Signaling Pathways Associated with Prior Cardiovascular Events in Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. A subset of patients experience major adverse cardiovascular event (MACE) including arrhythmias, stroke, and heart failure. However, molecular mechanisms underlying MACE in HCM are still not well understood. We therefore conducted a multicenter case-control study of patients with HCM comparing those with and without prior history of MACE to identify dysregulated signaling pathways through plasma proteomics profiling.

Source: Journal of Cardiac Failure - August 7, 2023 Category: Cardiology Authors: Charlotte Lee, Lusha W. Liang, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach Reilly, Yuichi J. Shimada Source Type: research