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A Tale of Two Cytokines: Interleukin-10 Blocks Interferon- γ in Influenza A Virus- Staphylococcus aureus Co-Infection
Am J Respir Cell Mol Biol. 2024 May 3. doi: 10.1165/rcmb.2024-0154ED. Online ahead of print.NO ABSTRACTPMID:38701437 | DOI:10.1165/rcmb.2024-0154ED (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - May 3, 2024 Category: Respiratory Medicine Authors: Christina Sul Eva Nozik Christina Malainou Source Type: research

Dereplication tools for Rhizophora mangle extracts from different mangrove areas and their potential against Staphylococcus aureus
This study aimed to investigate the chemical profile of Rhizophora mangle leaves from fringe, basin, and transition mangrove zones and their bactericidal/bacteriostatic potential against S. aureus. R. mangle leaves were collected monthly in 2018 from litterfall in three different zones of the mangrove of Guaratiba State Reserve: fringe, basin, and transition. Extracts were prepared from the material collected in October and December for LC-HRMS/MS analysis, and dereplication was performed using a molecular library search and the classical molecular networking GNPS platform. The minimum inhibitory concentrations (MICs) of t...
Source: Chemistry and Biodiversity - May 3, 2024 Category: Biochemistry Authors: Amanda Let ícia da Silva Pontes Carla Monteiro Leal Manuela Pereira Lucas Gabriela Caama ño Muiño da Silva Jo ão Vitor Braga Alves Peixoto Juliana Barbosa Succar Vinicius Ribeiro Flores Ida Carolina Neves Direito Antonio Jorge Ribeiro da Silva Filipe Source Type: research

A Tale of Two Cytokines: Interleukin-10 Blocks Interferon- γ in Influenza A Virus- Staphylococcus aureus Co-Infection
Am J Respir Cell Mol Biol. 2024 May 3. doi: 10.1165/rcmb.2024-0154ED. Online ahead of print.NO ABSTRACTPMID:38701437 | DOI:10.1165/rcmb.2024-0154ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - May 3, 2024 Category: Molecular Biology Authors: Christina Sul Eva Nozik Christina Malainou Source Type: research

Etiological Diagnosis and Treatment Value of mNGS in Alveolar Lavage Fluid of Children with Severe Pneumonia
CONCLUSION: mNGS is a promising technique for detecting co-pathogens in mixed pediatric lung infections, with potential benefits in terms of speed and sensitivity.PMID:38702151 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Wei Chen Haoquan Zhou Source Type: research

GSE266239 Single Cell Sequencing of Human Langerhans Cells Identifies Altered Gene Expression Profiles in Patients with Atopic Dermatitis
Contributors : Sara M Tamminga ; Marlot M van der Wal ; Femke van Wijk ; Nina M van SorgeSeries Type : Expression profiling by high throughput sequencingOrganism :Atopic dermatitis (AD) is characterized by dysregulated T cell immunity and skin microbiome dysbiosis with predominance of Staphylococcus aureus (S. aureus). Emerging evidence suggests a role for S. aureus in exacerbating AD skin inflammation. Interestingly, specific glycosylation of S. aureus cell wall structures amplifies skin inflammation through interaction with Langerhans cells (LCs). However, the role of LCs in AD remains poorly characterized. Here, we per...
Source: GEO: Gene Expression Omnibus - May 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Source Type: research

Molecules, Vol. 29, Pages 2128: Phytochemical Characterization, Antioxidant, and Antimicrobial Activity of the Vegetative Buds from Romanian Spruce, Picea abies (L.) H. Karst.
This study aims to investigate the vegetative buds from Picea abies (spruce), naturally found in a central region of Romania, through a comprehensive analysis of the chemical composition to identify bioactive compounds responsible for pharmacological properties. Using HPLC/derivatization technique of GC-MS and quantitative spectrophotometric assays, the phenolic profile, and main components of an ethanolic extract from the buds were investigated. The essential oil was characterized by GC-MS. Moreover, the antioxidant activity with the DPPH method, and the antimicrobial activity were tested. Heavy metal detection was perfor...
Source: Molecules - May 3, 2024 Category: Chemistry Authors: Roxana Colette Sandulovici Mona Luciana G ălăţanu Luiza M ădălina Cima Emilia Panus Elena Tru ţă Carmen Marinela Mih ăilescu Iulian S ârbu Daniel Cord Mirela Claudia R îmbu Ştefan Alexandru Anghelache Mariana Pan ţuroiu Tags: Article Source Type: research

