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Specialty: Cancer & Oncology
Condition: Ischemic Stroke

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Total 356 results found since Jan 2013.

Novel Oral Anticoagulant versus Warfarin in Cancer Patients with Atrial Fibrillation: An 8-Year Population-Based Cohort Study
Conclusion: In cancer patients with AF, NOAC were associated with significant reduced IS/SE, major bleeding, and ICH compared to warfarin.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Victor Chien-Chia Wu, Chun-Li Wang, Yu-Tung Huang, Wen-Ching Lan, Michael Wu, Chang-Fu Kuo, Shao-Wei Chen, Pao-Hsien Chu, Ming-Shien Wen, Chi-Ching Kuo, Shang-Hung Chang Tags: Research Paper Source Type: research

Gonadotropin-releasing hormone agonists, anti-androgens and the risk of cardio-cerebrovascular disease in prostate cancer patients: an asian population-based observational study
Conclusions: The current study based on Asian population suggests that treatment with neither GnRH agonist nor antiandrogens increases the risk of cardio-cerebrovascular disease compared to patients with ADT-naïve prostate cancer.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jong-Mi Seong, Dongho Shin, Jae Woo Sung, Shinjay Cho, Jonghyup Yang, Sungmin Kang, Hyong Woo Moon, Kyu Won Lee, U-Syn Ha Tags: Research Paper Source Type: research

A Review on the Use of Reversal Agents of Direct Oral Anticogulant Drugs in Case of Gastrointestinal Bleeding.
CONCLUSION: Although these agents have been marketed for five years (idarucizumab) and two years (andexanet alfa) respectively, and despite guidelines considering antidotes as first-line agents in treating life-threatening hemorrhage when available, these antidotes seem to gain access very slowly in the clinical practice. Cost, logistical aspects and need for plasma level determination of DOAC for an accurate therapeutic use probably have an impact on this phenomenon.. An expert multidisciplinary bleeding team should be established so as to implement international guidelines based on local resources and organization. ...
Source: Reviews on Recent Clinical Trials - June 23, 2020 Category: Cancer & Oncology Authors: Ojetti V, Saviano A, Brigida M, Saviano L, Migneco A, Franceschi F Tags: Rev Recent Clin Trials Source Type: research

Cancers, Vol. 12, Pages 1285: Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children
Conclusion: This represents the largest GWAS meta-analysis conducted to date associating SNPs to VTE in children and adolescents treated on childhood ALL protocols. Validation of these findings is needed and may then lead to patient stratification for VTE preventive interventions. As VTE hemostasis involves multiple pathways, a more powerful GWAS is needed to detect combination of variants associated with VTE.
Source: Cancers - May 18, 2020 Category: Cancer & Oncology Authors: Marion K. Mateos Morten Tulstrup Michael CJ Quinn Ruta Tuckuviene Glenn M. Marshall Ramneek Gupta Chelsea Mayoh Benjamin O. Wolthers Pasquale M. Barbaro Ellen Ruud Rosemary Sutton Pasi Huttunen Tamas Revesz Sonata S. Trakymiene Draga Barbaric Ulf Tedg år Tags: Article Source Type: research

DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues.
CONCLUSIONS: The results suggest different DNAm status of MMP24 between stable and unstable atherothrombotic carotid plaques, and between atherothrombotic stroke and controls in blood samples. PMID: 32206187 [PubMed]
Source: Oncotarget - March 26, 2020 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Oncotarget: DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques
(Impact Journals LLC) Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.
Source: EurekAlert! - Cancer - March 13, 2020 Category: Cancer & Oncology Source Type: news

Cancers, Vol. 12, Pages 616: Radiotherapy Is Associated with an Accelerated Risk of Ischemic Stroke in Oral Cavity Cancer Survivors after Primary Surgery
In conclusion, radiotherapy increased the risk of ischemic stroke by 68% and also accelerated the onset of stroke in long-term OCC survivors after primary surgery compared with matched normal controls. Secondary prevention should include stroke as a late complication in OCC survivorship programs.
Source: Cancers - March 5, 2020 Category: Cancer & Oncology Authors: Feng-Che Kuan Kuan-Der Lee Shiang-Fu Huang Ping-Tsung Chen Cih-En Huang Ting-Yao Wang Min-Chi Chen Tags: Article Source Type: research

Risk of ischemic stroke in patients with prostate cancer receiving androgen deprivation therapy in Taiwan
Androgen deprivation therapy (ADT) in the treatment of prostate cancer may be associated with an increased risk of thromboembolic disease. The aim of our study was to investigate the association of ADT in the ...
Source: BMC Cancer - December 30, 2019 Category: Cancer & Oncology Authors: Kuang-Ming Liao, Yaw-Bin Huang, Chung-Yu Chen and Chen-Chun Kuo Tags: Research article Source Type: research

