Immune response in LPD during methotrexate administration (MTX-LPD) in rheumatoid arthritis patients.
Authors: Saito S, Takeuchi T Abstract Methotrexate (MTX) is known as a first-line synthetic disease-modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). Although the risk of LPD development increases by RA inflammation itself, observation of spontaneous regression of LPD after MTX discontinuation lead to the theory of lymphomagenic role of MTX. In this review, we focused on the several immune response involved in LPD that developed under MTX administration in RA patients. PMID: 31866617 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Clinical features and treatment outcomes of opportunistic infections among human T-lymphotrophic virus type 1 (HTLV-1) carriers and patients with adult T-cell leukemia-lymphoma (ATL) at a single institution from 2006 to 2016.
In conclusion, opportunistic infections should be carefully followed among HTLV-1 carriers and ATL patients because of their aggressive clinical course and poor outcomes. Furthermore, early diagnosis and subsequent prompt treatment are necessary in clinical practice. PMID: 31866618 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Phase I study of ibrutinib in Japanese patients with treatment-na ïve chronic lymphocytic leukemia/small lymphocytic lymphoma.
Phase I study of ibrutinib in Japanese patients with treatment-naïve chronic lymphocytic leukemia/small lymphocytic lymphoma. J Clin Exp Hematop. 2019;59(4):179-186 Authors: Shibayama H, Teshima T, Choi I, Hatake K, Sekiguchi N, Yoshinari N Abstract This phase I study evaluated the safety and efficacy of single-agent ibrutinib in Japanese patients with treatment-naïve chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (aged 20-69 years and ineligible for chemotherapy using fludarabine or cyclophosphamide, or aged ≥70 years). Eight patients received oral ibrutinib 420 mg once dai...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Expression of mucosal addressin cell adhesion molecule-1 on the reticular framework between white pulp and the marginal zone in the human spleen.
Authors: Satoh T, Oikawa H, Yashima-Abo A, Nishiya M, Masuda T Abstract The antigenic heterogeneity of the reticular framework of the white pulp and marginal zone is well documented in the human adult spleen. Immunostaining of α-smooth muscle actin characterizes the heterogeneity of the reticular framework of the white pulp and marginal zone. In the human spleen, the blood cells flow in an open circulation. T and B lymphocytes flow out from the arterial terminal, and migrate in the reticular framework. Homing of lymphocytes to lymphoid tissues is regulated by selective interactions between cell surface homing...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Gamma heavy chain disease ( γ-HCD) as iatrogenic immunodeficiency- associated lymphoproliferative disorder: Possible emergent subtype of rheumatoid arthritis-associated γ-HCD.
Gamma heavy chain disease (γ-HCD) as iatrogenic immunodeficiency- associated lymphoproliferative disorder: Possible emergent subtype of rheumatoid arthritis-associated γ-HCD. J Clin Exp Hematop. 2019;59(4):196-201 Authors: Tsunemine H, Zushi Y, Sasaki M, Nishikawa Y, Tamura A, Aoyama Y, Kodaka T, Itoh T, Takahashi T Abstract Gamma heavy chain disease (γ-HCD) is a rare B-cell neoplasm that produces a truncated immunoglobulin γ-heavy chain lacking the light chain. The clinical features of γ-HCD are heterogeneous, resembling different types of B-cell lymphomas. Although rheum...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

T-cell large granular lymphocytic (LGL) leukemia consists of CD4+/CD8dim and CD4-/CD8+ LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis.
Authors: Kuwahara N, Kodaka T, Zushi Y, Sasaki M, Goka T, Maruoka H, Aoyama Y, Tsunemine H, Yamane T, Kobayashi J, Kawakami T, Ishida F, Itoh T, Takahashi T Abstract CD3+/CD57+ T-cell large granular lymphocyte leukemia (T-LGLL) is an indolent neoplasm, exhibiting mostly CD8+, less frequently CD4+ phenotypes, and T-LGLL consisting of 2 populations with CD8+ and CD4+ phenotypes is markedly rare. An 87-year-old female was admitted under a diagnosis of immune thrombocytopenia (ITP) with a platelet count of 5.0×109/L and increased number of LGL with unknown etiology. Her neutrophil count also decreased to 0.27&tim...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 25, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Epidemiological analysis of multicentric and unicentric Castleman disease and TAFRO syndrome in Japan.
