Genetic variants in eleven central and peripheral chemoreceptor genes in sudden infant death syndrome
CONCLUSIONS: Genetic variants in genes involved in respiratory chemoreception may be a risk factor in a fraction of SIDS cases and may thereby contribute to the multifactorial etiology of SIDS.IMPACT: What is the key message of your article? Gene variants encoding proteins involved in respiratory chemoreception may play a role in a minority of SIDS cases. What does it add to the existing literature? Although impaired respiratory chemoreception has been suggested as an important risk factor for SIDS, genetic variants in single genes seem to play a minor role. What is the impact? This study supports previous findings, which ...
Source: Pediatric Research - February 1, 2022 Category: Pediatrics Authors: Jacqueline Neubauer Anna-Lena Forst Richard Warth Christian Peter Both Cordula Haas J örg Thomas Source Type: research

Mitochondrial DNA content: a new potential biomarker for Sudden Infant Death Syndrome
CONCLUSIONS: Our study revealed for the first time higher mtDNAcn in the cerebral cortex of the SIDS cases than the controls, indicating metabolic alterations. MtDNAcn plays an important role in compensatory mechanisms against environmental factors affecting human health. Despite the small sample size, mtDNA may prove to be a potential forensic biomarker for autopsied SIDS victims for gaining new insights into the etiology of SIDS.IMPACT: Mitochondrial DNA content evaluated in cerebral cortex samples is higher in SIDS victims than controls. These results represent a novel line of investigation for the etiology of SIDS and ...
Source: Pediatric Research - February 1, 2022 Category: Pediatrics Authors: Roberta Danusso Graziella Alfonsi Stefano Ferrero Anna Maria Lavezzi Debora Lattuada Source Type: research

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In Canada, from 2015 to 2020, there were approximately 1,700 deaths per year among infants under the age of 1. On average, 1 in 15 (110) of these deaths occurred while the infant was sleeping. While a number of deaths that occurred during sleep were of natural causes, such as respiratory diseases or congenital defects, the majority (83%) were sudden and unexpected and occurred in otherwise healthy infants. Sudden and unexpected sleep-related deaths are either caused by a threat to breathing such as suffocation or strangulation, or an undetermined cause, where a cause of death cannot be determined from the investigation or ...
Source: Statistics Canada, The Daily: Health - January 19, 2022 Category: Statistics Authors: Statistics Canada Source Type: research

Infant urinary metabolomic profile in a fatal acute methadone intoxication
AbstractA case report suspicious for a Sudden Infant Death Syndrome is here described. Pathological findings were consistent with an acute respiratory failure while toxicological analysis revealed an elevated blood methadone concentration. Death was then ascribed to an acute methadone intoxication. In addition to the routinary approach, the urinary sample collected at autopsy was investigated with a1H NMR metabolomic approach and the identified metabolomic profile was challenged with the urinary metabolomic profiles previously obtained from 10 newborns who experienced perinatal asphyxia and 16 healthy control newborns. Int...
Source: International Journal of Legal Medicine - January 11, 2022 Category: Medical Law Source Type: research

Every ounce counts: A call for comprehensive support for breastfeeding surgeons by the Association of Women Surgeons
Breastfeeding is a vital component of global health. Breastmilk is the optimal nutrition for infants, and breastfeeding confers unparalleled health benefits to women and children including decreased infant mortality and morbidity from infectious diseases, sudden infant death syndrome, necrotizing enterocolitis, leukemia, and chronic illnesses as well as lower rates of maternal breast and ovarian cancers and chronic diseases.1 Tragically, no country in the world meets minimum standards for breastfeeding established by the Global Breastfeeding Collective, led by the World Health Organization (WHO). (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 4, 2022 Category: Surgery Authors: Helen M. Johnson, Madeline B. Torres, Leah C. Tatebe, Maria S. Altieri, from the Publications Committee of the Association of Women Surgeons Source Type: research

Mothers' Decision Making Concerning Safe Sleep for Preterm Infants: What Are the Influencing Factors?
This study used a mixed-methods design. Recruitment was through social media messaging by 2 parent support organizations. An online survey was used to assess factors influencing mothers' decisions regarding sleep practices for preterm infants.FINDINGS/RESULTS: Survey participants (n = 98) were from across the United States. Mothers of preterm infants (mean gestational age at birth = 29.42 weeks) most often reported positioning infants on their back to sleep (92.3%) and a low (15.4%) use of a pacifier at sleep time. Three themes emerged for the decisions made: adherence to SSR; nonadherence to SSR; and infant-guided decisio...
Source: Advances in Neonatal Care - December 30, 2021 Category: Nursing Authors: Beverly Capper Elizabeth G Damato Sarah Gutin-Barsman Donna Dowling Source Type: research

Mothers' Decision Making Concerning Safe Sleep for Preterm Infants: What Are the Influencing Factors?
This study used a mixed-methods design. Recruitment was through social media messaging by 2 parent support organizations. An online survey was used to assess factors influencing mothers' decisions regarding sleep practices for preterm infants.FINDINGS/RESULTS: Survey participants (n = 98) were from across the United States. Mothers of preterm infants (mean gestational age at birth = 29.42 weeks) most often reported positioning infants on their back to sleep (92.3%) and a low (15.4%) use of a pacifier at sleep time. Three themes emerged for the decisions made: adherence to SSR; nonadherence to SSR; and infant-guided decisio...
Source: Advances in Neonatal Care - December 30, 2021 Category: Nursing Authors: Beverly Capper Elizabeth G Damato Sarah Gutin-Barsman Donna Dowling Source Type: research

