N vacancy and self-enhancement induced high anodic electrochemiluminescence of 3D g-C < sub > 3 < /sub > N < sub > 4 < /sub > for sensitive staphylococcus aureus analysis
Talanta. 2024 Apr 23;275:126144. doi: 10.1016/j.talanta.2024.126144. Online ahead of print.ABSTRACTHere, 3D g-C3N4 with dense N vacancy in its 3D porous interconnected open-framework was synthesized, and the co-reactive 3-(dibutylamino)propylamine (DBAPA) was further covalently coupled onto the surface, resulting in a strong self-enhanced anodic electrochemiluminescence (ECL). Through introduction of high-density N vacancy, for the obtained 3D g-C3N4-NV, the band gap was broadened and the electrical conductivity was enhanced, realizing an obvious ECL improvement. Moreover, after the covalent binding of co-reactive DBAPA, t...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Yuxuan Wang Xinya Jiang Weiwei Cao Haijun Wang Ruo Yuan Source Type: research
Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcusaureus
Biochem Biophys Res Commun. 2024 Apr 20;714:149974. doi: 10.1016/j.bbrc.2024.149974. Online ahead of print.ABSTRACTDue to the rapid emergence of antibiotic resistant new bacterial strains and new infections, there is an urgent need for novel or newly modified and efficient alternatives of treatment. However, conventional antibiotics are still used in therapeutic settings but their efficacy is uncertain due to the rapid evolution of drug resistance. In the present study, we have synthesized a new derivative of conventional antibiotic ampicillin using SN2-type substitution reaction. NMR and mass analysis of the newly synthes...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sourav Chakraborty Piyush Baindara Suresh K Mondal Dinata Roy Santi M Mandal Source Type: research
Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro
CONCLUSION: S. aureus readily invaded human chondrocytes (C20A4) in vitro and persisted viably for 6 days after infection, evading extracellular antibiotics. Chondrocytes demonstrated a greater level of intracellular invasion and persistence by S. aureus than positive control human osteoblast (MG63) and mouse fibroblast (NIH3T3) cell lines.CLINICAL RELEVANCE: Chondrocyte invasion and persistence may contribute to recurrent bone and joint infections. Additional research should assess longer periods of persistence and whether this mechanism is present in vivo.PMID:38662927 | DOI:10.1097/CORR.0000000000003074 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Jerry Chang David Kerr Megan Zheng Thorsten Seyler Source Type: research
Green Synthesis of Silver Nanoparticles Using Cirsium Congestum Extract Modified by Chitosan/Alginate: Bactericidal Activity against Pathogenic Bacteria and Cytotoxicity Analysis in Normal Cell Line
CONCLUSION: Current findings introduce novel gAgNPs modified with chitosan/alginate for use in medicine.PMID:38661036 | DOI:10.2174/0113816128304460240408085736 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 25, 2024 Category: Drugs & Pharmacology Authors: Mahnaz Mohtasham Alieh Rezagholizade-Shirvan Zahra Hojat Bonab Mohammad Reza Amiryousefi Majid Darroudi Mobina Sadat Ahmadi Solimani Sajad Yaghoobi Samaneh Dolatabadi Ahmad Ghasemi Amir Abbas Momtazi-Borojeni Source Type: research
Static Versus Articulating Spacer: Does Infectious Pathogen Type Affect Treatment Success?
CONCLUSION: The lack of a difference in failure-free survival and insufficient evidence of a difference in the association between spacer type and treatment failure by pathogen type suggests that infectious organism may not be an important consideration in the decision about spacer treatment type. Further studies should aim to elucidate which patient factors are the most influential in surgeon decision-making when choosing a spacer type in patients with PJI of the knee.Level of Evidence Level III, therapeutic study.PMID:38662933 | DOI:10.1097/CORR.0000000000003075 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 25, 2024 Category: Orthopaedics Authors: Caitlin Grant Jerry Chang Emily Poehlein Cynthia L Green Jessica Seidelman William Jiranek Source Type: research
Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro
CONCLUSION: S. aureus readily invaded human chondrocytes (C20A4) in vitro and persisted viably for 6 days after infection, evading extracellular antibiotics. Chondrocytes demonstrated a greater level of intracellular invasion and persistence by S. aureus than positive control human osteoblast (MG63) and mouse fibroblast (NIH3T3) cell lines.CLINICAL RELEVANCE: Chondrocyte invasion and persistence may contribute to recurrent bone and joint infections. Additional research should assess longer periods of persistence and whether this mechanism is present in vivo.PMID:38662927 | DOI:10.1097/CORR.0000000000003074 (Source: Clinica...