Incidence rates of cardiovascular outcomes in a community ‐based population of cancer patients
ConclusionsIn a population of patients with cancer not exposed to TKIs, cardiovascular risk factors and outcomes are very common, regardless of cancer type. These data can inform the evaluation of potential excess cardiovascular risks from new interventions.
Source: Cancer Medicine - October 29, 2019 Category: Cancer & Oncology Authors: Rajeev Masson, Lina Titievsky, Douglas A. Corley, Wei Zhao, Alfredo R. Lopez, Jennifer Schneider, Jonathan G. Zaroff Tags: ORIGINAL RESEARCH Source Type: research

Retrospective study on bevacizumab in the treatment of non-small cell lung cancer with brain metastases
ConclusionsThis retrospective study shows that bevacizumab has efficacy and favorable toxicity in patients with NSCLC and brain metastases and cardiovascular disease might be a risk factor for cerebral toxicity.
Source: International Journal of Clinical Oncology - October 4, 2019 Category: Cancer & Oncology Source Type: research

439OA first in human, phase I trial of NP137, a first-in-class antibody targeting netrin-1, in patients with advanced refractory solid tumors
ConclusionsNP137 was well-tolerated, with mild to moderate IRR as the most frequent treatment-related AEs and showed encouraging signs of clinical activity. Updated data will be presented at the meeting.Clinical trial identificationNCT02977195.Legal entity responsible for the studyCentre L éon Bérard.FundingNetris Pharma.DisclosureP. Cassier: Honoraria (self), Research grant / Funding (self), Research grant / Funding (institution), Travel / Accommodation / Expenses: AstraZeneca; Research grant / Funding (institution), Travel / Accommodation / Expenses: BMS; Research grant / Funding (institution), Travel / Accommodation /...
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Accelerated Risk of Premature Ischemic Stroke in 5‐Year Survivors of Nasopharyngeal Carcinoma
Conclusion.Not only was the stroke risk in NPC survivors higher than that in the general population, but the onset age was also 10 years earlier. Future survivorship care should include ischemic stroke as a late complication, for its proper prevention and management.Implications for Practice.Nasopharyngeal carcinoma (NPC) is endemic in Taiwan, and its 5‐year survival is 65.2%. With the increased 5‐year cancer survivors, survivorship has become an important issue. However, research on NPC survivorship is very rare. To the authors’ knowledge, this is the first population‐based study on long‐term NPC survivors. This...
Source: The Oncologist - September 10, 2019 Category: Cancer & Oncology Authors: Min-Chi Chen, Feng-Che Kuan, Shiang-Fu Huang, Chang-Hsien Lu, Ping-Tsung Chen, Cih-En Huang, Ting-Yao Wang, Chih-Cheng Chen, Kuan-Der Lee Tags: Head and Neck Cancers, Health Outcomes and Economics of Cancer Care Source Type: research

Increased risk for cancer after stroke at a young age: etiological relevance or incidental finding?
ConclusionIn our cohort, young individuals aged  ≤ 55 years who suffered a stroke had twice as high risk for developing cancer within 10 years after the index event compared to the control group. Stroke might have implication regarding the subsequent development of cancer and vice versa.
Source: Journal of Cancer Research and Clinical Oncology - September 9, 2019 Category: Cancer & Oncology Source Type: research

Repurposing antimycotic ciclopirox olamine as a promising anti-ischemic stroke agent
Publication date: Available online 14 August 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Hongxuan Feng, Linghao Hu, Hongwen Zhu, Lingxue Tao, Lei Wu, Qinyuan Zhao, Yemi Gao, Qi Gong, Fei Mao, Xiaokang Li, Hu Zhou, Jian Li, Haiyan ZhangAbstractIschemic stroke is a severe disorder resulting from acute cerebral thrombosis. Here we demonstrated that post-ischemic treatment with ciclopirox olamine (CPX), a potent antifungal clinical drug, alleviated brain infarction, neurological deficits and brain edema in a classic rat model of ischemic stroke. Single dose post-ischemic administration of CPX provided a long-lasting neur...
Source: Acta Pharmaceutica Sinica B - August 15, 2019 Category: Cancer & Oncology Source Type: research

Infections Tied to Subsequent Risk for Acute Ischemic Stroke
Correlation highest for UTI; smaller - magnitude associations seen for UTI with intracerebral hemorrhage
Source: The Doctors Lounge - Oncology - June 28, 2019 Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Infections, Internal Medicine, Critical Care, Emergency Medicine, Neurology, Oncology, Urology, Journal, Source Type: news