The epidemiology of multiple sclerosis in the Scottish Highlands: prevalence, incidence and time to confirmed diagnosis and treatment initiation.
Publication date: Available online 28 November 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Francisco Javier Carod Artal (Source: Multiple Sclerosis and Related Disorders)
Source: Multiple Sclerosis and Related Disorders - November 28, 2020 Category: Neurology Source Type: research

Effectiveness of Alberta Family Integrated Care on infant length of stay in level II neonatal intensive care units: a cluster randomized controlled trial
Parents of infants in neonatal intensive care units (NICUs) are often unintentionally marginalized in pursuit of optimal clinical care. Family Integrated Care (FICare) was developed to support families as part... (Source: BMC Pediatrics)
Source: BMC Pediatrics - November 28, 2020 Category: Pediatrics Authors: Karen M. Benzies, Khalid Aziz, Vibhuti Shah, Peter Faris, Wanrudee Isaranuwatchai, Jeanne Scotland, Jill Larocque, Kelly J. Mrklas, Christopher Naugler, H. Thomas Stelfox, Radha Chari, Amuchou Singh Soraisham, Albert Richard Akierman, Ernest Phillipos, Ha Tags: Research article Source Type: research

The Experience of the Infant Entering Refuge (Shelter) Setting with Their Mothers After Fleeing Family Violence
AbstractAlmost nothing is known about how the infant may experience being in a women ’s Refuge (Shelter) setting with their mother after fleeing family violence, despite the high numbers of infants and young children in Refuges or Shelters. This research was concerned with exploring how the infant experienced refuge within a Refuge setting post family violence. Using a non-intrusi ve, ethically informed, ‘infant led’ approach, this research involved ten infants (aged 3 weeks to 16 months), ten mothers, and 13 staff in eight Refuges from three countries: Australia, Scotland and England. Data was ...
Source: Journal of Family Violence - November 26, 2020 Category: Psychiatry & Psychology Source Type: research

Providing a specialist nursing service to cardiac patients.
Abstract Susanne Christie, Arrhythmia Nurse Specialist, NHS Tayside (, runner-up in the Cardiovascular Nurse of the Year category of the BJN Awards 2020. PMID: 33242278 [PubMed - as supplied by publisher] (Source: British Journal of Nursing)
Source: British Journal of Nursing - November 26, 2020 Category: Nursing Authors: Christie S Tags: Br J Nurs Source Type: research

[ASAP] How Safe Is Your Playground? Analyzing Soil in Scottish Schools through a University Outreach Project
Journal of Chemical EducationDOI: 10.1021/acs.jchemed.0c00061 (Source: Journal of Chemical Education)
Source: Journal of Chemical Education - November 24, 2020 Category: Chemistry Authors: Debra Willison, Christine M. Davidson, and Fraser J. Scott Source Type: research

Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy
This cohort study uses UK Biobank data to estimate the risk for primary hepatic carcinoma and cancer-related death by HFE variant status among community-dwelling individuals of European ancestry in England, Scotland, and Wales. (Source: JAMA)
Source: JAMA - November 24, 2020 Category: General Medicine Source Type: research

Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK
by Ify R. Mordi, Benjamin K. Chan, N. David Yanez, Colin N. A. Palmer, Chim C. Lang, James D. Chalmers BackgroundThere are conflicting reports regarding the association of the macrolide antibiotic clarithromycin with cardiovascular (CV) events. A possible explanation may be that this risk is partly mediated through drug –drug interactions and only evident in at-risk populations. To the best of our knowledge, no studies have examined whether this association might be mediated via P-glycoprotein (P-gp), a major pathway for clarithromycin metabolism. The aim of this study was to examine CV risk following prescriptio n o...
Source: PLoS Medicine - November 23, 2020 Category: Internal Medicine Authors: Ify R. Mordi Source Type: research

