Update on T-Cell Lymphoma Epidemiology
AbstractPurpose of ReviewT-cell lymphomas (TCLs) are a group of rare subtypes of non-Hodgkin lymphoma derived from mature T-lymphocytes. Recent updates in lymphoma classification based on the cell-of-origin pathogenesis have shed new light on TCL epidemiology and outcomes. Contemporary regional consortia and international studies, including those conducted recently in Asia and South America, have provided an updated delineation of the major subtypes across various global regions.Recent FindingsPeripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), remains the most common subtype globally except in Asia, where extr...
Source: Current Hematologic Malignancy Reports - March 7, 2024 Category: Hematology Source Type: research
An unusual presentation of subcutaneous panniculitis ‐like T‐cell lymphoma: Extensive necrosis and hemophagocytic lymphohistiocytosis: A case report
We report here an aggressive case of disseminated SPTCL with HLH involving a young woman who presented with extensive necrosis and ulceration at diagnosis. The report highlights the aggressive course of the disease, the occurrence of facial and breast nodules, the association with HLH, and the extent of necrosis and ulceration. The report highlights the poor prognosis despite polychemotherapy regimen use. (Source: Clinical Case Reports)
Source: Clinical Case Reports - March 6, 2024 Category: General Medicine Authors: Mehdi Loukhnati,
Khaoula Khalil,
Fatima Ezzahra Lahlimi,
Illias Tazi Tags: CASE REPORT Source Type: research
IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/ β-catenin signaling pathway
Mol Cell Biochem. 2024 Mar 5. doi: 10.1007/s11010-024-04944-y. Online ahead of print.ABSTRACTExtranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to unearth the role of interleukin-33 (IL-33) in ENKTCL. RT-qPCR was conducted to assess mRNA levels of ENKTCL tissues and cells, while western blot assay was performed for evaluating protein levels. Plate cloning experiment and transwell assay were employed to measure aggressiveness of ENKTCL. Tube formation assay was executed to determine the angiogenesis ability. Mice ENKTCL xenograft mo...
Source: Molecular and Cellular Biochemistry - March 5, 2024 Category: Biochemistry Authors: Mingli Ni Yuhui Wang Jiezhi Yang Qianwen Ma Wei Pan Yulin Li Qian Xu Hongqiong Lv Yunlong Wang Source Type: research
IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/ β-catenin signaling pathway
Mol Cell Biochem. 2024 Mar 5. doi: 10.1007/s11010-024-04944-y. Online ahead of print.ABSTRACTExtranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to unearth the role of interleukin-33 (IL-33) in ENKTCL. RT-qPCR was conducted to assess mRNA levels of ENKTCL tissues and cells, while western blot assay was performed for evaluating protein levels. Plate cloning experiment and transwell assay were employed to measure aggressiveness of ENKTCL. Tube formation assay was executed to determine the angiogenesis ability. Mice ENKTCL xenograft mo...
Source: Molecular and Cellular Biochemistry - March 5, 2024 Category: Biochemistry Authors: Mingli Ni Yuhui Wang Jiezhi Yang Qianwen Ma Wei Pan Yulin Li Qian Xu Hongqiong Lv Yunlong Wang Source Type: research
IL-33 aggravates extranodal NK/T cell lymphoma aggressiveness and angiogenesis by activating the Wnt/ β-catenin signaling pathway
Mol Cell Biochem. 2024 Mar 5. doi: 10.1007/s11010-024-04944-y. Online ahead of print.ABSTRACTExtranodal NK/T cell lymphoma (ENKTCL) is an extremely aggressive form of lymphoma and lacks of specific diagnostic markers. The study intended to unearth the role of interleukin-33 (IL-33) in ENKTCL. RT-qPCR was conducted to assess mRNA levels of ENKTCL tissues and cells, while western blot assay was performed for evaluating protein levels. Plate cloning experiment and transwell assay were employed to measure aggressiveness of ENKTCL. Tube formation assay was executed to determine the angiogenesis ability. Mice ENKTCL xenograft mo...
Source: Molecular and Cellular Biochemistry - March 5, 2024 Category: Biochemistry Authors: Mingli Ni Yuhui Wang Jiezhi Yang Qianwen Ma Wei Pan Yulin Li Qian Xu Hongqiong Lv Yunlong Wang Source Type: research
Role of upfront autologous transplant for peripheral T-cell lymphoma patients achieving a complete remission with first-line therapy: a systematic review and meta-analysis
Bone Marrow Transplantation, Published online: 05 March 2024; doi:10.1038/s41409-024-02254-xRole of upfront autologous transplant for peripheral T-cell lymphoma patients achieving a complete remission with first-line therapy: a systematic review and meta-analysis (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - March 5, 2024 Category: Hematology Authors: L. Girard Y. J. Koh L. P. Koh Y. L. Chee H. L. Chan J. Lee S. de Mel L. M. Poon M. Samuel Source Type: research
Predictive and prognostic biomarkers in patients with Mycosis fungoides and S ézary syndrome (BIO-MUSE): Study protocol for a translational study
CONCLUSIONS: The study aims to investigate blood and skin with focus on immune cells and the microbiological environment to identify potential new prognostic biomarkers in MF and SS.CLINICALTRIAL: Clinicaltrials.gov NCT04904146.PMID:38436589 | DOI:10.2196/55723 (Source: Cell Research)
Source: Cell Research - March 4, 2024 Category: Cytology Authors: Emma Belfrage Sara Ek Åsa Johansson Hanna Brauner Andreas Sonesson Kristina Drott Source Type: research
Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets
CONCLUSION: There appears to be a relationship between cutaneous T-cell lymphoma and the cutaneous and intestinal microbiome, as well as a possible pathophysiological pathway involved. The possible modulation of the cutaneous and intestinal microbiome or the action on the signaling inflammatory pathway, using pharmacological tools such as JAK inhibitors or IL-17 inhibitors in the latter case, could open the possibility for future therapeutic studies for cutaneous T-cell lymphoma.PMID:38435536 | PMC:PMC10904680 | DOI:10.1155/2024/9919225 (Source: Cell Research)
Source: Cell Research - March 4, 2024 Category: Cytology Authors: Daniel Rodr íguez Baeza L ía Bejarano Antonio Marta Gonz ález de Arriba Jos é Antonio Picó-Monllor Javier Ca ñueto Vicente Navarro-Lopez Source Type: research
Cutaneous T-Cell Lymphoma and Microbiota: Etiopathogenesis and Potential New Therapeutic Targets
CONCLUSION: There appears to be a relationship between cutaneous T-cell lymphoma and the cutaneous and intestinal microbiome, as well as a possible pathophysiological pathway involved. The possible modulation of the cutaneous and intestinal microbiome or the action on the signaling inflammatory pathway, using pharmacological tools such as JAK inhibitors or IL-17 inhibitors in the latter case, could open the possibility for future therapeutic studies for cutaneous T-cell lymphoma.PMID:38435536 | PMC:PMC10904680 | DOI:10.1155/2024/9919225 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - March 4, 2024 Category: Dermatology Authors: Daniel Rodr íguez Baeza L ía Bejarano Antonio Marta Gonz ález de Arriba Jos é Antonio Picó-Monllor Javier Ca ñueto Vicente Navarro-Lopez Source Type: research
