Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization
J Clin Exp Hematop. 2024;64(1):21-31. doi: 10.3960/jslrt.23053.ABSTRACTWe characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hy...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Hitoshi Ohno Fumiyo Maekawa Masahiko Hayashida Miho Nakagawa Katsuhiro Fukutsuka Mitsuko Matsumura Kayo Takeoka Wataru Maruyama Naoya Ukyo Shinji Sumiyoshi Yasuhiro Tanaka Hironori Haga Source Type: research
Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified
We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, asciti...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Kenta Hayashino Chikamasa Yoshida Yoshiyuki Ayata Ryouya Yukawa Aya Komura Makoto Nakamura Yusuke Meguri Kazuhiko Yamamoto Wakako Oda Kenji Imajo Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization
J Clin Exp Hematop. 2024;64(1):21-31. doi: 10.3960/jslrt.23053.ABSTRACTWe characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hy...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Hitoshi Ohno Fumiyo Maekawa Masahiko Hayashida Miho Nakagawa Katsuhiro Fukutsuka Mitsuko Matsumura Kayo Takeoka Wataru Maruyama Naoya Ukyo Shinji Sumiyoshi Yasuhiro Tanaka Hironori Haga Source Type: research
Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified
We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, asciti...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Kenta Hayashino Chikamasa Yoshida Yoshiyuki Ayata Ryouya Yukawa Aya Komura Makoto Nakamura Yusuke Meguri Kazuhiko Yamamoto Wakako Oda Kenji Imajo Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization
J Clin Exp Hematop. 2024;64(1):21-31. doi: 10.3960/jslrt.23053.ABSTRACTWe characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hy...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Hitoshi Ohno Fumiyo Maekawa Masahiko Hayashida Miho Nakagawa Katsuhiro Fukutsuka Mitsuko Matsumura Kayo Takeoka Wataru Maruyama Naoya Ukyo Shinji Sumiyoshi Yasuhiro Tanaka Hironori Haga Source Type: research
Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified
We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, asciti...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Kenta Hayashino Chikamasa Yoshida Yoshiyuki Ayata Ryouya Yukawa Aya Komura Makoto Nakamura Yusuke Meguri Kazuhiko Yamamoto Wakako Oda Kenji Imajo Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization
J Clin Exp Hematop. 2024;64(1):21-31. doi: 10.3960/jslrt.23053.ABSTRACTWe characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hy...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Hitoshi Ohno Fumiyo Maekawa Masahiko Hayashida Miho Nakagawa Katsuhiro Fukutsuka Mitsuko Matsumura Kayo Takeoka Wataru Maruyama Naoya Ukyo Shinji Sumiyoshi Yasuhiro Tanaka Hironori Haga Source Type: research
Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified
We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, asciti...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Kenta Hayashino Chikamasa Yoshida Yoshiyuki Ayata Ryouya Yukawa Aya Komura Makoto Nakamura Yusuke Meguri Kazuhiko Yamamoto Wakako Oda Kenji Imajo Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
Diverse B-cell tumors associated with t(14;19)(q32;q13)/IGH::BCL3 identified by G-banding and fluorescence in situ hybridization
J Clin Exp Hematop. 2024;64(1):21-31. doi: 10.3960/jslrt.23053.ABSTRACTWe characterized 5 B-cell tumors carrying t(14;19)(q32;q13) that creates the IGH::BCL3 fusion gene. The patients' ages ranged between 55 and 88 years. Two patients presented with progression or recurrence of B-cell chronic lymphocytic leukemia (B-CLL)/small lymphocytic lymphoma (SLL), two with diffuse large B-cell lymphoma (DLBCL) of non-germinal center B-like phenotype, and the remaining one with composite angioimmunoblastic T-cell lymphoma and Epstein-Barr virus-positive DLBCL. The presence of t(14;19)(q32;q13) was confirmed by fluorescence in situ hy...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Hitoshi Ohno Fumiyo Maekawa Masahiko Hayashida Miho Nakagawa Katsuhiro Fukutsuka Mitsuko Matsumura Kayo Takeoka Wataru Maruyama Naoya Ukyo Shinji Sumiyoshi Yasuhiro Tanaka Hironori Haga Source Type: research
Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified
We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, asciti...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Kenta Hayashino Chikamasa Yoshida Yoshiyuki Ayata Ryouya Yukawa Aya Komura Makoto Nakamura Yusuke Meguri Kazuhiko Yamamoto Wakako Oda Kenji Imajo Source Type: research
Extranodal NK/T-cell lymphoma with localized relapse in bone marrow of lower leg detected using PET-CT
We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE). After induction therapy (RT-2/3 DeVIC), PET-CT revealed abnormal uptake only in the right fibula. Case 2: A 68-year-old man with a skin nodule/ulcer and an enlarged right inguinal lymph node was diagnosed with advanced ENKTL. A PET-CT scan revealed abn...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 27, 2024 Category: Hematology Authors: Takahisa Nakamura Hiro Tatetsu Yusuke Higuchi Shinya Endo Shinya Shiraishi Koichi Kawanaka Daisuke Imakane Miyu Sonoda Rie Furuta Takafumi Shichijo Yumi Honda Kennosuke Karube Yoshiki Mikami Kisato Nosaka Masao Matsuoka Jun-Ichirou Yasunaga Source Type: research