Phytotoxicity of short-term exposure to excess zinc or copper in Scots pine seedlings in relation to growth, water status, nutrient balance, and antioxidative activity.
Abstract The toxic effects of heavy metals pose a significant threat to the productivity and stability of forest ecosystems. Changes in the agrochemical properties of polluted forest soils due to global climate changes can increase the bioavailability of previously immobilized heavy metals. To test this hypothesis, we studied the effects of short-term shock exposure to ZnSO4 (50, 150, 300 μM) or CuSO4 (2.5, 5, 10 μM) in hydroculture on 4- to 6-week-old seedlings of Scots pine (Pinus sylvestris L.) with well-developed root systems. The effects of the excess heavy metals on mineral nutrients and the functionin...
Source: Environmental Science and Pollution Research International - November 21, 2020 Category: Environmental Health Authors: Ivanov YV, Ivanova AI, Kartashov AV, Kuznetsov VV Tags: Environ Sci Pollut Res Int Source Type: research

Assessing the Impact of the Timing of a Psychiatric Diagnosis on mTBI Rehabilitation
To investigate the impact of a pre-injury psychiatric diagnosis on response to a 4-day PCS treatment in a cohort of 117 individuals with a comorbid psychiatric diagnosis. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - November 20, 2020 Category: Rehabilitation Authors: Lindsey Holbrook, Scot Hill, Alina Fong Tags: Late Breaking Research Poster Source Type: research

Assessing mTBI Treatment Protocol for Latent Subgroups
To evaluate a treatment cohort of 117 individuals with PCS and a comorbid psychiatric diagnosis (pre- or post-injury) for unique profiles of treatment response in a novel PCS treatment. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - November 20, 2020 Category: Rehabilitation Authors: Lindsey holbrook, Scot Hill, Alina Fong Tags: Late Breaking Research Poster Source Type: research

IJERPH, Vol. 17, Pages 8641: Health Literacy for Cardiac Rehabilitation: An Examination of Associated Illness Perceptions, Self-Efficacy, Motivation and Physical Activity
This study used the Health Literacy Questionnaire (HLQ) to examine the health literacy and associated health, health behaviours and psychological profiles of cardiac rehabilitation patients from a remote and rural regional programme in the Scottish Highlands. Consecutive patients referred to the service in a calendar year were sent a cross-sectional questionnaire by post. Hierarchical cluster analysis grouped respondents based on their health literacy profile, and nonparametric methods were used to analyse differences between clusters on the other measures. A total of 282 participants responded (45.7%). Respondents were ol...
Source: International Journal of Environmental Research and Public Health - November 20, 2020 Category: Environmental Health Authors: Walters Leslie Sixsmith Gorely Tags: Article Source Type: research

Mode of birth and risk of infection-related hospitalisation in childhood: A population cohort study of 7.17 million births from 4 high-income countries
by Jessica E. Miller, Raphael Goldacre, Hannah C. Moore, Justin Zeltzer, Marian Knight, Carole Morris, Sian Nowell, Rachael Wood, Kim W. Carter, Parveen Fathima, Nicholas de Klerk, Tobias Strunk, Jiong Li, Natasha Nassar, Lars H. Pedersen, David P. Burgner BackgroundThe proportion of births via cesarean section (CS) varies worldwide and in many countries exceeds WHO-recommended rates. Long-term health outcomes for children born by CS are poorly understood, but limited data suggest that CS is associated with increased infection-related hospitalisation. We investigated the relationship between mode of birth and childhood inf...
Source: PLoS Medicine - November 19, 2020 Category: Internal Medicine Authors: Jessica E. Miller Source Type: research

Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder.
h AM, Whalley HC Abstract Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD); however, the relationship between peripheral inflammation, brain structure and depression remains unclear, partly due to complexities around the use of acute/phasic inflammatory biomarkers. Here, we report the first large-scale study of both serological and methylomic signatures of CRP (considered to represent acute and chronic measures of inflammation respectively) and their associations with depression status/symptoms, and structural neuroimaging phenotypes (T1 and diffusion MRI) in a large commun...
Source: Brain, Behavior, and Immunity - November 19, 2020 Category: Neurology Authors: Green C, Shen X, Stevenson AJ, Conole ELS, Harris MA, Barbu MC, Hawkins EL, Adams MJ, Hillary RF, Lawrie SM, Evans KL, Walker RM, Morris SW, Porteous DJ, Wardlaw JM, Douglas Steele J, Waiter GD, Sandu AL, Campbell A, Marioni RE, Cox SR, Cavanagh J, McInto Tags: Brain Behav Immun Source Type: research

