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Antipsychotic drugs in first-episode psychosis: A target trial emulation in the FEP-CAUSAL Collaboration
Am J Epidemiol. 2024 Apr 3:kwae029. doi: 10.1093/aje/kwae029. Online ahead of print.ABSTRACTGood adherence to antipsychotic therapy helps prevent relapses in First Episode Psychosis (FEP). We used data from the FEP-CAUSAL Collaboration, an international consortium of observational cohorts to emulate a target trial comparing antipsychotics with treatment discontinuation as the primary outcome. Other outcomes included all-cause hospitalization. We benchmarked our results to estimates from EUFEST, a randomized trial conducted in the 2000s. We included 1097 patients with a psychotic disorder and less than 2 years since psychos...
Source: Am J Epidemiol - April 5, 2024 Category: Epidemiology Authors: Alejandro G Szmulewicz Gonzalo Mart ínez-Alés Roger Logan Maria Ferrara Christian Kelly Diane Fredrikson Juan Gago Sarah Conderino Covadonga M D íaz-Caneja Joaqu ín Galvañ Lorna Thorpe Vinod Srihari Lakshmi Yatham Deepak K Sarpal Ann K Shinn Celso Ar Source Type: research

Clozapine, LAIs Found Effective in Patients With First-Episode Psychosis and Cannabis Use Disorder
Individuals with first-episode psychosis (FEP) and cannabis use disorder who were prescribed any antipsychotic were significantly less likely to be hospitalized for psychosis than similar patients who did not receive an antipsychotic, according to areport inSchizophrenia Bulletin.Clozapine and long-acting injectable (LAI) formulations of risperidone, aripiprazole, and paliperidone were the most effective medications at preventing relapse and hospitalization due to psychosis. Clozapine was also most effective at preventing hospitalization due to substance use.Alexander Denissoff, M.D., of the University of Turku, Finland, a...
Source: Psychiatr News - April 3, 2024 Category: Psychiatry Tags: cannabis Finland first-episode psychosis health registries hospitalization relapse schizophrenia substance use disorder Source Type: research

Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium: Randomized Controlled Trial
ConclusionsQuetiapine may be equally as effective as haloperidol in treating the symptoms of hyperactive delirium in critically ill patients, with no mortality benefit. (Source: Neurocritical Care)
Source: Neurocritical Care - April 1, 2024 Category: Neurology Source Type: research

Minor tranquillizers for short-term treatment of newly onset symptoms of anxiety and distress: a systematic review with network meta-analysis of randomized trials
AbstractUnspecific symptoms of anxiety and distress are frequently encountered in patients in both general practice and acute psychiatric services. Minor tranquillizers may be a treatment option when non-pharmacological interventions are insufficient or unavailable. We conducted a systematic review with network meta-analysis of the evidence for short-term (1 –4 weeks) pharmacological treatment of newly onset symptoms of anxiety and distress. We searched the PsycInfo, MEDLINE, EMBASE and Cochrane Library databases and extracted data following a predefined hierarchy of outcomes. We assessed risk of bias using the Cochrane...
Source: European Archives of Psychiatry and Clinical Neuroscience - April 1, 2024 Category: Neuroscience Source Type: research

The influence of concomitant antidepressant and antipsychotic medication on antidepressant effect and seizure duration of electroconvulsive therapy
ConclusionTaken together, our study underlines that concomitant psychotropic medication while doing electroconvulsive therapy does not bare the risk of prolonged seizure duration or does it reduce the effectiveness of ECT. To the best of our knowledge, this study is the first to examine the effect of treatment with antidepressants in combination with antipsychotics while doing ECT. In light of our results, this combination therapy is safe and effective. Bearing in mind the delay in onset of antidepressant action of medication and the importance of antidepressant medication for relapse prevention, this study further support...
Source: Frontiers in Psychiatry - March 18, 2024 Category: Psychiatry Source Type: research

Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication
Brain Res Bull. 2024 Mar 12:110927. doi: 10.1016/j.brainresbull.2024.110927. Online ahead of print.ABSTRACTSchizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine the effect of quetiapine on WM and S100B in schizophrenia patients, we determined serum S100B levels with solid phas...
Source: Brain Research - March 14, 2024 Category: Neurology Authors: Han Shi Yan Zhang YongFeng Yang HaiSan Zhang WenQiang Li ZhaoXi Zhong LuXian Lv Source Type: research

Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication
Brain Res Bull. 2024 Mar 12:110927. doi: 10.1016/j.brainresbull.2024.110927. Online ahead of print.ABSTRACTSchizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine the effect of quetiapine on WM and S100B in schizophrenia patients, we determined serum S100B levels with solid phas...
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Han Shi Yan Zhang YongFeng Yang HaiSan Zhang WenQiang Li ZhaoXi Zhong LuXian Lv Source Type: research

Prevalence of use of on-label and off-label psychotropics in the Greek pediatric population
With a global increased use of psychotropics in pediatrics, their off-label use is a concern due to uncertainty and risk. Data on psychotropics use in the Greek pediatric population do not exist to date. We analyzed retrospective data from the nationwide pharmacy claim database, to estimate the prevalence of psychotropics in pediatrics focusing on off-label use (March 2016-October 2019). In total 63,782 pediatric subjects had at least one identified psychotropic prescription. The prevalence of psychotropics use was 5.1–14.6/1,000 pediatric inhabitants. When excluding 42,508 subjects who received only short-time hydroxyzi...
Source: Frontiers in Pharmacology - March 14, 2024 Category: Drugs & Pharmacology Source Type: research

Treatment resistance in anxiety disorders-Definition and treatment options
Nervenarzt. 2024 Mar 4. doi: 10.1007/s00115-024-01627-3. Online ahead of print.ABSTRACTTreatment resistance in anxiety disorders represents a clinical challenge, contributes to the chronicity of the diseases as well as sequential comorbidities, and is associated with a significant individual and socioeconomic burden. This narrative review presents the operational definition of treatment resistance in anxiety disorders according to international consensus criteria (< 50% reduction in the Hamilton Anxiety Scale, HAM‑A, score or < 50% reduction in the Beck Anxiety Inventory, BAI, score or a clinical global impression-...
Source: Der Nervenarzt - March 4, 2024 Category: Neurology Authors: Katharina Domschke Andreas Str öhle Peter Zwanzger Source Type: research

Esketamine Is Superior to Quetiapine for Remission of Treatment-Resistant Depression
Am Fam Physician. 2024 Feb;109(2):Online.NO ABSTRACTPMID:38393811 (Source: American Family Physician)
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Mark H Ebell Source Type: research