CORAL study on renal artery stenting

CORAL study on renal artery stenting In the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study, 947 patients who had atherosclerotic renal artery stenosis and either systolic hypertension while taking two or more antihypertensive medications or chronic kidney disease were evaluated. It was a multi-center, open-label, randomized, controlled trial. Patients were randomized to either medical therapy plus renal artery stenting or medical therapy alone [1]. Previous randomized trials on renal angioplasty had failed to show significant benefit in control of blood pressure [2,3]. Another two randomized trials checking the effect of renal artery stenting in atherosclerotic renal artery stenosis did not show any benefit with respect to kidney function [4.5]. Adverse cardiovascular and renal events were checked in the CORAL study. Composite end point was death from cardiovascular or renal causes, myocardial infarction, stroke, hospitalization for congestive heart failure, progressive renal insufficiency or need for renal replacement therapy. Median follow up period in the trial was 43 months [1]. There were no significant differences in all cause mortality or the individual components of the primary composite endpoint between the study and control groups. There was a modest decrease of systolic blood pressure in the stenting group (mean 2.3 mm Hg). Final data reported was from 931 participants, after excluding one center due to quality issues. Authors were consider...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology Source Type: blogs