What does the angiogram show? The Echo? The CT coronary angiogram? How do you explain this?
A 70-something female with no previous cardiac history presented with acute chest pain. She awoke from sleep last night around 4:45 AM (3 hours prior to arrival) with pain that originated in her mid back. She stated the pain was achy/crampy. Over the course of the next hour, this pain turned into a pressure in her chest. She said this was midsternal and felt like a tightness. This originally radiated into her left arm. Over some time and the pain moved into her other arm as well as her jaw. She also had some shortness of breath. She was brought in by ambulance and re...
Source: Dr. Smith's ECG Blog - November 15, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Rosuvastatin or Atorvastatin , Which is good and safe ?
Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry.
Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically establishe...
Source: Dr.S.Venkatesan MD - November 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs
How Do Medicines Work?
Credit: iStock.
What we put into our bodies can affect how they function and what they do. For example, a sugary snack will probably make you feel differently than a high-protein meal. Similarly, different medicines elicit different responses in your body, and pharmacologists try to fine-tune each medicine to balance the desired (on-target) with the undesired (off-target) effects—a branch of pharmacology called pharmacodynamics.
Most medicines work by binding to a molecular target, usually proteins like receptors or enzymes, and either blocking or supporting its activity, which results in their therapeutic effects.
...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - October 16, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Common questions Medicines Miniseries Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Funding for the Longevity Industry Continues, Even in a Poor Market
Setting aside the movements of the broader market from year to year, and noting that this past year has been a poor time for venture funding, we should expect the funding available for biotech companies in the longevity industry to continue to increase in the years ahead. The fundamental reasons for this trend appear at the end of this article: the science looks very promising, there are many good projects sitting on the sidelines waiting for a champion to take them forward, and the upside for investors seems high. A therapy that targets one or more underlying mechanisms of aging will likely be applicable to a long list of...
Source: Fight Aging! - October 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Adoptive Transfer of Regulatory T Cells as a Way to Treat Atherosclerosis
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution. (Source: Fight Aging!)
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
New Pill Cuts Cholesterol And Has Lower Risk Of Side-Effects
Bempedoic acid is cholesterol-lowering option for statins users who experience some side effects. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 11, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cholesterol Source Type: blogs
What is the natural history of TCFA “ Thin cap fibro atheroma ” ?
(Why should the number 65 bother us in TCFA-detected by OCT? Does this number really deserve that respect? Trying to find some truths from 8 questions with & without evidence.)
1. Does TCFA really make a plaque vulnerable?
A.Yes
B. No
C. Maybe
Answer: Yes & Maybe. But there seem to be more important factors other than TCFA for a plaque to become vulnerable making TCFA not really a big deal.
2. TCFP is more common in which lesions?
A.Flow limiting lesion
B.Nonflow limiting lesion
C.No relationship between TCFA and flow
Answer: No relation, rather a random relationship.
3. What...
Source: Dr.S.Venkatesan MD - October 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
What does statin do to Cholesterol absorbtion from Intestine ?
A.Reduces
B Increases
C.No effect
D. Iam not sure
Does this sound a difficult question ?
Many felt so. Hence, I decided to ask the all too popular AI machine.
It became a brief little chat with GPT, that surprised me .
https://chat.openai.com/share/6b96c54e-ad52-472a-9ebd-b7b1e1c762be
Statin: Some untold story.
Last century’s rockstar drug, statin do stimulate Cholesterol abosorbtion as well as hepatic synthesis.We must be aware, It is a less popularised truth (Intentionally ? ) among the cardiolgy community,
Ofcourse LDL comes down, at the cost of residual pre -choleterol particles th...
Source: Dr.S.Venkatesan MD - August 19, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Are The Risks Of Taking Statins Worth The Benefits? Study Unveils Shocking Results
The benefits of statins versus the side-effects: is it worth taking the medication? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 19, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Cholesterol Source Type: blogs
When Mark Cuban Cost Plus Drug Company Says Your Prescription is " Out of stock "
My followers may recall that about a year ago (on August 22, 2023), I blogged about (see https://blog.sstrumello.com/2022/08/generic-crestor-pricing-insanity.html for the post) that I had made a conscious decision to simply disintermediate my own insurance pharmacy benefit to buy an inexpensive generic statin drug because my own pharmacy benefit manager was screwing me. Currently, I ' m covered by Aetna which is now owned by CVS Health, which also owns the PBM known as Caremark. Caremark was robbing me on the statin. It was overcharging me. They were trying to charge me $33.85 for a 90-day supply of a cheap...
Source: Scott's Web Log - August 1, 2023 Category: Endocrinology Tags: 2023 cash pharmacy cash-only pharmacy Crestor Mark Cuban Cost Plus Drug Company rosuvastatin calcium Source Type: blogs
Statins Side-Effects: 20 Percent Report These Unwanted Issues
Statins may reduce the risk of a heart attack by as much as one-third. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 30, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Cholesterol Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop
I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year. This event series provides a chance to make connections with some of the longevity industry figures and academic researchers in the field of aging that are associated with the Bay Area venture and futurist communities. The format this year was rapid-fire seven minute presentations and longer discussions; the presentations are shared online. I presented an informal, abbreviated version of the Repair Biotechnologies viewpoint on the role of cholesterol in aging and disease, trying to cover at least the important points in the time all...
Source: Fight Aging! - July 27, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
