Diagnostic challenges and forensic implications in a case of infantile fatal myocarditis
We present the case of a 23-month-old child who died less than 24  h after the onset of cardiac symptoms, despite being admitted to the hospital 72 h earlier. Autopsy revealed no significant macroscopic changes, and histologic examination revealed focal lymphocytic myocarditis with myocyte disruption, diffuse alveolar damage in the exudative phase, and generaliz ed lymphocytic immune activation in other organs. Ante-mortem and post-mortem microbiological exams did not clearly prove a causative role of infectious agents. The peculiarity of this case was characterized by the contrast between the severe clinical features a...
Source: Forensic Science, Medicine, and Pathology - June 19, 2023 Category: Forensic Medicine Source Type: research

Advances in Our Understanding Neurodevelopmental Benefits of Both Mother's Milk and Infant Formula Supplemented with Bovine Milk Fat Globule Membrane and Bovine Lactoferrin
The beneficial effects of mother's milk in have been shown in multiple domains, including decreased rates of infection, necrotizing enterocolitis, allergic disorders, asthma, diarrhea, and sudden infant death syndrome, and improved survival, cognition, and behavior in term and preterm infants.1-3 Reports also demonstrate the relationship between human milk, improved neurodevelopment, and enhanced infant brain development.4,5 In addition, breast feeding has been shown to be beneficial for both maternal and infant health. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 30, 2023 Category: Pediatrics Authors: Betty R. Vohr Tags: Editorials Source Type: research

Cell death in the lateral geniculate nucleus, and its possible relationship with nicotinic receptors and sudden infant death syndrome (SIDS)
In conclusion, our findings do not support a role for the α7 and β2 nAChRs in apoptotic regulation of the LGN layers during infa ncy. However, for SIDS victims, an inverse correlation between the changes for markers of apoptosis and the β2 nAChR subunit expression suggests altered LGN function. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - May 28, 2023 Category: Neurology Source Type: research

Sudden infant death syndrome may have a biological cause
The condition may at least partly be caused by insufficient binding of a neurotransmitter to receptors in the brainstem (Source: New Scientist - Health)
Source: New Scientist - Health - May 25, 2023 Category: Consumer Health News Source Type: research

Qualitative assessment of infant sleep practices and other risk factors of sudden infant death syndrome (SIDS) among mothers in Lusaka, Zambia
There is very little information on the beliefs and perceptions of mothers about SIDS and its related risk factors in Africa. To better understand parental decisions about infant sleep practices and other risk... (Source: BMC Pediatrics)
Source: BMC Pediatrics - May 18, 2023 Category: Pediatrics Authors: Godwin K. Osei-Poku, Lawrence Mwananyanda, Patricia A. Elliott, William B. MacLeod, Somwe Wa Somwe, Rachel C. Pieciak, Arnold Hamapa and Christopher J. Gill Tags: Research Source Type: research

Current SIDS research: time to resolve conflicting research hypotheses and collaborate
Pediatr Res. 2023 May 12. doi: 10.1038/s41390-023-02611-4. Online ahead of print.ABSTRACTFrom the earliest publications on cot death or sudden infant death syndrome (SIDS) through to this day, clinical pathology and epidemiology have strongly featured infection as a constant association. Despite mounting evidence of the role of viruses and common toxigenic bacteria in the pathogenesis of SIDS, a growing school of thought featuring a paradigm based on the triple risk hypothesis that encompasses vulnerability through deranged homoeostatic control of arousal and/or cardiorespiratory function has become the mainstream view and...
Source: Pediatric Research - May 12, 2023 Category: Pediatrics Authors: Paul N Goldwater Source Type: research

Current SIDS research: time to resolve conflicting research hypotheses and collaborate
Pediatr Res. 2023 May 12. doi: 10.1038/s41390-023-02611-4. Online ahead of print.ABSTRACTFrom the earliest publications on cot death or sudden infant death syndrome (SIDS) through to this day, clinical pathology and epidemiology have strongly featured infection as a constant association. Despite mounting evidence of the role of viruses and common toxigenic bacteria in the pathogenesis of SIDS, a growing school of thought featuring a paradigm based on the triple risk hypothesis that encompasses vulnerability through deranged homoeostatic control of arousal and/or cardiorespiratory function has become the mainstream view and...
Source: Pediatric Research - May 12, 2023 Category: Pediatrics Authors: Paul N Goldwater Source Type: research

