Furore over FOURIER is (un)warranted : Evolocumab is an Innocent molecule !
Welcome back to the big molecular science of PCSK and its antagonist Evolocumab, a monoclonal antibody designed to target and prevent the LDL receptor catabolism inside the lysosomes. Evolocumab was approved by FDA for aggressive lowering of LDL, following a customary study published in NEJM 2017, that released this double-edged anti-lipid molecule into the human domain with all fanfare.
It aimed to reduce the LDL as low as possible in selected patients with familial LDLemia & and those who don’t tolerate statins. Now, a study was silently released in BMJ open, at the fag end of 2002, which is causing ripp...
Source: Dr.S.Venkatesan MD - January 16, 2023 Category: Cardiology Authors: dr s venkatesan Tags: lipid metabolism evolocumab fourier study how low ldl can go inclisiron lipid guidelines acc aha esc csi Source Type: blogs
Avoid Statin Side-Effects With This Once-A-Day Pill
A cholesterol-lowering option for statins users who experience some side effects. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 29, 2022 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cholesterol Source Type: blogs
Statins Side-Effects: Two Signs In Your Hands And Feet
How to reduce 'bad' cholesterol levels in 30 days without statins, using only natural, healthy foods. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 19, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Blood Pressure Source Type: blogs
Predisposition to statin adverse effects
Some situations likely to predispose to statin adverse effects are impaired renal or hepatic function, history of previous statin intolerance or muscle disorders and unexplained elevation of SGPT. In addition to these, age above 75 years, Asian ancestry and previous hemorrhagic stroke are potential conditions to considered while considering high intensity statin therapy with regard to predisposition for adverse effects. Concomitant usage of drugs likely to affect statin metabolism should also be considered. (Source: Cardiophile MD)
Source: Cardiophile MD - December 5, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Upon arrival to the emergency department, a senior emergency physician looked at the ECG and said " Nothing too exciting. "
This article fails to specify whether it was troponin I or T, but I contacted the institution and they used exclusively troponin I during that time period.Reference on Troponins: Xenogiannis I, Vemmou E, Nikolakopoulos I, et al. The impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy. J Electrocardiol [Internet] 2022;Available from: http://dx.doi.org/10.1016/j.jelectrocard.2022.09.009Cardiology opinion: Takotsubo Cardiomyopathy (EF 30-35%)V Fib Cardiac arrestProlonged QTCNSTEMI (Smith comment: is it NSTEMI or is it Takotsubo? -- these are entirely different)Moderate sin...
Source: Dr. Smith's ECG Blog - November 30, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs
Cigna-Express Scripts by InsideRx Strategy Modification, Mark Cuban Cost Plus Insulin Trial
Two years ago, I made a very well-informed decision to simply bypass our own healthcare insurance for a number of prescriptions used in my household because we were paying out-of-pocket until the deductible was satisfied anyway (which was about half the year), and our new insurance carrier Aetna and its PBM Caremark was obviously ripping us off by a fairly wide margin. In fact, the financial gamesmanship (or as the PBM ' s call it, " Price Arbitrage " ) was so overt, that it would have been financially foolish to stick with insurance under the presumption that it contributed toward satisfying the deductible (a falsehood; t...
Source: Scott's Web Log - November 21, 2022 Category: Endocrinology Tags: 2022 CIGNA coupon-generating websites apps coupons Express Scripts InsideRx PBM Source Type: blogs
Fight Aging! Newsletter, November 21st 2022
In this study researchers added new insight, showing that high-intensity aerobic exercise, which derives its energy from sugar, can reduce the risk of metastatic cancer by as much as 72%. If so far the general message to the public has been 'be active, be healthy', now researchers can explain how aerobic activity can maximize the prevention of the most aggressive and metastatic types of cancer.
The study combined an animal model in which mice were trained under a strict exercise regimen, with data from healthy human volunteers examined before and after running. The human data, obtained from an epidemiological study ...
Source: Fight Aging! - November 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What are the statin adverse effects with confirmed causality?
