An excerpt from the Revised & Expanded Edition of Wheat Belly
  The original Wheat Belly book rocked the nutritional world with its revolutionary ideas. But, as time has passed, I’ve added new strategies and concepts that have expanded the overall program and taken the health, weight, and youth-preserving benefits even further. I have therefore collected all this new material into a new Revised & Expanded Edition. The new Revised & Expanded Edition of Wheat Belly is now available at all major bookstores. Here is a brief excerpt from the new foreword: Wheat Belly began as my modest effort to help people with heart disease stop relying on the revolving door of angiop...
Source: Wheat Belly Blog - December 14, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune blood sugar bowel flora cholesterol diabetes Dr. Davis Gliadin gluten-free grain-free grains Inflammation low-carb microbiota prebiotic probiotic wheat belly Source Type: blogs

Medications as effective as stents for most with coronary artery disease
This study suggests that for most, managing CAD with medications alone (the conservative approach) is as safe and effective as the more invasive strategy of cardiac catheterization and opening of the blocked artery. Findings of the ISCHEMIA trial ISCHEMIA followed over 5,000 patients with significant narrowing in one or more coronary arteries. Half of the patients were randomly selected to receive conservative treatment with optimal medical therapy (OMT) and lifestyle changes to treat risk factors such as high blood pressure and high cholesterol. The other half were given OMT and also sent for cardiac catheterization (thre...
Source: Harvard Health Blog - December 9, 2019 Category: Consumer Health News Authors: Dara K. Lee Lewis, MD Tags: Health Source Type: blogs

MKSAP: 67-year-old man with a carotid bruit
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 67-year-old man is evaluated for a carotid bruit detected on routine medical examination. He reports no history of previous focal neurologic symptoms or visual loss. He has type 2 diabetes mellitus and hyperlipidemia treat ed with metformin, moderate-intensity pravastatin, and aspirin. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 23, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Cardiology Source Type: blogs

MKSAP: 38-year-old woman with primary membranous glomerulopathy
Test your medicine knowledge with the  MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated during a follow-up visit for primary membranous glomerulopathy. Diagnosis was made by kidney biopsy 4 months ago, and she was found to be positive for anti–phospholipase A2 receptor (PLA2R) antibodies. Medications are furosemide, losartan, and simvastatin. […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 16, 2019 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > < /span > Tags: Conditions Nephrology renal cell renal cell carcinoma Source Type: blogs

High-Sensitivity Troponin is not a Myth, and “Myth-busting” is often another Myth to be Busted
Conclusion: Early rule out protocol is effective and safe.We refer interested readers to the following excellent reviews of high-sensitivity troponin implementation:Twerenbold, R. et al.JACC70 (8): 996 –1012.https://doi.org/10.1016/j.jacc.2017.07.718.Yader S. et al. 2016. Am J Med 129 (4): 354 –65.https://doi.org/10.1016/j.amjmed.2015.12.005.Response to the 2nd “Myth-busting” articleInterestingly, on Nov 5, Dr. Spiegel publishedanother “Myths in EM” piece in EM News: “Is hs-cTnT Worth the Downstream Testing?. The piece assesses a new randomized trial of the Roche hs -cTnT (not the Abbott Troponin I,...
Source: Dr. Smith's ECG Blog - November 9, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs

Could it really be this easy?
If you take blood pressure medication (and a lot of people do, or should)a new study find that taking them at night instead of morning cuts your risk of cardiac events in half, including death. Normally we like to provide information on absolute rather than relative risk, so here it is:Commenting on the findings, Tim Chico, professor of cardiovascular medicine at the University of Sheffield, UK, said, “The results are impressive. From the 19 084 people who took part and were randomised to taking their tablets at either bedtime or morning, just over 9% suffered a heart problem over the 6.4 years of the study. Of these, ...
Source: Stayin' Alive - November 1, 2019 Category: American Health Source Type: blogs

How my dog helps motivate me to manage my high cholesterol
This post is sponsored by Kowa Pharmaceuticals America, Inc. Personal opinions and thoughts are my own. As a wellness author and speaker, people often ask me questions about cholesterol and heart disease.  In partnership with Take Cholesterol to Heart, I’m answering some of the most common questions. Want to learn more? Be sure to visit Take Cholesterol to Heart for more information on managing your cholesterol levels. Q: I know that exercise is an important piece of a cholesterol management plan, but I find it hard to get motivated. Do you have any advice? A: Yes! As the video below shows, partnering with an enthusias...
Source: Embrace Your Heart Wellness Initiative - October 29, 2019 Category: Cardiology Authors: Eliz Greene Tags: Exercise Tips Heart Disease Risk Factors Heart Health cholesterol Take Cholesterol To Heart Source Type: blogs