Outcomes of conventionally-treated systemic sclerosis patients eligible for autologous haematopoietic stem cell transplantation.
CONCLUSIONS: Wider availability and physician's early acknowledgement and referral of eligible patients for HSCT could significantly improve disease outcomes of rapidly progressive diffuse SSc patients. PMID: 33200737 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - November 18, 2020 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Osteoporosis in older adults
Osteoporosis is a symptomless disease resulting in an increased risk of low-trauma fracture, common fracture sites including the wrist, spine and hip. Comprehensive clinical guidelines for the diagnosis and treatment of osteoporosis in adults include those produced by the National Institute for Health and Care Excellence, National Osteoporosis Guideline Group and Scottish Intercollegiate Guideline Network. However, older people bear the greatest health burden from osteoporosis and the applicability to this age group of guidelines, clinical risk factors and bone mineral density (BMD) measurements must be considered. (Source: Medicine)
Source: Medicine - November 18, 2020 Category: Internal Medicine Authors: Louise Statham, Terry J. Aspray Tags: Medicine in older adults Source Type: research

Congenital hypothyroidism: Space-time clustering of thyroid dysgenesis indicates a role for environmental factors in disease etiology.
Authors: McNally R, Jones JH, Shaikh MG, Donaldson M, Blakey K, Cheetham T Abstract BACKGROUND: The etiology of most cases of congenital hypothyroidism (CHT) due to thyroid dysgenesis is unknown. If transient environmental factors can impact on thyroid gland development then clustering of cases in time and / or space may occur and this would be more likely in thyroid dysgenesis than dyshormonogenesis. METHODS: The newborn screening programme for CHT in Scotland is linked to a central database that includes case details such as post-code. The etiology of CHT is investigated in many cases of CHT using scintigraph...
Source: Thyroid : official journal of the American Thyroid Association - November 17, 2020 Category: Endocrinology Tags: Thyroid Source Type: research

Risk Factor Control and Cardiovascular Event Risk in People With Type 2 Diabetes in Primary and Secondary Prevention Settings.
Abstract BACKGROUND: To examine the association between the degree of risk factor control and cardiovascular disease (CVD) risk in type 2 diabetes and to assess if the presence of cardio-renal disease modifies these relationships. METHODS: A retrospective cohort study using data from English practices from CPRD GOLD (Clinical Practice Research Datalink) and the SCI-Diabetes dataset (Scottish Care Information-Diabetes), with linkage to hospital and mortality data. We identified 101 749 with type 2 diabetes (T2D) in CPRD matched with 378 938 controls without diabetes and 330 892 with type 2...
Source: Circulation - November 17, 2020 Category: Cardiology Authors: Wright AK, Suarez-Ortegon MF, Read SH, Kontopantelis E, Buchan I, Emsley R, Sattar N, Ashcroft DM, Wild SH, Rutter MK Tags: Circulation Source Type: research

A cluster analysis of bronchiectasis patients based on the airway immune profile.
A CLUSTER ANALYSIS OF BRONCHIECTASIS PATIENTS BASED ON THE AIRWAY IMMUNE PROFILE. Chest. 2020 Nov 17;: Authors: Perea L, Cantó E, Suarez-Cuartin G, Aliberti S, Chalmers JD, Sibila O, Vidal S Abstract BACKGROUND: Clinical heterogeneity in bronchiectasis remains a challenge to improve the appropriate targeting of therapies and patient management. Antimicrobial peptides (AMPs) have been linked to disease severity and phenotype. RESEARCH QUESTION: Can we identify clusters of patients based on the levels of AMPs, airway inflammation, tissue remodeling and damage; and to establish their relation...
Source: Chest - November 17, 2020 Category: Respiratory Medicine Authors: Perea L, Cantó E, Suarez-Cuartin G, Aliberti S, Chalmers JD, Sibila O, Vidal S Tags: Chest Source Type: research

