Exploring the multifaceted bioactivities of < em > Lavandula pinnata L. < /em > essential oil: promising pharmacological activities
This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus nige...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Mounir Haddou Amine Elbouzidi Mohamed Taibi Abdellah Baraich El Hassania Loukili Reda Bellaouchi Ennouaamane Saalaoui Abdeslam Asehraou Ahmad Mohammad Salamatullah Mohammed Bourhia Hiba-Allah Nafidi Mohamed Addi Bouchra El Guerrouj Khalid Chaabane Source Type: research
N vacancy and self-enhancement induced high anodic electrochemiluminescence of 3D g-C < sub > 3 < /sub > N < sub > 4 < /sub > for sensitive staphylococcus aureus analysis
Talanta. 2024 Apr 23;275:126144. doi: 10.1016/j.talanta.2024.126144. Online ahead of print.ABSTRACTHere, 3D g-C3N4 with dense N vacancy in its 3D porous interconnected open-framework was synthesized, and the co-reactive 3-(dibutylamino)propylamine (DBAPA) was further covalently coupled onto the surface, resulting in a strong self-enhanced anodic electrochemiluminescence (ECL). Through introduction of high-density N vacancy, for the obtained 3D g-C3N4-NV, the band gap was broadened and the electrical conductivity was enhanced, realizing an obvious ECL improvement. Moreover, after the covalent binding of co-reactive DBAPA, t...
Source: Talanta - April 25, 2024 Category: Chemistry Authors: Yuxuan Wang Xinya Jiang Weiwei Cao Haijun Wang Ruo Yuan Source Type: research
Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcusaureus
Biochem Biophys Res Commun. 2024 Apr 20;714:149974. doi: 10.1016/j.bbrc.2024.149974. Online ahead of print.ABSTRACTDue to the rapid emergence of antibiotic resistant new bacterial strains and new infections, there is an urgent need for novel or newly modified and efficient alternatives of treatment. However, conventional antibiotics are still used in therapeutic settings but their efficacy is uncertain due to the rapid evolution of drug resistance. In the present study, we have synthesized a new derivative of conventional antibiotic ampicillin using SN2-type substitution reaction. NMR and mass analysis of the newly synthes...
Source: Biochemical and Biophysical Research communications - April 25, 2024 Category: Biochemistry Authors: Sourav Chakraborty Piyush Baindara Suresh K Mondal Dinata Roy Santi M Mandal Source Type: research
A comprehensive synthetic library of poly-N-acetyl glucosamines enabled vaccine against lethal challenges of Staphylococcus aureus
Nat Commun. 2024 Apr 24;15(1):3420. doi: 10.1038/s41467-024-47457-4.ABSTRACTPoly-β-(1-6)-N-acetylglucosamine (PNAG) is an important vaccine target, expressed on many pathogens. A critical hurdle in developing PNAG based vaccine is that the impacts of the number and the position of free amine vs N-acetylation on its antigenicity are not well understood. In this work, a divergent strategy is developed to synthesize a comprehensive library of 32 PNAG pentasaccharides. This library enables the identification of PNAG sequences with specific patterns of free amines as epitopes for vaccines against Staphylococcus aureus (S. aure...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Zibin Tan Weizhun Yang Nicholas A O'Brien Xingling Pan Sherif Ramadan Terence Marsh Neal Hammer Colette Cywes-Bentley Mariana Vinacur Gerald B Pier Jeffrey C Gildersleeve Xuefei Huang Source Type: research
Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel
This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Amos Luanda M Manohar Rompicherla Narayana Charyulu Vishalakshi Badalamoole Source Type: research
Effect of Antimicrobial Agent Coating on Physicochemical and Biologic Properties of Implant Abutments: A Systematic Review
CONCLUSIONS: This review showed that there is still no consensus on which is the better antimicrobial agent and which coated materials have the better performance. However, the association of surface coating of abutments with antimicrobials is feasible and can benefit many patients, which can support their clinical use to favor the healing process and prevent infections that can lead to treatment failure with dental implants.PMID:38657216 | DOI:10.11607/jomi.9992 (Source: International Journal of Oral and Maxillofacial Implants)
