Block an Enzyme, Save a Life

Vern Schramm, professor of biochemistry at Albert Einstein College of Medicine, Bronx, New York. Credit: Albert Einstein College of Medicine. Enzymes drive life. Without them, we couldn’t properly digest food, make brain chemicals, move—or complete myriad other vital tasks. Unfortunately, in certain cases, enzymes also can trigger a host of health problems, including cancer, bacterial infections, and hypertension (high blood pressure). Understanding how enzymes work has been the research focus of Vern Schramm for more than 4 decades. “When we started our work, we were driven not by the desire to find drugs, but to understand the nature of enzymes, which are critical to human life,” Schramm says. But his research already led to one drug, and promises many more. An NIGMS grantee and professor of biochemistry at Albert Einstein College of Medicine in the Bronx, New York, Schramm discovered how to block, or inhibit, a specific enzyme’s activity.  With support from researchers around the world, this work led directly to the development of a lifesaving medication for T-cell lymphoma. Schramm has been particularly interested in an enzyme called PNP (purine nucleoside phosphorylase). This enzyme is vital to the health of white blood cells known as T-cells, which play a key role in the body’s immune system. When T-cells multiply uncontrollably, they can cause autoimmune diseases and two types of blood cancer: T-c...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Being a Scientist Cellular Processes Diseases Precision Medicine Source Type: blogs

Related Links:

In this study, we investigated the antitumor activity of H2Mab-19 in an LN229 glioblastoma xenograft model. H2Mab-19 showed high binding affinity (KD: 1.1 × 10-8 M) against LN229 cells. Furthermore, H2Mab-19 significantly reduced tumor development in an LN229 xenograft. These results suggest that treatment with H2Mab-19 may be a useful therapy for patients with HER2-expressing glioblastomas. PMID: 32644843 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Publication date: Available online 10 July 2020Source: Food Quality and PreferenceAuthor(s): Nobu Shirai, Chizuru Take Homma, Chinatsu Kon, Tomoko Imura, Yuji Wada
Source: Food Quality and Preference - Category: Food Science Source Type: research
AbstractSouth Texas has experienced local transmission of Zika virus and of other mosquito-borne viruses such as chikungunya virus and dengue virus in the last decades. Using a mosquito surveillance program in the Lower Rio Grande Valley (LRGV) and San Antonio, TX, from 2016 to 2018, we detected the presence of an insect-specific virus, cell fusing agent virus (CFAV), in theAedes aegypti mosquito population. We tested 6,326 females and 1,249 males from the LRGV and 659 females from San Antonio for CFAV by RT-PCR using specific primers. Infection rates varied from 0 to 261 per 1,000 mosquitoes in the LRGV and 115 to 208 per...
Source: Archives of Virology - Category: Virology Source Type: research
AbstractTo evaluate the efficacy and safety of holmium laser enucleation of prostate (HoLEP) for treating urinary retention in patients with advanced prostate cancer. Thirty-eight cases of advanced prostate cancer with urinary retention were enrolled in this retrospective study. All the 38 patients were treated with CAB as a basis. Among them, 21 cases chose HoLEP additionally (HoLEP group). Seventeen cases stuck to CAB alone (CAB group). Serum PSA level, International Prostate Symptom Score (IPSS), quality of life score (QoLs), maximal flow rate (Qmax), and post-void residual volume (PVR) at 3, 6, 12, and 18 months after ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
CONCLUSION: As far as we know from the literature, this is the largest mesenteric fibromatosis tumour ever to be excised. We also noticed that this is the first reported case of the concomitant presence of mesenteric fibromatosis and non-Hodgkin lymphoma that is not related to any of the described risk factors. Further research is needed to establish what type of association this presentation may indicate. PMID: 32644849 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Authors: John J, Henry M, Ringoir A, Pinto G, Kesner K, Lazarus J, Sinha S Abstract BACKGROUND: The standard of care for surgically resectable disease renal cell carcinoma (RCC) is a nephrectomy. Post-nephrectomy, these patients are at risk for the development of new onset chronic kidney disease or the progression of pre-existing chronic kidney disease. We aimed to report the changes in renal function in patients who had a nephrectomy for RCC. METHODS: This retrospective, descriptive, cross-sectional study identified 137 patients who had a nephrectomy for RCC from 1 January 2009 to 31 December 2017. The pre-nep...
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
CONCLUSION: Core needle biopsy and receptor analysis should be considered on the positive axillary nodes in breast cancer patients. Adjuvant treatment should be targeted to the receptor profile of the lymph node metastases. PMID: 32644312 [PubMed - as supplied by publisher]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
CONCLUSION: Multivisceral resection of locally advanced (T4b) CRC is feasible in the African context. Complete resection improves survival and should be the goal. PMID: 32644308 [PubMed - as supplied by publisher]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
Authors: Kleymann J, Schütz C, Körholz J, Taube F, Vogler M, Halank M, Kolditz M, Langner S, Geberzahn L, Holotiuk O, Roesler J, Koschel D Abstract Chronic granulomatous disease (CGD) should be considered as a differential diagnosis in children and adolescents with frequent infections, especially when caused by certain specific pathogens.This case report describes a 64-year-old female with multiple recurrent and complicated bronchopulmonary infections, caused by common, but also rare pathogens, autoimmune phenomena, malignancies and recurrent organizing pneumonia (OP) with granulomas. Finally, the patient...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Publication date: Available online 9 July 2020Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Azmi Khan, Pratika Singh, Amrita Srivastava
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
More News: Australia Health | Autoimmune Disease | Biochemistry | Blogging | Brain | Brain Cancers | Cancer | Cancer & Oncology | Chemistry | Clinical Trials | Ebola | Harvard | Hypertension | Japan Health | Laboratory Medicine | Leukemia | Lymphoma | Marburg Virus | Neurology | Research | T-cell Lymphoma | Zika Virus