MKSAP: 49-year-old-man with right arm weakness
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 49-year-old-man is evaluated 1 day after having an episode of right arm weakness without pain that lasted 5 minutes. He is now asymptomatic. The patient has type 2 diabetes mellitus and dyslipidemia. Medications are aspiri n, metformin, and atorvastatin. On physical […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 24, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Neurology Source Type: blogs
Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined.
Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Implications of Greater Amounts of Remnant Cholesterol in the Bloodstream
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined.
Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 7, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
On The Pulse - July 2019
Current statin use associated with lower risk of biliary tract cancers (Source: OnMedica Blogs)
Source: OnMedica Blogs - July 25, 2019 Category: General Medicine Source Type: blogs
Landmark Results Achieved in Aging and Chronic Disease: Danish Group Extends Disease-free Life by 8 Years
By WILLIAM H. BESTERMANN JR., MD
New Scientific Breakthroughs Can
Provide a Longer Healthier Life
Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - July 11, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs
Should you eat cholesterol lowering foods?
The short answer: No, absolutely not.
You’ll find no lack of conversations, however, that tell you to consume more oatmeal, nuts, garlic or soy to reduce total and LDL cholesterol, perhaps thereby avoiding statin drugs. Or add more fiber to your diet or take red yeast rice.
These foods and supplements do indeed reduce total and LDL cholesterol . . . but who cares? Don’t waste your time and energy on this useless exercise, especially efforts to reduce the absurd, outdated, imprecise calculated LDL cholesterol.
But doesn’t reducing LDL cholesterol, the “bad,” in particular reduce risk for cardio...
Source: Wheat Belly Blog - June 28, 2019 Category: Cardiology Authors: Dr. Davis Tags: Cholesterol wheat belly Source Type: blogs
Is it SAFE to be grain-free?
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime.
First of a...
Source: Wheat Belly Blog - June 25, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
A poor sense of smell might matter more than you thought
As one of the five major senses, you could argue that our sense of smell is the least important. Sight, hearing, touch, and taste may poll better than smell, but try telling that to someone who has lost their sense of smell entirely.
The truth is that loss of the ability to smell comes with a significant cost, because olfaction serves several purposes that affect quality of life and even safety, including
stimulation of appetite
enhancement of the sense of taste
alerting you to which foods should not be eaten (if they’re rotting, for example)
warning you of danger (as with smoke warning of fire).
Loss of smell can also...
Source: Harvard Health Blog - June 18, 2019 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Alzheimer's Disease Brain and cognitive health Ear, nose, and throat Source Type: blogs
What your doctor may not know about cholesterol
Confusion over cholesterol issues is everywhere and shared by most people, including doctors. Unfortunately, it means that, by seeing your primary care doctor or even cardiologist, you are being advised with information that is superficial and largely ineffective while ignoring the MANY issues that really should be addressed to manage risk for cardiovascular disease. Admittedly, these are somewhat complicated issues and even I have been guilty at times of giving overlysimplistic answers. I’ll try to keep this as straightforward as possible, but it is a bit hairy.
I blame this situation on the statin drug industry, as...
Source: Wheat Belly Blog - June 17, 2019 Category: Cardiology Authors: Dr. Davis Tags: Cholesterol undoctored wheat belly Source Type: blogs
Master health musings : Where did Alexander the Great, checked his LDL and Chenghis khan recorded his BP ?
A middle-aged man a Biotech engineer, who is just back from his annual health check, sitting in front of me with a deeply anguished face and said “Doctor my LDL is 130mg, and my diastolic BP is 90 mmHg and fasting sugar is 120 mg .I am very much worried about my future”
Wait , let me go through your file, I said ,
Isn’t a serious Issue doctor?
No, its not ,
But , doctor, I have read about ASCOT, SPRINT and HOPE-3 trials. I guess they tell us to keep the LDL, blood sugar and diastolic BP all these three parameters around 80. Isn’t doctor? He went on to add, that his old fashioned family physician ha...
Source: Dr.S.Venkatesan MD - June 2, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized master health check up in cardiology preventive health care Source Type: blogs
Fight Aging! Newsletter, May 27th 2019
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - May 26, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Survey for Athletes with AF
Hey Athletes:
My colleague, Professor Rachel Lampert, from Yale, along with the StopAF.org patient group, seek to learn more about how atrial fibrillation (AF) and its treatments affect athletic people. If you are an athlete or if you regularly exercise vigorously, please give the Yale researchers a few moments of your time.
Here is the link to the survey.
Since I had AF in the past, I filled it out. It takes only a few minutes.
Prof. Lampert’s research into this area is important because AF affects people in vastly different ways.
It’s weird; while most AF stems from advanced age or lifestyle...
Source: Dr John M - May 23, 2019 Category: Cardiology Authors: Dr John Source Type: blogs
Another Cholesterol-Lowering Variant that Reduces Heart Disease Risk, but This One Has Unfortunate Side Effects
In recent years, researchers have discovered a number of human gene variants or mutations that significantly lower blood cholesterol, and this also the risk of heart disease, such as DSCAML1, ANGPTL4, and ASGR1. Why does this work? Oxidized cholesterol contributes to the development of atherosclerosis with advancing age, by causing macrophages to falter in their work of removing cholesterol from blood vessel walls, become inflammatory, transform into foam cells, and die, leaving debris that grows the lesions the cells are trying to repair. Reducing overall cholesterol works because it reduces oxidized cholesterol as well.
...
Source: Fight Aging! - May 21, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Four Dangers of Stopping a Statin Drug
Doctors tell us that it is dangerous and foolhardy to stop a statin cholesterol drug and that heart attack may be imminent if you do.
Is there any truth to these claims?
The post The Four Dangers of Stopping a Statin Drug appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - May 12, 2019 Category: Cardiology Authors: Dr. Davis Tags: Statin drugs cholesterol undoctored wheat belly Source Type: blogs
Fight Aging! Newsletter, May 6th 2019
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an ass...
Source: Fight Aging! - May 5, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