Source: International Journal of Oral and Maxillofacial Implants - April 24, 2024 Category: ENT & OMF Authors: Murilo Rodrigues de Campos Andr éa Cândido Dos Reis Source Type: research
Synergistic antimicrobial action of nanocellulose, nanoselenium, and nanocomposite against pathogenic microorganisms
In this study, nanocellulose was extracted from algae, biomolecule substances synthesized selenium nanoparticles, and a simple nanocomposite of nanocellulose and nanoselenium was elaborated using nanocellulose as a reducing agent under hydrothermal conditions. These nanocomposite materials have markedly improved properties at low concentrations. Our obtained polymers were characterized using techniques including Fourier-transform infrared spectroscopy, X-ray powder diffraction, Thermo gravimetric analysis (TGA), Scanning electron microscopic (SEM), Energy Dispersive X-ray analysis (EDX), Transmission electron microscopic (...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Mostafa M El-Sheekh Wesam E Yousuf Tarek M Mohamed El-Refaie Kenawy Source Type: research
Potential prebiotic and antibacterial activities of fucoidan from Laminaria japonica
Int J Biol Macromol. 2024 Apr 22:131776. doi: 10.1016/j.ijbiomac.2024.131776. Online ahead of print.ABSTRACTFucoidan from Laminaria japonica became sterilized with an autoclave and ultraviolet (UV) radiation. Potential prebiotic and antibacterial activities of sterilized fucoidans (SF) were the subject of investigation. Molecular weight, monosaccharide composition, FTIR, and NMR spectra of SF underwent evaluations to elucidate the relationship between the structure and activities of SF. The growth of Lactobacillus rhamnosus GG and L. acidophilus with autoclave sterilized fucoidan (ASF) and the growth of L. plantarum, L. ga...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Maryam Habibi Mohammad-Taghi Golmakani Mohammad Hadi Eskandari Seyed Mohammad Hashem Hosseini Source Type: research
Evaluation of drug release efficiency and antibacterial property of a pH-responsive dextran-based silver nanocomposite hydrogel
This study aims to develop dextran-graft-poly(4-acryloylmorpholine) silver nanocomposite using a microwave-assisted method to evaluate its drug-release efficiency and antimicrobial activity. The materials were characterized by FT-IR, FE-SEM, EDS, XRD, HR-TEM, TGA, and BET techniques. Drug loading and release efficiency were evaluated using CUR as the model drug. The swelling and drug release studies were conducted in buffer solutions of pH 1.2 and 7.4. Staphylococcus aureus and Escherichia coli were employed to evaluate the antibacterial activity. The cytotoxicity was assessed by MTT assay against the breast MCF-10. Higher...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Amos Luanda M Manohar Rompicherla Narayana Charyulu Vishalakshi Badalamoole Source Type: research
Fabrication and characterization of pullulan/tapioca starch-based antibacterial films incorporated with Litsea cubeba essential oil for meat preservation
Int J Biol Macromol. 2024 Apr 22:131775. doi: 10.1016/j.ijbiomac.2024.131775. Online ahead of print.ABSTRACTActive packaging is a novel technology that utilizes active materials to interact with products and the environment, improving food shelf life. The purpose of this work was to fabricate a multifunctional film using Litsea cubeba essential oil (LC-EO) (1 %, 3 %, 5 %, and 7 %) as the active ingredient and pullulan(P)/tapioca starch (TS) as the carrier material. Adding essential oil improves the films properties, such as barrier ability, anti-oxidant, and antibacterial activity. However, tensile strength (TS) and elonga...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Mawardi Yusufe Adame Ce Shi Changzhu Li Tariq Aziz Metab Alharbi Haiying Cui Lin Lin Source Type: research
Polydopamine contained hydrogel nanocomposites with combined antimicrobial and antioxidant properties for accelerated wound healing