Statin adverse effects with confirmed causality, though rare are:
a) Myalgia/myopathy
b) Temporary elevation of alanine aminotransferase
c) New onset diabetes mellitus
Reference
Banach M et al; International Lipid Expert Panel (ILEP). The Role of Nutraceuticals in Statin Intolerant Patients. J Am Coll Cardiol. 2018 Jul 3;72(1):96-118. doi: 10.1016/j.jacc.2018.04.040. PMID: 29957236. (Source: Cardiophile MD)
Source: Cardiophile MD - November 16, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
The Risk of Suffering Dementia is Declining
Numerous epidemiological studies have shown that the risk of suffering dementia in later life is in decline, even as demographic aging of the population drives an increase in the overall incidence of age-related disease. Why is the individual risk of dementia declining? It is potentially a consequence of the broad use of statins to reduce the consequences of atherosclerosis, as well as ever greater attention given to control of blood pressure in later life. The state of the vasculature is an important contribution to the state of the aging brain, with a variety of different mechanisms involved. The brain is an energy-hungr...
Source: Fight Aging! - November 15, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Statins Side-Effects: 20 Percent Report These Unwanted Issues
Statins may reduce the risk of a heart attack by as much as one-third. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 1, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Cholesterol Source Type: blogs
Podcast Recommendation: Global Healthy Living Foundation " Healthcare Matters "
Although I have considered the idea, I don ' t necessarily envision myself as a podcaster, but Ihave found a number of different podcasts rather informative (some are also entertaining).So I thought why don ' t I share some of the podcasts that I ' ve learned from here?First up is one from the Global Healthy Living Foundationhttps://ghlf.org/ which actually has several podcasts. The podcast I ' m referring you to today is the podcast they refer to as " Healthcare Matters "https://ghlf.org/healthcarematters/, and more specifically an episode of that podcast entitled " S3, Ep 2 entitled " A Failed Promise: Why Are Patients O...
Source: Scott's Web Log - October 20, 2022 Category: Endocrinology Tags: 2022 podcast robert popovian Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Important blood tests in relation to the heart – Cardiology Basics
Important blood tests in relation to the heart – Cardiology Basics
Here are some important blood tests in relation to the heart. Normal ranges of some of these tests may vary between labs.
Cholesterol is a type of fat found in the blood and has a role in the development of atherosclerosis in the coronary arteries as well as other arteries. Desirable value of total cholesterol in blood is less than 200 milligrams per decilitre.
Triglycerides is another type of fat found in the blood. Desirable value is less than 150 milligrams per decilitre. Very high levels of triglycerides carry a risk of pancreatitis. Calorie restr...
Source: Cardiophile MD - October 11, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
RAS/MAPK Pathway Inhibition as an Example of the Way in Which Cancer Research Informs Aging Research
A sizable number of potential approaches to slowing aging via metabolic manipulation were first tested in the cancer research community. In part, this is because that side of the research community has tested near every compound in the libraries at some point in time, but it is also the case there are deep ties between approaches that might impact cancer and changes that might slow aging. This is particularly the case in the matter of cellular senescence, of great relevance to both cancer and aging, and the first senolytic drugs to clear senescent cells had already seen some success in the cancer field. In at least one cas...
Source: Fight Aging! - October 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Weekly Overseas Health IT Links – 8th October, 2022.
This report aligns with the reality that healthcare organizations are facing in terms of the effects to patient safety, " said Anahi Santiago, chief information security officer at Delaware-based ChristianaCare.She and other healthcare cybersecurity leaders spoke withHealthcare IT News about the connection between cyber hygiene and patient safety and how to prepare for healthcare cyber attacks. -----https://ehrintelligence.com/news/meaningful-use-ehrs-may-be-key-to-improved-quality-of-care‘Meaningful Use’ EHRs May Be Key to Improved Quality of CareHospitals that meet the “Meaningful Use” EHR requirements were ...
Source: Australian Health Information Technology - October 8, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
