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Specialty: Cancer & Oncology
Condition: Ischemic Stroke
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Total 356 results found since Jan 2013.
Short - Term Risk of Arterial Embolism Up in Cancer Patients
Increased risk of arterial thromboembolism, MI, ischemic stroke for cancer patients
Source: The Doctors Lounge - Oncology - August 15, 2017 Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Internal Medicine, Critical Care, Emergency Medicine, Neurology, Oncology, Journal, Source Type: news
An analysis of inpatient pediatric sickle cell disease: Incidence, costs, and outcomes
ConclusionInpatient hospitalizations for secondary manifestations of pediatric SCD were associated with significant healthcare expenditures. Patients with an increased statistical risk for death during hospitalization included Caucasians with SCD complications of ACS and VOC, and patients <1‐year‐old with ACS. Further research is needed to substantiate the associated clinical significance of these findings.
Source: Pediatric Blood and Cancer - August 12, 2017 Category: Cancer & Oncology Authors: Laura M. Bou ‐Maroun, Fabien Meta, Curtis J. Hanba, Andrew D. Campbell, Gregory A. Yanik Tags: RESEARCH ARTICLE Source Type: research
The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury.
Authors: Zhou Y, Zhou B, Tu H, Tang Y, Xu C, Chen Y, Zhao Z, Miao Z
Abstract
Mixed lineage kinase domain-like (MLKL) protein was recently found to play a critical role in necrotic cell death. To explore its role in neurological diseases, we measured MLKL protein expression after ischemia injury in a mouse model. We found that MLKL expression significantly increased 12 h after ischemia/reperfusion (I/R) injury with peak levels at 48 h. Inhibition of MLKL by intraperitoneal administration of NSA significantly reduced infarct volume and improved neurological deficits after 75 min of ischemia and 24 h of reperfusion. F...
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Circulating long-chain n-3 polyunsaturated fatty acid and incidence of stroke: a meta-analysis of prospective cohort studies.
CONCLUSIONS: Circulating LC n-3 PUFAs were linearly associated with reduced risk of stroke, especially 22:5n-3 and 22:6n-3. Such findings highlight the importance of circulating LC n-3 PUFA in the development of ischemic stroke.
PMID: 28767407 [PubMed - as supplied by publisher]
Source: Oncotarget - August 4, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Combined renin-angiotensin-aldosterone system blockade and statin therapy effectively reduces the risk of cerebrovascular accident in autosomal dominant polycystic kidney disease: a nationwide population-based cohort study.
In conclusion, ADPKD was associated with an increased risk of CVA occurrence. Combined RAAS blockade and statin therapy effectively reduces the risk of CVA in ADPKD.
PMID: 28711910 [PubMed - as supplied by publisher]
Source: Oncotarget - July 18, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron –astrocyte co-culture system through neurotrophy and neuroinflammation pathway
In conclusion, the present study demonstrates that the neuroprotective effects of d,l-PHPB were improved by astrocytes, mainly mediated by increasing the release of BDNF/NGF and attenuating inflammatory cytokines. Graphical abstract
Source: Acta Pharmaceutica Sinica B - July 15, 2017 Category: Cancer & Oncology Source Type: research
Neuroprotective effect of a novel gastrodin derivative against ischemic brain injury: involvement of peroxiredoxin and TLR4 signaling inhibition.
Authors: Mao XN, Zhou HJ, Yang XJ, Zhao LX, Kuang X, Chen C, Liu DL, Du JR
Abstract
The inhibition of extracellular inflammatory peroxiredoxin (Prx) signaling appears to be a potential therapeutic strategy for neuroinflammatory injury after acute ischemic stroke. Gastrodin (Gas) is a phenolic glycoside that is used for the treatment of cerebral ischemia, accompanied by regulation of the autoimmune inflammatory response. The present study investigated the neuroprotective effects of Gas and its derivative, Gas-D, with a focus on the potential mechanism associated with inflammatory Prx-Toll-like receptor 4 (TLR4) sign...
Source: Oncotarget - July 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Ischemic stroke after radiation therapy for pituitary adenomas: a systematic review
In conclusion, complications of cerebral ischemia after radiotherapy for pituitary adenoma are infrequently reported. Moreover, after correction for several confounders, no significant difference in ischemic stroke rate between irradiated and non-irradiated patients could be identified.