In conclusion, MCD, UCD and TAFRO syndrome may not be as rare as previously estimated in Japan. PMID: 31708515 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 13, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Potential mechanisms of spontaneous regression in patients with B-cell lymphoma; the significance of co-stimulatory molecules in lymphoma cells.
Authors: Komohara Y, Harada M PMID: 31708516 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 13, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas?
This study reviewed 22 consecutive patients with primary intraocular lymphoma diagnosed by immunostaining of vitrectomy cell blocks, and examined whether they developed central nervous system lymphoma. Seventeen patients developed central nervous system lymphoma: 3 patients developed intraocular and central nervous system lymphoma simultaneously, 9 patients developed central nervous system lymphoma 1 month to 5 years (median, 3 months) after intraocular lymphoma, and 5 patients developed central nervous system lymphoma preceding the diagnosis of intraocular lymphoma by 3 months to 9 years and 8 months (median, 1.5 years). ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 17, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

A case series of adult T-cell leukemia-lymphoma, associated with human T-cell leukemia virus type-1, at a single center in a non-viral-endemic metropolitan area.
In conclusion, at a center in a metropolitan and HTLV-1 non-endemic area in Japan, patients with ATL were relatively young and mainly presented with aggressive subtypes. At initial referral to our center, all 13 patients were suspected of having lymphoma but only two of having ATL. For centers in similar areas of Japan, prompt diagnosis and appropriate treatment of ATL patients will become increasingly necessary following the recent migration of HTLV-1 carriers to non-endemic areas. PMID: 31564712 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Maf expression in human macrophages and lymph node sinus macrophages in patients with esophageal cancer.
Authors: Takeya H, Ohnishi K, Shiota T, Saito Y, Fujiwara Y, Yagi T, Kiyozumi Y, Baba Y, Yoshida N, Asano K, Tanaka M, Baba H, Komohara Y Abstract The large Maf transcription factors are expressed in immune cells including macrophages and lymphocytes. To investigate the distribution of Maf expression in human organs, immunostaining for Maf was performed using sections of several human organs. High Maf expression was seen in the nucleus of macrophages in the gastrointestinal tract and lymph node sinus macrophages (LySMs). Then, we assessed whether Maf expression in LySMs was correlated with CD169 expression and the ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan-special focus on primary sinonasal diffuse large B-cell lymphoma.
Authors: Murakami D, Miyashita K, Koyama T, Omori H, Miyamoto Y, Sawatsubashi M, Nakagawa T Abstract The present study investigated histological subtypes of lymphoma in patients newly diagnosed with malignant lymphoma in the human T-cell leukemia virus type 1 (HTLV-1) endemic area of Japan, and further analyzed the clinicopathological features and clinical outcomes of patients with primary sinonasal lymphoma. We retrospectively examined 151 patients aged 18-90 years in Fukuoka, Japan. Subtypes of lymphoma were determined according to the WHO classification. Among the 151 patients, 104 were diagnosed with malignant ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Gamma-heavy chain monoclonal gammopathy with undetermined significance (MGUS).
Authors: Zushi Y, Sasaki M, Saitoh T, Aoyama Y, Gotoh Y, Tsunemine H, Kodaka T, Okamura A, Takahashi T Abstract Gamma-heavy chain disease (γ-HCD) is a rare B-cell tumor producing truncated IgG lacking the light chain. The clinical features of γ-HCD are heterogeneous, similar to lymphoplasmacytic lymphoma, and most patients have generalized and progressive disease. In some γ-HCD patients, autoimmune diseases are associated. Thus, γ-HCD as a restricted or indolent disease is exceptional. A 66-year-old male was referred to our hospital because of subungual hemorrhage at the bilateral halluces. ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

IgA-producing lymphoplasmacytic lymphoma carrying the chromosomal abnormality t(8;14).
Authors: Gotoh Y, Aoyama Y, Tsunemine H, Idei Y, Mori A, Kodaka T, Iba S, Tomita A, Itoh T, Takahashi T Abstract IgA-producing lymphoplasmacytic lymphoma (LPL) is rare and IgH/c-myc translocation is rare in LPL. This is the first report of a case of IgA-producing LPL carrying t(8;14). An 86-year-old woman presented inguinal and intra-abdominal lymph node swelling, and lytic bone lesions in the lumbar vertebrae. A diagnosis of IgA-producing LPL was immunohistochemically made by inguinal lymph node biopsy. The serum IgA level was 1,180 mg/dL, which was revealed to be composed of IgA-λ monoclonal protein. Bone ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Hodgkin-like adult T-cell leukemia/lymphoma that developed during the follow-up of HTLV-1 associated myelopathy/tropical spastic paraparesis.
