Scotland Health Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Multidisciplinary Treatment in Patients with Craniofacial, Neurocognitive, and Neuromuscular Disorders with Obstructive Sleep Apnea: A Systematic Review of the Literature
Pediatr Ann. 2024 Feb;53(2):e62-e69. doi: 10.3928/19382359-20231205-04. Epub 2024 Feb 1.ABSTRACTObstructive sleep apnea (OSA) is a respiratory disorder that has a high prevalence in patients with craniofacial, neurocognitive, and neuromuscular disorders. Currently, the treatments for this population are diverse and depend on the individual conditions of the patient and the severity of the case. However, there are no multidisciplinary dental treatment guidelines. The aim of the present study was to determine the multidisciplinary dental treatment alternatives in patients with craniofacial, neurocognitive, and neuromuscular ...
Source: Pediatric Annals - February 1, 2024 Category: Pediatrics Authors: Julian F Beltran Oscar E Ramirez Angela Carrillo Eneida L ópez Angela Su árez Lucas Guimar ães-Abreu Sonia M Restrepo-Gualteros Carlos E Rodriguez-Martinez Liliana Otero Source Type: research

Tissue ‐specific expression differences in Ras‐related GTP‐binding proteins in male rats
AbstractThe protein kinase Mechanistic Target of Rapamycin (mTOR) in Complex 1 (mTORC1) is regulated in part by the Ras-related GTP-binding proteins (Rag GTPases). Rag GTPases form a heterodimeric complex consisting of either RagA or RagB associated with either RagC or RagD and act to localize mTORC1 to the lysosomal membrane. Until recently, RagA and RagB were thought to be functionally redundant, as were RagC and RagD. However, recent research suggests that the various isoforms differentially activate mTORC1. Here, the mRNA expression and protein abundance of the Rag GTPases was compared across male rat skeletal muscle, ...
Source: Physiological Reports - February 1, 2024 Category: Physiology Authors: Gregory N. Kincheloe, Paul A. Roberson, Leonard S. Jefferson, Scot R. Kimball Tags: ORIGINAL ARTICLE Source Type: research

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization
by Stephanie E. Martinez, Amit V. Pandey, Tania E. Perez Jimenez, Zhaohui Zhu, Michael H. Court Greyhounds metabolize cytochrome P450 (CYP) 2B11 substrates more slowly than other dog breeds. However,CYP2B11 gene variants associated with decreasedCYP2B11 expression do not fully explain reduced CYP2B11 activity in this breed. P450 oxidoreductase (POR) is an essential redox partner for all CYPs. POR protein variants can enhance or repress CYP enzyme function in a CYP isoform and substrate dependent manner. The study objectives were to identify POR protein variants in greyhounds and determine their effect on coexpressed CYP2B...
Source: PLoS One - February 1, 2024 Category: Biomedical Science Authors: Stephanie E. Martinez Source Type: research

Vaccination against COVID-19 reduced the mortality risk of COVID-positive hip fracture patients to baseline levels: the nationwide data-linked IMPACT Protect study
ConclusionVaccination was associated with lower COVID-19 infection risk. Vaccinated COVID-positive patients had a similar mortality risk to COVID-negative patients, suggesting a reduced severity of infection. This study demonstrates the efficacy of vaccination in this vulnerable patient group, and presents data that will be valid in the management of future outbreaks. (Source: Osteoporosis International)
Source: Osteoporosis International - February 1, 2024 Category: Orthopaedics Source Type: research

Factors that affect powered wheelchair use for an adult population: a systematic review
CONCLUSIONS: This review demonstrates that powered wheelchair use is a multifaceted and multidisciplinary phenomenon that is dependent on numerous interconnected factors including individual adjustment, stakeholder cooperation, societal attitudes, functional performance, and environmental features. Based on the review findings, there are several applied learning outcomes and practical applications to the powered wheelchair prescription and provision.PMID:38287878 | DOI:10.1080/17483107.2024.2304122 (Source: Disability and Rehabilitation. Assistive Technology.)
Source: Disability and Rehabilitation. Assistive Technology. - January 30, 2024 Category: Rehabilitation Authors: Lucy Fishleigh Rachel Taylor Gabrielle Hale Daniel Sam Bowers Source Type: research

Prognostic value of the Scottish Inflammatory prognostic Score in patients with NSCLC expressing PD-L1  ≥ 50 % progressing on first-line pembrolizumab
Approximately 100 people die of lung cancer in the UK each day [1]. Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, accounting for 85  % of all cases. In Scotland approximately 45 % of patients diagnosed with NSCLC have stage IV disease [2]. Pembrolizumab is an established first-line treatment option for patients with advanced NSCLC expressing PD-L1 ≥ 50 %. Such high PD-L1 expression is observed in approximately 25 % of patients with advanced NSCLC screened in clinical trials [3,4]. (Source: Lung Cancer)
Source: Lung Cancer - January 28, 2024 Category: Cancer & Oncology Authors: Mark Stares, Emma Doyle, Sally Chapple, George Raynes, James MacDonald, Colin Barrie, Barry Laird, Melanie MacKean, Iain Philips Source Type: research

Dual diagnosis of epilepsy and dissociative seizures: Prescription patterns, feasibility and safety of rationalising antiseizure medication
CONCLUSIONS: Clinicians should consider the development of co-morbid DS in patients with epilepsy not responding to an escalation of ASM, especially if presenting with a new seizure type. Patients with a dual-diagnosis of epilepsy and DS, particularly those with well controlled epilepsy, are likely overtreated with ASM. Medication review in a tertiary epilepsy centre allows for safe rationalisation of ASM and likely contributes to the need for fewer hospital attendances.PMID:38277845 | DOI:10.1016/j.yebeh.2024.109661 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - January 26, 2024 Category: Neurology Authors: Andrew Whitfield Emma Leighton Heather Boagey Maria Oto Source Type: research