Co-inhibition of TGF- β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - March 20, 2024 Category: Cancer & Oncology Authors: Reshmi NairTamsin R. M. LannaganRene JackstadtAnna AndrusaiteJohn ColeCaitlin BoyneRobert J. B. NibbsOwen J. SansomSimon Millinga School of infection and immunity, University of Glasgow, Glasgow, UKb Cancer Research UK Scotland Institute, Glasgow, UKc Sch Source Type: research
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases < em > v. < /em > controls in two large population samples
CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.PMID:38497116 | DOI:10.1017/S0033291724000643 (Source: Psychological Medicine)
Source: Psychological Medicine - March 18, 2024 Category: Psychiatry Authors: Gladi Thng Xueyi Shen Aleks Stolicyn Mark J Adams Hon Wah Yeung Venia Batziou Eleanor L S Conole Colin R Buchanan Stephen M Lawrie Mark E Bastin Andrew M McIntosh Ian J Deary Elliot M Tucker-Drob Simon R Cox Keith M Smith Liana Romaniuk Heather C Whalley Source Type: research
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases < em > v. < /em > controls in two large population samples
CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.PMID:38497116 | DOI:10.1017/S0033291724000643 (Source: Psychological Medicine)
Source: Psychological Medicine - March 18, 2024 Category: Psychiatry Authors: Gladi Thng Xueyi Shen Aleks Stolicyn Mark J Adams Hon Wah Yeung Venia Batziou Eleanor L S Conole Colin R Buchanan Stephen M Lawrie Mark E Bastin Andrew M McIntosh Ian J Deary Elliot M Tucker-Drob Simon R Cox Keith M Smith Liana Romaniuk Heather C Whalley Source Type: research
Myeloablation followed by hematopoietic stem cell transplantation leads to long ‐term normalization of systemic sclerosis molecular signatures
ConclusionParalleling the observed clinical benefit, HSCT leads to durable long-term normalization of the molecular signature in SSc with completion of immune resetting to 54 months post-HSCT. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - March 18, 2024 Category: Rheumatology Authors: Nancy Wareing,
Xuan Wang,
Lynette Keyes ‐Elstein,
Ellen A. Goldmuntz,
Marka A. Lyons,
Peter McSweeney,
Daniel E. Furst,
Richard A. Nash,
Leslie J. Crofford,
Beverly Welch,
Ashley Pinckney,
Maureen D. Mayes,
Keith M. Sullivan,
Shervin Assass Tags: Brief Report Source Type: research
Rurality, healthcare and crises: Investigating experiences, differences, and changes to medical care for people living in rural areas
Health Place. 2024 Mar 16;87:103217. doi: 10.1016/j.healthplace.2024.103217. Online ahead of print.ABSTRACTHealthcare provision in rural areas is a global challenge, characterised by a dispersed patient population, difficulties in the recruitment and retention of healthcare professionals and a physical distance from hospital care. This research brings together both public and doctor perspectives to explore the experience of healthcare across rural Scotland, against the backdrop of contemporary crises, including a global pandemic and extreme weather events. We draw on two studies on rural healthcare provision to understand ...
Source: Health and Place - March 17, 2024 Category: Environmental Health Authors: Andrew S Maclaren Louise Locock Zo ë Skea Diane Sk åtun Philip Wilson Source Type: research
Rurality, healthcare and crises: Investigating experiences, differences, and changes to medical care for people living in rural areas
Health Place. 2024 Mar 16;87:103217. doi: 10.1016/j.healthplace.2024.103217. Online ahead of print.ABSTRACTHealthcare provision in rural areas is a global challenge, characterised by a dispersed patient population, difficulties in the recruitment and retention of healthcare professionals and a physical distance from hospital care. This research brings together both public and doctor perspectives to explore the experience of healthcare across rural Scotland, against the backdrop of contemporary crises, including a global pandemic and extreme weather events. We draw on two studies on rural healthcare provision to understand ...
Source: Health and Place - March 17, 2024 Category: Environmental Health Authors: Andrew S Maclaren Louise Locock Zo ë Skea Diane Sk åtun Philip Wilson Source Type: research
Rurality, healthcare and crises: Investigating experiences, differences, and changes to medical care for people living in rural areas
Health Place. 2024 Mar 16;87:103217. doi: 10.1016/j.healthplace.2024.103217. Online ahead of print.ABSTRACTHealthcare provision in rural areas is a global challenge, characterised by a dispersed patient population, difficulties in the recruitment and retention of healthcare professionals and a physical distance from hospital care. This research brings together both public and doctor perspectives to explore the experience of healthcare across rural Scotland, against the backdrop of contemporary crises, including a global pandemic and extreme weather events. We draw on two studies on rural healthcare provision to understand ...
