Sudden Infant Death Syndrome Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nonsyndromic Craniofacial Disorders
We describe the investigation and management of select pediatric craniofacial disorders their recent advances. Positional plagiocephaly: The incidence of positional plagiocephaly has increased since the institution of the "safe to sleep" campaign to reduce sudden infant death syndrome. Positional plagiocephaly may be associated with underlying developmental delay. Nonsyndromic craniosynostosis: Treatment of nonsyndromic craniosynostosis depends on the age of the patient and the suture involved. Pediatric skull lesions: Management of skull lesions depends on histologic diagnosis. Some benign skull lesions are managed conser...
Source: The Surgical Clinics of North America - November 19, 2023 Category: Surgery Authors: Antonia L Watson Ryan Winters Source Type: research

Exome analysis focusing on epilepsy-related genes in children and adults with sudden unexplained death
Sudden infant death syndrome (SIDS) is defined as the sudden death of an infant under one year of age, which remains unexplained after a thorough case investigation, including a complete autopsy, examination of the death scene, and review of the clinical history [1]. The ‘back to sleep’ campaign in the 1980ties, which recommended a supine sleeping position and a safe sleeping environment, contributed significantly to the decline of SIDS incidence [2]. However, the current incidence still adds up to 0.1 - 0.8 deaths per 1’000 live births and the underlying path ophysiological mechanisms of SIDS are not well understood...
Source: Seizure: European Journal of Epilepsy - November 1, 2023 Category: Neurology Authors: Sarah E. Buerki, Cordula Haas, Jacqueline Neubauer Source Type: research

The diminishing role of the pathologist in sudden infant death syndrome
AbstractAll major definitions of sudden infant death syndrome (SIDS) specify that a careful pathological examination must be conducted which includes performance of a “complete” autopsy. Unfortunately, there is an increasing trend for cases to be classified as SIDS without fulfilling the required criteria, even including cases where an autopsy has not been performed. Failure to have an experienced pathologist with an understanding of SIDS involved in every st ep of the investigation and follow-up, with or without subsequent studies, may severely undermine the veracity of the diagnosis and the reliability of subsequent ...
Source: Forensic Science, Medicine, and Pathology - October 25, 2023 Category: Forensic Medicine Source Type: research

Aberrant colon metabolome and the sudden infant death syndrome
CONCLUSIONS: This study demonstrates increased variability in the colonic metabolome and a trend towards increased colonic serotonin in SIDS. The underlying cause of colon metabolomic variability, and its potential role in SIDS pathogenesis, warrants further investigation.IMPACT STATEMENT: The key message of this article is that SIDS is associated with an aberrant colonic metabolome. This is a novel observation suggesting another component in the pathophysiology underlying SIDS. Investigation of why the colonic metabolome is aberrant may offer new insights to SIDS pathogenesis and new strategies to reduce risk.PMID:3783353...
Source: Pediatric Research - October 13, 2023 Category: Pediatrics Authors: Jefferson Terry Roger A Dyer Source Type: research

Changes in background characteristics and risk factors among SIDS infants in England: cohort comparisons from 1993 to 2020
Conclusions A more targeted approach is needed with vulnerable families emphasising the importance of sleeping infants on their back and proactive planning infant sleep when there are disruptions to the normal routine, in particular to avoid hazardous co-sleeping. (Source: BMJ Open)
Source: BMJ Open - October 13, 2023 Category: General Medicine Authors: Pease, A., Turner, N., Ingram, J., Fleming, P., Patrick, K., Williams, T., Sleap, V., Pitts, K., Luyt, K., Ali, B., Blair, P. Tags: Open access, Epidemiology Source Type: research

Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category
This study aimed to determine the percentage of positive ChAT and AChE neurons within the infant DMNV through immunohistochemistry at the three levels of the brainstem medulla (caudal, intermediate, and rostral), to investigate whether the proportion of neurons positive for these enzymes differs amongst the diagnostic subgroups of SIDS compared to those with an explained cause of Sudden unexpected death in infancy (eSUDI), and whether there were any associations with SIDS risk factors (male gender, cigarette smoke exposure, co-sleeping/bed sharing, and prone sleeping). Results showed that ChAT-positive neurons were lower i...
Source: Neurobiology of Disease - October 9, 2023 Category: Neurology Authors: Masarra Joda Karen A Waters Rita Machaalani Source Type: research