Source: Clinical Orthopaedics and Related Research - April 25, 2024 Category: Orthopaedics Authors: Jerry Chang David Kerr Megan Zheng Thorsten Seyler Source Type: research
Gut bacterium Burkholderia cepacia (BsNLG8) and immune gene Defensin A contribute to the resistance against Nicotine-induced stress in Nilaparvata lugens (St ål)
Ecotoxicol Environ Saf. 2024 Apr 24;277:116371. doi: 10.1016/j.ecoenv.2024.116371. Online ahead of print.ABSTRACTNicotine, a naturally occurring alkaloid found in tobacco, is a potent neurotoxin extensively used to control Nilaparvata lugens (Stål), a destructive insect pest of rice crops. The insect gut harbors a wide array of resident microorganisms that profoundly influence several biological processes, including host immunity. Maintaining an optimal gut microbiota and immune homeostasis requires a complex network of reciprocal regulatory interactions. However, the underlying molecular mechanisms driving these symbioti...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Xuemei Wang Junaid Zafar Xiaotong Yang Surajit De Mandal Yingying Hong Fengliang Jin Xiaoxia Xu Source Type: research
Biological effects of vanillic acid, iso-vanillic acid, and orto-vanillic acid as environmental pollutants
This study evaluated the toxicity of VA and its isomers, iso-VA and orto-VA. Firstly, the antimicrobial effect of VA and its isomers iso-VA and orto-VA (in doses of 1000; 100, 10, 1; 0.1; 0.01 mg/L) against Escherichia coli, Sarcina spp., Enterobacter homaechei, Staphylococcus aureus and Candida albicans were identified. The toxic effect and protein degradation potential of VA and its isomers were determined using E. coli grpE:luxCDABE and lac:luxCDABE biosensor strains. However, the genotoxicity and oxidative stress generation were assessed with the E. coli recA:luxCDABE biosensor and E. coli strain. The results showed th...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Marzena Matejczyk Piotr Ofman Edyta Juszczuk-Kubiak Renata Świsłocka Wong Ling Shing Kavindra Kumar Kesari Balu Prakash W łodzimierz Lewandowski Source Type: research
N vacancy and self-enhancement induced high anodic electrochemiluminescence of 3D g-C < sub > 3 < /sub > N < sub > 4 < /sub > for sensitive staphylococcus aureus analysis
Talanta. 2024 Apr 23;275:126144. doi: 10.1016/j.talanta.2024.126144. Online ahead of print.ABSTRACTHere, 3D g-C3N4 with dense N vacancy in its 3D porous interconnected open-framework was synthesized, and the co-reactive 3-(dibutylamino)propylamine (DBAPA) was further covalently coupled onto the surface, resulting in a strong self-enhanced anodic electrochemiluminescence (ECL). Through introduction of high-density N vacancy, for the obtained 3D g-C3N4-NV, the band gap was broadened and the electrical conductivity was enhanced, realizing an obvious ECL improvement. Moreover, after the covalent binding of co-reactive DBAPA, t...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Yuxuan Wang Xinya Jiang Weiwei Cao Haijun Wang Ruo Yuan Source Type: research
Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcusaureus
Biochem Biophys Res Commun. 2024 Apr 20;714:149974. doi: 10.1016/j.bbrc.2024.149974. Online ahead of print.ABSTRACTDue to the rapid emergence of antibiotic resistant new bacterial strains and new infections, there is an urgent need for novel or newly modified and efficient alternatives of treatment. However, conventional antibiotics are still used in therapeutic settings but their efficacy is uncertain due to the rapid evolution of drug resistance. In the present study, we have synthesized a new derivative of conventional antibiotic ampicillin using SN2-type substitution reaction. NMR and mass analysis of the newly synthes...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sourav Chakraborty Piyush Baindara Suresh K Mondal Dinata Roy Santi M Mandal Source Type: research
Green Synthesis of Silver Nanoparticles Using Cirsium Congestum Extract Modified by Chitosan/Alginate: Bactericidal Activity against Pathogenic Bacteria and Cytotoxicity Analysis in Normal Cell Line