Authors: Nakaya Y, Yoshida M, Tsutsumi M, Fuseya H, Horiuchi M, Yoshimura T, Hayashi Y, Nakao T, Koh KR, Niino D, Inoue T, Yamane T Abstract Hodgkin-like adult T-cell leukemia/lymphoma (ATLL) is a rare variant of ATLL, which represents the early neoplastic phase of ATLL that follows an indolent clinical course compared with typical ATLL. Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder characterized by the paralysis of lower limbs and urinary disturbance. Although these diseases are caused by HTLV-1 infection, there are no reports des...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Plasma cell myeloma positive for t(14;20) with relapse in the central nervous system.
We present a 63-year-old Japanese female with PCM positive for t(14;20). The tumor responded well to a proteasome inhibitor, bortezomib, and the patient achieved complete remission. Six months after remission, tumor relapse was noted in the left cerebellum and the right frontal lobe of the cerebrum. After whole brain radiation therapy, the tumor masses decreased in size. The patient was followed up with best-care support, but died of the disease 29 months after the initial PCM diagnosis. t(14;20)-positive PCM responded well to bortezomib at the time of the initial treatment. The CNS tumor involvement, which is rare in PCM,...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Pulmonary intravascular large B-cell lymphoma accompanying synchronous primary pulmonary adenocarcinoma and benign interstitial lesions.
We report a rare case of pulmonary IVLBCL accompanying lung cancer and interstitial lesions. A 73-year-old man with a history of pneumonia underwent a follow-up examination. Computed tomography revealed diffuse, bilateral ground-glass opacities (GGO) with a partial solid mass. Histologically, the mass consisted of adenocarcinoma. However, two other types of interstitial lesions were scattered throughout the resected lung: 1) peribronchovascular thickening with the aggregation of macrophages and anthracosis, and 2) alveolar septal thickening in the centrilobular area with atypical CD20-positive large cells in the capillarie...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 10, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Highlights: Focus on immunodeficiency-associated lymphoproliferative disorders.
Authors: Sato Y PMID: 31257344 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Iatrogenic immunodeficiency-associated lymphoproliferative disorders of B-cell type that develop in patients receiving immunosuppressive drugs other than in the post-transplant setting.
Authors: Momose S, Tamaru JI Abstract In the current revised 4th edition of the World Health Organization (WHO) classification, 'other iatrogenic immunodeficiency-associated lymphoproliferative disorders (Oii-LPDs)' is listed in the last section in the chapter on immunodeficiency-associated lymphoproliferative disorders. Oii-LPDs cover a broad spectrum from benign lesions to lymphoma, and correspond to one of the subtypes in the WHO classification for immunocompetent patients.The WHO classification does not clearly indicate the histological subtype of this disease category; however, the framework of subtype classif...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders with a T- or NK-cell phenotype.
Authors: Satou A, Tsuzuki T, Nakamura S Abstract Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPDs) with a T- or NK-cell phenotype are markedly rare, with only a limited number of cases having been reported thus far. Methotrexate (MTX) is the most common agent used for OIIA-LPD patients, and 43 cases of MTX-associated T-LPDs (MTX T-LPDs) and five cases of MTX-associated NK/T-LPDs (MTX NK-LPDs) have been described. In addition to MTX T-LPDs and MTX NK/T-LPDs, T-LPD and NK/T-LPDs have been reported in patients receiving other immunosuppressive agents such as thiopurines, TNF antago...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects.
Authors: Ikeda T, Gion Y, Yoshino T, Sato Y Abstract Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous regression. Histologically, EBVMCUs are characterized by the prolife...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders.
Authors: Tokuhira M, Tamaru JI, Kizaki M Abstract Other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD), a category of immunodeficiency-associated LPD according to the World Health Organization classification, is associated with immunosuppressive drugs (ISDs). Several factors, including autoimmune disease (AID) activity, Epstein-Barr virus (EBV) infection, ISD usage, and aging, influence the development of OIIA-LPD, resulting in complicated clinical courses and outcomes. Most OIIA-LPD develops in patients with rheumatoid arthritis using methotrexate (MTX-LPD). The management of MTX-L...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

DLBCL developed into fatal liver failure during rituximab-containing chemotherapy.
