Optimal lipid control & Oligonucleotides
Sharing a presentation on lipid control done in 2020. This talks about newer strategies beyond statins.
PDF version
lipid-metabolism Download
(Source: Dr.S.Venkatesan MD)
Source: Dr.S.Venkatesan MD - August 8, 2021 Category: Cardiology Authors: dr s venkatesan Tags: lipids lipid metabolism Uncategorized dyslipdemia inclisiran j curve in ldl j curve in lipid control pcsk blockers ppt on lipid metabolism siRNA pcsk lipid metabolism ssss trial simvastatin statins in primary prevention Source Type: blogs
Pancreatitis with Bizarre T-wave inversions and a normal echo. Is it takotsubo?
I was shown this ECG and told that the patient is suffering from another bout of chronic pancreatitis. I was told there was no chest discomfort or SOB. What do you think?I said " this looks like takotsubo " .With this ECG and the presumptive diagnosis of pancreatitis, takotsubo stress cardiomyopathy is by far most likely. It is possible that it is due to ACS, but thebizarre diffuse T-wave inversions with a very long QT are nearly pathognomonic of takotsubo. (They can also be seen in apical hypertrophic cardiomyopathy, but this patient did not have any such history and previous ECGs were different)If ...
Source: Dr. Smith's ECG Blog - July 31, 2021 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, July 12th 2021
In conclusion, our study demonstrated that elevated cumulative SBP or DBP was independently associated with increased risk of CVD in the Chinese population. Among participants with 15-year cumulative BP levels higher than the median, that is, 1970.8/1239.9 mmHg-year for cumulative SBP/DBP, which was equivalent to maintaining SBP/DBP level higher than 131/83 mmHg in 15 years, the CVD risk would increase significantly irrespective of whether or not the BP measurements at one examination was high. Our findings emphasize the importance of cumulative BP level in identifying individuals with high risk of CVD in the future.
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Source: Fight Aging! - July 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Macrophage Dysfunction is the Important Target if Seeking to Treat Atherosclerosis
Atherosclerosis is characterized by the formation of fatty plaques in blood vessel walls, narrowing and weakening vessels. It leads to heart failure, as well as heart attack and stroke as the result of rupture of a blood vessel or plaque. Near all treatments for atherosclerosis are preventative, which is the better approach to medicine, and are focused on the outcome of lowering LDL cholesterol in the bloodstream, which is, unfortunately, not the better approach to atherosclerosis.
Atherosclerosis is, at root, a condition caused by macrophage dysfunction. Macrophages are the innate immune cells tasked with clearing ...
Source: Fight Aging! - July 6, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 5th 2021
In conclusion, the findings suggest that DNAm GrimAge is a strong predictor of mortality independent of genetic influences.
Heart Failure Correlates with Increased Cancer Risk
https://www.fightaging.org/archives/2021/07/heart-failure-correlates-with-increased-cancer-risk/
Age-related disease results from the underlying cell and tissue damage that causes aging. Different people accumulate that damage at modestly different rates, the result of lifestyle choices and exposure to infectious disease. Thus the presence of a sufficient burden of damage to produce one age-related disease will be accompanied by a...
Source: Fight Aging! - July 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ignoring Drug Trademarks
Erika Lietzan (University of Missouri), Ignoring Drug Trademarks, Wake Forest L. Rev. (forthcoming): If you walk into a pharmacy with a prescription for Merck ’s ZOCOR, which contains simvastatin, the pharmacist will probably give you a product containing simvastatin made by... (Source: HealthLawProf Blog)
Source: HealthLawProf Blog - July 1, 2021 Category: Medical Law Authors: Katharine Van Tassel Source Type: blogs
Actually, We Really Do Need to Keep Talking About Radical Life Extension as the Primary Goal of Research and Industry
There is a faction within the research and development community who feel that we shouldn't talk about ambitious goals when it comes to human rejuvenation and adding many years to human life spans. They think that the best strategy is to focus on very incremental, modest goals in the treatment of aging. At the present time, that really means calorie restriction mimetic drugs and the like, approaches that are unlikely to be capable of outperforming the effects of good lifestyle choices. This seems like an extension of the old, bad days, in which researchers refused to talk about intervening in the aging process at all. It i...
Source: Fight Aging! - June 30, 2021 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Foreword to Wheat Belly Revised & Expanded Edition
An excerpt from the Wheat Belly Revised & Expanded Edition:
Have you ever come home from the grocery store with a fresh container of milk, opened it and immediately realized that it was bad—sour-smelling, curdled, unfit to drink?
Feed it to the cat? Probably not. Lighten your coffee? I don’t think so. Pour it down the sink—yeah, that’s the ticket. Or maybe go back to the store with some of the curdled remains and ask for your money back.
That is what your reaction to conventional dietary advice should be. You should wrinkle your nose at the bad smell that emanates from advice that creates an astonish...
Source: Wheat Belly Blog - May 7, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open grain-free wheat belly Source Type: blogs
What is an Intermediate coronary lesion & What shall we do with it ?
This question might squeeze the collective coronary knowledge of any cardiologist. (At least, it does for me !)
What is an intermediate coronary lesion? (ICL)
Traditionally it is an “angio-ocular reflex” measurement of coronary arterial diameter stenosis that lies between 40 to 70% (Mind you, 70 diameter stenosis is 90% area. So,we must be clear what we really mean in any revascularisation debate).
Above one is the simplest expression of ICL. (* While 70% cutoff is fairly constant, the lower limit 40% is still not a settled issue. It can even be 30 %. I think we haven’t yet named th...
Source: Dr.S.Venkatesan MD - April 25, 2021 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized diameter vs area stenosis fame s fame study ffr ifr qfr intermediate coronary lesion minimal cad coronary erosion what is intermediate coronary lesion ? Source Type: blogs
CORAL study on renal artery stenting
In the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study, 947 patients who had atherosclerotic renal artery stenosis and either systolic hypertension while taking two or more antihypertensive medications or chronic kidney disease were evaluated. It was a multi-center, open-label, randomized, controlled trial. Patients were randomized to either medical therapy plus renal artery stenting or medical therapy alone [1].
Previous randomized trials on renal angioplasty had failed to show significant benefit in control of blood pressure [2,3]. Another two randomized trials checking the effect of renal artery...
Source: Cardiophile MD - April 7, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, April 5th 2021
In this study, the research team designed a way to identify small molecules that improve the function of ABCA1 in the body while avoiding unwanted effects to the liver. The researchers honed in on a specific small molecule, CL2-57, due to its ability to stimulate ABCA1 activity with positive effects on liver and plasma triglycerides. The use of this compound showed improved glucose tolerance and insulin sensitivity, as well as reduced weight gain, among other beneficial effects.
Age-Related Upregulation of Autophagy as a Possible Contribution to Bat Longevity
https://www.fightaging.org/archives/2021/04/age-rel...
Source: Fight Aging! - April 4, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Digital Therapeutics, Megan & Me!
Anyone who follows me knows that I’ve been questioning whether digital therapeutics are real and more importantly whether the people building and trying to sell them are simply trying to replicate the American drug pricing model–patent, protect, prescribe & price gouge. So who better to have this conversation with than the person in charge of explaining and selling the notion of digital therapeutics to the world? Megan Coder is Executive Director of the Digital Therapeutics Alliance. She graciously and bravely agreed to talk to me. Who won the argument? You’ll have to watch to decide, but I found our ...
Source: The Health Care Blog - March 31, 2021 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Matthew Holt digital therapeutics dtx Megan Coder Source Type: blogs
James Peyer of Cambrian Biopharma on Defining Aging as a Disease
James Peyer was involved in the aging-focused fund Apollo Ventures before he moved on to the more recent venture industry initiative that evolved into Cambrian Biopharma. Cambrian is arguably even more focused on creating new biotech startups to treat aging, rather than investing in existing companies, than is the case for Apollo. Many venture capitalists are coming to the conclusion that the pace at which new biotech companies in this space are arising is too slow to provide sufficient opportunities for the capital that could be harnessed to produced progress. That pace must thus be accelerated.
Peyer is a regular ...
Source: Fight Aging! - March 30, 2021 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
What statin drugs do to your coronary calcium score
The post What statin drugs do to your coronary calcium score appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - March 4, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle cholesterol undoctored Source Type: blogs
Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases.
Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