Molecules, Vol. 29, Pages 2126: Synthesis, Electronic, and Antibacterial Properties of 3,7-Di(hetero)aryl-substituted Phenothiazinyl N-Propyl Trimethylammonium Salts
In this study, a library of 3,7-di(hetero)aryl-substituted 10-(3-trimethylammoniumpropyl)10H-phenothiazine salts is prepared. These title compounds and their precursors are reversible redox systems with tunable potentials. The Hammett correlation gives a very good correlation of the first oxidation potentials with &sigma;p parameters. Furthermore, the title compounds and their precursors are blue to green-blue emissive. Screening of the salts reveals for some derivatives a distinct inhibition of several pathogenic bacterial strains (Mycobacterium tuberculosis, Staphylococcus aureus, Escherichia coli, Aconetobacter ...
Source: Molecules - May 3, 2024 Category: Chemistry Authors: Hilla Khelwati Lasse van Geelen Rainer Kalscheuer Thomas J. J. M üller Tags: Article Source Type: research

Electrospun photothermal tellurium nanosheet-loaded polycaprolactone/gelatin nanofibers to promote wound healing
Journal of Innovative Optical Health Sciences, Ahead of Print. Low-cost and biodegradable photothermal wound dressings with remarkable therapeutic effects are highly desirable for next-generation wound healing. Herein, we report an efficient photothermal wound dressing mat made of tellurium nanosheet (TeNS)-loaded electrospun polycaprolactone/gelatin (PCL/GEL) nanofibers. The TeNS-loaded PCL/GEL nanofibrous architectures showed antibacterial efficacy against Escherichia coli and Staphylococcus aureus of 87.68% and 94.57%, respectively. Under near-infrared (NIR) light illumination, they can facilitate cell proliferation as ...
Source: Journal of Innovative Optical Health Sciences - May 3, 2024 Category: Biomedical Science Authors: Fangjia Li Jing Zhang Huan Xiong Lihua Min Li Gou Source Type: research

A challenging diagnosis of chronic osteomyelitis in a child with congenital insensitivity to pain: a case report
CONCLUSION: This case highlights the challenges faced in diagnosing osteomyelitis among CIP patients and emphasizes the need for other diagnostic criteria apart from pain.PMID:38694364 | PMC:PMC11060246 | DOI:10.1097/MS9.0000000000001971 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Hazem Kamil Riffa Alassri Douaa Albelal Abu Baker Alassri Nafiza Martini Jaber Mahmod Source Type: research

 Microbacterium salsuginis sp. nov., a halotolerant actinobacterium with antimicrobial activity
Int J Syst Evol Microbiol. 2024 May;74(5). doi: 10.1099/ijsem.0.006362.ABSTRACTA novel Gram-staining-positive actinobacterium with antimicrobial activity, designated CFH 90308T, was isolated from the sediment of a salt lake in Yuncheng, Shanxi, south-western China. The isolate exhibited the highest 16S rRNA gene sequence similarities to Microbacterium yannicii G72T, Microbacterium hominis NBRC 15708T and Microbacterium xylanilyticum S3-ET (98.5, 98.4 and 98.2 %, respectively), and formed a separate clade with M. xylanilyticum S3-ET in phylogenetic trees. The strain grew at 15-40 ºC, pH 6.0-8.0 and could tolerate NaCl up t...
Source: International Journal of Systematic and Evolutionary Microbiology - May 2, 2024 Category: Microbiology Authors: Qingyang Su Yuwei Liu Tingting Xia Shuanglong Wei Caixia Cui Zhao Zhang Xudong Liu Guoxing Nie Hong Ming Source Type: research

Development of a prototypic, field-usable diagnostic tool for the detection of gram-positive cocci-induced mastitis in cattle
CONCLUSIONS: Our study shows that EF-Tu is a promising target for LFIA and we have delivered evidence that further evaluation could improve test parameters and fill the gap in the mastitis diagnostics market.PMID:38698383 | DOI:10.1186/s12917-024-04028-5 (Source: Cell Research)
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Anna Dobrut Jakub Skibi ński Adrian Bekier Kamil Dro żdż Karolina Rudnicka Przemys ław Płociński Izabela Siemi ńska Monika Brzychczy-W łoch Source Type: research

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300
by Aravindh Nagarajan, Kristin Scoggin, Jyotsana Gupta, Manuchehr Aminian, L. Garry Adams, Michael Kirby, David Threadgill, Helene Andrews-PolymenisStaphylococcus aureus (S.aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistantS.aureus (MRSA) and monitored disease progression for seven days using a surgically implanted telemetry system. CC strains varied widely in thei...
Source: PLoS Genetics - May 2, 2024 Category: Genetics & Stem Cells Authors: Aravindh Nagarajan Source Type: research