Chondrocyte Invasion May Be a Mechanism for Persistent Staphylococcus Aureus Infection In Vitro

CONCLUSION: S. aureus readily invaded human chondrocytes (C20A4) in vitro and persisted viably for 6 days after infection, evading extracellular antibiotics. Chondrocytes demonstrated a greater level of intracellular invasion and persistence by S. aureus than positive control human osteoblast (MG63) and mouse fibroblast (NIH3T3) cell lines.CLINICAL RELEVANCE: Chondrocyte invasion and persistence may contribute to recurrent bone and joint infections. Additional research should assess longer periods of persistence and whether this mechanism is present in vivo.PMID:38662927 | DOI:10.1097/CORR.0000000000003074
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Source Type: research