Evaluation of the efficiency of genomic versus pedigree predictions for growth and wood quality traits in Scots pine
Genomic selection (GS) or genomic prediction is a promising approach for tree breeding to obtain higher genetic gains by shortening time of progeny testing in breeding programs. As proof-of-concept for Scots p... (Source: BMC Genomics)
Source: BMC Genomics - November 16, 2020 Category: Genetics & Stem Cells Authors: Ainhoa Calleja-Rodriguez, Jin Pan, Tomas Funda, Zhiqiang Chen, John Baison, Fikret Isik, Sara Abrahamsson and Harry X. Wu Tags: Research article Source Type: research

Scottish Pharmacy Board meeting: 8 October 2020
The Scottish Pharmacy Board discussed work on inclusion and diversity to encourage members to stand at the national pharmacy board elections, as well as careers support and ideas around changing the structure of board meetings. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - November 13, 2020 Category: Drugs & Pharmacology Source Type: research

What Proportion of Patients with Bone and Soft-Tissue Tumors Contracted Coronavirus-19 and Died From Surgical Procedures During the Initial Period of the COVID-19 Pandemic? Results From the Multicenter British Orthopaedic Oncology Society Observational Study.
Abstract BACKGROUND: Delivering uninterrupted cancer treatment to patients with musculoskeletal tumors has been essential during the rapidly evolving coronavirus 2019 (COVID-19) pandemic, as delays in management can be detrimental. Currently, the risk of contracting COVID-19 in hospitals when admitted for surgery and the susceptibility due to adjuvant therapies and associated mortality due to COVID-19 is unknown, but knowledge of these potential risks would help treating clinicians provide appropriate cancer care. QUESTIONS/PURPOSES: (1) What is the risk of hospital-acquired COVID-19 in patients with musculos...
Source: Clinical Orthopaedics and Related Research - November 13, 2020 Category: Orthopaedics Authors: Rajasekaran RB, Ashford RU, Cosker TDA, Stevenson JD, Jeys L, Pollock R, Rankin KS, Cool P, Patton JT, Whitwell D, Gibbons CLMH, Carr A, and the British Orthopaedic Oncology Society Collaborative Group* Tags: Clin Orthop Relat Res Source Type: research

Refractory Human Cutaneous Protothecosis.
Abstract A 67-year-old Scottish woman presented to her general practitioner with a subcentimeter lump between her shoulder blades. The lump was suspected to be an epidermal cyst and was excised. The patient had a history of controlled diabetes. Most summers, she spent a month near a beach resort in Mexico. The lump reappeared after 6 months within the scar area and was re- excised. Both skin excisions were performed in the primary care setting without histologic assessment. PMID: 33160443 [PubMed - in process] (Source: Skinmed)
Source: Skinmed - November 11, 2020 Category: Dermatology Authors: Allam MM, Bal AM, Allen SH, Waters A, Strick M, Elgoweini M Tags: Skinmed Source Type: research

´Feet are second class citizens`: exploring the perceptions of Scottish and Portuguese older adults about feet, falls and exercise- a qualitative study
Foot problems are likely to contribute to falls risk in older adults. Foot and ankle exercises may be beneficial, but uptake may be influenced by cultural factors. Few studies have explored the views of older ... (Source: Journal of Foot and Ankle Research)
Source: Journal of Foot and Ankle Research - November 11, 2020 Category: Podiatry Authors: Monserrat Conde, Gordon J. Hendry, Jim Woodburn and Dawn A. Skelton Tags: Research Source Type: research

Response to: Khusid, Atallah, and Gupta re: “Metabolic Syndrome Negatively Impacts Stone-Specific Quality of Life” by Lim et al.
Journal of Endourology,Volume 34, Issue 11, Page 1209-1210, November 2020. (Source: Journal of Endourology)
Source: Journal of Endourology - November 10, 2020 Category: Urology & Nephrology Authors: Jonathan R.Z. Lim Kymora B. Scotland Seth K. Bechis Roger L. Sur Stephen Y. Nakada Jodi A. Antonelli Necole M. Streeper Sri Sivalingam Davis P. Viprakasit Timothy D. Averch Jaime Landman Thomas Chi Vernon M. Pais Vincent G. Bird Sero Andonian Naeem Bhojan Source Type: research

