Acute quetiapine overdose is associated with risk of ectopic atrial rhythm
Actas Esp Psiquiatr. 2023 Sep;51(5):216-219. Epub 2023 Sep 1.ABSTRACTQuetiapine overdose is commonly associated with coma, respiratory depression, hypotension, tachycardia, and QTc interval prolongation on the electrocardiogram.PMID:38117261 (Source: Actas Espanolas de Psiquiatria)
Source: Actas Espanolas de Psiquiatria - December 20, 2023 Category: Psychiatry Authors: Miguel Pires Diana Brigadeiro Francisco Lu ís Juliana Nunes Source Type: research
Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research
Oral and long-acting injectable antipsychotic discontinuation and relationship to side effects in people with first episode psychosis: a longitudinal analysis of electronic health record data
CONCLUSION: Earlier treatment discontinuation associated with sexual or extrapyramidal side effects could be related to their rapid onset and poor tolerability. Later treatment discontinuation associated with clozapine and PP1M could be related to the relative efficacy of these treatments. These findings merit consideration when selecting antipsychotic therapy for people with FEP.PMID:38107162 | PMC:PMC10725124 | DOI:10.1177/20451253231211575 (Source: Adv Data)
Source: Adv Data - December 18, 2023 Category: Epidemiology Authors: Rashmi Patel Aimee Brinn Jessica Irving Jaya Chaturvedi Shanmukha Gudiseva Christoph U Correll Paolo Fusar-Poli Philip McGuire Source Type: research
Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research
Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research
Insights into the population pharmacokinetics and pharmacodynamics of quetiapine: a systematic review
CONCLUSIONS: Concurrent administration of potent or moderate CYP3A4 inducers and inhibitors need to be avoided in quetiapine-treated patients. When co-medication is required, it is recommended to adjust the dosage based on therapeutic drug monitoring. Additional research is warranted to delineate the dose-exposure-response relationships of quetiapine and norquetiapine in pediatrics, geriatrics, hepatically-impaired patients, and women using contraceptives or are pregnant or menopausal.PROSPERO REGISTRATION: CRD42023446654.PMID:38108086 | DOI:10.1080/17512433.2023.2295428 (Source: Expert Review of Clinical Pharmacology)
Source: Expert Review of Clinical Pharmacology - December 18, 2023 Category: Drugs & Pharmacology Authors: Lu Han Jia-Qin Gu Jue-Hui Mao Xiao-Qin Liu Zheng Jiao Source Type: research
Pica in a girl with non-suicidal self-injury: a case report
In this report, we discuss a complex case involving the co-occurrence of pica and non-suicidal self-injury. A 13-year-old girl was admitted to our hospital due to ingesting two batteries. She features a persistent, intense appetite along with sudden and compulsive behaviors such as consuming inedible items or self-inflicted cutting. After receiving a combination of pharmacological treatments (quetiapine, lithium and sertraline), cognitive behavioral therapy (CBT) and modified electroconvulsive therapy (MECT) for 25 days, she was discharged with relief from her clinical symptoms. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - December 18, 2023 Category: Psychiatry Source Type: research
Risk of long-term care admissions among Medicare beneficiaries treated with pimavanserin or quetiapine for Parkinson's disease psychosis in USA: a retrospective administrative claims database analysis
Conclusion: The 20% lower risk of LTCA (i.e., greater delay) with PIM versus QUE in this analysis may suggest that PIM should be started early for the treatment of PDP.PMID:38099518 | DOI:10.57264/cer-2023-0114 (Source: Journal of Comparative Effectiveness Research)
Source: Journal of Comparative Effectiveness Research - December 15, 2023 Category: General Medicine Authors: Krithika Rajagopalan Nazia Rashid Dilesh Doshi Source Type: research
