Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Exploring the impact of pharmacogenetics on personalized medicine: A systematic review
CONCLUSION: The studies analyzed in this review suggest a strong correlation between genetic variability and individual drug responses, supporting the use of pharmacogenetics for treatment optimization. However, for certain drugs like metformin or quetiapine, the influence of genotype on their response remains unclear. More studies with larger sample sizes, greater ethnic diversity, and consideration of non-genetic factors are needed. The lack of standardization in analysis methods and accessibility to genetic testing are significant challenges in this field. As a conclusion, pharmacogenetics shows immense potential in per...
Source: Farmacia Hospitalaria - February 10, 2024 Category: Drugs & Pharmacology Authors: Laura Amaro- Álvarez Jaime Cordero-Ramos Miguel Ángel Calleja-Hernández Source Type: research
Effectiveness of antipsychotics for managing agitated delirium in patients with advanced cancer: a secondary analysis of a multicenter prospective observational study in Japan (Phase-R)
ConclusionsThe findings suggest that olanzapine may effectively improve delirium agitation in patients with advanced cancer. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - February 8, 2024 Category: Cancer & Oncology Source Type: research
40-Year-Old Woman Presenting With Heartburn
A 40-year-old woman presented to the outpatient clinic with a 3-month history of worsening heartburn and regurgitation. Symptoms occurred nearly daily, were worse after spicy foods and carbonated beverages, and were relieved by calcium carbonate. She had no associated fever, weight loss, changes in bowel habits, or dysphagia. She had never traveled internationally. Her medical history was notable only for bipolar I disorder well controlled with lithium and quetiapine. She had no history of abdominal surgery or tobacco use, and she consumed 4 ounces of wine 3 to 4 times per week. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - February 6, 2024 Category: Internal Medicine Authors: Lauren Loeb, Andree H. Koop Tags: Residents ’ clinic Source Type: research
Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research
Research encouraging off-label use of quetiapine: A systematic meta-epidemiological analysis
CONCLUSION: Many small, post-approval studies suggested the promise of quetiapine for numerous off-label indications. These findings generally went unconfirmed in large, blinded, randomized trials years after first being published. The imbalance of exploratory and confirmatory studies likely encourages ineffective off-label treatment.PMID:38284364 | DOI:10.1177/17407745231225470 (Source: Clinical Trials)
Source: Clinical Trials - January 29, 2024 Category: Research Authors: Peter Grabitz Lana Saksone Susanne Gabriele Schorr Johannes Schwietering Merlin Bittlinger Jonathan Kimmelman Source Type: research
Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats
AbstractSchizophrenia (SCZ) response to pharmacological treatment is highly variable. Quetiapine (QTP) administered as QTP lipid core nanocapsules (QLNC) has been shown to modulate drug delivery to the brain of SCZ phenotyped rats (SPR). In the present study, we describe the brain concentration –effect relationship after administrations of QTP as a solution or QLNC to SPR and naïve animals. A semimechanistic pharmacokinetic (PK) model describing free QTP concentrations in the brain was linked to a pharmacodynamic (PD) model to correlate the drug kinetics to changes in dopamine (DA) medi al prefrontal cortex extracellula...