Total aortic arch replacement and frozen elephant trunk
Objective: Aortic arch pathologies have been a surgical challenge, involving cerebral, visceral and myocardial protection. Innovative techniques including total arch replacement and frozen elephant trunk had evolved over last decades with promising mid-term outcomes. We evaluate our mid-term outcomes on total arch replacement with frozen elephant trunk and the role of timely second staged interventions. Methods: Between August 2014 and April 2020, 41 patients with aortic arch pathologies underwent total arch replacement with frozen elephant trunk with Thoraflex-Hybrid-Plexus device (Vascutek, Inchinnan, Scotland). (Source:...
Source: Seminars in Thoracic and Cardiovascular Surgery - November 9, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Jacky Y.K. Ho, Simon C.Y. Chow, Micky W.T. Kwok, Takuya Fujikawa, Randolph H.L. Wong Tags: ADULT – Original Submission Source Type: research

A need for clarity on Surgical Management of Breast Sarcoma: Scottish Sarcoma Network Guidelines and Regional Audit
Currently there are no comprehensive breast sarcoma guidelines in the UK. There is therefore a need for guidelines to clarify surgical management, which we have based on data from our regional audit, current evidence, and consensus between West of Scotland Breast Cancer and Scottish Sarcoma Managed Clinical Networks.Methods and Results:46 patients were treated with breast sarcoma in the West of Scotland from 2007 to 2019.Sarcoma Centre versus Peripheral Hospitals: Incomplete excision rate was 0% at sarcoma centre, and 50% at peripheral hospitals (p=0.0002, Odds Ratio 43). (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - November 9, 2020 Category: Cosmetic Surgery Authors: Steven Lo, Naomi Foster, Lindsay Campbell, Jeff White, Ioanna Nixon, James Mansell, Mark McCleery, Lynsey White, Fiona Cowie Source Type: research

CCR5 Inhibition in Critical COVID-19 Patients Decreases Inflammatory Cytokines, Increases CD8 T-Cells, and Decreases SARS-CoV2 RNA in Plasma by Day 14
Since the initial cases of COVID-19 were reported from Wuhan, China in December 2019 (Huang et al., 2020), SARS-CoV-2 has emerged as a global pandemic with an ever increasing number of severe and critical cases requiring invasive external ventilation that threatens to overwhelm health care systems (World Health Organization, 2020). While it remains unclear why COVID-19 patients experience a spectrum of clinical outcomes ranging from asymptomatic to severe disease, features of critical COVID-19 include rampant inflammation and cytokine release syndrome (CRS) leading to ARDS (Mehta et al., 2020, Qin et al., 2020). (Source: I...
Source: International Journal of Infectious Diseases - November 9, 2020 Category: Infectious Diseases Authors: Bruce K. Patterson, Harish Seethamraju, Kush Dhody, Michael J. Corley, Kazem Kazempour, Jay Lalezari, Alina P.S. Pang, Christopher Sugai, Eisa Mahyari, Edgar B. Francisco, Amruta Pise, Hallison Rodrigues, Helen L. Wu, Gabriela M. Webb, Byung S. Park, Scot Source Type: research

426 Use of Coronary Computed Tomographic Angiography (CCTA) for Absolute Risk Reduction in a Rapid Access Cardiology Clinic (RACC)
The RACC service within the Central Coast Local Health District utilises CCTA for quick and accurate investigation of patients discharged from the Emergency Department with low- intermediate risk chest pain. As demonstrated in the SCOT-HEART trial, CCTA identifies Coronary Artery Disease (CAD) in patients with chest pain, and facilitates appropriate and timely use of medical therapy, and supports more judicious use of invasive angiography1. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - November 8, 2020 Category: Cardiology Authors: W. Lennox-Bradley, C. Said, E. Coote, J. Mooney Source Type: research

