Enhancing clinical decision support with genomic tools in breast cancer: A Scottish perspective
CONCLUSIONS: Genomic assays offer the potential for risk-stratified decision making regarding the use of chemotherapy. They can help reduce unnecessary chemotherapy treatment and identify a subgroup of patients with more adverse genomic tumour biology. A recent publication by Health Improvement Scotland (HIS) has updated guidance on use of the RS test for NHS Scotland. It suggests to limit its use to the intermediate risk PREDICT group. Our study shows the impact of the RS test in the low and high risk PREDICT groups. The implementation across Scotland has resulted in a notable shift in practice, leading to a significant r...
Source: Breast - April 24, 2024 Category: Cancer & Oncology Authors: A L Peters P S Hall L B Jordan F Y Soh L Hannington S Makaranka G Urquhart M Vallet D Cartwright H Marashi B Elsberger Source Type: research
Community-based sustainability initiatives: the quality of relationships matter?
This study examines the role of the qualities of social relationships within 22 different community-based sustainability initiatives each framed round different types of sustainability challenges, from flooding and climate change to community development and youth engagement. Research involved 37 semi structured interviews, combined with visual techniques, to explore the qualities of different relationship from the perspective of actors actively engaged in developing and progressing initiatives with different communities across Scotland. A typology of relationship qualities (tense, pragmatic and supportive qualities) is pr...
Source: Sustainability Science - April 24, 2024 Category: Science Source Type: research
The cost-effectiveness of a bimekizumab versus IL-17A inhibitors treatment-pathway in patients with active axial spondyloarthritis in Scotland
Conclusions remained unchanged in most scenarios. Results' drivers included BASDAI50 response rate and disease management cost.CONCLUSION: The bimekizumab treatment-pathway represents a cost-effective option across the axSpA disease spectrum in Scotland. Bimekizumab is cost-effective compared to a secukinumab-pathway that includes dose up-titration, and has similar costs and QALYs to an ixekizumab-pathway.PMID:38650583 | DOI:10.1080/13696998.2024.2342209 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 23, 2024 Category: Health Management Authors: Michael F M ørup Vanessa Taieb Damon Willems Micah Rose Nikos Lyris Mark Lamotte Laetitia Gerlier Howard Thom Source Type: research
The Introduction of Magtrace Lymphatic Tracer for Axillary Sentinel Node Biopsy for Breast Cancer in a Rural Scottish District General Hospital: Initial Experience, Perspectives, Outcomes and Learning Curves
CONCLUSION: This study suggests that introducing Magtrace was feasible and safe in the context of a rural breast cancer service. A possible strategy to ameliorate the learning curve associated with these procedures is the routine dual localisation in the initial phases of performing Magtrace localisation.PMID:38653647 | DOI:10.1016/j.clbc.2024.03.013 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Chia Yew Kong Jacob Williams Niroshini Hemadasa Dermot Murphy Maria Bews-Hair Source Type: research
Are legal experts better decision makers than jurors? A psychological evaluation of the role of juries in the 21st century
Lee Curley, Till Neuhaus Journal of Criminal Psychology, Vol. ahead-of-print, No. ahead-of-print, pp.- The Scottish Government hope to pilot judge only rape trials to increase the woefully low rape conviction rates in Scotland. The reasoning is that by removing jurors, the court will be attenuating the role that rape myths and other cognitive and social biases have on conviction rates. However, a plethora of research from cognitive and social psychology, legal literature and decision-making science has shown that experts, including judges and other legal professionals, may be no less biased than laypeople. This paper aims...
Source: Journal of Criminal Psychology - April 23, 2024 Category: Criminology Authors: Lee Curley Till Neuhaus Source Type: research
Clinical practice guidelines for diagnostic and treatment of the chronic heart failure
Arch Cardiol Mex. 2024;94(Supl 1):1-74. doi: 10.24875/ACM.M24000095.ABSTRACTChronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients. This document establishes ...
Source: Archivos de Cardiologia de Mexico - April 22, 2024 Category: Cardiology Authors: Abel A Pav ía-López Jos é A Magaña-Serrano Jos é A Cigarroa-López Adolfo Ch ávez-Mendoza Jos é L Mayorga-Butrón Diego Araiza-Garaygordobil Juan B Ivey-Miranda Gustavo F M éndez-Machado H éctor González-Godínez Luisa F Aguilera-Mora Antonio Jo Source Type: research
Clinical practice guidelines for diagnostic and treatment of the chronic heart failure
Arch Cardiol Mex. 2024;94(Supl 1):1-74. doi: 10.24875/ACM.M24000095.ABSTRACTChronic heart failure continues to be one of the main causes of impairment in the functioning and quality of life of people who suffer from it, as well as one of the main causes of mortality in our country and around the world. Mexico has a high prevalence of risk factors for developing heart failure, such as high blood pressure, diabetes, and obesity, which makes it essential to have an evidence-based document that provides recommendations to health professionals involved in the diagnosis and treatment of these patients. This document establishes ...
