Electroconductive cardiac patch based on bioactive PEDOT:PSS hydrogels
This study introduces a synthetic patch with a bioactive surface designed to swiftly restore functionality to the damaged myocardium. The patch combines a composite, soft, and conductive hydrogel-based on (3,4-ethylenedioxythiophene):polystyrene-sulfonate (PEDOT:PSS) and polyvinyl alcohol (PVA). This cardiac patch exhibits a reasonably high electrical conductivity (40 S/cm) and a stretchability up to 50% of its original length. Our findings reveal its resilience to 10% cyclic stretching at 1 Hz with no loss of conductivity over time. To mediate a strong cell-scaffold adhesion, we biofunctionalize the hydrogel with a N-cadh...
Source: Biomed Res - May 1, 2024 Category: Research Authors: Erwan Sauvage Justin Matta Cat-Thy Dang Jiaxin Fan Graziele Cruzado Fabio Cicoira G éraldine Merle Source Type: research
Novel natural osthole-inspired amphiphiles as membrane targeting antibacterials against methicillin-resistant Staphylococcus aureus (MRSA)
Eur J Med Chem. 2024 Apr 26;271:116449. doi: 10.1016/j.ejmech.2024.116449. Online ahead of print.ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) is a widespread pathogen causing clinical infections and is multi-resistant to many antibiotics, making it urgent need to develop novel antibacterials to combat MRSA. Herein, we designed and prepared a series of novel osthole amphiphiles 6a-6ad by mimicking the structures and function of antimicrobial peptides (AMPs). Antibacterial assays showed that osthole amphiphile 6aa strongly inhibited S. aureus and 10 clinical MRSA isolates with MIC values of 1-2 μg/mL, comparab...
Source: European Journal of Medicinal Chemistry - May 1, 2024 Category: Chemistry Authors: Ruige Yang Zihan Xue Xinhui Li Ting Xu Yan Zhong Songlin Hu Shangshang Qin Yong Guo Source Type: research
Widespread Adoption of Microincision Vitrectomy Surgery Improves Visual Outcomes in Endogenous Endophthalmitis with Poor Initial Vision: A 21-Year Experience in Taiwan
CONCLUSION: In endogenous endophthalmitis patients presenting with poor initial visual acuity, vitrectomy was a better visual prognostic factor. MIVS has allowed more patients to undergo vitrectomy and improved visual outcomes.PMID:38691837 | DOI:10.1080/09273948.2024.2338272 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: Shih-Chou Chen Tsung-Tien Wu Chun-Hao Yin Jin-Shuen Chen Yao-Shen Chen Source Type: research
Construction of atom co-sharing Bi/Bi < sub > 4 < /sub > O < sub > 5 < /sub > Br < sub > 2 < /sub > nanosheet heterojunction for plasmonic-enhanced visible-light-driven photocatalytic antibacterial activity
Colloids Surf B Biointerfaces. 2024 Apr 18;238:113923. doi: 10.1016/j.colsurfb.2024.113923. Online ahead of print.ABSTRACTThe rapid advancement of photodynamic therapy (PDT) antibacterial materials has led to promising alternatives to antibiotics for treating bacterial infections. However, antibacterial drugs have poor light absorption and utilization rates, which limits their practical application. Constructing two-dimensional (2D) heterojunctions from materials with matching photophysical properties has emerged as a highly effective strategy for achieving high-efficiency photo-antibacterial performance. Here, we designed...
Source: Colloids and Surfaces - May 1, 2024 Category: Biotechnology Authors: Guixue Zhang Jie Pan Xiaoyi Dong Xue Li Zhiguo Song Yan Liu Xiaomeng Liu Yongjin Li Qiyan Li Source Type: research
The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin-resistant < em > Staphylococcus aureus < /em >
Antimicrob Agents Chemother. 2024 May 1:e0033524. doi: 10.1128/aac.00335-24. Online ahead of print.ABSTRACTInfections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a leading cause of mortality worldwide. MRSA has acquired resistance to next-generation β-lactam antibiotics through the horizontal acquisition of the mecA resistance gene. Development of high resistance is, however, often associated with additional mutations in a set of chromosomal core genes, known as potentiators, which, through poorly described mechanisms, enhance resistance. The yjbH gene was recently identified as a hot spot for adaptiv...