Shape Matters: The Application of Activity ‐Based In Vitro Bioassays and Chiral Profiling to the Pharmacological Evaluation of Synthetic Cannabinoid Receptor Agonists in Drug‐Infused Papers Seized in Prisons
AbstractSynthetic cannabinoid receptor agonists (SCRAs) elicit many of their psychoactive effects via type ‐1 human cannabinoid (CB1) receptors. Enantiomer pairs of eighttert‐leucinate or valinate indole‐ and indazole‐3‐carboxamide SCRAs were synthesized and their CB1 potency and efficacy assessed using anin vitroβ‐arrestin recruitment assay in a HEK239T stable cell system. A chiral high‐performance liquid chromatography method with photodiode array and/or quadrupole‐time of flight mass spectrometry detection (HPLC‐PDA and HPLC‐PDA‐QToF‐MS) was applied to 177 SCRA infused paper samples seized i...
Source: Drug Testing and Analysis - November 8, 2020 Category: Drugs & Pharmacology Authors: Lysbeth H. Antonides, Annelies Cannaert, Caitlyn Norman, Niamh Nic Daeid, Oliver B. Sutcliffe, Christophe P. Stove, Craig McKenzie Tags: RESEARCH ARTICLE Source Type: research

Basic research and surgical techniques for brain arteriovenous malformations.
We reported the advantages of serial indocyanine green videoangiography, which is used to assess the blood flow during AVM nidus removal. Since publication of the ARUBA trial and Scottish Audit, treatments with high morbidity have not been allowed. It is especially important for neurosurgeons to treat low Spetzler-Martin grade AVMs with low morbidity. J. Med. Invest. 67 : 222-228, August, 2020. PMID: 33148892 [PubMed - in process] (Source: Journal of Medical Investigation)
Source: Journal of Medical Investigation - November 6, 2020 Category: General Medicine Tags: J Med Invest Source Type: research

Gamma radiation effects on passive silicon photonic waveguides using phase sensitive methods
Passive silicon photonic waveguides are exposed to gamma radiation to understand how the performance of silicon photonic integrated ... (Source: Optics Express)
Source: Optics Express - November 5, 2020 Category: Physics Authors: Nicholas Boynton Michael Gehl Christina Dallo Andrew Pomerene Andrew Starbuck Dana Hood Paul Dodd Scot Swanson Douglas Trotter Christopher DeRose Anthony Lentine Source Type: research

The experience of point-of-care testing for influenza in Scotland in 2017/18 and 2018/19 – no gain without pain
ConclusionThis study has shown an improvement in capture of data from influenza mPOCT and has highlighted issues that need to be addressed for results to be accurately captured in national surveillance. With the clear benefit to patient management we suggest careful consideration should be given to the connectivity aspects of the technology in order to ensure minimal impact on national surveillance. (Source: Eurosurveillance)
Source: Eurosurveillance - November 5, 2020 Category: Infectious Diseases Authors: Elizabeth M Dickson, Diogo FP Marques, Sandra Currie, Annette Little, Kirsty Mangin, Michael Coyne, Arlene Reynolds, Jim McMenamin and David Yirrell Source Type: research

Development of the voiceless sibilant fricative contrast in three-year-olds: an ultrasound and acoustic study.
Abstract The study analysed spectral and tongue shape dynamics of voiceless alveolar and postalveolar fricatives produced by ten children learning Scottish English. Synchronised ultrasound tongue imaging data and acoustic data were used to characterise children's productions of the phonemic contrast. Six children had consistently accurate productions of both fricative targets, with some cross-consonant phonetic differences in the direction previously demonstrated for older children and adults, as well as some immature acoustic and articulatory dynamic patterns. Instrumental analyses made it possible to describe to...
Source: Journal of Child Language - November 4, 2020 Category: Speech-Language Pathology Authors: Zharkova N Tags: J Child Lang Source Type: research

Contextual Health Information Behavior in the Daily Lives of People with Type 2 Diabetes: A Diary Study in Scotland
. (Source: Health Communication)
Source: Health Communication - November 2, 2020 Category: Health Management Authors: Marijke Broekhuis Lex van Velsen Dominic De Franco Alison Pease Hermie Hermens Source Type: research

