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Specialty: Cardiology
Condition: Cardiomyopathy

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Total 533 results found since Jan 2013.

The potential predictive value of cardiac mechanics for left ventricular reverse remodelling in dilated cardiomyopathy
ConclusionsPatients with LVRR had a lower LV volume index, lower LVSV index, lower LGE extent, higher LVRI, and preserved myocardial deformation in the longitudinal direction at baseline. LVRI and rGLPS at baseline were independent determinants of LVRR.
Source: ESC Heart Failure - September 12, 2023 Category: Cardiology Authors: Ao Kan, Qimin Fang, Shuhao Li, Wenying Liu, Xinwei Tao, Kaiyao Huang, Mengyao Hu, Zhaofeng Feng, Lianggeng Gong Tags: Original Article Source Type: research

Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
In this study, we investigated the anti-ferroptosis effects of suberosin (SBR; a prenylated coumarin) in diabetic Sprague Dawley rats. Further, we assessed the effects of co-administration of SBR (30 and 90 mg/kg/day) with thiazolidinedione (TZ at 15 mg/kg) to mitigate TZ-induced cardiomyopathy in diabetic rats. Our results showed that cardiac output, stroke volume, left ventricle systolic and diastolic pressures were aggravated in diabetic rats treated with TZ alone after 4 weeks. TZ treatments induced ferroptosis as well as marked histoarchitecture disarrangements in rat cardiomyocytes. The study found that optimizing vo...
Source: Cardiovascular Toxicology - September 7, 2023 Category: Cardiology Authors: Shabnoor Iqbal Farhat Jabeen Ivan Kahwa Timothy Omara Source Type: research

State-of-the-Art Review: Alcohol Septal Ablation in Hypertrophic Cardiomyopathy
The objective of this review is to provide the reader with a synopsis of percutaneous alcohol septal ablation (ASA) as an effective and time-honored treatment modality in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).Recent findingsPatients who have medically refractory symptoms of dynamic left ventricular outflow tract obstruction may benefit from septal reduction therapy including septal myectomy or ASA. ASA involves infusion of alcohol into an epicardial septal artery supplying the basal septum to generate an iatrogenic infarction and, thus, reduce outflow tract obstruction due to targeted hypo...
Source: Current Treatment Options in Cardiovascular Medicine - August 21, 2023 Category: Cardiology Source Type: research

Signaling Pathways Associated with Prior Cardiovascular Events in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. A subset of patients experience major adverse cardiovascular event (MACE) including arrhythmias, stroke, and heart failure. However, molecular mechanisms underlying MACE in HCM are still not well understood. We therefore conducted a multicenter case-control study of patients with HCM comparing those with and without prior history of MACE to identify dysregulated signaling pathways through plasma proteomics profiling.
Source: Journal of Cardiac Failure - August 7, 2023 Category: Cardiology Authors: Charlotte Lee, Lusha W. Liang, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach Reilly, Yuichi J. Shimada Source Type: research

The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
Curr Opin Lipidol. 2023 Jul 28. doi: 10.1097/MOL.0000000000000890. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis.RECENT FINDINGS: A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which leads to increased levels of bacterial lipopolysaccharide in the mucus of the small intestine and in plasma that increase systemic inflammation, and enhance dyslipidemia and aortic atherosclerosis. Decreasing LPA production in enterocytes reduces the impact of the diet. LPA signaling inhibit...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: Arnab Chattopadhyay Srinivasa T Reddy Alan M Fogelman Source Type: research

Gender Differences in Atrial Fibrosis and Cardiomyopathy Assessed by Left Atrial Low-Voltage Areas During Catheter Ablation of Atrial Fibrillation
This study aimed to delineate gender differences in the prevalence, predictors, and prognostic impact of left atrial low-voltage areas (LVAs). This observational study included 1,488 consecutive patients who underwent initial ablation for AF. Voltage mapping was performed after pulmonary vein isolation during sinus rhythm.
Source: The American Journal of Cardiology - July 21, 2023 Category: Cardiology Authors: Masaharu Masuda, Yasuhiro Matsuda, Hiroyuki Uematsu, Ayako Sugino, Hirotaka Ooka, Satoshi Kudo, Subaru Fujii, Mitsutoshi Asai, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takuya Tsujimura, Yosuke Hata, Taku Toyoshima, Naoko Higashino, Sho Source Type: research