Source: Antimicrobial Agents and Chemotherapy - May 1, 2024 Category: Microbiology Authors: Tobias Krogh Nielsen Ida Birkj ær Petersen Lijuan Xu Maria Disen Barbuti Viktor Mebus Anni Justh Abdulelah Ahmed Alqarzaee Nicolas Jacques C écile Oury Vinai Thomas Morten Kjos Camilla Henriksen Dorte Frees Source Type: research
Widespread Adoption of Microincision Vitrectomy Surgery Improves Visual Outcomes in Endogenous Endophthalmitis with Poor Initial Vision: A 21-Year Experience in Taiwan
CONCLUSION: In endogenous endophthalmitis patients presenting with poor initial visual acuity, vitrectomy was a better visual prognostic factor. MIVS has allowed more patients to undergo vitrectomy and improved visual outcomes.PMID:38691837 | DOI:10.1080/09273948.2024.2338272 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 1, 2024 Category: Allergy & Immunology Authors: Shih-Chou Chen Tsung-Tien Wu Chun-Hao Yin Jin-Shuen Chen Yao-Shen Chen Source Type: research
Construction of atom co-sharing Bi/Bi < sub > 4 < /sub > O < sub > 5 < /sub > Br < sub > 2 < /sub > nanosheet heterojunction for plasmonic-enhanced visible-light-driven photocatalytic antibacterial activity
Colloids Surf B Biointerfaces. 2024 Apr 18;238:113923. doi: 10.1016/j.colsurfb.2024.113923. Online ahead of print.ABSTRACTThe rapid advancement of photodynamic therapy (PDT) antibacterial materials has led to promising alternatives to antibiotics for treating bacterial infections. However, antibacterial drugs have poor light absorption and utilization rates, which limits their practical application. Constructing two-dimensional (2D) heterojunctions from materials with matching photophysical properties has emerged as a highly effective strategy for achieving high-efficiency photo-antibacterial performance. Here, we designed...
Source: Colloids and Surfaces - May 1, 2024 Category: Biotechnology Authors: Guixue Zhang Jie Pan Xiaoyi Dong Xue Li Zhiguo Song Yan Liu Xiaomeng Liu Yongjin Li Qiyan Li Source Type: research
Quorum-sensing < em > agr < /em > system of < em > Staphylococcus aureus < /em > primes gene expression for protection from lethal oxidative stress
Elife. 2024 Apr 30;12:RP89098. doi: 10.7554/eLife.89098.ABSTRACTThe agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that protection by agr surprisingly extends beyond post-exponential growth to the exit from stationary phase when the agr system is no longer turned on. Thus, agr can be considered a constitutive protective factor. Deletion of agr resulted in decreased ATP levels and growth, despite increased rates of respiration or fermentation at ap...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Magdalena Podkowik Andrew I Perault Gregory Putzel Andrew Pountain Jisun Kim Ashley L DuMont Erin E Zwack Robert J Ulrich Theodora K Karagounis Chunyi Zhou Andreas F Haag Julia Shenderovich Gregory A Wasserman Junbeom Kwon John Chen Anthony R Richardson J Source Type: research
Delayed infections following polybutylate-coated polyester (Ethibond) suture frontalis suspension surgery for severe blepharoptosis
CONCLUSION: Frontalis suspension with Ethibond has an 8% incidence of delayed infections, with Staphylococcus aureus as the most common organism. The authors recommend early sling removal in all patients with infection and recommend consideration of an alternative material in the event of future revision surgery.PMID:38687955 | DOI:10.1080/01676830.2024.2338789 (Source: Orbit)
Source: Orbit - April 30, 2024 Category: Opthalmology Authors: Ayushi Agarwal Joveeta Joseph Milind N Naik Source Type: research
Isolation, Structural Elucidation of Bioactive Compounds and Their Wound-Healing Ability, Antibacterial and In Silico Molecular Docking Applications
Environ Res. 2024 Apr 27:119023. doi: 10.1016/j.envres.2024.119023. Online ahead of print.ABSTRACTAndrographis echioides has been extensively utilized in traditional Indian folk medicines for several skin disorders and other biological actions such as diuretic, antimicrobial, anthelmintic, anti-ulcer, and hepatoprotective properties. Different crude extracts were extracted from A. echioides leaves using various solvents such as methanol and water. The prepared crude extracts were utilized to formulate different herbal ointments. Further, the prepared ointments were examined against wounds and bacterial pathogens. The wound...