CONCLUSION: Current findings introduce novel gAgNPs modified with chitosan/alginate for use in medicine.PMID:38661036 | DOI:10.2174/0113816128304460240408085736 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 25, 2024 Category: Drugs & Pharmacology Authors: Mahnaz Mohtasham Alieh Rezagholizade-Shirvan Zahra Hojat Bonab Mohammad Reza Amiryousefi Majid Darroudi Mobina Sadat Ahmadi Solimani Sajad Yaghoobi Samaneh Dolatabadi Ahmad Ghasemi Amir Abbas Momtazi-Borojeni Source Type: research
Gut bacterium Burkholderia cepacia (BsNLG8) and immune gene Defensin A contribute to the resistance against Nicotine-induced stress in Nilaparvata lugens (St ål)
Ecotoxicol Environ Saf. 2024 Apr 24;277:116371. doi: 10.1016/j.ecoenv.2024.116371. Online ahead of print.ABSTRACTNicotine, a naturally occurring alkaloid found in tobacco, is a potent neurotoxin extensively used to control Nilaparvata lugens (Stål), a destructive insect pest of rice crops. The insect gut harbors a wide array of resident microorganisms that profoundly influence several biological processes, including host immunity. Maintaining an optimal gut microbiota and immune homeostasis requires a complex network of reciprocal regulatory interactions. However, the underlying molecular mechanisms driving these symbioti...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Xuemei Wang Junaid Zafar Xiaotong Yang Surajit De Mandal Yingying Hong Fengliang Jin Xiaoxia Xu Source Type: research
Biological effects of vanillic acid, iso-vanillic acid, and orto-vanillic acid as environmental pollutants
This study evaluated the toxicity of VA and its isomers, iso-VA and orto-VA. Firstly, the antimicrobial effect of VA and its isomers iso-VA and orto-VA (in doses of 1000; 100, 10, 1; 0.1; 0.01 mg/L) against Escherichia coli, Sarcina spp., Enterobacter homaechei, Staphylococcus aureus and Candida albicans were identified. The toxic effect and protein degradation potential of VA and its isomers were determined using E. coli grpE:luxCDABE and lac:luxCDABE biosensor strains. However, the genotoxicity and oxidative stress generation were assessed with the E. coli recA:luxCDABE biosensor and E. coli strain. The results showed th...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Marzena Matejczyk Piotr Ofman Edyta Juszczuk-Kubiak Renata Świsłocka Wong Ling Shing Kavindra Kumar Kesari Balu Prakash W łodzimierz Lewandowski Source Type: research
Green Synthesis of Silver Nanoparticles Using Cirsium Congestum Extract Modified by Chitosan/Alginate: Bactericidal Activity against Pathogenic Bacteria and Cytotoxicity Analysis in Normal Cell Line
CONCLUSION: Current findings introduce novel gAgNPs modified with chitosan/alginate for use in medicine.PMID:38661036 | DOI:10.2174/0113816128304460240408085736 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 25, 2024 Category: Drugs & Pharmacology Authors: Mahnaz Mohtasham Alieh Rezagholizade-Shirvan Zahra Hojat Bonab Mohammad Reza Amiryousefi Majid Darroudi Mobina Sadat Ahmadi Solimani Sajad Yaghoobi Samaneh Dolatabadi Ahmad Ghasemi Amir Abbas Momtazi-Borojeni Source Type: research
A comprehensive synthetic library of poly-N-acetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus
Nat Commun. 2024 Apr 24;15(1):3420. doi: 10.1038/s41467-024-47457-4.ABSTRACTPoly-β-(1-6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of free amine vs N-acetylation on its antigenicity are not well understood. In this work, a divergent strategy is developed to synthesize a comprehensive library of 32 PNAG pentasaccharides. This library enables the identification of PNAG sequences with specific patterns of free amines as epitopes for vaccines against Staphylococcus aureus (S. aure...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Zibin Tan Weizhun Yang Nicholas A O'Brien Xingling Pan Sherif Ramadan Terence Marsh Neal Hammer Colette Cywes-Bentley Mariana Vinacur Gerald B Pier Jeffrey C Gildersleeve Xuefei Huang Source Type: research