Risk of cardioembolic ischemic events and relation to atrial fibrillation/flutter in patients with arrhythmogenic cardiomyopathy during a long-term follow-up
This study sought to determine the occurrence of cardioembolic ischemic events (CIEs) in ACM patients and to identify clinical and imaging predictors of CIEs.
Source: International Journal of Cardiology - July 21, 2023 Category: Cardiology Authors: Elisabetta Toso, Francesca De Lio, Pier Paolo Bocchino, Claudia Raineri, Francesco Fioravanti, Elena Maria Richiardi, Gianluca Marcelli, Tania Sacco, Carla Giustetto, Fiorenzo Gaita Source Type: research

EXPRESS: Magnetic resonance imaging for diagnostic workup of Embolic Stroke of Undetermined Source: a systematic review
CONCLUSION: MRI techniques allow to identify additional cardiac and vascular embolic sources and may further decrease the prevalence of patients with the diagnosis of ESUS.PMID:37435743 | DOI:10.1177/17474930231189946
Source: Atherosclerosis - July 12, 2023 Category: Cardiology Authors: Natallia Khenkina Alberto Aimo Iacopo Fabiani Pier Giorgio Masci Dimitrios Sagris Steven E Williams George Mavraganis Hui-Sheng Chen Max Wintermark Patrik Michel George Ntaios George Georgiopoulos Source Type: research

Surgical ablation in hypertrophic obstructive cardiomyopathy: What is the real deal?
Atrial fibrillation (AF) is the most common tachyarrhythmia in patients with hypertrophic obstructive cardiomyopathy (HOCM), with an estimated prevalence of approximately 20% [1]. AF is associated with malignant outcomes in patients with HOCM, with an increased risk of embolic stroke, heart failure, severe functional impairment and mortality [2]. Furthermore, AF is poorly tolerated by patients with HOCM, with increased heart failure episodes, hemodynamic instability and impaired quality of life [3].
Source: International Journal of Cardiology - July 8, 2023 Category: Cardiology Authors: Alessandra Sala, Ottavio Alfieri Tags: Editorial Source Type: research

The real world of stroke incidence in patients with hypertrophic cardiomyopathy
We have read a paper with great interest written by Fumagalli and colleagues concerning “the incidence of stroke in patients with hypertrophic cardiomyopathy (HCM) among different heart rhythm” [1]. In this paper, the authors found that stroke rates in HCM patients no prior history of atrial fibrillation (AF), stroke rates were similar in those with de novo AF or stable sinus rate (SR). And they further observed that severe left atrium dilatation was a powerful risk factor, irrespective of AF. The results provided evidence for the anticoagulation strategies to prevent stroke in patients with HCM.
Source: International Journal of Cardiology - July 7, 2023 Category: Cardiology Authors: Xinru Chen Tags: Letter to the Editor Source Type: research

Impact of comorbidities on health status measured using the Kansas City Cardiomyopathy Questionnaire in patients with HFrEF and HFpEF
ConclusionsCardiac and non-cardiac comorbidities are common in both HFrEF and HFpEF patients and most are associated with reductions in health status although the impact varied among comorbidities, by the number of comorbidities, and by HF phenotype. Treating/correcting comorbidity is a therapeutic approach that may improve the health status of patients with HF.This article is protected by copyright. All rights reserved.
Source: European Journal of Heart Failure - July 4, 2023 Category: Cardiology Authors: Mingming Yang, Toru Kondo, Carly Adamson, Jawad H. Butt, William T. Abraham, Akshay S. Desai, Karola S. Jering, Lars K øber, Mikhail N. Kosiborod, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Muthiah Vaduganathan, Michael R. Zile, Pard Tags: Research Article Source Type: research

Cardiovascular Effects of Cannabinoids
Cardiol Rev. 2023 Jun 29. doi: 10.1097/CRD.0000000000000566. Online ahead of print.ABSTRACTMarijuana is now one of the most widely used substances in the United States that has been rising in prevalence given increasing legalization and recreational and medical usage. Despite its widespread use, there have been increasing concerns regarding the cardiovascular safety of marijuana. Recent studies have found a link between marijuana use and the development of cardiovascular disease. Most notably, marijuana has been found to be associated with various cardiac complications, including atherosclerosis, myocardial infarction, str...
Source: Atherosclerosis - June 29, 2023 Category: Cardiology Authors: Andy Wang Subo Dey Sarah Subhan Jay Patel William H Frishman Wilbert S Aronow Source Type: research