Authors: Shimazu Y, Nohgawa M PMID: 31257349 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Spontaneous remission of acute monocytic leukemia with trisomy 8 and trisomy 18.
Authors: Suyama T, Hasebe K PMID: 31257350 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Final analysis of a phase II study of ibrutinib in Japanese patients with relapsed/refractory mantle cell lymphoma.
Authors: Maruyama D, Nagai H, Fukuhara N, Kitano T, Ishikawa T, Nishikawa T PMID: 31257351 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 2, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

High TNFRSF14 and low BTLA are associated with poor prognosis in Follicular Lymphoma and in Diffuse Large B-cell Lymphoma transformation.
Authors: Carreras J, Lopez-Guillermo A, Kikuti YY, Itoh J, Masashi M, Ikoma H, Tomita S, Hiraiwa S, Hamoudi R, Rosenwald A, Leich E, Martinez A, Roncador G, Villamor N, Colomo L, Perez P, Tsuji NM, Campo E, Nakamura N Abstract The microenvironment influences the behavior of follicular lymphoma (FL) but the specific roles of the immunomodulatory BTLA and TNFRSF14 (HVEM) are unknown. Therefore, we examined their immunohistochemical expression in the intrafollicular, interfollicular and total histological compartments in 106 FL cases (57M/49F; median age 57-years), and in nine relapsed-FL with transformation to DLBCL ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 30, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Spontaneous regression of diffuse large B-cell lymphoma in the small intestine with multiple lymphadenopathy.
Authors: Tanaka Y, Ishihara M, Miyoshi H, Hashimoto A, Shinzato I, Ohshima K Abstract Diffuse large B cell lymphoma (DLBCL) is classified as an aggressive lymphoma due to its poor prognosis regardless of the treatment. Almost all cases of DLBCL are treated using rituximab-combination chemotherapy, but spontaneous regression without any therapeutic modalities may rarely occur. A 35-year-old man complained of abdominal pain and discomfort. Positron emission tomography-computed tomography (PET-CT) demonstrated abnormal accumulation of fluorodeoxyglucose in the thickened wall of the small intestine and multiple lymphad...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 30, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Anaplastic large cell lymphoma, with 1,25(OH)2D3-mediated hypercalcemia: A case report.
Authors: Mitobe M, Kawamoto K, Suzuki T, Kiryu M, Nanba A, Suwabe T, Tanaka T, Fuse K, Shibasaki Y, Masuko M, Miyoshi H, Ohshima K, Sone H, Takizawa J Abstract Hypercalcemia due to malignant tumors including malignant lymphomas is relatively common. Among cancer patients with hypercalcemia, humoral hypercalcemia of malignancy is the most common and accounts for about 80% of all cases with hypercalcemia. 1,25-dihydroxyvitamin D3(1,25(OH)2D3)-mediated hypercalcemia is relatively rare. Although malignant lymphoma has been also reported to cause 1,25(OH)2D3-mediated hypercalcemia, it is not known whether there is any a...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 30, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma.
Authors: Kawai H, Matsushita H, Kawakami S, Furuya D, Shiraiwa-Hara S, Ichiki A, Hara R, Aoyama Y, Ogiya D, Suzuki R, Machida S, Onizuka M, Shirasugi Y, Ogawa Y, Kawada H, Nakamura N, Ando K Abstract Composite lymphoma (CL) is defined as the occurrence of two distinct types of lymphoma within the same patient. Most cases of CL involve Hodgkin and non-Hodgkin lymphomas or two distinct types of B-cell lymphomas; true CL is a composite B-cell and T-cell lymphoma, and is rare. We herein report a case involving concurrent extranodal NK/T-cell lymphoma, nasal-type and diffuse large B-cell lymphoma, which has not been pre...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 30, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Atraumatic splenic ruptures triggered both remission and death in a single case of blastic plasmacytoid dendritic cell neoplasm.
Authors: Daitoku S, Onimaru M, Tanimoto K, Kuroiwa M PMID: 30918143 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - March 30, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis.
