have read in the news recently of the crippling effects it had on an unwitting Welsh gardener. His bare legs brushing against the plant developed nasty and deep blisters in the coming days and awful pain. He is apparently still unable to walk because of the damage done by the plant.
The plan...
Source: David Bradley Sciencebase - Songs, Snaps, Science - June 6, 2018 Category: Science Authors: David Bradley Tags: Science Source Type: blogs
Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs
AdDRESSing the Causes of Rash
Conclusion: DRESS syndrome is a rare but potentially life-threatening condition with an estimated mortality rate of 10 percent. Suspicion must be high because it may present as a spectrum of nonspecific clinical and laboratory findings.Tags: rash, tox cave, DRESS, DRESS syndrome, RegiSCAR, hepatitis, myocarditis, myositisPublished: 8/7/2014 2:50:00 PM (Source: The Tox Cave)
Source: The Tox Cave - August 7, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
AdDRESSing the Causes of Rash
Conclusion: DRESS syndrome is a rare but potentially life-threatening condition with an estimated mortality rate of 10 percent. Suspicion must be high because it may present as a spectrum of nonspecific clinical and laboratory findings.Tags: rash, tox cave, DRESS, DRESS syndrome, RegiSCAR, hepatitis, myocarditis, myositisPublished: 8/7/2014 2:50:00 PM (Source: The Tox Cave)
Source: The Tox Cave - August 7, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Level 2 vs. Level 3 H&P Coding Comparison.
This lecture will assist physicians and other non-physician practitioners (NPPs) determine if their initial hospital admission note documentation meets criteria for a level 2 (mid level H&P) or a level 3 (high level H&P) evaluation and management (E/M) code. Recovery Audit Contractors will likely continue to target high level initial hospital encounters for improper payments. Physicians and other NPPs must continue to pursue documentation education to prevent accusations of over billing and to prevent under billing for work provided. I am an internal medicine physician with over 10 years experienc...
Source: The Happy Hospitalist - April 10, 2014 Category: Internists and Doctors of Medicine Authors: Tamer Mahrous Source Type: blogs
Level 2 vs. Level 3 H & P Coding Comparison.
This lecture will assist physicians and other non-physician practitioners (NPPs) determine if their initial hospital admission note documentation meets criteria for a level 2 (mid level H&P) or a level 3 (high level H&P)evaluation and management (E/M) code. Recovery Audit Contractors will likely continue to target high level initial hospital encounters for improper payments. Physicians and other NPPs must continue to pursue documentation education to prevent accusations of overbilling and to prevent under billing for work provided. I am an internal medicine physician with over 10 years experience ...
Source: The Happy Hospitalist - April 10, 2014 Category: Internal Medicine Authors: The Happy Hospitalist Source Type: blogs
Alzheimer's Miracle Drug Bexarotene Doesn't Work as Reported
“We all went back to our labs and tried to confirm these promising findings” ... “We repeated the initial experiments — a standard process in science. Combined results are really important in this field. None of us found anything like what they described in the 2012 paper.”
By +Bob DeMarco
+Alzheimer's Reading Room
Co-authors Karthikeyan Veeraraghavalu and
Sangram Sisodia of the University of Chicago
Three teams of highly respected Alzheimer’s researchers failed to replicate what appeared to be breakthrough results for the treatment of Alzheimer's disease using existing cancer drug Targretin® (br...
Source: Alzheimer's Reading Room, The - May 23, 2013 Category: Dementia Authors: Bob DeMarco Source Type: blogs
Role of Excisional lymph node biopsy, Core needle biopsy and FNAC in Lymphoma diagnosis
The newly developed and more sophisticated techniques for analysis of lymphoma cells have provided us with the tools necessary for precise classification of non-Hodgkin ’s lymphoma. Nonetheless, routine histologic studies remain the gold standard for diagnosis. Excisional BiopsyA well-processed hematoxylin and eosin (H&E) stained section of an excised lymph node is the mainstay of pathologic diagnosis. Most often, the diagnosis of difficult lesions relies heavily on a careful assessment of the underlying architecture. Lymphoma diagnoses are much less about cytologic detail and far more about altered architecture...
Source: Oncopathology - January 29, 2013 Category: Cancer & Oncology Tags: core boiopsy. FNAC lymph node biopsy lymphoma Source Type: blogs
Role of Excisional lymph node biopsy, Core needle biopsy and FNAC in Lymphoma diagnosis
The newly developed and more sophisticated techniques for
analysis of lymphoma cells have provided us with the tools necessary for
precise classification of non-Hodgkin’s lymphoma. Nonetheless, routine
histologic studies remain the gold standard for diagnosis.
Excisional Biopsy
A well-processed hematoxylin and eosin (H&E) stained
section of an excised lymph node is the mainstay of pathologic diagnosis. Most
often, the diagnosis of difficult lesions relies heavily on a careful
assessment of the underlying architecture. Lymphoma diagnoses are much less
about cytologic detail and far more about altered archite...
Source: Oncopathology - January 29, 2013 Category: Pathologists Tags: FNAC lymph node biopsy lymphoma core boiopsy. Source Type: blogs
