Landmark Results Achieved in Aging and Chronic Disease: Danish Group Extends Disease-free Life by 8 Years
By WILLIAM H. BESTERMANN JR., MD New Scientific Breakthroughs Can Provide a Longer Healthier Life Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biology that causes chronic disease and aging. These same medications will likely produce similar results in patients with congestive heart failure, chronic kidney disease, arterial disease, history of heart attack, hypertension, and angina. Simple medical interventions can extend healthy lifespan today. Better Chronic Disease Management Can Improve Health and Lower Costs 90% of health care costs come from chronic diseases and aging which are both related. The same biochemistry that causes aging causes chronic disease. Eating processed food, gaining weight, smoking cigarettes, and sitting on the couch accelerate aging and chronic condition development. Those activities switch on genes that should be quiet. Eating real food, avoiding cigarettes, activity, lisinopril, losartan, atorvastatin, metformin, (and spironolactone) are now proven to extend healthy li...
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Qi Fu, Zhenhai Yu
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Lakshmikripa Jagannathan, Emily Socks, Priya Balasubramanian, Robert McGowan, Thomas M. Herdt, Reza Kianian, Sheba M.J. MohanKumar, P.S. MohanKumar
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Nagesh Kishan Panchal, E.P. Sabina
Publication date: Available online 29 May 2020Source: Carbohydrate PolymersAuthor(s): Juntao Tang, Yang Li, Yang Song, Xinyun Wu, Guipeng Yu, Kam Chiu Tam
Publication date: Available online 29 May 2020Source: Carbohydrate PolymersAuthor(s): Katarzyna Nawrotek, Michał Tylman, Agnieszka Adamus-Włodarczyk, Karolina Rudnicka, Justyna Gatkowska, Marek Wieczorek, Radosław Wach
Publication date: Available online 29 May 2020Source: Carbohydrate PolymersAuthor(s): Noha Hesham Radwan, Maha Nasr, Rania A.H. Ishak, Nourtan F. Abdeltawab, Gehanne A.S. Awad
This study revealed the association between PAH exposure and markers of inflammation and oxidative stress, and the enhanced responses of pre-T2D patients suggested that individuals with metabolic disorders were more susceptible to the adverse health effects of PAH exposure. PMID: 32464779 [PubMed - in process]
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Donald Trump and Mike Pence witness launch in FloridaFirst attempt was cancelled minutes from blast-offA rocketship named Dragon breathed new fire into America ’s human spaceflight programme on Saturday, carrying two astronauts on a much-anticipated adventure.Related:Trump wants America looking at the stars as he drags it through the gutterContinue reading...
This study aimed to describe the epidemiology of pediatric upper extremity injury secondary to nonballistic firearms in the United States. METHODS: The National Electronic Injury Surveillance Survey (NEISS) database was queried between ...
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