PRIM1 deficiency causes a distinctive primordial dwarfism syndrome [Research Papers]
DNA replication is fundamental for cell proliferation in all organisms. Nonetheless, components of the replisome have been implicated in human disease, and here we report PRIM1 encoding the catalytic subunit of DNA primase as a novel disease gene. Using a variant classification agnostic approach, biallelic mutations in PRIM1 were identified in five individuals. PRIM1 protein levels were markedly reduced in patient cells, accompanied by replication fork asymmetry, increased interorigin distances, replication stress, and prolonged S-phase duration. Consequently, cell proliferation was markedly impaired, explaining the patien...
Source: Genes and Development - November 2, 2020 Category: Genetics & Stem Cells Authors: Parry, D. A., Tamayo-Orrego, L., Carroll, P., Marsh, J. A., Greene, P., Murina, O., Uggenti, C., Leitch, A., The Scottish Genomes Partnership, Kaposzta, R., Mero, G., Nagy, A., Orlik, B., Kovacs-Paszthy, B., Quigley, A. J., Riszter, M., Rankin, J., Reijns Tags: Research Papers Source Type: research

A rare case of dysplastic axillary artery aneurysm associated to arteriovenous malformation.
We report the case of a young man affected by a saccular axillary artery aneurysm associated to intramuscular arterio-venous malformation, without symptoms except for the presence of a pulsatile mass. Duplex scan and CT scan have been essential for a correct diagnosis and planning of the treatment. At first, the patient was submitted to coil embolization of an efferent vessel and then he was treated surgically through ligation and detachment of the aneurysm and replacement of part of the axillary artery with a Dacron graft (Vascutek, Inchinnan, Renfrewshire, Scotland, UK). (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - November 2, 2020 Category: Surgery Authors: Montanari Francesca, Codispoti Francesco Alberto, Tinelli Giovanni, Minelli Fabrizio, Tshomba Yamume Tags: Case Report Source Type: research

Transfers of remand and sentenced prisoners to hospital under the mental health (Care and Treatment) (Scotland) Act 2003
. (Source: Journal of Forensic Psychiatry and Psychology)
Source: Journal of Forensic Psychiatry and Psychology - November 1, 2020 Category: Psychiatry Authors: Unoma Okudo Source Type: research

The experience of point-of-care testing for influenza in Scotland in 2017/18 and 2018/19 - no gain without pain.
ConclusionThis study has shown an improvement in capture of data from influenza mPOCT and has highlighted issues that need to be addressed for results to be accurately captured in national surveillance. With the clear benefit to patient management we suggest careful consideration should be given to the connectivity aspects of the technology in order to ensure minimal impact on national surveillance. PMID: 33153519 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - November 1, 2020 Category: Infectious Diseases Authors: Dickson EM, Marques DF, Currie S, Little A, Mangin K, Coyne M, Reynolds A, McMenamin J, Yirrell D Tags: Euro Surveill Source Type: research

In Pursuit of a SARS-CoV-2 Vaccine
Publication date: November–December 2020Source: The Journal of Foot and Ankle Surgery, Volume 59, Issue 6Author(s): Alton R. Johnson, Adam R. McDonald, D. Scot Malay (Source: The Journal of Foot and Ankle Surgery)
Source: The Journal of Foot and Ankle Surgery - October 29, 2020 Category: Orthopaedics Source Type: research

Covid-19: 338 patients with the virus were discharged from Scottish hospitals to care homes
(Source: BMJ News)
Source: BMJ News - October 29, 2020 Category: General Medicine Source Type: research

RPS Scotland policy sets out how pharmacists can support people with mental health conditions
The Royal Pharmaceutical Society in Scotland ’s has published a policy on how pharmacists can improve care of people with mental health conditions. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - October 29, 2020 Category: Drugs & Pharmacology Source Type: research

Covid-19 Lockdown Affects Hearing Disability and Handicap in Diverse Ways: A Rapid Online Survey Study
Conclusions: With due regard for the limitations of this rapid study, we find that there are many negative—and a few positive—effects of Covid-19 restrictions and safety measures on people with hearing loss. From a societal perspective, the widespread adoption of clear face masks may alleviate some of the difficulties and anxieties this population experience. From an individual perspective, one may consider using live subtitles on video calls. Manufacturers of hearing devices should consider developing processing modes and accessories specifically designed for video calls. Finally, repair and maintenance serv...
Source: Ear and Hearing - October 29, 2020 Category: Audiology Tags: Research Articles Source Type: research

