Fight Aging! Newsletter, May 6th 2019
This study shows that mRNA levels of the aging related lamin A splice variant progerin, associated with premature aging in HGPS, were significantly upregulated in subjects with BMI ≥ 25 kg/m2. Moreover, our data revealed a significantly positive correlation of BMI with progerin mRNA. These data provide to our knowledge for the first-time evidence for a possible involvement of progerin in previously observed accelerated aging of overweight and obese individuals potentially limiting their longevity. Our results also showed that progerin mRNA was positively correlated with C-reactive protein (CRP). This might suggest an association of progerin with an inflammatory response triggering accelerated aging. Moreover, we found an increase of the acute phase protein CRP in patients with BMI ≥ 25, indicating a higher systemic inflammatory status in the overweight group. This is consistent with prior findings where obesity was considered to predispose to local and systemic inflammation with ongoing activation of immune cells. SIRT6 in Longer Lived Mammals Produces More Efficient DNA Repair https://www.fightaging.org/archives/2019/04/sirt6-in-longer-lived-mammals-produces-more-efficient-dna-repair/ The sirtuin gene SIRT6 is involved in DNA repair, among many other processes. Researchers here report that differences in SIRT6 between shorter and longer lived mammals give rise to more efficient DNA repair in the longer-lived species. This might be taken as evidence f...
Publication date: Available online 30 May 2020Source: Indian Heart JournalAuthor(s): Aditya Kapoor, Rakesh Yadav
Publication date: Available online 30 May 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Renjie Wang, Zhengwei Cao, Lan Wei, Lin Bai, Hui Wang, Shiyi Zhou, Shuyue Zhan, Bin Ji, Zibo Li, Shi Gao, Jin Xie, Qingjie Ma
Publication date: Available online 30 May 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Yi Qu, He-Ying Hu, Ya-Nan Ou, Xue-Ning Shen, Wei Xu, Zuo-Teng Wang, Qiang Dong, Lan Tan, Jin-Tai Yu
Publication date: Available online 30 May 2020Source: Obesity Research &Clinical PracticeAuthor(s): Chiaki Tanaka, Mark S. Tremblay, Masayuki Okuda, Shigeru Inoue, Shigeho Tanaka
(American Association for Cancer Research) Among patients with both colorectal cancer and diabetes in Korea, those who had a high adherence to their oral diabetes medication had a significantly reduced risk of overall mortality compared with those with lower adherence.
Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Deborah Delbue, Bruna S. Mendonça, Marcela C. Robaina, Lauana G.T. Lemos, Pedro I. Lucena, João P.B. Viola, Lídia M. Magalhães, Susanne Crocamo, Caio A.B. Oliveira, Felipe R. Teixeira, Raquel C. Maia, Gabriela Nestal de Moraes
Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Alpna Tyagi, Carol Mirita, Nadine Taher, Iman Shah, Emily Moeller, Anit Tyagi, Thomas Chong, Subbiah Pugazhenthi
Publication date: Available online 30 May 2020Source: Redox BiologyAuthor(s): Bong Jong Seo, Joonhyuk Choi, Hyeonwoo La, Omer Habib, Youngsok Choi, Kwonho Hong, Jeong Tae Do
Publication date: Available online 30 May 2020Source: Plant ScienceAuthor(s): Panpan Tong, Bin Huai, Ying Chen, Mei Bai, Hong Wu
Publication date: Available online 30 May 2020Source: Life Sciences in Space ResearchAuthor(s): Yongkang Tang, Ruixin Mao, Shuangsheng Guo
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