Source: Journal of Neuro-Oncology - June 28, 2017 Category: Cancer & Oncology Source Type: research
Ischemic stroke and intracranial hemorrhage in patients with recurrent glioblastoma multiforme, treated with bevacizumab
AbstractBevacizumab (BVZ), a monoclonal antibody directed against vascular endothelial growth factor (VEGF), has been suspected to increase the incidence of ischemic stroke (IS) and intracranial hemorrhage (ICH) in GBM patients. Intracranial vascular events, such as IS and ICH, were retrospectively analyzed in 364 MRI scans of 82 patients with recurrent GBM (1st/2nd/3rd relapse). Out of these 82 patients, 40 were treated with BVZ (178 scans) in addition to basic treatment, whereas 42 patients matching for age and gender received basic treatment (186 scans). Distribution of typical vascular risk factors between both groups ...
Source: Journal of Neuro-Oncology - May 29, 2017 Category: Cancer & Oncology Source Type: research
Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice
Publication date: Available online 9 May 2017 Source:Acta Pharmaceutica Sinica B Author(s): Chunyang Zhao, Weizhen Hou, Hui Lei, Longjian Huang, Shan Wang, Dandan Cui, Changhong Xing, Xiaoliang Wang, Ying Peng A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate (PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer׳s disease (AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a singl...
Source: Acta Pharmaceutica Sinica B - May 10, 2017 Category: Cancer & Oncology Source Type: research
PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction.
Authors: Huang L, Wang C, Zhao S, Ge R, Guan S, Wang JH
Abstract
Cerebral ischemia leads to neuronal death for stroke, in which the imbalance between glutamatergic neurons and GABAergic neurons toward neural excitotoxicity is presumably involved. GABAergic neurons are vulnerable to pathological factors and impaired in an early stage of ischemia. The rescue of GABAergic neurons is expected to be the strategy to reserve ischemic neuronal impairment. As protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMK-II) are activated during ischemia, we have investigated whether the inhibitions of these kinase...
Source: Oncotarget - April 27, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Pannexin1 knockout and blockade reduces ischemic stroke injury in female, but not in male mice.
Authors: Freitas-Andrade M, Bechberger JF, MacVicar BA, Viau V, Naus CC
Abstract
The membrane channel Pannexin 1 (Panx1) mediates apoptotic and inflammatory signaling cascades in injured neurons, responses previously shown to be sexually dimorphic under ischemic conditions. We tested the hypothesis that Panx1 plays an underlying role in mediating sex differences in stroke outcome responses. Middle-aged, 8-9 month old male and female wild type and Panx1 KO mice were subjected to permanent middle cerebral artery (MCA) occlusion, and infarct size and astrocyte and microglia activation were assessed 4 days later. The s...
Source: Oncotarget - April 27, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Dimethyl fumarate for ischemic stroke.
Authors: Kunze R
PMID: 28209921 [PubMed - as supplied by publisher]
Source: Oncotarget - February 18, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Abstract P2-01-23: Long-term follow-up of persistent breast dermopigmentation after sentinel lymph node identification using superparamagnetic iron oxide particles (SIENNA+(R))
Patients with breast cancer (BC) and those at high risk for BC are often reluctant to initiate Tamoxifen (Tam) due to potential adverse events (AEs) such as deep vein thrombosis (DVT), pulmonary embolus (PE), acute ischemic stroke (AIS), myocardial infarction (MI) and endometrial cancer (EC). Some decline this life saving therapy due to fear of AEs. AE rates from RCTs are low, but AE rates in the general population are not well documented.Methods: The MarketScanR database (2010-2013) was searched for patients aged 30-64 with a prescription of Tam active for more than 120 days. Patients with prior DVT, PE, AIS, MI or EC wer...
Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: K Hannebicque, L Boulanger, E Bogart, S Giard, MP Chauvet, JL Houpeau Tags: Poster Session Abstracts Source Type: research
Relationship of thyroid function with intracranial arterial stenosis and carotid atheromatous plaques in ischemic stroke patients with euthyroidism.
In conclusion, low free thyroxine levels were independently associated with carotid atheromatous plaques in ischemic stroke patients with euthyroidism, but thyroid function indicators were not associated with intracranial artery stenosis.
PMID: 28147329 [PubMed - as supplied by publisher]
Source: Oncotarget - February 3, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