Source: CPT: Pharmacometrics and Systems Pharmacology - January 29, 2024 Category: Drugs & Pharmacology Authors: Bruna Bernar Dias,
Fernando Carre ño,
Victória Etges Helfer,
Laura Ben Olivo,
Keli Jaqueline Staudt,
Karina Paese,
Fabiano Barreto,
Fabíola Schons Meyer,
Ana Paula Herrmann,
Sílvia Stanisçuaski Guterres,
Stela Maris Kuze Rates,
Bibiana Ver Tags: ARTICLE Source Type: research
Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report
CONCLUSION: This is the first report of quetiapine-induced central hypothyroidism in a patient with ASD, as determined by a thyrotropin-releasing hormone (TRH) loading test. TRH loading test may be useful in elucidating the pathogenesis of hypothyroidism in patients receiving quetiapine and VPA. Thyroid function monitoring in patients taking quetiapine and VPA may provide an opportunity to begin replacement therapy.PMID:38251700 | DOI:10.2174/0118715303261457231120114231 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 22, 2024 Category: Endocrinology Authors: Narantsatsral Daramjav Junko Takagi Hideyuki Iwayama Kousuke Kanemoto Kazuo Otake Source Type: research
Quetiapine and Valproic Acid-induced Central Hypothyroidism in a Patient with Autism Spectrum Disorder and Intractable Epilepsy: A Case Report
CONCLUSION: This is the first report of quetiapine-induced central hypothyroidism in a patient with ASD, as determined by a thyrotropin-releasing hormone (TRH) loading test. TRH loading test may be useful in elucidating the pathogenesis of hypothyroidism in patients receiving quetiapine and VPA. Thyroid function monitoring in patients taking quetiapine and VPA may provide an opportunity to begin replacement therapy.PMID:38251700 | DOI:10.2174/0118715303261457231120114231 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 22, 2024 Category: Drugs & Pharmacology Authors: Narantsatsral Daramjav Junko Takagi Hideyuki Iwayama Kousuke Kanemoto Kazuo Otake Source Type: research
Morphine concentrations in fatalities after palliative treatment of acute burn injury
AbstractThe evaluation of a morphine concentration in postmortem blood is routine for a forensic toxicologist. We here report three fatal cases where we found high morphine concentrations with 7.96, 4.30, and 5.82 mg/l in femoral blood that have to be estimated as unusually high. All these individuals died due to severe burn injuries and obtained morphine in the context of their palliative care in the last hours of their lives. According to the autopsy results, the cause of death in case 1 was burn disease with burns of about 90% of the body surface area (BSA), case 2 burn trauma, and case 3 burn shock. Besides morphine,...
Source: International Journal of Legal Medicine - January 17, 2024 Category: Medical Law Source Type: research
Incidences, risk factors, and clinical correlates of severe QT prolongation after the use of quetiapine or haloperidol
Case reports suggest that quetiapine or haloperidol use is associated with severe QT prolongation (SQTP) and torsades de pointes. (Source: Heart Rhythm)
Source: Heart Rhythm - January 14, 2024 Category: Cardiology Authors: Chun-Li Wang, Victor Chien-Chia Wu, Cheng Hung Lee, Chia-Ling Wu, Hui-Ming Chen, Yu-Tung Huang, Shang-Hung Chang Source Type: research
Lithium management of periodic mood fluctuations in behavioural frontotemporal dementia: a case report
This report highlights the potential use of lithium as a mood stabilizer in bvFTD patients with periodic mood fluctuations, refractory to standard treatments. Further research is needed to elucidate the mechanisms underlying lithium’s efficacy in bvFTD and to establish treatment guidelines. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - January 8, 2024 Category: Psychiatry Source Type: research
Comparison of antipsychotic drug use in children and adolescents in the Netherlands before and during the COVID-19 pandemic
This study aims to describe the patterns and trends in antipsychotic prescription among Dutch youth before and during the corona virus disease 2019 (COVID-19) pandemic (between 2017 and 2022). The study specifically aims to determine whether there has been an increase or decrease in antipsychotic prescription among this population, and whether there are any differences in prescription patterns among different age and sex groups. The study utilized the IADB database, which is a pharmacy prescription database containing dispensing data from approximately 120 community pharmacies in the Netherlands, to analyze the monthly pre...
Source: European Child and Adolescent Psychiatry - January 6, 2024 Category: Psychiatry Source Type: research
Predicting quetiapine dose in patients with depression using machine learning techniques based on real-world evidence
Being one of the most widespread, pervasive, and troublesome illnesses in the world, depression causes dysfunction in various spheres of individual and social life. Regrettably, despite obtaining evidence-base... (Source: Annals of General Psychiatry)
Source: Annals of General Psychiatry - January 6, 2024 Category: Psychiatry Authors: Yupei Hao, Jinyuan Zhang, Jing Yu, Ze Yu, Lin Yang, Xin Hao, Fei Gao and Chunhua Zhou Tags: Research Source Type: research
