Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Potential Drug Interactions in Terminally-Ill Cancer Patients, a Report from the Middle East
This study aims to evaluate the epidemiology of potential drug interactions in terminally-ill cancer patients receiving exclusively supportive care. In this cross-sectional study, during a 6-month follow-up, we considered the medical record of terminally-ill cancer patients referred to palliative care at the cancer center in Isfahan, Iran. Potential drug-drug interactions (DDIs) were assessed by Lexi-Interact ver.1.1 online software. During the study period, 133 terminally-ill cancer patients were recruited. We detected 1678 DDIs with moderate or major severity levels. Among them, 330, 219, 32, 1075, and 51 interactions we...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 15, 2023 Category: Palliative Care Authors: Hamed Mahzoni Erfan Naghsh Mehran Sharifi Ayda Moghaddas Mahnaz Momenzadeh Azadeh Moghaddas Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Potential Drug Interactions in Terminally-Ill Cancer Patients, a Report from the Middle East
This study aims to evaluate the epidemiology of potential drug interactions in terminally-ill cancer patients receiving exclusively supportive care. In this cross-sectional study, during a 6-month follow-up, we considered the medical record of terminally-ill cancer patients referred to palliative care at the cancer center in Isfahan, Iran. Potential drug-drug interactions (DDIs) were assessed by Lexi-Interact ver.1.1 online software. During the study period, 133 terminally-ill cancer patients were recruited. We detected 1678 DDIs with moderate or major severity levels. Among them, 330, 219, 32, 1075, and 51 interactions we...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 15, 2023 Category: Palliative Care Authors: Hamed Mahzoni Erfan Naghsh Mehran Sharifi Ayda Moghaddas Mahnaz Momenzadeh Azadeh Moghaddas Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Potential Drug Interactions in Terminally-Ill Cancer Patients, a Report from the Middle East
This study aims to evaluate the epidemiology of potential drug interactions in terminally-ill cancer patients receiving exclusively supportive care. In this cross-sectional study, during a 6-month follow-up, we considered the medical record of terminally-ill cancer patients referred to palliative care at the cancer center in Isfahan, Iran. Potential drug-drug interactions (DDIs) were assessed by Lexi-Interact ver.1.1 online software. During the study period, 133 terminally-ill cancer patients were recruited. We detected 1678 DDIs with moderate or major severity levels. Among them, 330, 219, 32, 1075, and 51 interactions we...
Source: Journal of Pain and Palliative Care Pharmacotherapy - September 15, 2023 Category: Palliative Care Authors: Hamed Mahzoni Erfan Naghsh Mehran Sharifi Ayda Moghaddas Mahnaz Momenzadeh Azadeh Moghaddas Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