Mothers' Decision Making Concerning Safe Sleep for Preterm Infants: What Are the Influencing Factors?
This study used a mixed-methods design. Recruitment was through social media messaging by 2 parent support organizations. An online survey was used to assess factors influencing mothers' decisions regarding sleep practices for preterm infants.FINDINGS/RESULTS: Survey participants (n = 98) were from across the United States. Mothers of preterm infants (mean gestational age at birth = 29.42 weeks) most often reported positioning infants on their back to sleep (92.3%) and a low (15.4%) use of a pacifier at sleep time. Three themes emerged for the decisions made: adherence to SSR; nonadherence to SSR; and infant-guided decisio...
Source: Advances in Neonatal Care - December 30, 2021 Category: Nursing Authors: Beverly Capper Elizabeth G Damato Sarah Gutin-Barsman Donna Dowling Source Type: research

Mothers' Decision Making Concerning Safe Sleep for Preterm Infants: What Are the Influencing Factors?
This study used a mixed-methods design. Recruitment was through social media messaging by 2 parent support organizations. An online survey was used to assess factors influencing mothers' decisions regarding sleep practices for preterm infants.FINDINGS/RESULTS: Survey participants (n = 98) were from across the United States. Mothers of preterm infants (mean gestational age at birth = 29.42 weeks) most often reported positioning infants on their back to sleep (92.3%) and a low (15.4%) use of a pacifier at sleep time. Three themes emerged for the decisions made: adherence to SSR; nonadherence to SSR; and infant-guided decisio...
Source: Advances in Neonatal Care - December 30, 2021 Category: Nursing Authors: Beverly Capper Elizabeth G Damato Sarah Gutin-Barsman Donna Dowling Source Type: research

Neurological Repercussions of Neonatal Nicotine Exposure: A Review
Int J Dev Neurosci. 2021 Dec 16. doi: 10.1002/jdn.10163. Online ahead of print.ABSTRACTSmoking during pregnancy is hazardous to both the mother and the fetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio-respiratory function. SIDS establishes a connection between depression, learning difficulties, and behavioral disorders. Prenat...
Source: International Journal of Developmental Neuroscience - December 16, 2021 Category: Neuroscience Authors: Joyal Xavier Sanjiv Singh Priyanka Kumari V Ravichandiran Source Type: research

Neurological Repercussions of Neonatal Nicotine Exposure: A Review
Int J Dev Neurosci. 2021 Dec 16. doi: 10.1002/jdn.10163. Online ahead of print.ABSTRACTSmoking during pregnancy is hazardous to both the mother and the fetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio-respiratory function. SIDS establishes a connection between depression, learning difficulties, and behavioral disorders. Prenat...
Source: International Journal of Developmental Neuroscience - December 16, 2021 Category: Neuroscience Authors: Joyal Xavier Sanjiv Singh Priyanka Kumari V Ravichandiran Source Type: research

Neurological Repercussions of Neonatal Nicotine Exposure: A Review
Int J Dev Neurosci. 2021 Dec 16. doi: 10.1002/jdn.10163. Online ahead of print.ABSTRACTSmoking during pregnancy is hazardous to both the mother and the fetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio-respiratory function. SIDS establishes a connection between depression, learning difficulties, and behavioral disorders. Prenat...
Source: International Journal of Developmental Neuroscience - December 16, 2021 Category: Neuroscience Authors: Joyal Xavier Sanjiv Singh Priyanka Kumari V Ravichandiran Source Type: research

Neurological Repercussions of Neonatal Nicotine Exposure: A Review
Int J Dev Neurosci. 2021 Dec 16. doi: 10.1002/jdn.10163. Online ahead of print.ABSTRACTSmoking during pregnancy is hazardous to both the mother and the fetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio-respiratory function. SIDS establishes a connection between depression, learning difficulties, and behavioral disorders. Prenat...
Source: International Journal of Developmental Neuroscience - December 16, 2021 Category: Neuroscience Authors: Joyal Xavier Sanjiv Singh Priyanka Kumari V Ravichandiran Source Type: research

Neurological Repercussions of Neonatal Nicotine Exposure: A Review
Int J Dev Neurosci. 2021 Dec 16. doi: 10.1002/jdn.10163. Online ahead of print.ABSTRACTSmoking during pregnancy is hazardous to both the mother and the fetus, according to a substantial amount of recorded data. Exposure to nicotine and other compounds in cigarette smoke increases the risk of sudden infant death syndrome (SIDS) by two to five times during pregnancy. Serotonergic abnormalities have been discovered in SIDS infants in the zone of the medulla oblongata, which is known to control cardio-respiratory function. SIDS establishes a connection between depression, learning difficulties, and behavioral disorders. Prenat...
Source: International Journal of Developmental Neuroscience - December 16, 2021 Category: Neuroscience Authors: Joyal Xavier Sanjiv Singh Priyanka Kumari V Ravichandiran Source Type: research

Population-Based Survey Showing That Breastfed Babies Have a Lower Frequency of Risk Factors for Sudden Infant Death Syndrome Than Nonbreastfed Babies
Breastfeeding Medicine, Ahead of Print. (Source: Breastfeeding Medicine)
Source: Breastfeeding Medicine - December 16, 2021 Category: Perinatology & Neonatology Authors: Jos é Leonardo Landa-Rivera Juan P érez-Pérez Mar ía del Pilar González-Núñez Regina Andrea Gil-Miralles Yolanda Jover-Escolano Vanesa Fern ández-Pan Astacio Source Type: research