Authors: Aoyama Y, Sakai K, Kodaka T, Tsunemine H, Nishio K, Itoh T, Inoue D, Takahashi T Abstract Myelodysplastic/myeloproliferative neoplasm (MDS/MPN) with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T), which exhibits both an increased number of marrow ring sideroblasts and thrombocytosis, is a rare disorder classified as one of the newly established forms of MDS/MPN in the WHO 2016 classification. A 77-year-old female with marked thrombocytosis of 1,024×109/L was tentatively diagnosed with essential thrombocythemia in 2011, and the thrombocytosis was controlled using hydroxycarbamide and low-dos...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - February 7, 2019 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.
Authors: Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S Abstract The c-fms proto-oncogene is also known as macrophage colony stimulating factor receptor (M-CSFR) or colony-stimulating factor-1 receptor (CSF-1R), and is expressed on several types of malignant tumor cells and myeloid cells. In the present study, we found that overexpression of M-CSFR was present in adult T-cell leukemia/lymphoma (ATLL) cases. M-CSFR signaling was associated with lymphoma cell proliferation, and M-CSFR inhibition induced apoptosis in lymphoma cells. ...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - December 15, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia.
Authors: Nishino S, Kodaka T, Sawada Y, Goka T, Gotoh Y, Tsunemine H, Takahashi T Abstract Acquired amegakaryocytic thrombocytopenia (AATP) is a rare disease characterized by thrombocytopenia and the disappearance of marrow megakaryocytes. A 43-year-old man was admitted because of thrombocytopenia of 1.0×109/L. Bone marrow aspirate demonstrated normal hematopoiesis lacking megakaryocytes, and AATP was diagnosed. The serum concentration of thrombopoietin (TPO) was high (7.72 fmol/mL). Prednisolone (PSL) at 60 mg/day was started and the platelet count recovered to 1,335×109/L; however, excessive megakaryo...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Hypercalcemia and osteolytic bone lesions as the major symptoms in a chronic lymphocytic leukemia/small lymphocytic lymphoma patient: a rare case.
We report a 40-year-old woman who presented with multiple osteolytic bone lesions and hypercalcemia, which are rarely caused by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although receiving intensive chemotherapy and allogeneic transplantation, the patient had a poor outcome with an overall survival of 2 years. To our knowledge, this presentation is extremely rare for B-chronic lymphocytic leukemia, and new treatment strategies may be needed for long-term control of the disease. PMID: 30416172 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Intraocular lymphoma as relapse after chemotherapy for primary breast diffuse large B-cell lymphoma.
Authors: Matsuo T, Tanaka T, Yano T PMID: 30416173 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - November 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Rare concurrent indolent B-cell lymphoma and plasmablastic transformation of myeloma.
Authors: Saburi M, Ogata M, Itani K, Kohno K, Soga Y, Kondo Y, Kawano Y, Nakayama T PMID: 30305474 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 13, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Cladribine treatment for Erdheim-Chester disease involving the central nervous system and concomitant polycythemia vera: A case report.
We report the case of a 66-year-old Japanese patient with ECD involving the CNS who harbored the BRAF V600E mutation and also concomitantly developed polycythemia vera with the JAK2 V617F mutation. We confirmed 2-chlorodeoxyadenosine (cladribine) therapy to be effective for the patient in this case. PMID: 30305475 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 13, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) chemotherapy.
Authors: Matsukawa T, Suto K, Miyoshi H, Oshimi K, Ohshima K, Miyagishima T PMID: 30305476 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - October 13, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Therapy-related Myelodysplastic Syndrome after Autologous Stem Cell Transplantation Using Plerixafor for Mobilized Stem Cells in a Patient with Multiple Myeloma.
Authors: Tanaka H, Kuwabara C, Kayamori K, Shimizu R, Suzuki Y PMID: 30089748 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 11, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1-associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation.
Authors: Kawano N, Yoshida S, Kawano S, Kuriyama T, Tahara Y, Toyofuku A, Manabe T, Doi A, Terasaka S, Yamashita K, Ueda Y, Ochiai H, Marutsuka K, Yamano Y, Shimoda K, Kikuchi I Abstract Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1-associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear.We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 11, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Pulmonary extranodal marginal zone lymphoma that presented with macroglobulinemia and marked plasmacytic cell proliferation carrying the t(14;18)(q32;q21)/MALT1-immunoglobulin heavy-chain fusion gene in pleural fluid.