In Pursuit of a SARS-CoV-2 Vaccine
Recently, some of our patients have inquired about the availability of a vaccine for the prevention of COVID-19 disease. Currently, everyone wants to know when a safe and effective vaccine for the SARS-CoV-2 coronavirus will be ready to administer to the world's citizenry. In an effort to provide foot and ankle surgeons with information that they can use to accurately respond to their anxious patients, we are providing a synopsis of the current status or coronavirus vaccine development. (Source: Journal of Foot and Ankle Surgery)
Source: Journal of Foot and Ankle Surgery - October 29, 2020 Category: Orthopaedics Authors: Alton R. Johnson, Adam R. McDonald, D. Scot Malay Tags: Editorial Source Type: research

Clare Morrison: ‘I honestly think this is the most exciting role in pharmacy in Scotland’
Clare Morrison, the Royal Pharmaceutical Society ’s new director for Scotland, explains why being part of leading a professional body is a massive opportunity to achieve her ambitions for pharmacy in her country. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - October 28, 2020 Category: Drugs & Pharmacology Source Type: research

RPS Wales and Scotland publish manifestos ahead of 2021 devolved parliamentary elections
The Royal Pharmaceutical Society in Wales and in Scotland have published their manifestos ahead of the 2021 parliamentary elections in their respective nations. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - October 28, 2020 Category: Drugs & Pharmacology Source Type: research

What respiratory teaching is currently being delivered to pre-registration nurses in the United Kingdom?
The content of respiratory teaching and learning in pre-registration United Kingdom (UK) nursing programmes is unknown. This descriptive study examines taught respiratory skills/knowledge in UK universities.75 Universities offering pre-registration nursing in the UK were identified. Freedom of information requests were emailed asking for details on time spent teaching specific respiratory topics and skills.Data was entered from 74/75 UK Universities [58-England, 11-Scotland, 4-Wales, 2-Northern Ireland]. Within the curriculum universities spent>4 hours on respiratory anatomy and physiology (61%), respiratory pathophysio...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Roberts, N. J., Lippiett, K., Kelly, C. Tags: Nurses Source Type: research

The burden of Idiopathic Pulmonary Fibrosis (IPF): a multimodal study of prevalence, healthcare utilization and survival
Conclusion: Primary care codes may contain significant inaccuracies and national prevalence estimates based upon these are liable to significant error. IPF prevalence in our area is 48-63/100,000. CT screening identifies otherwise unrecognised or unreported IPF, with associated high mortality regardless of final diagnosis IPF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Chia, W. L., Harrison, F., Hartley, T., Szapiro, D., Dhasmana, D. Tags: Idiopathic interstitial pneumonias Source Type: research

What Tools and Resources do Pulmonary Rehabilitation Teams use to Deliver Education?
Conclusions: Research needs to identify what patients want to know, and materials should be developed to ensure patients receive the information they need to manage their condition. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Roberts, N. J., Kidd, L., Kirkwood, K., Cross, J., Partridge, M. Tags: Rehabilitation and chronic care Source Type: research

Long term follow up of antenatally detected congenital lung malformation suggests lung health is not dependent on early surgery
Conclusion: These data suggest that while lung function is reduced in a large number of school age children born with CLM, surgery in infancy does not influence long term spirometry. Parents of infants with antenatal CLM can be reassured by these long term outcomes when facing management choices. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Macleod, K. A., Burns, P., Marei, M. M., Thomson, L. Tags: Paediatric respiratory physiology and sleep Source Type: research

Quality of online information on pulmonary arterial hypertension
Conclusions: There is a relative lack of easily readable, comprehensive and transparent online patient information on PAH. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Saleh, D., Fisher, J., Provencher, S., Ryerson, C., Weatherald, J. Tags: Pulmonary hypertension Source Type: research