On  The Pulse   
Benefits of statins in primary prevention ‘may be marginal at best’ (Source: OnMedica Blogs)
Source: OnMedica Blogs - October 24, 2019 Category: General Medicine Source Type: blogs

FFR negative & OCT positive LAD lesion: What shall we do ?
Rules of the PCI game  Mind the physiology. It is the new norm in selecting the lesions for stenting. Now, If physiology is ok, you have to mind the Anatomy and vice versa. If Anatomical (severity of block )is ok, then, you have to mind the morphology and vulnerability. Finally. and most importantly mind the patient’s symptoms and clinical scenario. So what should we do in a case of 70 % LAD with  .9 FFR ? (Still shabby looking, eccentric plaque, looks vulnerable  with a thin cap on OCT) I will stent, no doubt. I shall wait, and treat with Intensive optimal medical management (OMT).High dose statins will surely...
Source: Dr.S.Venkatesan MD - October 2, 2019 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha esc steminstemi ccs management guidelines acute coroanry syndrome managment decision making in pci evidence based coronary care fame 1 fame 2 ffr cut off value ffr vs oct forza trial study tct 2019 nstemi unstable a Source Type: blogs

Study supports benefit of statin use for older adults
In this study, the most common reason that patients or their doctors stopped statins was the development of advanced cancer or other major illness. In my practice, I have also cared for many patients who have stopped taking statins or who express reluctance to take statins due to side effects. The most common side effect is muscle ache (typically tenderness or soreness of the large muscle groups, such as the biceps and thighs), which affects about 20% of statin takers and reverses when the statin is discontinued. There is also a slightly increased risk of diabetes with long-term statin use and, very rarely, liver problems....
Source: Harvard Health Blog - October 2, 2019 Category: Consumer Health News Authors: Dara K. Lee Lewis, MD Tags: Drugs and Supplements Health Healthy Aging Heart Health Source Type: blogs

Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Leg pain when you walk? Don ’t ignore it
Walking is often touted as a perfect exercise to improve multiple aspects of health. But what if walking causes leg pain? Many people shrug off leg pain when they walk as a normal part of aging. In some cases, though, it’s the sign of peripheral artery disease (PAD), which can put heart and brain health at risk. While PAD doesn’t usually run in families, it’s more likely to occur as people age, or among people who smoke or have high blood pressure, high cholesterol, or diabetes. What causes leg pain if you have PAD? People with PAD have fatty deposits in arteries outside the heart — most often in their legs. Pain o...
Source: Harvard Health Blog - September 6, 2019 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Exercise and Fitness Healthy Aging Heart Health Hypertension and Stroke Pain Management Source Type: blogs

Inhibiting TGF ß Receptors Reduces Chronic Inflammation and Plaque in Atherosclerosis
Atherosclerosis involves the development of lipid deposits, called plaques, in blood vessel walls. Plaques narrow and weaken those vessels, ultimately producing the inevitable structural failure of a stroke or heart attack. Perhaps a sixth of humanity dies because of atherosclerosis, but means to treat the condition are so far only capable of somewhat slowing it down, with little reversal of existing plaque. Most approaches, such as statin drugs, focus on reducing the level of lipids in circulation in the bloodstream. Why does a reduction of blood lipids work to slow atherosclerosis? Atherosclerosis is a condition o...
Source: Fight Aging! - September 3, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, September 2nd 2019
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise. Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/ One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick wit...
Source: Fight Aging! - September 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Large Polypill Clinical Trial Shows a Third Reduction in Cardiovascular Events
The research and medical communities are slow to undertake work on combination therapies. Regulation makes it exceedingly expensive to assess multiple combinations, and there are numerous other perverse incentives to challenge any effort to build combination therapies with components developed and manufactured by different groups. Short of working around the existing system of regulation, and methods of doing this at scale are lacking at the present time, this is a challenging problem to solve. People follow incentives. Given this, it it is entirely plausible that there are many largely unexplored instances in which existi...
Source: Fight Aging! - August 30, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs