Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
CLIMAVORE: Divesting from Fish Farms Towards the Tidal Commons
AbstractIn Scotland, residents have fought open-net salmon farms and their toll on human and nonhuman bodies for decades. This paper recollects seven years of work in Skye and Raasay, two islands off the northwest coast of the country, developing strategies to divest away from salmon aquaculture. Addressing the contemporary wave of underwater clearances created by UK’s top food export industry, it unpacks the implementation of a transition into alternative horizons by embracing t he legacies of toxicity inherited from salmon extractivist industries. CLIMAVORE, a framework developed as a research-led artistic practice b...
Source: Journal of Agricultural and Environmental Ethics - March 25, 2024 Category: Medical Ethics Source Type: research
Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Investigating the Value of the 'Activate your heart Therapeutic E-intervention) randomised controlled trial
The objectives of this study are to compare the effectiveness and cost-effectiveness of the ‘Activate Your Heart’ cardiac rehabilitation programme for people with chronic stable angina compared with usual care.
Methods and analysis
ACTIVATE is a multicentre, parallel-group, two-arm, superiority, pragmatic randomised controlled trial, with recruitment from primary and secondary care centres in England and Wales and a target sample size of 518 (1:1 allocation; allocation sequence by minimisation programme with built-in random element). The study uses secure web-based allocation concealment. The two treatments wi...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Williams, N. H., Collins, B., Comerford, T. J., Dodd, S., Fisher, M., Hardwick, B., Hennessy, S., Jolly, K., Jones, I., Lane, D., Lip, G. Y. H., Morgan, E., Ralph, P., Thijssen, D., Singh, S. J. Tags: Open access, General practice / Family practice Source Type: research
Loneliness, social support, and social networks: urban –rural variation and links to wellbeing in Scotland
ConclusionOverall, findings highlight key place-based differences that inform the design of efforts to promote social connectivity and enhance wellbeing. Given that urban residents had lower wellbeing and higher levels of loneliness, coupled with evidence demonstrating the importance of close, supportive social relationships, intervention efforts that promote social connectivity in urban environments are particularly needed. (Source: Journal of Public Health)
Source: Journal of Public Health - March 25, 2024 Category: Health Management Source Type: research
An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study
Conclusions/interpretationUsing machine learning approaches, we show that insulin requirement risk can be modestly well predicted by predominantly clinical variables. Inclusion of molecular markers improves the prognostic performance beyond that of clinical variables by up to 5%. Such prognostic models could be useful for identifying people with diabetes at high risk of progressing quickly to treatment intensification.Data availabilitySummary statistics of lipidomic, proteomic and metabolomic data are available from a Shiny dashboard athttps://rhapdata-app.vital-it.ch.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 24, 2024 Category: Endocrinology Source Type: research
Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes
Conclusions/interpretationPrecision medicine approaches can facilitate effective individualised treatment choice between SGLT2i and GLP1-RA therapies, and the use of routinely collected clinical features for treatment selection could support low-cost deployment in many countries.Graphical Abstract (Source: Diabetologia)
Source: Diabetologia - March 24, 2024 Category: Endocrinology Source Type: research
Multi-omics subgroups associated with glycaemic deterioration in type 2 diabetes: an IMI-RHAPSODY Study
CONCLUSIONS: Using an unsupervised network-based fusion method on plasma lipidomics and proteomics data from two independent cohorts, we were able to identify two subgroups of T2D patients differing in terms of disease severity. The molecular signatures identified within these subgroups provide insights into disease mechanisms and possibly new prognostic markers for T2D.PMID:38510703 | PMC:PMC10951062 | DOI:10.3389/fendo.2024.1350796 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 21, 2024 Category: Genetics & Stem Cells Authors: Shiying Li Iulian Dragan Van Du T Tran Chun Ho Fung Dmitry Kuznetsov Michael K Hansen Joline W J Beulens Leen M 't Hart Roderick C Slieker Louise A Donnelly Mathias J Gerl Christian Klose Florence Mehl Kai Simons Petra J M Elders Ewan R Pearson Guy A Rutt Source Type: research
Multi-omics subgroups associated with glycaemic deterioration in type 2 diabetes: an IMI-RHAPSODY Study
CONCLUSIONS: Using an unsupervised network-based fusion method on plasma lipidomics and proteomics data from two independent cohorts, we were able to identify two subgroups of T2D patients differing in terms of disease severity. The molecular signatures identified within these subgroups provide insights into disease mechanisms and possibly new prognostic markers for T2D.PMID:38510703 | PMC:PMC10951062 | DOI:10.3389/fendo.2024.1350796 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - March 21, 2024 Category: Genetics & Stem Cells Authors: Shiying Li Iulian Dragan Van Du T Tran Chun Ho Fung Dmitry Kuznetsov Michael K Hansen Joline W J Beulens Leen M 't Hart Roderick C Slieker Louise A Donnelly Mathias J Gerl Christian Klose Florence Mehl Kai Simons Petra J M Elders Ewan R Pearson Guy A Rutt Source Type: research
Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models
Cytotherapy. 2024 Feb 24:S1465-3249(24)00058-6. doi: 10.1016/j.jcyt.2024.02.011. Online ahead of print.ABSTRACTEx vivo resting culture is a standard procedure following genome editing in hematopoietic stem and progenitor cells (HSPCs). However, prolonged culture may critically affect cell viability and stem cell function. We investigated whether varying durations of culture resting times impact the engraftment efficiency of human CD34+ HSPCs edited at the BCL11A enhancer, a key regulator in the expression of fetal hemoglobin. We employed electroporation to introduce CRISPR-Cas9 components for BCL11A enhancer editing and co...
Source: Cancer Control - March 20, 2024 Category: Cancer & Oncology Authors: Selami Demirci Muhammad B N Khan Gabriela Hinojosa Anh Le Alexis Leonard Khaled Essawi Bjorg Gudmundsdottir Xiong Liu Jing Zeng Zaina Inam Rebecca Chu Naoya Uchida Daisuke Araki Evan London Henna Butt Stacy A Maitland Daniel E Bauer Scot A Wolfe Andre Lar Source Type: research
Co-inhibition of TGF- β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - March 20, 2024 Category: Cancer & Oncology Authors: Reshmi NairTamsin R. M. LannaganRene JackstadtAnna AndrusaiteJohn ColeCaitlin BoyneRobert J. B. NibbsOwen J. SansomSimon Millinga School of infection and immunity, University of Glasgow, Glasgow, UKb Cancer Research UK Scotland Institute, Glasgow, UKc Sch Source Type: research
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases < em > v. < /em > controls in two large population samples
CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.PMID:38497116 | DOI:10.1017/S0033291724000643 (Source: Psychological Medicine)
Source: Psychological Medicine - March 18, 2024 Category: Psychiatry Authors: Gladi Thng Xueyi Shen Aleks Stolicyn Mark J Adams Hon Wah Yeung Venia Batziou Eleanor L S Conole Colin R Buchanan Stephen M Lawrie Mark E Bastin Andrew M McIntosh Ian J Deary Elliot M Tucker-Drob Simon R Cox Keith M Smith Liana Romaniuk Heather C Whalley Source Type: research
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases < em > v. < /em > controls in two large population samples
CONCLUSION: Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.PMID:38497116 | DOI:10.1017/S0033291724000643 (Source: Psychological Medicine)
Source: Psychological Medicine - March 18, 2024 Category: Psychiatry Authors: Gladi Thng Xueyi Shen Aleks Stolicyn Mark J Adams Hon Wah Yeung Venia Batziou Eleanor L S Conole Colin R Buchanan Stephen M Lawrie Mark E Bastin Andrew M McIntosh Ian J Deary Elliot M Tucker-Drob Simon R Cox Keith M Smith Liana Romaniuk Heather C Whalley Source Type: research