Source: Archivos de Cardiologia de Mexico - April 22, 2024 Category: Cardiology Authors: Abel A Pav ía-López Jos é A Magaña-Serrano Jos é A Cigarroa-López Adolfo Ch ávez-Mendoza Jos é L Mayorga-Butrón Diego Araiza-Garaygordobil Juan B Ivey-Miranda Gustavo F M éndez-Machado H éctor González-Godínez Luisa F Aguilera-Mora Antonio Jo Source Type: research
Impact of the COVID-19 Pandemic on HIV Test Uptake Among People Who Inject Drugs in the Context of an HIV Outbreak
In conclusion, progress in increasing testing in response to the HIV outbreak has been eroded by COVID-19. Adoption of a linked data approach could be warranted in other settings to inform efforts to eliminate HIV transmission. (Source: AIDS and Behavior)
Source: AIDS and Behavior - April 22, 2024 Category: Infectious Diseases Source Type: research
Community antibiotic prescribing in patients with COVID-19 across three pandemic waves: a population-based study in Scotland, UK
Conclusion
Community antibiotic prescriptions in COVID-19 episodes were uncommon in this population and likelihood was associated with patient factors. The reduction over pandemic waves may represent increased knowledge regarding COVID-19 treatment and/or evolving symptomatology. (Source: BMJ Open)
Source: BMJ Open - April 19, 2024 Category: General Medicine Authors: Ciaccio, L., Donnan, P. T., Parcell, B. J., Marwick, C. A. Tags: Open access, Infectious diseases, COVID-19 Source Type: research
Outcomes of patients with Juvenile Polyposis-Hereditary Haemorrhagic Telangiectasia caused by pathogenic SMAD4 variants in a pan-Scotland cohort
European Journal of Human Genetics, Published online: 16 April 2024; doi:10.1038/s41431-024-01607-wOutcomes of patients with Juvenile Polyposis-Hereditary Haemorrhagic Telangiectasia caused by pathogenic SMAD4 variants in a pan-Scotland cohort (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - April 16, 2024 Category: Genetics & Stem Cells Authors: Madeline Pearson Ruth McGowan Philip Greene Wayne Lam Zofia Miedzybrodzka Jonathan Berg Source Type: research
'Bitesize' primary care focused education programme for GP trainees in their hospital component: an evaluation of a national teaching pilot
Educ Prim Care. 2024 Apr 14:1-5. doi: 10.1080/14739879.2024.2336218. Online ahead of print.ABSTRACTThere is need for a greater connection between General Practice and GP trainees in their hospital component of training. Currently, in Scotland, there are no national education programmes specifically designed for GP trainees during their hospital component of training. Our aim was to develop and evaluate the feasibility of a national online 'bitesize' education programme delivered live for GP trainees in their hospital component of training. The study also aims to assess the barriers to attending these teaching sessions and ...
Source: Primary Care - April 14, 2024 Category: Primary Care Authors: Tina Huang Amy Proudfoot Andrew McClarey Kirsty Abraham Jennifer Craig Source Type: research
'Bitesize' primary care focused education programme for GP trainees in their hospital component: an evaluation of a national teaching pilot
Educ Prim Care. 2024 Apr 14:1-5. doi: 10.1080/14739879.2024.2336218. Online ahead of print.ABSTRACTThere is need for a greater connection between General Practice and GP trainees in their hospital component of training. Currently, in Scotland, there are no national education programmes specifically designed for GP trainees during their hospital component of training. Our aim was to develop and evaluate the feasibility of a national online 'bitesize' education programme delivered live for GP trainees in their hospital component of training. The study also aims to assess the barriers to attending these teaching sessions and ...
Source: Education for Primary Care - April 14, 2024 Category: Primary Care Authors: Tina Huang Amy Proudfoot Andrew McClarey Kirsty Abraham Jennifer Craig Source Type: research
Gut Microbial Dysbiosis Differs in Two Distinct Cachectic Tumor-Bearing Models Consuming the Same Diet
This study assessed the effect of two cachectic-producing tumor types on the gut microbiota to determine if a similar dysbiosis could be found. In addition, it was determined if a diet containing an immunonutrient-rich food (walnuts) known to promote the growth of probiotic bacteria in the colon could alter the dysbiosis and slow cachexia. Male Fisher 344 rats were randomly assigned to a semi-purified diet with or without walnuts. Then, within each diet group, rats were further assigned randomly to a treatment group: tumor-bearing ad libitum fed (TB), non-tumor-bearing ad libitum fed (NTB-AL), and non-tumor-bearing group p...
Source: Cancer Control - April 13, 2024 Category: Cancer & Oncology Authors: Lauri O Byerley Brittany Lorenzen Hsiao-Man Chang William G Hartman Michael J Keenan Ryan Page Meng Luo Scot E Dowd Christopher M Taylor Source Type: research