Authors: Akasaka T, Kishimori C, Maekawa F, Takeoka K, Hayashida M, Gomyo H, Murayama T, Ohno H Abstract An 80-year-old man presented with the accumulation of pleural fluid in the right thoracic cavity. Serum electrophoresis revealed an M-component and immunofixation confirmed IgM/λ. The level of IgM was 1,526 mg/dL. Imaging studies showed an infiltrative condition of the ipsilateral lung parenchyma. The fluid contained abundant neoplastic cells with the morphological and immunophenotypic features of plasma cells, which expressed IgM/λ monoclonal immunoglobulins on the cell surface and in the cytoplas...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - August 11, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Transformation of double-hit follicular lymphoma to plasmablastic lymphoma: a partial role of MYC gene rearrangement.
This study will broaden our understanding of the pathogenesis of high-grade transformation of FL and help improve patient outcome. PMID: 30012920 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 18, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

A case of chronic lymphocytic leukemia complicated by autoimmune hemolytic anemia due to ibrutinib treatment.
Authors: Suzuki T, Miyakoshi S, Nanba A, Uchiyama T, Kawamoto K, Aoki S Abstract Ibrutinib (IBR) covalently binds to the active site of Bruton's tyrosine kinase (BTK) and is used for the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL). Approximately 5-10% of CLL is complicated by autoimmune cytopenia (AIC), such as autoimmune hemolytic anemia (AIHA). Several cases of AIC have reportedly demonstrated improvement during IBR treatment. However, in our case, the patient developed AIHA during oral IBR treatment. As AIHA is exacerbated by the increased number of CLL cells in the peripheral blood, it m...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 18, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Characteristic Histological Findings of Asymptomatic EBV-associated Lymphoproliferative Disorders in Tonsils.
Authors: Jamiyan T, Nakazato Y, Kuroda H, Kojima M, Imai Y PMID: 30012922 [PubMed - as supplied by publisher] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 18, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Highlights: Focus on Bone Marrow Pathology.
Authors: Ito M PMID: 29998974 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Histological evaluation of myeloproliferative neoplasms.
This article highlights particularly the morphology of megakaryocytes and evaluation of myelofibrosis for pathological diagnosis, and immunohistochemistry which can detect somatic mutation. PMID: 29998975 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

Histopathology in the diagnosis of high-risk myelodysplastic syndromes.
Authors: Kayano H PMID: 29998976 [PubMed - in process] (Source: Journal of Clinical and Experimental Hematopathology : JCEH)
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

The histopathology of myeloma in the bone marrow.
Authors: Fujino M Abstract Myeloma is characterized by the neoplastic proliferation of monoclonal plasma cells. A diagnosis of myeloma is based on the criteria proposed by the International Myeloma Working Group and the pathological findings.Myeloma cells are classified into four types: mature, immature, pleomorphic, and plasmablastic. There are three patterns in which myeloma infiltrates bone marrow - nodular, interstitial, and diffuse. Dutcher bodies are highly specific to neoplastic myeloma cells. On immunohistochemical staining, the specificity of CD138 is high for plasma cells. As a clear image is often not ob...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

The histopathology of bone marrow failure in children.
Authors: Iwafuchi H Abstract Bone marrow failure (BMF) is a rare but life-threatening disorder that usually manifests as (pan)cytopenia. BMF can be caused by a variety of diseases, but inherited BMF (IBMF) syndromes are a clinically important cause, especially in children. IBMF syndromes are a heterogeneous group of genetic disorders characterized by BMF, physical abnormalities, and predisposition to malignancy. An accurate diagnosis is critical, as disease-specific management, surveillance, and genetic counselling are required for each patient. The major differential diagnoses of IBMF syndromes are acquired aplast...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research

The expression of PD-1 ligands and IDO1 by macrophage/microglia in primary central nervous system lymphoma.
Authors: Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y Abstract Recent progress in anti-tumor immunotherapy has focused on the significance of the tumor microenvironment in tumor progression and resistance to chemo/radio-therapy. Myeloid cells such as macrophages are predominant stromal components in hematological malignancies. In the present study, we investigated the regulation of programmed death-1 (PD-1) ligand expression in primary central nervous system lymphoma (PCNSL) using PCNSL cell lines and human monocyte-derived macrophages. TK PCNSL cell li...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - July 14, 2018 Category: Hematology Tags: J Clin Exp Hematop Source Type: research