Int J Biol Macromol. 2024 Apr 22:131700. doi: 10.1016/j.ijbiomac.2024.131700. Online ahead of print.ABSTRACTOverproduction of reactive oxygen species (ROS) in infected wounds induces a tremendous inflammatory reaction to delay wound healing. To address this problem, we designed a multifunctional polyacrylamide/PVA-based hydrogel containing synthesized poly(1-glycidyl-3-butylimidazolium salicylate) (polyGBImSal) and fabricated polydopamine-coated polyphenolic nanosheet (PDA@PNS) for wound dressing. The PDA@PNS particles were designed to induce I) antioxidant and anti-inflammatory features through ROS-scavenging and II) cell...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Mahin Abdollahi Sina Andablib Roghayeh Ghorbani Davoud Afshar Mohammad Gholinejad Hamed Abdollahi Ali Akbari Nasser Nikfarjam Source Type: research
Genes, Vol. 15, Pages 532: Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations: A Cross-Sectional Study
Patricia Poeta
This cross-sectional study investigates the methicillin-resistant Staphylococcus aureus (MRSA): its prevalence, antimicrobial resistance, and molecular characteristics in healthy swine populations in central Portugal. A total of 213 samples were collected from pigs on twelve farms, and MRSA prevalence was assessed using selective agar plates and confirmed via molecular methods. Antimicrobial susceptibility testing and whole genome sequencing (WGS) were performed to characterize resistance profiles and genetic determinants. Among the 107 MRSA-positive samples (83.1% prevalence), fattening pigs and breed...
Source: Genes - April 24, 2024 Category: Genetics & Stem Cells Authors: Vanessa Silva Adriana Silva Raquel Barbero Mario Romero Rosa del Campo Manuela Cani ça Rui Cordeiro Gilberto Igrejas Patricia Poeta Tags: Article Source Type: research
Molecules, Vol. 29, Pages 1939: Fractionation of Carlina acaulis L. Root Methanolic Extract as a Promising Path towards New Formulations against Bacillus cereus and Methicillin-Resistant Staphylococcus aureus
In this study, the fractionation of methanol extract from the root was conducted. Four fractions (A, B, C, and D) were obtained and tested against a range of bacteria and fungi. The results showed promising antibacterial activity, especially against Bacillus cereus, where the minimal inhibitory concentration (MIC) was determined to be equal to 0.08 mg/mL and 0.16 mg/mL for heptane (fraction B) and ethyl acetate (fraction C), respectively. In the case of the methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 strain, the same fractions yielded higher MIC values (2.5 and 5.0 mg/mL, respectively). This was accompani...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Sylwia Wnorowska Agnieszka Grzegorczyk Jacek Kurzepa Filippo Maggi Maciej Strzemski Tags: Article Source Type: research
Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with < em > Staphylococcus Aureus < /em > by pharmacokinetic/pharmacodynamic analysis
J Chemother. 2024 Apr 22:1-8. doi: 10.1080/1120009X.2024.2343963. Online ahead of print.ABSTRACTOmadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study is to evaluate the effectiveness of omadacycline for treating CABP patients infected with Staphylococcus aureus, including Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Susceptible Staphylococcus aureus (MSSA), using pharmacokinetic/pharmacodynamic (PK/PD) analysis. Monte Carlo simulations (MCSs) were performed by utilizing omadacycline pharmacokinetic (PK) parameters, minimum inhibitory concent...
Source: Journal of Chemotherapy - April 23, 2024 Category: Cancer & Oncology Authors: Gaoqi Xu Xin Liu Jiaqi Wang Yuqing Mei Dihong Yang Chaoneng He Like Zhong Junfeng Zhu Haiying Ding Luo Fang Source Type: research
Microbial keratitis in Southern Malawi: a microbiological pilot study
CONCLUSIONS: In a resource-poor setting, a CIM can be used to safely sample the cornea in patients presenting with suspected MK, enabling identification of causative microorganisms by culture and PCR. Although the microbiological spectrum found was limited to the dry season, these preliminary results could be used to guide empirical treatment.PMID:38653537 | DOI:10.1136/bmjophth-2024-001682 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Tobi F Somerville Shaffi Mdala Thokozani Zungu Moira Gandiwa Rose Herbert Dean Everett Caroline E Corless Nicholas A V Beare Timothy Neal Malcolm J Horsburgh Alistair Darby Stephen B Kaye Petros C Kayange Source Type: research