Source: Environmental Research - April 30, 2024 Category: Environmental Health Authors: Mathivanan Dhamodiran Kamaraj Chinnaperumal Dhanish J Geetha Venkatesan Maha A Alshiekheid S R Suseem Source Type: research
Antioxidant and Antimicrobial Potential of Peptide from Rabbit Meat Hydrolysate Prepared by Trypsin and Zingibain
Conclusion:</b> The combination zingibain enzyme and trypsin is feasible for hydrolyzing rabbit meat and the optimum hydrolysis time was 24 hrs with IC<sub>50</sub> 52.45 ppm, although accompanied by reduction in antibacterial activities.PMID:38686737 | DOI:10.3923/pjbs.2024.152.159 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Eka Wulandari Wendry Setiyadi Putranto Andry Pratama Jajang Gumilar Rani Maharani Source Type: research
Effectiveness of Gel from Andaliman Fruit ( < em > Zanthoxylum acanthopodium < /em > DC.) Extract on Wound Inflammation
Conclusion:</b> Finally, analgesic gel spray made from the Andaliman fruit at a 15% concentration can help with pain and also be antibacterial, reduce inflammation and help wounds heal.</p>.PMID:38686736 | DOI:10.3923/pjbs.2024.142.151 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Elsa Izza Sabila Annisa Ayu Ramadhani Hanif Fadhilah Balqis Nur Nasution None Fathiya Putri Cahaya Situmorang Source Type: research
Synthesis, characterization, and investigation of antibacterial activity of Novel CMC/CuO NPs/CQDs bionanocomposite coating
Int J Biol Macromol. 2024 Apr 28:131922. doi: 10.1016/j.ijbiomac.2024.131922. Online ahead of print.ABSTRACTIn recent decades, healthcare-associated infections (HAIs) have become a common problem in healthcare facilities such as hospitals. As a result, researchers are currently developing nanocomposite coatings that are strengthened with antibacterial nanoparticles. In this research, a novel antibacterial bionanocomposite coating based on carboxymethyl cellulose polymer/copper oxide nanoparticles/carbon quantum dots was coated on medical grade 316 stainless steel by sol-gel dip-coating method. The effect of the concentrati...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: Hamidreza Amoon Ayoub Moghadam Maryam Chalabi Hajkarim Source Type: research
On-site detection of methicillin-resistant Staphylococcus aureus (MRSA) utilizing G-quadruplex based isothermal exponential amplification reaction (GQ-EXPAR)
Talanta. 2024 Apr 13;275:126073. doi: 10.1016/j.talanta.2024.126073. Online ahead of print.ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) has a high incidence in infectious hospitals and communities, highlighting the need for early on-site detection due to its resistance to methicillin antibiotics. The present study introduces a highly sensitive detection system for mecA, a crucial methicillin marker, utilizing an RCA-based isothermal exponential amplification reaction. The G-quadruplex-based isothermal exponential amplification reaction (GQ-EXPAR) method designs probes to establish G-quadruplex secondary struc...
Source: Talanta - April 30, 2024 Category: Chemistry Authors: Seung Beom Seo Jina Lee Eunjung Kim Jaewoo Lim Soojin Jang Seong Uk Son Yeonwoo Jeong Taejeoon Kang Juyeon Jung Kyoung G Lee Sung-Woon Lee Kyujung Kim Eun-Kyung Lim Source Type: research