Source: Health and Place - March 17, 2024 Category: Environmental Health Authors: Andrew S Maclaren Louise Locock Zo ë Skea Diane Sk åtun Philip Wilson Source Type: research
Rurality, healthcare and crises: Investigating experiences, differences, and changes to medical care for people living in rural areas
Health Place. 2024 Mar 16;87:103217. doi: 10.1016/j.healthplace.2024.103217. Online ahead of print.ABSTRACTHealthcare provision in rural areas is a global challenge, characterised by a dispersed patient population, difficulties in the recruitment and retention of healthcare professionals and a physical distance from hospital care. This research brings together both public and doctor perspectives to explore the experience of healthcare across rural Scotland, against the backdrop of contemporary crises, including a global pandemic and extreme weather events. We draw on two studies on rural healthcare provision to understand ...
Source: Health and Place - March 17, 2024 Category: Environmental Health Authors: Andrew S Maclaren Louise Locock Zo ë Skea Diane Sk åtun Philip Wilson Source Type: research
Rurality, healthcare and crises: Investigating experiences, differences, and changes to medical care for people living in rural areas
Health Place. 2024 Mar 16;87:103217. doi: 10.1016/j.healthplace.2024.103217. Online ahead of print.ABSTRACTHealthcare provision in rural areas is a global challenge, characterised by a dispersed patient population, difficulties in the recruitment and retention of healthcare professionals and a physical distance from hospital care. This research brings together both public and doctor perspectives to explore the experience of healthcare across rural Scotland, against the backdrop of contemporary crises, including a global pandemic and extreme weather events. We draw on two studies on rural healthcare provision to understand ...
Source: Health and Place - March 17, 2024 Category: Environmental Health Authors: Andrew S Maclaren Louise Locock Zo ë Skea Diane Sk åtun Philip Wilson Source Type: research
Integrating Shared Socioeconomic Pathway-informed adaptation into temperature-related mortality projections under climate change
Environ Res. 2024 Mar 14:118731. doi: 10.1016/j.envres.2024.118731. Online ahead of print.ABSTRACTThe extent to which populations will successfully adapt to continued warming temperatures will be a crucial factor in determining future health burdens. Previous health impact assessments of future temperature-related mortality burdens mostly disregard adaptation or make simplistic assumptions. We apply a novel evidence-based approach to model adaptation that takes into account the fact that adaptation potential is likely to vary at different temperatures. Temporal changes in age-specific mortality risk associated with low and...
Source: Environmental Research - March 16, 2024 Category: Environmental Health Authors: Kai Wan Shakoor Hajat Ruth M Doherty Zhiqiang Feng Source Type: research
Integrating Shared Socioeconomic Pathway-informed adaptation into temperature-related mortality projections under climate change
Environ Res. 2024 Mar 14:118731. doi: 10.1016/j.envres.2024.118731. Online ahead of print.ABSTRACTThe extent to which populations will successfully adapt to continued warming temperatures will be a crucial factor in determining future health burdens. Previous health impact assessments of future temperature-related mortality burdens mostly disregard adaptation or make simplistic assumptions. We apply a novel evidence-based approach to model adaptation that takes into account the fact that adaptation potential is likely to vary at different temperatures. Temporal changes in age-specific mortality risk associated with low and...
Source: Environmental Research - March 16, 2024 Category: Environmental Health Authors: Kai Wan Shakoor Hajat Ruth M Doherty Zhiqiang Feng Source Type: research
Police custody in rural Scotland: negotiating boundaries, risk and organisational change
Police custody in rural Scotland: negotiating boundaries, risk and organisational change Andrew Wooff Policing: An International Journal, Vol. ahead-of-print, No. ahead-of-print, pp.- This paper explores the challenging nexus of police custody, risk and intra-organisational boundaries in the context of a recently reformed national police service. Police custody is an often-hidden aspect of policing, away from the public gaze and scrutiny. Although there is increasing recognition of the importance of rural policing (e.g. Harkness (2020); Mawby and Yarwood (2011); Ruddell and Jones (2020); Yarwood and Wooff (2016)), there h...
Source: Policing: An International Journal of Police Strategies and Management - March 15, 2024 Category: Criminology Authors: Andrew Wooff Source Type: research
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
CONCLUSION: IS is prognostic in stage III CRC treated with FOLFOX or CAPOX, including within clinically relevant tumor subgroups. Possible variation in IS prognostic value by age and MMR status, and prediction of benefit from extended adjuvant therapy merit validation.PMID:38484206 | DOI:10.1200/JCO.23.01648 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Enric Domingo Caroline Kelly Jennifer Hay Owen Sansom Noori Maka Karin Oien Tim Iveson Mark Saunders Rachel Kerr Ian Tomlinson Joanne Edwards Andrea Harkin Marta Nowak Viktor Koelzer Alistair Easton Ioannis Boukovinas Eleni Moustou Ippokratis Messaritakis Source Type: research