Ventilatory response to added dead space in infants exposed to second-hand smoke in pregnancy
Conclusion: Second-hand smoke exposure during pregnancy was associated with a delayed newborn ventilatory response.What is Known:• Maternal cigarette smoking in pregnancy can adversely affect infant respiratory control.• The potential impact of maternal second-hand smoke exposure, however, has not yet been determined.What is New:• We have assessed the ventilatory response to added dead-space (inducing hypercapnia) in newborns with second-hand smoke exposure during pregnancy, in infants whose mothers smoked, and in controls (non-smoke exposed).• Maternal second-hand smoke exposure, as well as maternal sm...
Source: European Journal of Pediatrics - May 11, 2023 Category: Pediatrics Source Type: research

Safe to Sleep in Tennessee: A Statewide Quality Improvement Initiative
Conclusion This project demonstrates the positive impact that a statewide quality improvement initiative can have on identifying and addressing barriers, sharing resources and education, and monitoring local and statewide data, which led to increased compliance with safe sleep recommendations in the hospital. Safe sleep education and monitoring should be ongoing as new parents and staff always need to be educated on safe sleep principles. Key Points [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |Â...
Source: American Journal of Perinatology - May 11, 2023 Category: Perinatology & Neonatology Authors: Gutman, Courtney E. Scott, Patricia A. Morad, Anna Barker, Brenda Scott, Theresa A. Tags: Original Article Source Type: research

Dysregulation of hypoxia-inducible factor 1 α in the sympathetic nervous system accelerates diabetic cardiomyopathy
An altered sympathetic nervous system is implicated in many cardiac pathologies, ranging from sudden infant death syndrome to common diseases of adulthood such as hypertension, myocardial ischemia, cardiac arr... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 18, 2023 Category: Cardiology Authors: Petra Hrabalova, Romana Bohuslavova, Katerina Matejkova, Frantisek Papousek, David Sedmera, Pavel Abaffy, Frantisek Kolar and Gabriela Pavlinkova Tags: Research Source Type: research

Bed-sharing and SIDS: an evidence-based approach
We read with interest the viewpoint article ‘Bed-sharing is a risk for sudden unexpected death in infancy’ written by David Tappin and his colleagues1 and feel the issues raised and some of the claims made need contextualising. Essentially this is a public health debate about which approach to use when the evidence gets more nuanced. Initial observations of an increased risk of sudden infant death syndrome (SIDS) associated with bed-sharing have come under scrutiny and revealed the risk is mainly limited to the particular circumstances in which bed-sharing occurs (if parents smoke, drink alcohol, take drugs or ...
Source: Archives of Disease in Childhood - March 17, 2023 Category: Pediatrics Authors: Blair, P. S., Ball, H. L., Pease, A., Fleming, P. J. Tags: Viewpoint Source Type: research

Modeling of infant safe sleep practice in a newborn nursery: a quality improvement initiative
This study demonstrates that implementing a quality improvement initiative to improve infant sleep practices in a low-volume nursery is feasible and impactful.PMID:36876256 | PMC:PMC9980643 | DOI:10.1080/08998280.2022.2139976 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - March 6, 2023 Category: Universities & Medical Training Authors: Eunice Hsu Lauren Isbell Danielle Arnold Maheswari Ekambaram Source Type: research

Modeling of infant safe sleep practice in a newborn nursery: a quality improvement initiative
This study demonstrates that implementing a quality improvement initiative to improve infant sleep practices in a low-volume nursery is feasible and impactful.PMID:36876256 | PMC:PMC9980643 | DOI:10.1080/08998280.2022.2139976 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - March 6, 2023 Category: Universities & Medical Training Authors: Eunice Hsu Lauren Isbell Danielle Arnold Maheswari Ekambaram Source Type: research

Modeling of infant safe sleep practice in a newborn nursery: a quality improvement initiative
This study demonstrates that implementing a quality improvement initiative to improve infant sleep practices in a low-volume nursery is feasible and impactful.PMID:36876256 | PMC:PMC9980643 | DOI:10.1080/08998280.2022.2139976 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - March 6, 2023 Category: Universities & Medical Training Authors: Eunice Hsu Lauren Isbell Danielle Arnold Maheswari Ekambaram Source Type: research